List of works - David Touboul

A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits

scientific article

A simple model for exploring conformation of highly-charged electrosprayed single-stranded oligonucleotides

scientific article published on 20 November 2008

An Integrative Approach to Decipher the Chemical Antagonism between the Competing Endophytes Paraconiothyrium variabile and Bacillus subtilis.

scientific article

Animal urine as painting materials in African rock art revealed by cluster ToF-SIMS mass spectrometry imaging.

scientific article

Annotation and quantification of N-acyl homoserine lactones implied in bacterial quorum sensing by supercritical-fluid chromatography coupled with high-resolution mass spectrometry

scientific article published on 09 January 2020

Antiparasitic Ovalicin Derivatives from Pseudallescheria boydii, a Mutualistic Fungus of French Guiana Termites ⬇️

scientific article published on 11 February 2022

Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach

scientific article published on 25 January 2019

Argon cluster ion source evaluation on lipid standards and rat brain tissue samples

scientific article published on 07 August 2013

Atmospheric pressure glow discharge desorption mass spectrometry for rapid screening of pesticides in food

scientific article

Atmospheric pressure photoionization as a powerful tool for large-scale lipidomic studies

scientific article

Atmospheric pressure photoionization coupled to porous graphitic carbon liquid chromatography for the analysis of globotriaosylceramides. Application to Fabry disease

scientific article

Bioactive natural products prioritization using massive multi-informational molecular networks

scientific article

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.

scientific article published on 2 March 2018

Biological tissue imaging with time-of-flight secondary ion mass spectrometry and cluster ion sources

scientific article published in August 2005

Biomedical studies by TOF-SIMS imaging.

scientific article

Changes of phospholipid composition within the dystrophic muscle by matrix-assisted laser desorption/ionization mass spectrometry and mass spectrometry imaging.

scientific article published in January 2004

Characterization of alpha-parvalbumin on muscle tissue sections by in situ calcium attachment

scientific article published on 01 January 2007

Chemical cross-linking with NHS esters: a systematic study on amino acid reactivities

scientific article

Chiral calcium-BINOL phosphate catalyzed diastereo- and enantioselective synthesis of syn-1,2-disubstituted 1,2-diamines: scope and mechanistic studies

scientific article

Choline-Containing Phospholipids in Microdissected Human Alzheimer’S Disease Brain Senile Plaque Versus Neuropil ⬇️

scientific article published on September 1, 2012

Classification of Environmental Strains from Order to Genus Levels Using Lipid and Protein MALDI-ToF Fingerprintings and Chemotaxonomic Network Analysis

scientific article published in 2022

Cluster TOF-SIMS imaging as a tool for micrometric histology of lipids in tissue

scientific article published on 21 November 2013

Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization for a lipidomic analysis of Leishmania donovani

scientific article

Comprehensive characterization of Annonaceous acetogenins within a complex extract by HPLC-ESI-LTQ-Orbitrap® using post-column lithium infusion

scientific article published on 01 November 2012

Conference report: 60th American Society for MS Conference on MS and Allied Topics

scientific article

Confinement and Time Immemorial: Prebiotic Synthesis of Nucleotides on a Porous Mineral Nanoreactor

scientific article published on 15 July 2019

Dereplication, Annotation, and Characterization of 74 Potential Antimicrobial Metabolites from Penicillium Sclerotiorum Using t-SNE Molecular Networks

scientific article published in 2021

Design, synthesis of novel pyranotriazolopyrimidines and evaluation of their anti-soybean lipoxygenase, anti-xanthine oxidase, and cytotoxic activities.

scientific article published on 18 December 2015

Determination of ionization energies of a monoterpene series by atmospheric pressure photoionization using tunable vacuum ultraviolet synchrotron radiation.

scientific article published in January 2014

Development of HPLC-Orbitrap method for identification of N-bearing molecules in complex organic material relevant to planetary environments

scholarly article

Does the Phytochemical Diversity of Wild Plants Like the Erythrophleum genus Correlate with Geographical Origin?

scientific article published in 2021

Dual Beam Depth Profiling and Imaging with Argon and Bismuth Clusters of Prenylated Stilbenes on Glandular Trichomes of Macaranga vedeliana.

scientific article

Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata.

scientific article published on 19 September 2017

Evaluation of synthase and hemisynthase activities of glucosamine-6-phosphate synthase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

scientific article

Fast fingerprinting by MALDI-TOF mass spectrometry of urinary sediment glycosphingolipids in Fabry disease

scientific article published on 16 June 2005

Fingerprints of flower absolutes using supercritical fluid chromatography hyphenated with high resolution mass spectrometry

scientific article published on 02 June 2018

Gas-phase protonation thermochemistry of adenosine.

scientific article

Generation of a Molecular Network from Electron Ionization Mass Spectrometry Data by Combining MZmine2 and MetGem Software

scientific article published on 27 August 2019

How to deal with weak interactions in noncovalent complexes analyzed by electrospray mass spectrometry: cyclopeptidic inhibitors of the nuclear receptor coactivator 1-STAT6.

scientific article

Identification of Antagonistic Compounds between the Palm Tree Xylariale Endophytic Fungi and the Phytopathogen Fusarium oxysporum ⬇️

scientific article published in 2021

Identification of Antimicrobial Compounds from Sandwithia guyanensis-Associated Endophyte Using Molecular Network Approach

scientific article published on 29 December 2019

Identification of ritual blood in African artifacts using TOF-SIMS and synchrotron radiation microspectroscopies.

scientific article

Identification of the environmental neurotoxins annonaceous acetogenins in an Annona cherimolia Mill. Alcoholic Beverage Using HPLC-ESI-LTQ-Orbitrap.

scientific article

Impact of inhaled nitric oxide on the sulfatide profile of neonatal rat brain studied by TOF-SIMS imaging

scientific article

Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver

scientific article published on 12 March 2020

Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source

scientific article published in October 2005

In situ primary metabolites localization on a rat brain section by chemical mass spectrometry imaging.

scientific article

Innovative omics-based approaches for prioritisation and targeted isolation of natural products - new strategies for drug discovery

scientific article published on 01 June 2019

Insights into the MALDI Process after Matrix Deposition by Sublimation Using 3D ToF-SIMS Imaging

scientific article published on 3 January 2018

Insights on profiling of phorbol, deoxyphorbol, ingenol and jatrophane diterpene esters by high performance liquid chromatography coupled to multiple stage mass spectrometry

scientific article published on 13 October 2015

Internal Energy Distribution of Secondary Ions Under Argon and Bismuth Cluster Bombardments: "Soft" Versus "Hard" Desorption-Ionization Process

scientific article published on 12 November 2018

Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation

scientific article published on 05 June 2019

Investigation of deprotonation reactions on globular and denatured proteins at atmospheric pressure by ESSI-MS.

scientific article

Ion internal energy distributions validate the charge residue model for small molecule ion formation by spray methods

scientific article published in April 2008

Is methanol a dopant under atmospheric pressure photoionization conditions?

scientific article published on 16 January 2019

Isolation of Picrotoxanes from Austrobuxus carunculatus Using Taxonomy-Based Molecular Networking

scientific article published on 05 October 2020

Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking

scientific article

Lipid cartography of atherosclerotic plaque by cluster-TOF-SIMS imaging

scientific article published on 21 November 2006

Lipid imaging by gold cluster time-of-flight secondary ion mass spectrometry: application to Duchenne muscular dystrophy.

scientific article published on 16 April 2005

Lipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestion

scientific article

Lipidomics Conquers a Niche, Consolidates Growth

scientific article published on 29 June 2019

Lipidomics by Supercritical Fluid Chromatography

scientific article

Lipidomics of Alzheimer's disease

scientific article published on February 2014

Liquid chromatography on porous graphitic carbon with atmospheric pressure photoionization mass spectrometry and tandem mass spectrometry for the analysis of glycosphingolipids.

scientific article

Localisation and quantification of benzalkonium chloride in eye tissue by TOF-SIMS imaging and liquid chromatography mass spectrometry.

scientific article published on 21 February 2013

Low doses of arginine butyrate derivatives improve dystrophic phenotype and restore membrane integrity in DMD models.

scientific article published on 6 March 2014

MALDI imaging and structural analysis of rat brain lipid negative ions with 9-aminoacridine matrix.

scientific article

MALDI imaging mass spectrometry of lipids by adding lithium salts to the matrix solution.

scientific article

MALDI mass spectrometry imaging of 1-methyl-4-phenylpyridinium (MPP+) in mouse brain.

scientific article

MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections

scientific article

MZmine 2 Data-Preprocessing To Enhance Molecular Networking Reliability.

scientific article

Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source

scientific article

Mapping Dicorynia guianensis Amsh. wood constituents by submicron resolution cluster-TOF-SIMS imaging

scientific article published on June 2016

Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF-SIMS.

scientific article published on 27 August 2009

MetGem software for the generation of molecular networks based on t-SNE algorithm

scientific article published on 14 November 2018

Method development for quantification of the environmental neurotoxin annonacin in Rat plasma by UPLC-MS/MS and application to a pharmacokinetic study.

scientific article published on 30 September 2015

Micrometric molecular histology of lipids by mass spectrometry imaging.

scientific article

Monitoring of Cornea Elastic Properties Changes during UV-A/Riboflavin-Induced Corneal Collagen Cross-Linking using Supersonic Shear Wave Imaging: A Pilot Study

scientific article published on 31 August 2012

Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease.

scientific article

Nitrogen incorporation in Titan's tholins inferred by high resolution orbitrap mass spectrometry and gas chromatography–mass spectrometry

scholarly article

Optimization and validation of a label-free MRM method for the quantification of cytochrome P450 isoforms in biological samples.

scientific article

Pores formation on cell membranes by hederacolchiside A1 leads to a rapid release of proteins for cytosolic subproteome analysis.

scientific article

Quantification of the environmental neurotoxin annonacin in Rat brain by UPLC-MS/MS.

scientific article published on 4 April 2016

Quantification of tocopherols and tocotrienols in soybean oil by supercritical-fluid chromatography coupled to high-resolution mass spectrometry

scientific article

Rapid and precise measurements of gas-phase basicity of peptides and proteins at atmospheric pressure by electrosonic spray ionization-mass spectrometry

scientific article

Searching for original natural products by molecular networking: detection, isolation and total synthesis of chloroaustralasines

scientific article published in 2018

Semi-synthesis of new antimicrobial esters from the natural oleanolic and maslinic acids.

scientific article published on 14 March 2015

Structural Characterisation of Acetogenins from Annona muricata by Supercritical Fluid Chromatography Coupled to High-Resolution Tandem Mass Spectrometry

scientific article

Structural Identification of Antibacterial Lipids from Amazonian Palm Tree Endophytes through the Molecular Network Approach

scientific article published on 24 April 2019

Structural analysis of secondary ions by post-source decay in time-of-flight secondary ion mass spectrometry

scientific article published in January 2006

Structural characterization of phosphatidylcholines by atmospheric pressure photoionization mass spectrometry

scientific article

Structurally Diverse Diterpenoids from Sandwithia guyanensis

scientific article published in March 2018

Supercritical fluid chromatography coupled to mass spectrometry for lipidomics

scientific article published on 01 October 2019

Supersonic shear wave elastography for the in vivo evaluation of transepithelial corneal collagen cross-linking

scientific article published on 28 March 2014

TOF-SIMS imaging of lipids on rat brain sections

scientific article published in January 2015

Tandem Mass Spectrometry Imaging and in Situ Characterization of Bioactive Wood Metabolites in Amazonian Tree Species Sextonia rubra

scientific article published on 08 June 2018

Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients.

scientific article published on 7 September 2012

Time-of-flight secondary ion mass spectrometry imaging of biological samples with delayed extraction for high mass and high spatial resolutions.

scientific article published on July 2015

Tissue molecular ion imaging by gold cluster ion bombardment

scientific article published on 01 March 2004

Ultra performance liquid chromatography - mass spectrometry studies of formalin-induced alterations of human brain lipidome

scientific article published in October 2014

Validated Method for Strigolactone Quantification by Ultra High-Performance Liquid Chromatography - Electrospray Ionisation Tandem Mass Spectrometry Using Novel Deuterium Labelled Standards

scientific article

Validation data for the quantification of the Annonaceous acetogenin annonacin in Rat brain by UPLC-MS/MS.

scientific article

What more can TOF-SIMS bring than other MS imaging methods?

scientific article published on 19 February 2016

Which electrospray-based ionization method best reflects protein-ligand interactions found in solution? a comparison of ESI, nanoESI, and ESSI for the determination of dissociation constants with mass spectrometry.

scientific article

List of works by David Touboul

A new safety concern for glaucoma treatment demonstrated by mass spectrometry imaging of benzalkonium chloride distribution in the eye, an experimental study in rabbits

A simple model for exploring conformation of highly-charged electrosprayed single-stranded oligonucleotides

An Integrative Approach to Decipher the Chemical Antagonism between the Competing Endophytes Paraconiothyrium variabile and Bacillus subtilis.

Animal urine as painting materials in African rock art revealed by cluster ToF-SIMS mass spectrometry imaging.

Annotation and quantification of N-acyl homoserine lactones implied in bacterial quorum sensing by supercritical-fluid chromatography coupled with high-resolution mass spectrometry

Antiparasitic Ovalicin Derivatives from Pseudallescheria boydii, a Mutualistic Fungus of French Guiana Termites ⬇️

Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach

Argon cluster ion source evaluation on lipid standards and rat brain tissue samples

Atmospheric pressure glow discharge desorption mass spectrometry for rapid screening of pesticides in food

Atmospheric pressure photoionization as a powerful tool for large-scale lipidomic studies

Atmospheric pressure photoionization coupled to porous graphitic carbon liquid chromatography for the analysis of globotriaosylceramides. Application to Fabry disease

Bioactive natural products prioritization using massive multi-informational molecular networks

Bioactivity-Based Molecular Networking for the Discovery of Drug Leads in Natural Product Bioassay-Guided Fractionation.

Biological tissue imaging with time-of-flight secondary ion mass spectrometry and cluster ion sources

Biomedical studies by TOF-SIMS imaging.

Changes of phospholipid composition within the dystrophic muscle by matrix-assisted laser desorption/ionization mass spectrometry and mass spectrometry imaging.

Characterization of alpha-parvalbumin on muscle tissue sections by in situ calcium attachment

Chemical cross-linking with NHS esters: a systematic study on amino acid reactivities

Chiral calcium-BINOL phosphate catalyzed diastereo- and enantioselective synthesis of syn-1,2-disubstituted 1,2-diamines: scope and mechanistic studies

Choline-Containing Phospholipids in Microdissected Human Alzheimer’S Disease Brain Senile Plaque Versus Neuropil ⬇️

Classification of Environmental Strains from Order to Genus Levels Using Lipid and Protein MALDI-ToF Fingerprintings and Chemotaxonomic Network Analysis

Cluster TOF-SIMS imaging as a tool for micrometric histology of lipids in tissue

Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization for a lipidomic analysis of Leishmania donovani

Comprehensive characterization of Annonaceous acetogenins within a complex extract by HPLC-ESI-LTQ-Orbitrap® using post-column lithium infusion

Conference report: 60th American Society for MS Conference on MS and Allied Topics

Confinement and Time Immemorial: Prebiotic Synthesis of Nucleotides on a Porous Mineral Nanoreactor

Dereplication, Annotation, and Characterization of 74 Potential Antimicrobial Metabolites from Penicillium Sclerotiorum Using t-SNE Molecular Networks

Design, synthesis of novel pyranotriazolopyrimidines and evaluation of their anti-soybean lipoxygenase, anti-xanthine oxidase, and cytotoxic activities.

Determination of ionization energies of a monoterpene series by atmospheric pressure photoionization using tunable vacuum ultraviolet synchrotron radiation.

Development of HPLC-Orbitrap method for identification of N-bearing molecules in complex organic material relevant to planetary environments

Does the Phytochemical Diversity of Wild Plants Like the Erythrophleum genus Correlate with Geographical Origin?

Dual Beam Depth Profiling and Imaging with Argon and Bismuth Clusters of Prenylated Stilbenes on Glandular Trichomes of Macaranga vedeliana.

Environmentally Friendly Procedure Based on Supercritical Fluid Chromatography and Tandem Mass Spectrometry Molecular Networking for the Discovery of Potent Antiviral Compounds from Euphorbia semiperfoliata.

Evaluation of synthase and hemisynthase activities of glucosamine-6-phosphate synthase by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Fast fingerprinting by MALDI-TOF mass spectrometry of urinary sediment glycosphingolipids in Fabry disease

Fingerprints of flower absolutes using supercritical fluid chromatography hyphenated with high resolution mass spectrometry

Gas-phase protonation thermochemistry of adenosine.

Generation of a Molecular Network from Electron Ionization Mass Spectrometry Data by Combining MZmine2 and MetGem Software

How to deal with weak interactions in noncovalent complexes analyzed by electrospray mass spectrometry: cyclopeptidic inhibitors of the nuclear receptor coactivator 1-STAT6.

Identification of Antagonistic Compounds between the Palm Tree Xylariale Endophytic Fungi and the Phytopathogen Fusarium oxysporum ⬇️

Identification of Antimicrobial Compounds from Sandwithia guyanensis-Associated Endophyte Using Molecular Network Approach

Identification of ritual blood in African artifacts using TOF-SIMS and synchrotron radiation microspectroscopies.

Identification of the environmental neurotoxins annonaceous acetogenins in an Annona cherimolia Mill. Alcoholic Beverage Using HPLC-ESI-LTQ-Orbitrap.

Impact of inhaled nitric oxide on the sulfatide profile of neonatal rat brain studied by TOF-SIMS imaging

Impact of the gut microbiota on the m6A epitranscriptome of mouse cecum and liver

Improvement of biological time-of-flight-secondary ion mass spectrometry imaging with a bismuth cluster ion source

In situ primary metabolites localization on a rat brain section by chemical mass spectrometry imaging.

Innovative omics-based approaches for prioritisation and targeted isolation of natural products - new strategies for drug discovery

Insights into the MALDI Process after Matrix Deposition by Sublimation Using 3D ToF-SIMS Imaging

Insights on profiling of phorbol, deoxyphorbol, ingenol and jatrophane diterpene esters by high performance liquid chromatography coupled to multiple stage mass spectrometry

Internal Energy Distribution of Secondary Ions Under Argon and Bismuth Cluster Bombardments: "Soft" Versus "Hard" Desorption-Ionization Process

Investigation of Premyrsinane and Myrsinane Esters in Euphorbia cupanii and Euphobia pithyusa with MS2LDA and Combinatorial Molecular Network Annotation Propagation

Investigation of deprotonation reactions on globular and denatured proteins at atmospheric pressure by ESSI-MS.

Ion internal energy distributions validate the charge residue model for small molecule ion formation by spray methods

Is methanol a dopant under atmospheric pressure photoionization conditions?

Isolation of Picrotoxanes from Austrobuxus carunculatus Using Taxonomy-Based Molecular Networking

Isolation of Premyrsinane, Myrsinane, and Tigliane Diterpenoids from Euphorbia pithyusa Using a Chikungunya Virus Cell-Based Assay and Analogue Annotation by Molecular Networking

Lipid cartography of atherosclerotic plaque by cluster-TOF-SIMS imaging

Lipid imaging by gold cluster time-of-flight secondary ion mass spectrometry: application to Duchenne muscular dystrophy.

Lipidomic and spatio-temporal imaging of fat by mass spectrometry in mice duodenum during lipid digestion

Lipidomics Conquers a Niche, Consolidates Growth

Lipidomics by Supercritical Fluid Chromatography

Lipidomics of Alzheimer's disease

Liquid chromatography on porous graphitic carbon with atmospheric pressure photoionization mass spectrometry and tandem mass spectrometry for the analysis of glycosphingolipids.

Localisation and quantification of benzalkonium chloride in eye tissue by TOF-SIMS imaging and liquid chromatography mass spectrometry.

Low doses of arginine butyrate derivatives improve dystrophic phenotype and restore membrane integrity in DMD models.

MALDI imaging and structural analysis of rat brain lipid negative ions with 9-aminoacridine matrix.

MALDI imaging mass spectrometry of lipids by adding lithium salts to the matrix solution.

MALDI mass spectrometry imaging of 1-methyl-4-phenylpyridinium (MPP+) in mouse brain.

MALDI mass spectrometry imaging of lipids and primary metabolites on rat brain sections

MZmine 2 Data-Preprocessing To Enhance Molecular Networking Reliability.

Manipulation of charge states of biopolymer ions by atmospheric pressure ion/molecule reactions implemented in an extractive electrospray ionization source

Mapping Dicorynia guianensis Amsh. wood constituents by submicron resolution cluster-TOF-SIMS imaging

Mass spectrometry imaging of rat brain sections: nanomolar sensitivity with MALDI versus nanometer resolution by TOF-SIMS.

MetGem software for the generation of molecular networks based on t-SNE algorithm

Method development for quantification of the environmental neurotoxin annonacin in Rat plasma by UPLC-MS/MS and application to a pharmacokinetic study.

Micrometric molecular histology of lipids by mass spectrometry imaging.

Monitoring of Cornea Elastic Properties Changes during UV-A/Riboflavin-Induced Corneal Collagen Cross-Linking using Supersonic Shear Wave Imaging: A Pilot Study

Neuroprotective effects of a brain permeant 6-aminoquinoxaline derivative in cell culture conditions that model the loss of dopaminergic neurons in Parkinson disease.