List of works - Maria Grazia Perrone

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators

scientific article published on 2 February 2008

4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes

scholarly article in RSC Advances, vol. 5 no. 58, 2015

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

scientific article published on 01 December 2020

A benzopyrane derivative as a P-glycoprotein stimulator: a potential agent to decrease β-amyloid accumulation in Alzheimer's disease

scientific article

A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists

scientific article

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments

scientific article published on 16 May 2013

Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity.

scientific article

Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition

scientific article published on 25 January 2012

General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model

scientific article published on 28 February 2015

In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: a new drug target for hypertension?

scientific article published in January 2012

Mucoadhesive Properties and Interaction with P-Glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study

scientific article published on 24 February 2014

Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors

scientific article

Myogenic effect of SP-1f and SP-1h two novel β3-adrenoceptor (β3-AR) agonists in human colonic circular smooth muscle.

scientific article published on 22 November 2013

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters

scientific article

New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands

scientific article published on 03 April 2018

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

scientific article

Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp

scientific article published on 5 January 2013

SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.

scientific article

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity

scientific article published on 21 February 2014

Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.

scientific article published on 2 January 2014

Selective COX-1 inhibition: A therapeutic target to be reconsidered.

scientific article published on January 2010

Selective Cyclooxygenase-1 Inhibition by P6 and Gastrotoxicity: Preliminary Investigation

scientific article published on 09 January 2015

Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.

scientific article

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

scientific article

Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.

scientific article

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

scientific article

Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors

scientific article published on 16 May 2013

The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists.

scientific article published in December 2009

Upregulation of β 3 -Adrenergic Receptor mRNA in Human Colon Cancer: A Preliminary Study

scientific article published on 14 October 2008

β(3)-Adrenoceptor ligand development history through patent review

scientific article published on 17 March 2011

List of works by Maria Grazia Perrone

4-Biphenyl and 2-naphthyl substituted 6,7-dimethoxytetrahydroisoquinoline derivatives as potent P-gp modulators

4-Nitro-2,1,3-benzoxadiazole derivatives as potential fluorescent sigma receptor probes

6,7-Dimethoxy-2-phenethyl-1,2,3,4-tetrahydroisoquinoline amides and corresponding ester isosteres as multidrug resistance reversers

A benzopyrane derivative as a P-glycoprotein stimulator: a potential agent to decrease β-amyloid accumulation in Alzheimer's disease

A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of beta3-adrenergic receptor agonists

Activity-lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments

Arylamino Esters As P-Glycoprotein Modulators: SAR Studies to Establish Requirements for Potency and Selectivity.

Diarylheterocycle Core Ring Features Effect in Selective COX-1 Inhibition

General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model

In-vivo administration of CLC-K kidney chloride channels inhibitors increases water diuresis in rats: a new drug target for hypertension?

Mucoadhesive Properties and Interaction with P-Glycoprotein (P-gp) of Thiolated-Chitosans and -Glycol Chitosans and Corresponding Parent Polymers: A Comparative Study

Multi-drug-resistance-reverting agents: 2-aryloxazole and 2-arylthiazole derivatives as potent BCRP or MRP1 inhibitors

Myogenic effect of SP-1f and SP-1h two novel β3-adrenoceptor (β3-AR) agonists in human colonic circular smooth muscle.

Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters

New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands

PET radiotracer [¹⁸F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: preliminary investigation.

Potent and selective tariquidar bioisosters as potential PET radiotracers for imaging P-gp

SAR studies on tetrahydroisoquinoline derivatives: the role of flexibility and bioisosterism to raise potency and selectivity toward P-glycoprotein.

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity

Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.

Selective COX-1 inhibition: A therapeutic target to be reconsidered.

Selective Cyclooxygenase-1 Inhibition by P6 and Gastrotoxicity: Preliminary Investigation

Selective κ opioid antagonists nor-BNI, GNTI and JDTic have low affinities for non-opioid receptors and transporters.

Small P-gp modulating molecules: SAR studies on tetrahydroisoquinoline derivatives

Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.

Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels

Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors

The tertiary amine nitrogen atom of piperazine sulfonamides as a novel determinant of potent and selective beta3-adrenoceptor agonists.

Upregulation of β 3 -Adrenergic Receptor mRNA in Human Colon Cancer: A Preliminary Study

β(3)-Adrenoceptor ligand development history through patent review