List of works - Jean-François Paquin

Activation of C-F bonds α to C-C multiple bonds

scientific article published on 01 September 2018

Activation of allylic C-F bonds: palladium-catalyzed allylic amination of 3,3-difluoropropenes.

scientific article published in February 2010

Amine-borane complex-initiated SF<sub>5</sub>Cl radical addition on alkenes and alkynes

scientific article published on 16 December 2020

Asymmetric synthesis of 3,3-diarylpropanals with chiral diene-rhodium catalysts.

scientific article published in August 2005

Characterization of the structure, dynamics and allosteric pathways of human NPP1 in its free form and substrate-bound complex from molecular modeling

scientific article published on 5 May 2017

Chiral [2.2.2] dienes as ligands for Rh(I) in conjugate additions of boronic acids to a wide range of acceptors.

scientific article published in October 2004

Design, synthesis, and applications of potential substitutes of t-Bu-phosphinooxazoline in Pd-catalyzed asymmetric transformations and their use for the improvement of the enantioselectivity in the Pd-catalyzed allylation reaction of fluorinated all

scientific article published on 07 December 2011

Diastereoselective palladium-catalyzed formate reduction of allylic carbonates as a new entry into propionate units

scientific article published on 01 September 2003

Diastereoselective palladium-catalyzed formate reduction of allylic carbonates en route to polypropionate systems

scientific article published in March 2006

Direct C-F bond formation using photoredox catalysis.

scientific article

Direct Esterification of Carboxylic Acids with Perfluorinated Alcohols Mediated by XtalFluor-E

scientific article published on 07 December 2016

Direct Hydrofluorination of Methallyl Alkenes Using a Methanesulfonic Acid/Triethylamine Trihydrofluoride Combination

scientific article published on 14 November 2019

Drastic fluorine effect: complete reversal of the selectivity in the Au-catalyzed hydroalkoxylation reaction of fluorinated haloalkynes

scientific article published on 29 April 2020

Efficient synthesis of silylated 2,2-difluorostyrene derivatives through Suzuki-Miyaura cross-coupling of 2,2-difluoro-1-iodo-1-silylethenes.

scientific article published in February 2013

Eliminative Deoxofluorination Using XtalFluor-E: A One-Step Synthesis of Monofluoroalkenes from Cyclohexanone Derivatives

scientific article published on 27 June 2017

Enabling nucleophilic substitution reactions of activated alkyl fluorides through hydrogen bonding.

scientific article published on 24 April 2013

Evaluation of the effect of fluorination on the property of monofluorinated dimyristoylphosphatidylcholines

scientific article published in July 2014

Exploiting a Difference in Leaving Group Ability: An Approach to β-Substituted Monofluoroalkenes Using gem-Chlorofluoropropenes

scientific article published on 04 April 2016

Fluorine transfer to alkyl radicals

scientific article published on 22 February 2012

Fluoroiodomethane

Gold-Catalyzed Hydrofluorination of Internal Alkynes Using Aqueous HF

scientific article published on 30 October 2019

Halogenation of primary alcohols using a tetraethylammonium halide/[Et2NSF2]BF4 combination

scientific article published on 16 October 2012

Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides.

scientific article published on 13 November 2017

In situ activation of benzyl alcohols with XtalFluor-E: formation of 1,1-diarylmethanes and 1,1,1-triarylmethanes through Friedel-Crafts benzylation

scientific article

Incorporating a Monofluoroalkene into the Backbones of Short Peptides: Evaluating the Impact on Local Hydrophobicity

scientific article published on 24 June 2019

Influence of the Length and Charge on the Activity of α-Helical Amphipathic Antimicrobial Peptides

scientific article

Introduction of the 4,4,4-trifluorobut-2-ene chain exploiting a regioselective Tsuji-Trost reaction catalyzed by palladium nanoparticles

scientific article published on 25 March 2015

Monofluorination of Organic Compounds: 10 Years of Innovation.

scientific article published on 09 April 2015

Monofluoroalkene-Isostere as a 19 F NMR Label for the Peptide Backbone: Synthesis and Evaluation in Membrane-Bound PGLa and (KIGAKI)3

scientific article published on 23 January 2020

Palladium-catalyzed sequential alkylation-alkenylation reactions and their application to the synthesis of fused aromatic rings.

scientific article published in November 2001

Palladium-catalyzed synthesis of monofluoroalkenes from 3,3-difluoropropenes using dimethylmalonate and derivatives as nucleophiles.

scientific article published on 28 February 2017

Progress in the synthesis of fluorinated phosphatidylcholines for biological applications

scientific article published on 01 July 2018

Racemic and enantioselective metal-catalyzed synthesis of SF5-containing diarylmethanols.

scientific article

Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres

scientific article published on 12 December 2017

Regioselective Gold-Catalyzed Hydration of CF3- and SF5-alkynes

scientific article published on 30 April 2019

S(N)2' reaction of allylic difluorides with lithium amides and thiolates

scientific article published on 12 November 2012

Silver-Promoted Synthesis of 5-[(Pentafluorosulfanyl)methyl]-2-oxazolines

scientific article published on 29 October 2018

Stereochemical outcomes of C-F activation reactions of benzyl fluoride.

scientific article published on 9 January 2018

Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1.

scientific article published on 2 February 2018

Synthesis and growth inhibition activity of fluorinated derivatives of tamoxifen.

scientific article published on 26 January 2013

Synthesis and properties of monofluorinated dimyristoylphosphatidylcholine derivatives: potential fluorinated probes for the study of membrane topology

scientific article published on 19 December 2011

Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

scientific article published on 07 December 2011

Synthesis of Acyl Fluorides from Carboxylic Acids Using NaF-Assisted Deoxofluorination with XtalFluor-E

scientific article published on 21 July 2020

Synthetic approaches to monofluoroalkenes.

scientific article published on 11 March 2011

The use of fluoride as a leaving group: SN2' displacement of a C-F bond on 3,3-difluoropropenes with organolithium reagents to give direct access to monofluoroalkenes

scientific article published on 28 September 2011

Triol-promoted activation of C-F bonds: Amination of benzylic fluorides under highly concentrated conditions mediated by 1,1,1-tris(hydroxymethyl)propane.

scientific article published on 13 November 2013

Use of XtalFluor-E as an Alternative to POCl3 in the Vilsmeier-Haack Formylation of C-2-Glycals

scientific article published on 10 July 2018

List of works by Jean-François Paquin

Activation of C-F bonds α to C-C multiple bonds

Activation of allylic C-F bonds: palladium-catalyzed allylic amination of 3,3-difluoropropenes.

Amine-borane complex-initiated SF<sub>5</sub>Cl radical addition on alkenes and alkynes

Asymmetric synthesis of 3,3-diarylpropanals with chiral diene-rhodium catalysts.

Characterization of the structure, dynamics and allosteric pathways of human NPP1 in its free form and substrate-bound complex from molecular modeling

Chiral [2.2.2] dienes as ligands for Rh(I) in conjugate additions of boronic acids to a wide range of acceptors.

Design, synthesis, and applications of potential substitutes of t-Bu-phosphinooxazoline in Pd-catalyzed asymmetric transformations and their use for the improvement of the enantioselectivity in the Pd-catalyzed allylation reaction of fluorinated all

Diastereoselective palladium-catalyzed formate reduction of allylic carbonates as a new entry into propionate units

Diastereoselective palladium-catalyzed formate reduction of allylic carbonates en route to polypropionate systems

Direct C-F bond formation using photoredox catalysis.

Direct Esterification of Carboxylic Acids with Perfluorinated Alcohols Mediated by XtalFluor-E

Direct Hydrofluorination of Methallyl Alkenes Using a Methanesulfonic Acid/Triethylamine Trihydrofluoride Combination

Drastic fluorine effect: complete reversal of the selectivity in the Au-catalyzed hydroalkoxylation reaction of fluorinated haloalkynes

Efficient synthesis of silylated 2,2-difluorostyrene derivatives through Suzuki-Miyaura cross-coupling of 2,2-difluoro-1-iodo-1-silylethenes.

Eliminative Deoxofluorination Using XtalFluor-E: A One-Step Synthesis of Monofluoroalkenes from Cyclohexanone Derivatives

Enabling nucleophilic substitution reactions of activated alkyl fluorides through hydrogen bonding.

Evaluation of the effect of fluorination on the property of monofluorinated dimyristoylphosphatidylcholines

Exploiting a Difference in Leaving Group Ability: An Approach to β-Substituted Monofluoroalkenes Using gem-Chlorofluoropropenes

Fluorine transfer to alkyl radicals

Fluoroiodomethane

Gold-Catalyzed Hydrofluorination of Internal Alkynes Using Aqueous HF

Halogenation of primary alcohols using a tetraethylammonium halide/[Et2NSF2]BF4 combination

Highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides.

In situ activation of benzyl alcohols with XtalFluor-E: formation of 1,1-diarylmethanes and 1,1,1-triarylmethanes through Friedel-Crafts benzylation

Incorporating a Monofluoroalkene into the Backbones of Short Peptides: Evaluating the Impact on Local Hydrophobicity

Influence of the Length and Charge on the Activity of α-Helical Amphipathic Antimicrobial Peptides

Introduction of the 4,4,4-trifluorobut-2-ene chain exploiting a regioselective Tsuji-Trost reaction catalyzed by palladium nanoparticles

Monofluorination of Organic Compounds: 10 Years of Innovation.

Monofluoroalkene-Isostere as a 19 F NMR Label for the Peptide Backbone: Synthesis and Evaluation in Membrane-Bound PGLa and (KIGAKI)3

Palladium-catalyzed sequential alkylation-alkenylation reactions and their application to the synthesis of fused aromatic rings.

Palladium-catalyzed synthesis of monofluoroalkenes from 3,3-difluoropropenes using dimethylmalonate and derivatives as nucleophiles.

Progress in the synthesis of fluorinated phosphatidylcholines for biological applications

Racemic and enantioselective metal-catalyzed synthesis of SF5-containing diarylmethanols.

Recent progress in the racemic and enantioselective synthesis of monofluoroalkene-based dipeptide isosteres

Regioselective Gold-Catalyzed Hydration of CF3- and SF5-alkynes

S(N)2' reaction of allylic difluorides with lithium amides and thiolates

Silver-Promoted Synthesis of 5-[(Pentafluorosulfanyl)methyl]-2-oxazolines

Stereochemical outcomes of C-F activation reactions of benzyl fluoride.

Synthesis and biological evaluation of novel quinazoline-4-piperidinesulfamide derivatives as inhibitors of NPP1.

Synthesis and growth inhibition activity of fluorinated derivatives of tamoxifen.

Synthesis and properties of monofluorinated dimyristoylphosphatidylcholine derivatives: potential fluorinated probes for the study of membrane topology

Synthesis of 1,3,4-oxadiazoles from 1,2-diacylhydrazines using [Et2NSF2]BF4 as a practical cyclodehydration agent

Synthesis of Acyl Fluorides from Carboxylic Acids Using NaF-Assisted Deoxofluorination with XtalFluor-E

Synthetic approaches to monofluoroalkenes.

The use of fluoride as a leaving group: SN2' displacement of a C-F bond on 3,3-difluoropropenes with organolithium reagents to give direct access to monofluoroalkenes

Triol-promoted activation of C-F bonds: Amination of benzylic fluorides under highly concentrated conditions mediated by 1,1,1-tris(hydroxymethyl)propane.

Use of XtalFluor-E as an Alternative to POCl3 in the Vilsmeier-Haack Formylation of C-2-Glycals