List of works - Lennart Lindbom

A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors

scientific article published in October 2006

ACE inhibition lowers angiotensin-II-induced monocyte adhesion to HUVEC by reduction of p65 translocation and AT 1 expression

scientific article published on 5 August 2005

An approach for studies of mediator-induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery.

scientific article

An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis.

scientific article

Anesthesia aggravates lung damage and precipitates hypotension in endotoxemic sheep ⬇️

scientific article published on October 1, 2010

Cathelicidin LL-37 induces angiogenesis via PGE2-EP3 signaling in endothelial cells, in vivo inhibition by aspirin

scientific article published on 13 June 2013

Characteristics of histamine‐induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery ⬇️

scientific article published on February 1, 1998

Cytokine-induced leukocyte rolling in mouse cremaster muscle arterioles in P-selectin dependent

scientific article published on 01 April 1997

Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities

scientific article published on 06 December 2008

Direct observations in vivo on the role of endothelial selectins and alpha(4) integrin in cytokine-induced leukocyte-endothelium interactions in the mouse aorta

scientific article published on 01 March 2000

Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins

scientific article published on 01 May 2001

Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice.

scientific article published on 14 May 2010

Effective treatment of mouse experimental colitis by alpha 2 integrin antibody: comparison with alpha 4 antibody and conventional therapy

scientific article published on 15 October 2012

Engagement of beta2 integrins induces surface expression of beta1 integrin receptors in human neutrophils

scientific article published on 01 October 2000

Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

scientific article

Heparin binding protein in patients with acute respiratory failure treated with granulocyte colony-stimulating factor (filgrastim) – a prospective, placebo-controlled, double-blind study ⬇️

scientific article published on January 30, 2013

Heparin-binding protein (HBP) in critically ill patients with influenza A(H1N1) infection

scientific article

Heparin-binding protein (HBP): an early marker of respiratory failure after trauma?

scientific article published on 16 January 2013

Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema?

scientific article published on 11 March 2014

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

scientific article published on 01 October 2001

Histamine potentiates leukotriene B4-induced leukocyte adhesion: a potential role of histamine1-receptor antagonism in allergic leukocyte recruitment

scientific article published on 01 January 1997

Imaging inflammatory plasma leakage in vivo

scientific article published on 24 March 2011

Immune cell recruitment to inflammatory loci is impaired in mice deficient in basement membrane protein laminin alpha4.

scientific article

Impaired leucocyte rolling, adhesion and transendothelial migration following cuprophane haemodialysis

scientific article published on 01 April 1997

Impaired release of antimicrobial peptides into nasal fluid of hyper-IgE and CVID patients

scientific article

Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo.

scientific article published on July 2001

In vivo rolling and endothelial selectin binding of mononuclear leukocytes is distinct from that of polymorphonuclear cells ⬇️

scientific article published on November 1, 1997

Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections ⬇️

scientific article published on June 13, 2012

Influence of local haemodynamics on leucocyte rolling and chemoattractant-induced firm adhesion in microvessels of the rat mesentery

scientific article published on 01 March 1999

Inhibitory effect of locally administered heparin on leukocyte rolling and chemoattractant‐induced firm adhesion in rat mesenteric venules in vivo ⬇️

scientific article published on November 1, 1997

Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue

scientific journal article

Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice

scientific article published in March 2006

Interactions between leukotrienes and other inflammatory mediators/modulators in the microvasculature.

scientific article

Kinetics of leukocyte-induced changes in endothelial barrier function.

scientific article published on November 1998

Laser-Doppler perfusion imaging of microvascular blood flow in rabbit tenuissimus muscle.

scientific article published on October 1995

Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin).

scientific article published on 16 January 2009

M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage

scientific article published in February 2004

Mechanisms underlying neutrophil-mediated monocyte recruitment

scientific article published on 20 August 2009

Microvascular actions of histamine: synergism with leukotriene B4 and role in allergic leucocyte recruitment

scientific article published on 01 April 1997

Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein

scientific article published on 05 March 2008

Neutrophil granule proteins tune monocytic cell function

scientific article published on 21 August 2009

Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages

scientific article

Neutrophil secretion products pave the way for inflammatory monocytes

scientific article

Neutrophil secretion products regulate anti-bacterial activity in monocytes and macrophages

scientific article

Neutrophil-derived cathelicidin promotes adhesion of classical monocytes

scientific article published on 02 January 2013

Neutrophil-derived heparin binding protein--a mediator of increased vascular permeability after burns?

scientific article published on 27 May 2009

Phagocyte partnership during the onset and resolution of inflammation.

scientific article published on June 2010

Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases

scientific article published on 3 March 2009

Regulation of vascular permeability by neutrophils in acute inflammation.

scientific article

Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system.

scientific article published on November 2000

Signaling via beta(2) integrins triggers neutrophil-dependent alteration in endothelial barrier function.

scientific article

Spontaneous leukocyte rolling in rat and mouse microvessels is independent of mast cell activity

scientific article published on 01 July 2000

The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia

scientific article published in April 2011

The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations

scientific article (publication date: November 2000)

Treatment with an anti-CD18 monoclonal antibody in rabbits inhibits pneumococcal-induced leukocyte recruitment in the skin, but not in the meninges

scientific article published on 03 April 2002

Tumor cell arrest in the microcirculation: lack of evidence for a leukocyte-like rolling adhesive interaction with vascular endothelium in vivo

scientific article published on 01 April 1997

β1 Integrins Are Critically Involved in Neutrophil Locomotion in Extravascular Tissue In Vivo ⬇️

scientific article published on June 15, 1998

List of works by Lennart Lindbom

A novel class of potent nonglycosidic and nonpeptidic pan-selectin inhibitors

ACE inhibition lowers angiotensin-II-induced monocyte adhesion to HUVEC by reduction of p65 translocation and AT 1 expression

An approach for studies of mediator-induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery.

An endothelial laminin isoform, laminin 8 (alpha4beta1gamma1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis.

Anesthesia aggravates lung damage and precipitates hypotension in endotoxemic sheep ⬇️

Cathelicidin LL-37 induces angiogenesis via PGE2-EP3 signaling in endothelial cells, in vivo inhibition by aspirin

Characteristics of histamine‐induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery ⬇️

Cytokine-induced leukocyte rolling in mouse cremaster muscle arterioles in P-selectin dependent

Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, *OH scavenging and anti-adhesive activities

Direct observations in vivo on the role of endothelial selectins and alpha(4) integrin in cytokine-induced leukocyte-endothelium interactions in the mouse aorta

Direct viewing of atherosclerosis in vivo: plaque invasion by leukocytes is initiated by the endothelial selectins

Distinct infiltration of neutrophils in lesion shoulders in ApoE-/- mice.

Effective treatment of mouse experimental colitis by alpha 2 integrin antibody: comparison with alpha 4 antibody and conventional therapy

Engagement of beta2 integrins induces surface expression of beta1 integrin receptors in human neutrophils

Eoxins are proinflammatory arachidonic acid metabolites produced via the 15-lipoxygenase-1 pathway in human eosinophils and mast cells

Heparin binding protein in patients with acute respiratory failure treated with granulocyte colony-stimulating factor (filgrastim) – a prospective, placebo-controlled, double-blind study ⬇️

Heparin-binding protein (HBP) in critically ill patients with influenza A(H1N1) infection

Heparin-binding protein (HBP): an early marker of respiratory failure after trauma?

Heparin-binding protein (HBP/CAP37) - a link to endothelin-1 in endotoxemia-induced pulmonary oedema?

Heparin-binding protein (HBP/CAP37): A missing link in neutrophil-evoked alteration of vascular permeability

Histamine potentiates leukotriene B4-induced leukocyte adhesion: a potential role of histamine1-receptor antagonism in allergic leukocyte recruitment

Imaging inflammatory plasma leakage in vivo

Immune cell recruitment to inflammatory loci is impaired in mice deficient in basement membrane protein laminin alpha4.

Impaired leucocyte rolling, adhesion and transendothelial migration following cuprophane haemodialysis

Impaired release of antimicrobial peptides into nasal fluid of hyper-IgE and CVID patients

Importance of primary capture and L-selectin-dependent secondary capture in leukocyte accumulation in inflammation and atherosclerosis in vivo.

In vivo rolling and endothelial selectin binding of mononuclear leukocytes is distinct from that of polymorphonuclear cells ⬇️

Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections ⬇️

Influence of local haemodynamics on leucocyte rolling and chemoattractant-induced firm adhesion in microvessels of the rat mesentery

Inhibitory effect of locally administered heparin on leukocyte rolling and chemoattractant‐induced firm adhesion in rat mesenteric venules in vivo ⬇️

Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue

Integrin alpha2beta1 regulates neutrophil recruitment and inflammatory activity in experimental colitis in mice

Interactions between leukotrienes and other inflammatory mediators/modulators in the microvasculature.

Kinetics of leukocyte-induced changes in endothelial barrier function.

Laser-Doppler perfusion imaging of microvascular blood flow in rabbit tenuissimus muscle.

Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin).

M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage

Mechanisms underlying neutrophil-mediated monocyte recruitment

Microvascular actions of histamine: synergism with leukotriene B4 and role in allergic leucocyte recruitment

Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein

Neutrophil granule proteins tune monocytic cell function

Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages

Neutrophil secretion products pave the way for inflammatory monocytes

Neutrophil secretion products regulate anti-bacterial activity in monocytes and macrophages

Neutrophil-derived cathelicidin promotes adhesion of classical monocytes

Neutrophil-derived heparin binding protein--a mediator of increased vascular permeability after burns?

Phagocyte partnership during the onset and resolution of inflammation.

Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases

Regulation of vascular permeability by neutrophils in acute inflammation.

Severe lung lesions caused by Salmonella are prevented by inhibition of the contact system.

Signaling via beta(2) integrins triggers neutrophil-dependent alteration in endothelial barrier function.

Spontaneous leukocyte rolling in rat and mouse microvessels is independent of mast cell activity

The effects of isoflurane anesthesia and mechanical ventilation on renal function during endotoxemia

The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations

Treatment with an anti-CD18 monoclonal antibody in rabbits inhibits pneumococcal-induced leukocyte recruitment in the skin, but not in the meninges

Tumor cell arrest in the microcirculation: lack of evidence for a leukocyte-like rolling adhesive interaction with vascular endothelium in vivo

β1 Integrins Are Critically Involved in Neutrophil Locomotion in Extravascular Tissue In Vivo ⬇️