Search filters

List of works by John A. Hamilton

A central role for the Hsp90.Cdc37 molecular chaperone module in interleukin-1 receptor-associated-kinase-dependent signaling by toll-like receptors.

scientific article

A novel 110 kDa form of myosin XVIIIA (MysPDZ) is tyrosine-phosphorylated after colony-stimulating factor-1 receptor signalling

scientific article published on May 2004

A potential role for the Src-like adapter protein SLAP-2 in signaling by the colony stimulating factor-1 receptor.

scientific article

A proteomics strategy for the enrichment of receptor-associated complexes

scientific journal article

Activation and proliferation signals in murine macrophages: Relationships among c-fos and c-myc expression, phosphoinositide hydrolysis, superoxide formation, and DNA synthesis

scientific article published in December 1989

Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced proliferative response to CSF-1 (M-CSF).

scientific article published in June 2002

Biochemical events accompanying macrophage activation and the inhibition of colony-stimulating factor-1-induced macrophage proliferation by tumor necrosis factor-?, interferon-?, and lipopolysaccharide

scientific article published in June 1992

Bone marrow transplantation in auto-immune disease.

scientific article published on November 1995

Brief Report: Granulocyte-Macrophage Colony-Stimulating Factor Drives Monosodium Urate Monohydrate Crystal-Induced Inflammatory Macrophage Differentiation and NLRP3 Inflammasome Up-Regulation in an In Vivo Mouse Model

scientific article published on 01 September 2014

CCL17 in Inflammation and Pain

scientific article published on 27 May 2020

CSF-1 in Inflammatory and Arthritic Pain Development

scientific article published on 17 August 2018

CSF-1 receptor signalling from endosomes mediates the sustained activation of Erk1/2 and Akt in macrophages.

scientific article published on 7 May 2012

CSF-1 stimulates Na+K+-ATPase mediated 86Rb+ uptake in mouse bone marrow-derived macrophages

scientific article published in October 1985

CSF-I signal transaction: what is of functional significance? ⬇️

scientific article published on July 1, 1997

Characterization of pathogenic human monoclonal autoantibodies against GM-CSF.

scientific article published on 25 April 2013

Coagulation of human plasma by asbestos fibers

scientific article published in October 1981

Colony stimulating factor-1 is a negative regulator of the macrophage respiratory burst.

scientific article

Colony stimulating factors and myeloid cell biology in health and disease.

scientific article published on 21 September 2012

Colony stimulating factors, cytokines and monocyte-macrophages--some controversies.

scientific article

Colony-stimulating factors in inflammation and autoimmunity.

scientific article published on July 2008

Comparison of the infectivity of the laboratory strain AD169 and a clinical isolate of human cytomegalovirus to human smooth muscle cells

scientific article published in January 1997

Control of macrophage lineage populations by CSF-1 receptor and GM-CSF in homeostasis and inflammation.

scientific article

Cyclic AMP inhibits expression of D-type cyclins and cdk4 and induces p27Kip1 in G-CSF-treated NFS-60 cells.

scientific article published on July 1996

Cytokine modulation of plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes. Down-regulation by tumor necrosis factor α and up-regulation by transforming growth factor-β and basic fibroblast growth fact

scientific article published in July 1994

Cytokine regulation of granulocyte-macrophage colony stimulating factor and macrophage colony-stimulating factor production in human arterial smooth muscle cells

scientific article published in March 1993

Defining GM-CSF- and macrophage-CSF-dependent macrophage responses by in vitro models

article

Dependence of interleukin-1-induced arthritis on granulocyte-macrophage colony-stimulating factor

scientific article published in January 2001

Detection and properties of the human proliferative monocyte subpopulation.

scientific article published on 24 January 2006

Direct Comparison of the Effects of CSF-1 (M-CSF) and GM-CSF on Human Monocyte DNA Synthesis and CSF Receptor Expression

scientific article published in April 1999

Direct binding of Shc, Grb2, SHP-2 and p40 to the murine granulocyte colony-stimulating factor receptor

scientific article

Disease-associated mutations in IRF6 and RIPK4 dysregulate their signalling functions

scientific article

Diverse morphological responses of normal human synovial fibroblasts to mononuclear leukocyte products: relationship to prostaglandin production and plasminogen activator activities, and comparison with the effects of purified interleukin 1

scientific article published in February 1987

Down-regulation of IRAK-4 is a component of LPS- and CpG DNA-induced tolerance in macrophages

scientific article published in February 2009

Effects of wortmannin and rapamycin on CSF-1-mediated responses in macrophages ⬇️

scientific article published on February 1, 1998

Exacerbation of acute inflammatory arthritis by the colony-stimulating factors CSF-1 and granulocyte macrophage (GM)-CSF: evidence of macrophage infiltration and local proliferation

scientific article published in February 2000

Extracellular mutations of non-obese diabetic mouse FcgammaRI modify surface expression and ligand binding.

scientific article

Extracellular proteomes of M-CSF (CSF-1) and GM-CSF-dependent macrophages

scientific article published on 27 July 2010

Extravascular coagulation and the plasminogen activator/plasmin system in rheumatoid arthritis

scientific article

Functions of granulocyte-macrophage colony-stimulating factor.

scientific article

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.

scientific article

G1 phase arrest of human smooth muscle cells by heparin, IL-4 and cAMP is linked to repression of cyclin D1 and cdk2

scientific article published in August 1997

GM-CSF Biology

scientific article

GM-CSF and IL-3 stimulate diacylglycerol generation in murine bone marrow-derived macrophages

scientific article published in August 1991

GM-CSF and uPA are required for Porphyromonas gingivalis-induced alveolar bone loss in a mouse periodontitis model.

scientific article published on 10 March 2015

GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential.

scientific article

GM-CSF in inflammation

scientific article published on 01 January 2020

GM-CSF in inflammation and autoimmunity.

scientific article

GM-CSF is not essential for optimal fertility or for weight control

scientific article published on 29 November 2011

GM-CSF- and IRF4-Dependent Signaling Can Regulate Myeloid Cell Numbers and the Macrophage Phenotype during Inflammation

scientific article published on 15 April 2019

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on type I interferon signaling.

scientific article published on 30 April 2009

GM-CSF-based treatments in COVID-19: reconciling opposing therapeutic approaches

scientific article published on 23 June 2020

GM-CSF: A Promising Target in Inflammation and Autoimmunity

scientific article published on 29 October 2020

Glucose metabolism is required for oxidized LDL-induced macrophage survival: role of PI3K and Bcl-2 family proteins.

scientific article published on 10 August 2009

Glycolytic control of adjuvant-induced macrophage survival: role of PI3K, MEK1/2, and Bcl-2.

scientific article published on 6 March 2009

Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis.

scientific article published on October 2001

Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development.

scientific article published on 20 September 2012

Granulocyte-macrophage colony-stimulating factor is a key mediator in inflammatory and arthritic pain ⬇️

scientific article published on July 24, 2012

Granulocyte-macrophage colony-stimulating factor is neuroprotective in experimental traumatic brain injury

scientific article

Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo.

scientific article

HUVEC co-culture and haematopoietic growth factors modulate human proliferative monocyte activity ⬇️

scientific article published on April 18, 2012

High numbers of circulating pigmented polymorphonuclear neutrophils as a prognostic marker for decreased birth weight during malaria in pregnancy

scientific article published on 31 December 2014

Hypoxia enhances the proliferative response of macrophages to CSF-1 and their pro-survival response to TNF.

scientific article

Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions.

scientific article published in June 2009

IRF6 Regulates the Expression of IL-36γ by Human Oral Epithelial Cells in Response to Porphyromonas gingivalis

scientific article published on 27 January 2016

Importance of the C-terminal domain of Harc for binding to Hsp70 and Hop as well as its response to heat shock.

scientific article published on December 2007

Inflammatory microcrystals induce murine macrophage survival and DNA synthesis

scientific article

Interferon regulatory factor 6 differentially regulates Toll-like receptor 2-dependent chemokine gene expression in epithelial cells.

scientific article

Interleukin-1? and interleukin-1? stimulate the N-acetyl-?-glucosaminidase activity of human synovial cells

scientific article published in December 1987

Interleukin-1β and interleukin-1α stimulate the plasminogen activator activity and prostaglandin E2 levels of human synovial cells

scientific article published in May 1987

Low dose metal particles can induce monocyte/macrophage survival

scientific article

M-CSF induces the stable interaction of cFms with αVβ3 integrin in osteoclasts

scientific article published in January 2006

Macrophage activation and differentiation signals regulate schlafen-4 gene expression: evidence for Schlafen-4 as a modulator of myelopoiesis

scientific article

Macrophage activation and polarization: nomenclature and experimental guidelines

scientific article (publication date: 17 July 2014)

Macrophage lineage phenotypes and osteoclastogenesis—Complexity in the control by GM-CSF and TGF-β

article

Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry

scientific article published on 02 September 2019

Monocytes and macrophages in malaria: protection or pathology?

scientific article

Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1.

scientific article published on 16 April 2007

N2 neutrophils, novel players in brain inflammation after stroke: modulation by the PPARγ agonist rosiglitazone.

scientific article

Neutralizing Granulocyte/Macrophage Colony–Stimulating Factor Inhibits Cigarette Smoke–induced Lung Inflammation

scientific article published in July 2010

Nondisposable materials, chronic inflammation, and adjuvant action.

scientific article

Oncostatin M stimulates urokinase-type plasminogen activator activity in human synovial fibroblasts

scientific article published in October 1991

Phospholipase D Is Activated by Phorbol Ester But Not CSF-1 in Murine Bone Marrow-Derived Macrophages

scientific article published in June 1994

Plasminogen activator/plasmin system in arthritis and inflammation: Friend or foe?

scientific article published in 2008

Plasminogen activators and their inhibitors in arthritic disease

scientific article published on December 4, 1992

Plasminogen-stimulated airway smooth muscle cell proliferation is mediated by urokinase and annexin A2, involving plasmin-activated cell signalling.

scientific article published on December 2013

Production of macrophage colony-stimulating factor (M-CSF) by human articular cartilage and chondrocytes. Modulation by interleukin-1 and tumor necrosis factor alpha.

scientific article

Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation.

scientific article

Proliferation-independent Induction of Macrophage Cyclin D2, and Repression of Cyclin D1, by Lipopolysaccharide

scientific article published in Journal of Biological Chemistry

Proliferative monocyte frequency is associated with circulating monocyte prevalence

scientific article published in August 2012

Protein kinase C has both stimulatory and suppressive effects on macrophage superoxide production

scientific article published in July 1992

Proteomic analysis of macrophage differentiation. p46/52(Shc) Tyrosine phosphorylation is required for CSF-1-mediated macrophage differentiation.

scientific article published on 4 April 2001

Receptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation

scientific article

Recombinant human inteleukin-1 inhibits plasminogen activator inhibitor-1 (PAI-1) production by human articular cartilage and chondrocytes

scientific article published in January 1991

Recombinant human interleukin-1 stimulates human articular cartilage to undergo resorption and human chondrocytes to produce both tissue- and urokinase-type plasminogen activator

scientific article published in November 1988

Reduction of tumor necrosis factor ? and interleukin-1? levels in human synovial tissue by interleukin-4 and glucocorticoid

scientific article published in 1992

Regulation of IRAK-1 activation by its C-terminal domain.

scientific article

Regulation of WAVE1 expression in macrophages at multiple levels.

scientific article

Regulation of systemic and local myeloid cell subpopulations by bone marrow cell-derived granulocyte-macrophage colony-stimulating factor in experimental inflammatory arthritis

scientific article published in August 2011

Regulation of the endosomal SNARE protein syntaxin 7 by colony-stimulating factor 1 in macrophages

scientific article published on 18 August 2008

Regulation of the plasminogen activator activity of macrophage tumor cell lines.

scientific article published in January 1980

Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor.

scientific article

Rheumatoid arthritis: opposing actions of haemopoietic growth factors and slow-acting anti-rheumatic drugs

scientific article published in The Lancet

Roles of the Mitogen-activated Protein Kinase Family in Macrophage Responses to Colony Stimulating Factor-1 Addition and Withdrawal

scientific article published in Journal of Biological Chemistry

Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPARγ and 5-LO-dependent pathways.

scientific article published on 12 December 2013

S100A8 chemotactic protein is abundantly increased, but only a minor contributor to LPS-induced, steroid resistant neutrophilic lung inflammation in vivo

scientific article published in January 2005

SAA drives proinflammatory heterotypic macrophage differentiation in the lung via CSF-1R-dependent signaling

scientific article

Serum IL-4, IL-10 and IL-6 levels in inflammatory arthritis

scientific article published in January 1995

Signaling crosstalk during sequential TLR4 and TLR9 activation amplifies the inflammatory response of mouse macrophages.

scientific article

Soluble CD163, a product of monocyte/macrophage activation, is inversely associated with haemoglobin levels in placental malaria

scientific article

Stimulation of human chondrocyte prostaglandin E2 production by recombinant human interleukin-1 and tumour necrosis factor

scientific article published in March 1990

Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones

scientific article published in July 1984

The TGF-β superfamily cytokine, MIC-1/GDF15: a pleotrophic cytokine with roles in inflammation, cancer and metabolism.

scientific article

The development of macrophages from human CD34+ haematopoietic stem cells in serum-free cultures is optimized by IL-3 and SCF

scientific article published in January 2013

The effect of cytokines on the expression of MHC antigens and ICAM-1 by normal and transformed synoviocytes

scientific article published on January 1, 1992

The effect of interleukin-4 on the macrophage respiratory burst is species dependent

scientific article published in January 1992

The effect of tissue type-plasminogen activator deletion and associated fibrin(ogen) deposition on macrophage localization in peritoneal inflammation

scientific article published in 2006

The generation and properties of human macrophage populations from hemopoietic stem cells.

scientific article published on 30 January 2009

The interface between cholinergic pathways and the immune system and its relevance to arthritis

scientific article

The interferon in TLR signaling: more than just antiviral

scientific article published on October 2003

The proliferative human monocyte subpopulation contains osteoclast precursors.

scientific article published on 17 February 2009

Therapeutic potential of targeting inflammation

scientific article published on 6 April 2013

Therapeutic potential of treating chronic obstructive pulmonary disease (COPD) by neutralising granulocyte macrophage-colony stimulating factor (GM-CSF).

scientific article

Tissue plasminogen activator does not alter development of acquired epilepsy

scientific article published on 7 September 2012

Type I interferons mediate the lipopolysaccharide induction of macrophage cyclin D2.

scientific article

Urokinase Plasminogen Activator Is a Central Regulator of Macrophage Three-Dimensional Invasion, Matrix Degradation, and Adhesion

scientific article published on 10 March 2014

Urokinase-type plasminogen activator and arthritis progression: contrasting roles in systemic and monoarticular arthritis models.

scientific article

Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement

scientific article

c-fos antisense DNA inhibits proliferation of osteoclast progenitors in osteoclast development but not macrophage differentiation in vitro

scientific article published in June 1996

cAMP Enhances CSF-1-Induced ERK Activity and c-fosmRNA Expression via a MEK-Dependent and Ras-Independent Mechanism in Macrophages

scientific article published on 01 March 1998

cAMP inhibits CSF-1-stimulated tyrosine phosphorylation but augments CSF-1R-mediated macrophage differentiation and ERK activation

scientific article published in August 2005

Paulina is supported by:

About Paulina

Help