List of works - José Renato Pinto

A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C

scientific article published on 11 November 2020

A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding

scientific article

A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.

scientific article published on 12 May 2009

A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation

scientific article

Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice

scientific article

Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion.

scientific article

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C

scientific article

Analysis of the molecular pathogenesis of cardiomyopathy-causing cTnT mutants I79N, ΔE96, and ΔK210.

scientific article published on May 2013

Ca(2+) and Mg(2+) binding to weak sites of TnC C-domain induces exposure of a large hydrophobic surface that leads to loss of TnC from the thin filament

scientific article published on 9 September 2005

Cardiomyocyte nuclearity and ploidy: when is double trouble?

scientific article published on 17 July 2019

Chemical treatment of mica for atomic force microscopy can affect biological sample conformation

scientific article published in April 2004

Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo

scientific article published on 2 March 2015

Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy

scientific article

Correction to Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.

scientific article published on 24 October 2017

Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C

scientific article published on 11 March 2016

Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: a clinical, genetic, and functional approach

scientific article

Fluorescent Protein-Based Ca2+ Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin C

scientific article

Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy.

scientific article

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

scientific article published on 22 April 2008

Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy ⬇️

scientific article published on November 15, 2011

Genotype-specific pathogenic effects in human dilated cardiomyopathy.

scientific article

Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation.

scientific article

Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.

scientific article published on 4 December 2017

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

scientific article

Increases of desmin and α-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction.

scientific article published on 31 October 2015

Ionic interventions that alter the association of troponin C C-domain with the thin filaments of vertebrate striated muscle

scientific article published on 19 October 2005

Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy

scientific article (publication date: 15 August 2014)

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

scientific article

Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.

scientific article

Myofilament calcium de-sensitization and contractile uncoupling prevent pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction

scientific article published on 06 April 2013

Myosin Rod Hypophosphorylation and CB Kinetics in Papillary Muscles from a TnC-A8V KI Mouse Model.

scientific article published in April 2017

Myosin cross-bridges do not form precise rigor bonds in hypertrophic heart muscle carrying troponin T mutations.

scientific article published on 12 June 2011

Oxidative Stress in Muscle Diseases: Current and Future Therapy 2019

scientific article published on 16 April 2020

Oxidative Stress in Muscle Diseases: Current and Future Therapy.

scientific article

Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.

scientific article published on November 2014

Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy

scientific article published on 24 February 2017

Pathogenic troponin T mutants with opposing effects on myofilament Ca2+ sensitivity attenuate cardiomyopathy phenotypes in mice

scientific article published on 13 November 2018

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

scientific article published on 03 May 2022

Redox state of troponin C cysteine in the D/E helix alters the C-domain affinity for the thin filament of vertebrate striated muscle

scientific article published on 09 December 2010

S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.

scientific article

Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy

scientific article published on 01 March 2020

Strong cross-bridges potentiate the Ca(2+) affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach.

scientific article

Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle

scientific article published on 21 August 2018

Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin.

scientific article

The missing links within troponin

scientific article published on 22 December 2018

Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.

scientific article

Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction

scientific article published on 4 December 2017

Will you still need me (Ca2+ , TnT, and DHPR), will you still cleave me (calpain), when I'm 64?

scientific article published on 23 December 2016

List of works by José Renato Pinto

A comprehensive guide to genetic variants and post-translational modifications of cardiac troponin C

A dilated cardiomyopathy troponin C mutation lowers contractile force by reducing strong myosin-actin binding

A functional and structural study of troponin C mutations related to hypertrophic cardiomyopathy.

A mutation in TNNC1-encoded cardiac troponin C, TNNC1-A31S, predisposes to hypertrophic cardiomyopathy and ventricular fibrillation

Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice

Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+ Ion.

Amide hydrogens reveal a temperature-dependent structural transition that enhances site-II Ca2+-binding affinity in a C-domain mutant of cardiac troponin C

Analysis of the molecular pathogenesis of cardiomyopathy-causing cTnT mutants I79N, ΔE96, and ΔK210.

Ca(2+) and Mg(2+) binding to weak sites of TnC C-domain induces exposure of a large hydrophobic surface that leads to loss of TnC from the thin filament

Cardiomyocyte nuclearity and ploidy: when is double trouble?

Chemical treatment of mica for atomic force microscopy can affect biological sample conformation

Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo

Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy

Correction to Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.

Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C

Fetal cardiac troponin isoforms rescue the increased Ca2+ sensitivity produced by a novel double deletion in cardiac troponin T linked to restrictive cardiomyopathy: a clinical, genetic, and functional approach

Fluorescent Protein-Based Ca2+ Sensor Reveals Global, Divalent Cation-Dependent Conformational Changes in Cardiac Troponin C

Functional characterization of TNNC1 rare variants identified in dilated cardiomyopathy.

Functional consequences of the human cardiac troponin I hypertrophic cardiomyopathy mutation R145G in transgenic mice

Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy ⬇️

Genotype-specific pathogenic effects in human dilated cardiomyopathy.

Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation.

Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes.

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene

Increases of desmin and α-actinin in mouse cardiac myofibrils as a response to diastolic dysfunction.

Ionic interventions that alter the association of troponin C C-domain with the thin filaments of vertebrate striated muscle

Long term ablation of protein kinase A (PKA)-mediated cardiac troponin I phosphorylation leads to excitation-contraction uncoupling and diastolic dysfunction in a knock-in mouse model of hypertrophic cardiomyopathy

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

Myofilament Ca2+ sensitization causes susceptibility to cardiac arrhythmia in mice.

Myofilament calcium de-sensitization and contractile uncoupling prevent pause-triggered ventricular tachycardia in mouse hearts with chronic myocardial infarction

Myosin Rod Hypophosphorylation and CB Kinetics in Papillary Muscles from a TnC-A8V KI Mouse Model.

Myosin cross-bridges do not form precise rigor bonds in hypertrophic heart muscle carrying troponin T mutations.

Oxidative Stress in Muscle Diseases: Current and Future Therapy 2019

Oxidative Stress in Muscle Diseases: Current and Future Therapy.

Pathogenesis associated with a restrictive cardiomyopathy mutant in cardiac troponin T is due to reduced protein stability and greatly increased myofilament Ca2+ sensitivity.

Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy

Pathogenic troponin T mutants with opposing effects on myofilament Ca2+ sensitivity attenuate cardiomyopathy phenotypes in mice

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and nonischemic human hearts

Redox state of troponin C cysteine in the D/E helix alters the C-domain affinity for the thin filament of vertebrate striated muscle

S-Nitrosylation of Sarcomeric Proteins Depresses Myofilament Ca2+)Sensitivity in Intact Cardiomyocytes.

Sexual dimorphism in cardiac transcriptome associated with a troponin C murine model of hypertrophic cardiomyopathy

Strong cross-bridges potentiate the Ca(2+) affinity changes produced by hypertrophic cardiomyopathy cardiac troponin C mutants in myofilaments: a fast kinetic approach.

Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle

Structural and protein interaction effects of hypertrophic and dilated cardiomyopathic mutations in alpha-tropomyosin.

The missing links within troponin

Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT.

Troponin through the looking-glass: emerging roles beyond regulation of striated muscle contraction

Will you still need me (Ca2+ , TnT, and DHPR), will you still cleave me (calpain), when I'm 64?