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List of works by Rik C Schoemaker

A Phase I Double‐Blind, Placebo‐Controlled, Single Rising Dose Study to Determine the Safety, Tolerability, and Pharmacokinetics of Oral YM934 in Healthy Male Volunteers ⬇️

scientific article published on January 1, 1998

A comparative study of two methods for attaining constant alcohol levels

scientific article

A comparison of the effects of propofol and midazolam on memory during two levels of sedation by using target-controlled infusion

scientific article published in November 2000

A comparison of the sensitivities of adaptive tracking, eye movement analysis and visual analog lines to the effects of incremental doses of temazepam in healthy volunteers

scientific article published in August 1991

A compartmental pharmacokinetic model of cyclosporin and its predictive performance after Bayesian estimation in kidney and simultaneous pancreas-kidney transplant recipients.

scientific article published in June 2003

A pharmacodynamic Markov mixed-effects model for the effect of temazepam on sleep

scientific article published in August 2000

A phase I study of recombinant human C1 inhibitor in asymptomatic patients with hereditary angioedema

scientific article published on 08 August 2005

A placebo-controlled parallel study of the effect of two types of coffee oil on serum lipids and transaminases: identification of chemical substances involved in the cholesterol-raising effect of coffee

scientific article published on 01 June 1995

A recirculatory model for tissue plasminogen activator with saturable endothelial binding.

scientific article

A study of the effects of long-term use on individual sensitivity to temazepam and lorazepam in a clinical population

scientific article

Acute MDMA and ethanol interaction effects on psychomotor performance.

scientific article published in April 2007

Analysis of asymmetry of agonist concentration-effect curves

scientific article published on 01 April 1999

Assessment of changes in liver blood flow after food intake--comparison of ICG clearance and echo-Doppler

scientific article published on October 1996

Assessment of hepatic blood flow using continuous infusion of high clearance drugs ⬇️

scientific article published on May 1, 1998

Autonomic nervous system function in chronic exogenous subclinical thyrotoxicosis and the effect of restoring euthyroidism

scientific article published on 8 April 2008

Bioequivalence of subcutaneous injections of recombinant human follicle stimulating hormone (Puregon(R)) by Pen-injector and syringe

scientific article published on 01 July 1999

Brivaracetam Population Pharmacokinetics and Exposure-Response Modeling in Adult Subjects With Partial-Onset Seizures.

scientific article published on 5 May 2016

Brivaracetam population pharmacokinetics in children with epilepsy aged 1 month to 16 years.

scientific article

CNS effects of sumatriptan and rizatriptan in healthy female volunteers.

scientific article published in May 2002

Ceftazidime pharmacokinetics in preterm infants: effects of renal function and gestational age

scientific article published on 01 December 1995

Central nervous system effects of alcohol at a pseudo-steady-state concentration using alcohol clamping in healthy volunteers.

scientific article published on October 2009

Central nervous system effects of moxonidine experimental sustained release formulation in patients with mild to moderate essential hypertension.

scientific article published in June 2003

Characterization of glutathione conjugation in humans: stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)- and (S)-2-bromoisovalerylurea in healthy volunteers

scientific article published on 01 January 1993

Characterizing the role of enterohepatic recycling in the interactions between mycophenolate mofetil and calcineurin inhibitors in renal transplant patients by pharmacokinetic modelling.

scientific article published in September 2005

Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine.

scientific article published in June 1993

Circadian rhythm of plasma leptin levels in upper and lower body obese women: influence of body fat distribution and weight loss

scientific article

Clinical ototoxicity of teicoplanin.

scientific article published in April 2004

Cognitive performance and serotonergic function in users of ecstasy.

scientific article

Concentration-effect relationships of two rilmenidine single-dose infusion rates in hypertensive patients.

scientific article published in October 2002

Continuous intravenous furosemide in haemodynamically unstable children after cardiac surgery.

scientific article published in April 2001

Dexamethasone concentration in the subretinal fluid after a subconjunctival injection, a peribulbar injection, or an oral dose

scientific article published on 01 October 2000

Dexamethasone concentration in vitreous and serum after oral administration

scientific article published on 01 May 1998

Diurnal rhythm in anticoagulant effect of heparin during a low dose constant rate infusion. A study in healthy volunteers

scientific article published on 01 July 1992

Dose-related effects of motilin on proximal gastrointestinal motility

scientific article published on 01 January 2002

Effect of changes in liver blood flow on the pharmacokinetics of saruplase in patients with acute myocardial infarction.

scientific article

Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects

scientific article published on 01 December 2006

Effect of intrapulmonary tetrahydrocannabinol administration in humans.

scientific article

Effect of isotretinoin on endogenous tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor 1 (PAI-1) in humans.

scientific article published in December 1993

Effects of changing liver blood flow by exercise and food on kinetics and dynamics of saruplase.

scientific article published in April 1995

Effects of increased liver blood flow on the kinetics and dynamics of recombinant tissue-type plasminogen activator

scientific article published on 01 November 1996

Effects of intravenous temazepam. I. Saccadic eye movements and electroencephalogram after fast and slow infusion to pseudo steady state

scientific article published on 01 May 1994

Effects of intravenous temazepam. II. A study of the long-term reproducibility of pharmacokinetics, pharmacodynamics, and concentration-effect parameters

scientific article published on 01 May 1994

Effects of liver blood flow on the pharmacokinetics of tissue-type plasminogen activator (alteplase) during thrombolysis in patients with acute myocardial infarction.

scientific article published in January 1998

Efficacy of 3,4-diaminopyridine and pyridostigmine in the treatment of Lambert-Eaton myasthenic syndrome: a randomized, double-blind, placebo-controlled, crossover study.

scientific article

Endothelial binding of recombinant tissue plasminogen activator: quantification in vivo using a recirculatory model

scientific article published on 01 February 2003

Estimating potency for the Emax-model without attaining maximal effects

scientific article published in October 1998

Estimation of growth hormone secretion rate: impact of kinetic assumptions intrinsic to the analytical approach

scientific article published in January 2001

Estimation of plasma serotonin using isopycnic centrifugation

scientific article published on 01 August 2000

Ethanol co-administration moderates 3,4-methylenedioxymethamphetamine effects on human physiology.

scientific article

Evaluation of biomarkers for cardiotoxicity of anthracyclin-based chemotherapy.

scientific article published on 15 March 2008

Evaluation of proinflammatory cytokines and inflammation markers as biomarkers for the action of thiazolidinediones in Type 2 diabetes mellitus patients and healthy volunteers

scientific article published in October 2006

Evidence for brain serotonin-mediated control of carbohydrate consumption in normal weight and obese humans

scientific article published on 01 September 1993

Extrapolation of a Brivaracetam Exposure-Response Model from Adults to Children with Focal Seizures.

scientific article published on 7 September 2017

Fetal rest-activity cycles and chronic exposure to antiepileptic drugs

scientific article published in September 1991

Food choice in hyperthyroidism: potential influence of the autonomic nervous system and brain serotonin precursor availability.

scientific article published in December 2001

Gastrointestinal blood loss after non-steroidal anti-inflammatory drugs. Measurement by selective determination of faecal porphyrins.

scientific article

Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans

scientific article published in October 1991

High concentration of dexamethasone in aqueous and vitreous after subconjunctival injection.

scientific article published in August 1999

Highly variable anticoagulant response after subcutaneous administration of high-dose (12,500 IU) heparin in patients with myocardial infarction and healthy volunteers

scientific article published on 01 November 1992

Influence of 1-desamino-8-D-vasopressin on endogenous fibrinolysis, haemodynamics and liver blood flow in healthy subjects.

scientific article

Influence of a microemulsion vehicle on cutaneous bioequivalence of a lipophilic model drug assessed by microdialysis and pharmacodynamics

scientific article published in May 2001

Influence of obesity and body fat distribution on growth hormone kinetics in humans

scientific article published on 01 November 1999

Influence of skinfold thickness on heparin absorption ⬇️

scientific article published on April 20, 1991

Inhibition of THC-induced effects on the central nervous system and heart rate by a novel CB1 receptor antagonist AVE1625.

scientific article

Integrated pharmacokinetics and pharmacodynamics of Ro 48–6791, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects ⬇️

scientific article published on November 1, 1997

Integrated pharmacokinetics and pharmacodynamics of Ro 48–8684, a new benzodiazepine, in comparison with midazolam during first administration to healthy male subjects ⬇️

scientific article published on November 1, 1997

Intraindividual variability in nifedipine pharmacokinetics and effects in healthy subjects

scientific article published on 01 April 1992

Intraocular penetration and systemic absorption after topical application of dexamethasone disodium phosphate

scientific article published on 01 October 2002

Liver blood flow as a major determinant of the clearance of recombinant human tissue-type plasminogen activator

scientific article published on 01 January 1992

Local tissue factor pathway inhibitor release in the human forearm

scientific article published on 01 March 2003

MK-0873, a PDE4 inhibitor, does not influence the pharmacokinetics of theophylline in healthy male volunteers

scientific article published on 3 February 2008

Modeling and simulation of the modified Rankin Scale and National Institutes of Health Stroke Scale neurological endpoints in intracerebral hemorrhage

scientific article published on 29 August 2019

Modeling the influence of growth hormone on lipolysis.

scientific article published in April 2002

Motilin effects on the proximal stomach in patients with functional dyspepsia and healthy volunteers

scientific article published on 02 January 2003

Motilin kinetics and effects on proximal stomach in patients with functional dyspepsia (FD) and healthy volunteers.

scientific article

No Influence of acute hypertriglyceridemia on plasma t-PA in healthy male volunteers.

scientific article published in July 2001

No evidence for functional involvement of 5-HT2B receptors in serotonin-induced vasodilatation in the human forearm

scientific article published on 01 December 2000

Onset of action during on-demand treatment with maalox suspension or low-dose ranitidine for heartburn.

scientific article

Performance of the SAEM and FOCEI Algorithms in the Open-Source, Nonlinear Mixed Effect Modeling Tool nlmixr

scientific article published on 18 November 2019

Peribulbar corticosteroid injection: vitreal and serum concentrations after dexamethasone disodium phosphate injection

scientific article published on 01 March 1997

Pharmacodynamic and pharmacokinetic effects of MK-0343, a GABA(A) alpha2,3 subtype selective agonist, compared to lorazepam and placebo in healthy male volunteers

scientific article

Pharmacodynamic and pharmacokinetic effects of TPA023, a GABA(A) alpha(2,3) subtype-selective agonist, compared to lorazepam and placebo in healthy volunteers.

scientific article

Pharmacodynamic interactions of diazepam and intravenous alcohol at pseudo steady state

scientific article published in January 1993

Pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam in healthy volunteers: an interethnic comparative study between Japanese and European volunteers

scientific article published on 01 December 1998

Pharmacodynamics of temazepam in primary insomnia: assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep

scientific article published on 01 October 1997

Pharmacokinetic and pharmacodynamic profile of oral and intravenous meta-chlorophenylpiperazine in healthy volunteers

scientific article

Pharmacokinetic and pharmacodynamic profiles of sumatriptan in migraine patients with headache recurrence or no response.

scientific article published on October 1996

Pharmacokinetic-pharmacodynamic relationships of central nervous system effects of scopolamine in healthy subjects.

scientific article published on June 2011

Pharmacokinetic/pharmacodynamic assessment of tolerance to central nervous system effects of a 3 mg sustained release tablet of rilmenidine in hypertensive patients.

scientific article

Pharmacokinetics and systemic endocrine effects of the phyto-oestrogen 8-prenylnaringenin after single oral doses to postmenopausal women

scientific article

Pharmacokinetics of interleukin-2 in two anephric patients with metastatic renal cell cancer

scientific article published on 01 November 1999

Pharmacokinetics of intravenous busulfan in children prior to stem cell transplantation

scientific article published on April 2002

Pharmacokinetics of oral fumarates in healthy subjects.

scientific article published in October 2004

Pharmacokinetics of rectal tramadol in postoperative paediatric patients.

scientific article

Pharmacokinetics of the conventional and microemulsion formulations of cyclosporine in pancreas-kidney transplant recipients with gastroparesis

scientific article published on 01 August 1996

Pharmacokinetics, pharmacodynamics and bioavailability of the ACE inhibitor ramipril

scientific article published on 01 January 1995

Pharmacology of rising oral doses of 5-hydroxytryptophan with carbidopa

scientific article

Placebo-controlled comparison of three dose-regimens of 5-hydroxytryptophan challenge test in healthy volunteers

scientific article published in April 2002

Plasma amino acid ratios related to brain serotonin synthesis in response to food intake in bulimia nervosa.

scientific article published in November 1995

Population Pharmacokinetics of Adjunctive Lacosamide in Pediatric Patients With Epilepsy

scientific article published on 14 November 2018

Population pharmacokinetics and covariate analysis of Sym004, an antibody mixture against the epidermal growth factor receptor, in subjects with metastatic colorectal cancer and other solid tumors

scientific article published on 02 November 2019

Pronounced effects of the combination of a new thromboxane antagonist (GR32191) and heparin on bleeding time in man

scientific article published on 01 July 1992

Psychomotor and cognitive effects of a single oral dose of talnetant (SB223412) in healthy volunteers compared with placebo or haloperidol.

scientific article published on 28 August 2008

Quantitated fetal heart rhythm at 20, 32 and 38 weeks of gestation and dependence on rest-activity patterns

scientific article published on 01 January 1992

Relationship between airway responsiveness to neurokinin A and methacholine in asthma.

scientific article published on 22 January 2005

Saccadic peak velocity and EEG as end-points for a serotonergic challenge test.

scientific article published in March 2002

Self-medication of a single headache episode with ketoprofen, ibuprofen or placebo, home-monitored with an electronic patient diary.

scientific article published on October 1996

Self-selection for personality variables among healthy volunteers ⬇️

scientific article published on January 1, 1992

Sorbitol as a marker for drug-induced decreases of variable duration in liver blood flow in healthy volunteers.

scientific article

Specific stimulation of brain serotonin mediated neurotransmission by dexfenfluramine does not restore growth hormone responsiveness in obese women

scientific article published on 01 May 1996

Stereoselective pharmacokinetics of oral felodipine and nitrendipine in healthy subjects: correlation with nifedipine pharmacokinetics

scientific article published on 01 January 1993

Sympathovagal imbalance in hyperthyroidism.

scientific article published in July 2001

The Neurotoxicity Scale: the validity of a patient-based scale, assessing neurotoxicity

scientific article published on 01 March 1995

The bioavailability of digoxin from three oral formulations measured by a specific h.p.l.c. assay

scientific article

The effect of asphyxia on the pharmacokinetics of ceftazidime in the term newborn.

scientific article

The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients

scientific article published on 01 March 1995

The effect of m-CPP on tics and obsessive-compulsive phenomena in Gilles de la Tourette syndrome

scientific article published on 01 May 1999

The effect of motilin on the rectum in healthy volunteers.

scientific article published in June 2003

The effect of warfarin on the pharmacokinetics and pharmacodynamics of napsagatran in healthy male volunteers.

scientific article published in April 2001

The effects of TPA023, a GABAAα2,3 subtype-selective partial agonist, on essential tremor in comparison to alcohol

scientific article

The effects of a novel histamine-3 receptor inverse agonist on essential tremor in comparison to stable levels of alcohol

scientific article published on 18 February 2011

The effects of clonazepam and vigabatrin in hyperekplexia

scientific article published on 01 July 1997

The gastrointestinal passage and release of beclomethasone dipropionate from oral delivery systems in ileostomy volunteers ⬇️

scientific article published on September 1, 1998

The influence of cisapride and clarithromycin on QT intervals in healthy volunteers.

scientific article published on November 1998

The influence of nifedipine and captopril on liver blood flow in healthy subjects.

scientific article published on May 1998

The influence of reduced liver blood flow on the pharmacokinetics and pharmacodynamics of recombinant tissue factor pathway inhibitor.

scientific article

The influence of the hand circulation on the assessment of venous distensibility of the human forearm with venous occlusion plethysmography.

scientific article published on December 2000

The oral bioavailability of pentosan polysulphate sodium in healthy volunteers

scientific article published on 01 February 1999

The psychomotor effects of carbamazepine in epileptic patients and healthy volunteers.

scientific article published in September 2003

The sensitivity of pharmacodynamic tests for the central nervous system effects of drugs on the effects of sleep deprivation

scientific article

Tinnitus suppression by intravenous lidocaine in relation to its plasma concentration.

scientific article

Tobramycin population pharmacokinetics in neonates.

scientific article published on October 1997

Variability of splanchnic blood flow measurements using MR velocity mapping under fasting and post-prandial conditions--comparison with echo-Doppler

scientific article published in February 1997

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