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List of works by Albert J Fornace

A Comprehensive Metabolomic Investigation in Urine of Mice Exposed to Strontium-90.

scientific article published on 26 May 2015

A Lipidomic and Metabolomic Serum Signature from Nonhuman Primates Exposed to Ionizing Radiation.

scientific article published on 15 March 2016

A functional role for p38 MAPK in modulating mitotic transit in the absence of stress

scientific article published on 4 June 2007

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

scientific article (publication date: 13 November 1992)

A novel DNA damage-inducible transcript, gadd7, inhibits cell growth, but lacks a protein product

scientific article

A predictive toxicogenomics signature to classify genotoxic versus non-genotoxic chemicals in human TK6 cells

scientific article

AMP-activated protein kinase promotes human prostate cancer cell growth and survival

scientific article published on April 2009

ATF3 induction following DNA damage is regulated by distinct signaling pathways and over-expression of ATF3 protein suppresses cells growth

scientific article

Accelerated hematopoietic toxicity by high energy (56)Fe radiation

scientific article published on 12 December 2011

Activating p38 MAPK: new tricks for an old kinase.

scientific article

Activation of HIV type 1 long terminal repeat by ultraviolet light is serum and strain specific.

scientific article published on July 1994

Addition of metabolomics to the omics spectrum for cancer biomarker development– demonstration with the KrasG12D mouse model for pancreatic carcinoma

scientific article

Administration of ON 01210.Na after exposure to ionizing radiation protects bone marrow cells by attenuating DNA damage response

scientific article published on 20 January 2012

Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast.

scientific article published in May 2000

Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases

scientific article

Alzheimer's disease fibroblasts have normal repair of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage determined by the alkaline elution technique

scientific article published in December 1987

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

scientific article (publication date: June 2002)

An informatics approach identifying markers of chemosensitivity in human cancer cell lines.

scientific article

An information-intensive approach to the molecular pharmacology of cancer.

scientific article published on January 1997

Analysis of the mammalian gadd45 gene and its response to DNA damage

scientific article

Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin.

scientific article

Application of the TGx-28.65 transcriptomic biomarker to classify genotoxic and non-genotoxic chemicals in human TK6 cells in the presence of rat liver S9

scientific article

Atm-, p53-, and Gadd45a-deficient mice show an increased frequency of homologous recombination at different stages during development

article

BRCA1 activation of the GADD45 promoter.

scientific article published in August 2000

Boolean relationships among genes responsive to ionizing radiation in the NCI 60 ACDS.

scientific article

Casein kinase 2- and protein kinase A-regulated adenomatous polyposis coli and beta-catenin cellular localization is dependent on p38 MAPK.

scientific article

Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells

scientific article published in December 1996

Cell survival and a Gadd45-factor deficiency

scientific article published on 01 August 2003

Cells lacking CIP1/WAF1 genes exhibit preferential sensitivity to cisplatin and nitrogen mustard

article

Characterization and interlaboratory comparison of a gene expression signature for differentiating genotoxic mechanisms

scientific article published on 22 May 2009

Characterization of DNA polymerase beta mRNA: cell-cycle and growth response in cultured human cells

scientific article

Characterization of an hsp70 related clone encoding a 33 kDa protein with homology to a protein which associates with polysomes

scientific article published in October 1996

Characterization of p21Cip1/Waf1 peptide domains required for cyclin E/Cdk2 and PCNA interaction.

scientific article published on February 1996

Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

scientific article published on October 1997

Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis

scientific article published on 23 October 2005

Chemotherapeutic Targeting of p53

scientific article published on 01 January 2002

Chromatin relaxation by overexpression of mutant p53, HPV16-E6, or cyclin G transgenes.

scientific article published on July 1998

Colorectal Carcinogenesis, Radiation Quality, and the Ubiquitin-Proteasome Pathway

scientific article

Comparative Analysis of the Genetic Structure and Chromosomal Mapping of the Murine Gadd45g/CR6 Gene

article

Comparison of mouse urinary metabolic profiles after exposure to the inflammatory stressors γ radiation and lipopolysaccharide

scientific article published on 30 November 2011

Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in drinking water

scientific article

Concepts and challenges in cancer risk prediction for the space radiation environment

journal article published in 2015

Coordinate induction of metallothioneins I and II in rodent cells by UV irradiation

scientific article published on November 1988

Correspondence re: J. S. DeFrank et al., p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine. Cancer Res., 56: 5365-5368, 1996

scientific article published on 01 December 1997

Cyclobutane pyrimidine dimers in UV-DNA induce release of soluble mediators that activate the human immunodeficiency virus promoter.

scientific article

Cytokine-driven cell cycling is mediated through Cdc25A.

scientific article

DNA repair in a fanconi's anemia fibroblast cell strain ⬇️

scientific article published on January 26, 1979

DNA repair in human bronchial epithelial cells.

scientific article published in January 1982

DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein

scientific journal article

DNA single-strand breaks during repair of UV damage in human fibroblasts and abnormalities of repair in xeroderma pigmentosum ⬇️

scientific article published on January 1, 1976

DNA-damage inducible genes.

scientific article published on January 1991

DNA-damage-inducible genes in mammalian cells.

scientific article published in January 1990

DNA-protein cross-linking by chemical carcinogens in mammalian cells ⬇️

scientific article published on March 1, 1979

DNA-protein cross-linking by chromium salts

scientific article published on 01 September 1981

DNA-protein cross-linking by ultraviolet radiation in normal human and xeroderma pigmentosum fibroblasts

scientific article published on 01 June 1976

Death and decoy receptors and p53-mediated apoptosis.

scientific article

Decreased RXRα is Associated with Increased β-Catenin/TCF4 in (56)Fe-Induced Intestinal Tumors

scientific article

Deletion of XPC leads to lung tumors in mice and is associated with early events in human lung carcinogenesis

scientific article

Detection of DNA single-strand breaks during the repair of UV damage in xeroderma pigmentosum cells

scientific article published on 01 January 1983

Detection of Radiation-Exposure Biomarkers by Differential Mobility Prefiltered Mass Spectrometry (DMS-MS).

scientific article

Detection of messenger RNA from O6-methylguanine-DNA methyltransferase gene MGMT in human normal and tumor tissues

scientific article published in March 1992

Development and validation of a high-throughput transcriptomic biomarker to address 21st century genetic toxicology needs

scientific article published on 4 December 2017

Development of a metabolomic radiation signature in urine from patients undergoing total body irradiation

scientific article

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells

scientific article published on 2 March 2015

Development of urinary biomarkers for internal exposure by cesium-137 using a metabolomics approach in mice

scientific article

Differential mobility spectrometry with nanospray ion source as a compact detector for small organics and inorganics

scientific article published on September 2013

Differential responses of stress genes to low dose-rate gamma irradiation ⬇️

scientific article published on April 1, 2003

Differing sensitivity to fluorescent light in Chinese hamster cells containing equally incorporated quantities of BUdR versus IUdR

article

Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency.

scientific article

Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

scientific article published on April 1995

Distinct serum metabolomics profiles associated with malignant progression in the KrasG12D mouse model of pancreatic ductal adenocarcinoma

scientific article

Dual phosphorylation controls Cdc25 phosphatases and mitotic entry

scientific article

Editorial comment: Mutation Research Special Issue on stress responses

article

Effects of expression of p53 and Gadd45 on osmotic tolerance of renal inner medullary cells.

scientific article

Enhanced intestinal tumor multiplicity and grade in vivo after HZE exposure: mouse models for space radiation risk estimates

scientific article published on 20 May 2010

Enhancement of radiation damage in cellular DNA following unifilar substitution with iododeoxyuridine.

scientific article published on April 1990

Estimation of relative mRNA content by filter hybridization to a polyuridylic probe

scientific article published on 01 October 2000

Evidence for Distinct Kinase-Mediated Pathways in gadd Gene Responses

article

Evolution and structure of the fibrinogen genes. Random insertion of introns or selective loss?

scientific article published in September 1985

Exome Sequencing of Normal and Isogenic Transformed Human Colonic Epithelial Cells (HCECs) Reveals Novel Genes Potentially Involved in the Early Stages of Colorectal Tumorigenesis

scientific article

Exposure to heavy ion radiation induces persistent oxidative stress in mouse intestine

scientific article

Exposure to ionizing radiation causes long-term increase in serum estradiol and activation of PI3K-Akt signaling pathway in mouse mammary gland

scientific article published on 28 February 2012

Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland

scientific article published on 5 December 2012

Exposure to ionizing radiation reveals global dose- and time-dependent changes in the urinary metabolome of rat.

scientific article

Expression of the poly(ADP-ribose) polymerase gene following natural and induced DNA strand breakage and effect of hyperexpression on DNA repair.

scientific article published on January 1990

Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses.

scientific article published on June 1999

Formaldehyde damage to DNA and inhibition of DNA repair in human bronchial cells.

scientific article published in April 1983

Functional genomics as a window on radiation stress signaling

scientific article

Functional genomics of UV radiation responses in human cells

scientific article published on May 2004

G1/S arrest induced by histone deacetylase inhibitor sodium butyrate in E1A + Ras-transformed cells is mediated through down-regulation of E2F activity and stabilization of beta-catenin.

scientific article

G2/M arrest by 1,25-dihydroxyvitamin D3 in ovarian cancer cells mediated through the induction of GADD45 via an exonic enhancer

scientific article

Gadd34 functional domains involved in growth suppression and apoptosis

scientific article (publication date: 19 June 2003)

Gadd34 requirement for normal hemoglobin synthesis

scientific article published on March 2006

Gadd45 in stress signaling, cell cycle control, and apoptosis.

scientific article published on January 2013

Gadd45a acts as a modifier locus for lymphoblastic lymphoma

scientific article published on 01 May 2005

Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress ⬇️

scientific article published on November 23, 2010

Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53

scientific article published on 01 December 2002

Gadd45a regulates matrix metalloproteinases by suppressing DeltaNp63alpha and beta-catenin via p38 MAP kinase and APC complex activation

scientific article published on March 2004

Gadd45alpha regulates p38-dependent dendritic cell cytokine production and Th1 differentiation.

scientific article published in April 2007

Gamma tocotrienol, a potent radioprotector, preferentially upregulates expression of anti-apoptotic genes to promote intestinal cell survival

scientific article published on 11 August 2013

Gene expression profiles for monitoring radiation exposure.

scientific article

Generation of cancerous neural stem cells forming glial tumor by oncogenic stimulation.

scientific article

Genetic interactions between Brca1 and Gadd45a in centrosome duplication, genetic stability, and neural tube closure

scientific journal article

Genetic toxicity assessment: employing the best science for human safety evaluation Part VII: Why not start with a single test: a transformational alternative to genotoxicity hazard and risk assessment

scientific article published on 4 June 2007

Genomic instability and the role of p53 mutations in cancer cells

scientific article published on January 1, 1995

Genomic instability in Gadd45a-deficient mice

scientific article published on 01 October 1999

Genomic instability, centrosome amplification, cell cycle checkpoints and Gadd45a

scientific article

Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest

scientific article (publication date: 21 November 1992)

Global Metabolomic Identification of Long-Term Dose-Dependent Urinary Biomarkers in Nonhuman Primates Exposed to Ionizing Radiation

scientific article

Heavy ion radiation exposure triggered higher intestinal tumor frequency and greater β-catenin activation than γ radiation in APC(Min/+) mice

scientific article published on 21 March 2013

Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis

scientific article published in November 2005

High-energy particle-induced tumorigenesis throughout the gastrointestinal tract

scientific article published on 10 February 2014

Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients

scientific article

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

scientific article published on September 1994

Identification of an additional p53-responsive site in the human epidermal growth factor receptor gene promotor ⬇️

scientific article published on August 28, 1997

Identification of noninvasive biomarkers for alcohol-induced liver disease using urinary metabolomics and the Ppara-null mouse.

scientific article

Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation.

scientific article published on September 2000

Identification of serum insulin-like growth factor binding protein 1 as diagnostic biomarker for early-stage alcohol-induced liver disease

scientific article

Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein.

scientific article

Identifying radiation exposure biomarkers from mouse blood transcriptome

scientific article

Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival

scientific article published on May 2008

Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16(Ink4a)-p19(Arf) pathway

scientific article published on 29 February 2004

Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C

scientific article

Induction of BCL2 family member MCL1 as an early response to DNA damage

scientific article published in March 1997

Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents.

scientific article

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis

scientific article published on 01 December 1994

Induction of cellular p53 activity by DNA-damaging agents and growth arrest.

scientific article published on July 1993

Induction of fos RNA by DNA-damaging agents

scientific article published on 01 April 1989

Induction of gadd153 gene in G0-specific ts mutant cells at nonpermissive temperature.

scientific article published on April 1995

Induction of p53-, MDM2-, and WAF1/CIP1-like Molecules in Insect Cells by DNA-Damaging Agents ⬇️

scientific article published on April 1, 1995

Induction of stress genes by low doses of gamma rays.

scientific article published on September 1999

Inhibition of the ATR/Chk1 pathway induces a p38-dependent S-phase delay in mouse embryonic stem cells

scientific article published on 26 October 2005

Inhibition of the ligase step of excision repair by 2-chloroethyl isocyanate, a decomposition product of 1,3-bis(2-chloroethyl)-1-nitrosourea

scientific article published in April 1978

Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase

scientific article (publication date: 3 May 2001)

Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen

scientific article published on January 2008

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells.

scientific article published on 2 March 2015

Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships

scientific article published on 05 June 2013

Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen

scientific article

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

scientific article published in March 1995

Ionizing Radiation Impairs T Cell Activation by Affecting Metabolic Reprogramming

scientific article published on 15 May 2015

Isolation and characterization of the hamster gadd153 gene. Activation of promoter activity by agents that damage DNA.

scientific article

Isolation, characterization and chromosomal localization of the human GADD153 gene

scientific article published on July 15, 1992

Long-term differential changes in mouse intestinal metabolomics after γ and heavy ion radiation exposure

scientific article (publication date: 2014)

Loss of Gadd45a does not modify the pulmonary response to oxidative stress

scientific article published on 14 January 2005

Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a

scientific article

Low-ratio hybridization subtraction ⬇️

scientific article published on June 1, 1990

Mammalian genes induced by radiation; activation of genes associated with growth control.

scientific article

Measurement of M. luteus endonuclease-sensitive lesions by alkaline elution

scientific article published on 01 June 1982

Mechanisms and consequences of DNA damage processing

MetaboLyzer: a novel statistical workflow for analyzing Postprocessed LC-MS metabolomics data

scientific article

Metabolic phenotyping reveals a lipid mediator response to ionizing radiation

scientific article

Metabolomic analysis in severe childhood pneumonia in the Gambia, West Africa: findings from a pilot study

scientific article

Metabolomic and lipidomic analysis of serum from mice exposed to an internal emitter, cesium-137, using a shotgun LC-MS(E) approach

scientific article

Metabolomic profiling of urine samples from mice exposed to protons reveals radiation quality and dose specific differences

scientific article published on 13 March 2015

Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.

scientific article published in April 2002

Microarray approaches for analysis of cell cycle regulatory genes

scientific article published in January 2004

Microarray approaches for analysis of tumor suppressor gene function

article

Modulation of fatty acid and bile acid metabolism by peroxisome proliferator-activated receptor α protects against alcoholic liver disease

scientific article

Monitoring human radiation exposure by gene expression profiling: possibilities and pitfalls

scientific article published in July 2003

Mutations that affect meiosis in male mice influence the dynamics of the mid-preleptotene and bouquet stages

scientific journal article

Myc represses the growth arrest gene gadd45

article

Myc suppresses induction of the growth arrest genes gadd34, gadd45, and gadd153 by DNA-damaging agents

scientific journal article

Neural tube development requires the cooperation of p53- and Gadd45a-associated pathways

scientific article published in February 2006

New and emerging technologies for genetic toxicity testing

scientific article published on 25 August 2010

Normal repair of DNA single-strand breaks in patients with ataxia telangiectasia

scientific article published on 01 May 1980

Normal repair of ultraviolet-induced DNA damage in a hypersensitive strain of fibroblasts from a patient with Gardner's syndrome

scientific article published on 01 December 1983

Normal response of Fanconi's anemia cells to high concentrations of O2 as determined by alkaline elution

scientific article published on 01 September 1982

Nuclear factor-kappaB (NF-kappaB) is a novel positive transcriptional regulator of the oncogenic Wip1 phosphatase

scientific article

Off-target response of a Wip1 chemical inhibitor in skin keratinocytes

scientific article published on 13 September 2013

Oligomerization of human Gadd45a protein

scientific article (publication date: 19 October 2001)

PPARβ/δ modulates ethanol-induced hepatic effects by decreasing pyridoxal kinase activity.

scientific article published on 10 July 2013

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

scientific article

Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437.

scientific article published on August 1999

Protracted upregulation of leptin and IGF1 is associated with activation of PI3K/Akt and JAK2 pathway in mouse intestine after ionizing radiation exposure

scientific article

Quantitation of mitochondrial DNA in human lymphoblasts by a competitive polymerase chain reaction method: application to the study of inhibitors of mitochondrial DNA content

scientific article published on 01 December 1994

REGULATION AND CHARACTERIZATION OF THE mRNAs FOR THE A?, B? AND ? CHAINS OF FIBRINOGEN

scientific article published on 01 June 1983

Radiation metabolomics and its potential in biodosimetry

scientific article (publication date: August 2011)

Radiation metabolomics. 1. Identification of minimally invasive urine biomarkers for gamma-radiation exposure in mice

scientific article published on July 2008

Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice

scientific article published on July 2009

Radiation persistently promoted oxidative stress, activated mTOR via PI3K/Akt, and downregulated autophagy pathway in mouse intestine

scientific article

Radioprotective effects of ON 01210.Na upon oral administration

scientific article published on 11 May 2012

Rapid activation of G2/M checkpoint after hypertonic stress in renal inner medullary epithelial (IME) cells is protective and requires p38 kinase

scientific article

Recombination of parent and daughter strand DNA after UV-irradiation in mammalian cells.

scientific article published on August 1983

Recovery of mitomycin C-treated mouse 10T12 cells during confluent holding

scientific article published on 01 March 1988

Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

scientific article

Regulation of insulin-like growth factor II P3 promotor by p53: a potential mechanism for tumorigenesis.

scientific article

Regulation of the Wip1 phosphatase and its effects on the stress response.

scientific article

Regulation of translation initiation following stress.

scientific article

Relationship of DNA repair and chromosome aberrations to potentially lethal damage repair in X-irradiated mammalian cells

scientific article published on 01 January 1980

Relationship of DNA repair to chromosome aberrations, sister-chromatid exchanges and survival during liquid-holding recovery in X-irradiated mammalian cells

scientific article published on 01 May 1980

Relationship of enhanced survival during confluent holding recovery in ultraviolet-irradiated human and mouse cells to chromosome aberrations, sister chromatid exchanges, and DNA repair

scientific article published on 01 December 1982

Relative Biological Effectiveness of Energetic Heavy Ions for Intestinal Tumorigenesis Shows Male Preponderance and Radiation Type and Energy Dependence in APC(1638N/+) Mice

scientific article published on 31 October 2015

Relative biological effectiveness of 12C and 28Si radiation in C57BL/6J mice

scientific article

Repair of gamma-ray-induced DNA base damage in xeroderma pigmentosum cells

scientific article published on 01 April 1986

Repair of trans-Pt(II)diamminedichloride DNA—protein crosslinks in normal and excision-deficient human cells

scientific article published on 01 June 1982

Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism

scientific article

Role of p21Waf1/Cip1/Sdi1 in cell death and DNA repair as studied using a tetracycline-inducible system in p53-deficient cells

scientific article published on 01 April 1997

Role of retinoblastoma gene product in p53-mediated DNA damage response.

scientific article published on December 1994

Roles for p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress

scientific article published on 01 December 1998

STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation

scientific journal article

Selective paired ion contrast analysis: a novel algorithm for analyzing postprocessed LC-MS metabolomics data possessing high experimental noise

scientific article

Senescent growth arrest in mesenchymal stem cells is bypassed by Wip1-mediated downregulation of intrinsic stress signaling pathways

scientific article published on August 2009

Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells

scientific article published on 01 June 1999

Serum Dyslipidemia Is Induced by Internal Exposure to Strontium-90 in Mice, Lipidomic Profiling Using a Data-Independent Liquid Chromatography-Mass Spectrometry Approach

scientific article published on 11 August 2015

Serum Metabolomic Alterations Associated with Cesium-137 Internal Emitter Delivered in Various Dose Rates

scientific article published on 30 June 2020

Serum lipidomic analysis from mixed neutron/X-ray radiation fields reveals a hyperlipidemic and pro-inflammatory phenotype

scientific article published on 14 March 2019

Sex-dependent differences in intestinal tumorigenesis induced in Apc1638N/+ mice by exposure to γ rays

scientific article published on 13 April 2012

Signaling events controlling the molecular response to genotoxic stress.

scientific article published on January 1996

Similarity of the DNA-damage responsiveness and growth-suppressive properties of waf1/cip1 and gadd45

scientific article published on 01 May 1995

Single-copy inverted repeats associated with regional genetic duplications in gamma fibrinogen and immunoglobulin genes

scientific article

Single-strand scission and repair of DNA in mammalian cells by bleomycin ⬇️

scientific article published on October 1, 1976

Small molecule metabolite extraction strategy for improving LC/MS detection of cancer cell metabolome.

scientific article published on April 2011

Space radiation triggers persistent stress response, increases senescent signaling, and decreases cell migration in mouse intestine

article published in the Proceedings of the National Academy of Sciences of the United States of America

Stress-specific signatures: expression profiling of p53 wild-type and -null human cells

scientific article

Structure of the human gamma-fibrinogen gene. Alternate mRNA splicing near the 3' end of the gene produces gamma A and gamma B forms of gamma-fibrinogen.

scientific article published in October 1984

Surrogate tissue analysis: monitoring toxicant exposure and health status of inaccessible tissues through the analysis of accessible tissues and cells

scientific article published on January 2004

The ATF/CREB transcription factor-binding site in the polymerase beta promoter mediates the positive effect of N-methyl-N'-nitro-N-nitrosoguanidine on transcription ⬇️

scientific article published on May 1, 1991

The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression

scientific article

The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract

scientific article (publication date: 15 July 1999)

The apoptosis-associated gamma-ray response of BCL-X(L) depends on normal p53 function.

scientific article

The autoimmune suppressor Gadd45alpha inhibits the T cell alternative p38 activation pathway.

scientific article published on 27 February 2005

The complexity of radiation stress responses: analysis by informatics and functional genomics approaches.

scientific article

The dark side of light: the damaging effects of UV rays and the protective efforts of MAP kinase signaling in the epidermis

scientific article published on June 2004

The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1

scientific article

The effect of low dose rate on metabolomic response to radiation in mice

scientific article

The human toxome project

scientific article

The involvement of aryl hydrocarbon receptor in the activation of transforming growth factor-beta and apoptosis

scientific article

The p53-Regulated Cyclin G Gene Promotes Cell Growth: p53 Downstream Effectors Cyclin G and Gadd45 Exert Different Effects on Cisplatin Chemosensitivity

article

The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia

scientific article published on 01 October 1994

The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein.

scientific article published on August 1995

The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis.

scientific article

Therapeutic and space radiation exposure of mouse brain causes impaired DNA repair response and premature senescence by chronic oxidant production.

scientific article published on August 2013

Toxicogenomics: overview and potential applications for the study of non-covalent DNA interacting chemicals

scientific article published on 21 April 2007

Transforming growth factor-beta-induced apoptosis is mediated by Smad-dependent expression of GADD45b through p38 activation

scientific article

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding ⬇️

scientific article published on May 1, 1998

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding.

scientific article

Tumor Susceptibility and Apoptosis Defect in a Mouse Strain Expressing a Human p53 Transgene

scientific article published on 15 March 2006

UPLC-ESI-TOFMS-based metabolomics and gene expression dynamics inspector self-organizing metabolomic maps as tools for understanding the cellular response to ionizing radiation.

scientific article

UPLC-MS-based urine metabolomics reveals indole-3-lactic acid and phenyllactic acid as conserved biomarkers for alcohol-induced liver disease in the Ppara-null mouse model

scientific article

Ubiquitin mRNA is a major stress-induced transcript in mammalian cells

scientific article

Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1

scientific article published on 01 November 1998

Understanding gas phase modifier interactions in rapid analysis by differential mobility-tandem mass spectrometry

scientific article published on 23 January 2014

Voluntary exploratory data submissions to the US FDA and the EMA: experience and impact

scientific article published in June 2010

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

scientific article published on 01 September 2006

Wip1 abrogation decreases intestinal tumor frequency in APC(Min/+) mice irrespective of radiation quality

scientific article published on 12 August 2014

Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response

scientific article published on 11 May 2010

Wip1-expressing feeder cells retain pluripotency of co-cultured mouse embryonic stem cells under leukemia inhibitory factor-deprivated condition

scientific article published on 28 August 2010

Zap70 functions to maintain stemness of mouse embryonic stem cells by negatively regulating Jak1/Stat3/c-Myc signaling

scientific article

p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation.

scientific article

p21 controls patterning but not homologous recombination in RPE development.

scientific article

p21Waf1is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate ⬇️

scientific article published on October 26, 2010

p38 Mitogen-activated protein kinase inhibitor protects the epidermis against the acute damaging effects of ultraviolet irradiation by blocking apoptosis and inflammatory responses

scientific article published in February 2004

p38 and Chk1 kinases: different conductors for the G(2)/M checkpoint symphony

scientific article

p53 Regulates Human Insulin-Like Growth Factor II Gene Expression through Active P4 Promoter in Rhabdomyosarcoma Cells

article

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents

scientific article published in November 1994

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha

article

p53-mediated protective responses to UV irradiation.

scientific article

t4 workshop report: Pathways of Toxicity

scientific article (publication date: 2014)

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