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List of works by Melvin Khee-Shing Leow

1-year pulmonary function and health status in survivors of severe acute respiratory syndrome

scientific article published in September 2005

A Review of the Phenomenon of Hysteresis in the Hypothalamus-Pituitary-Thyroid Axis

scientific article

A hypothetical index of hypothalamic-pituitary-adrenal (HPA) axis function.

scientific article

A mathematical model of pituitary--thyroid interaction to provide an insight into the nature of the thyrotropin--thyroid hormone relationship

scientific article published on 18 May 2007

A novel minimal mathematical model of the hypothalamus-pituitary-thyroid axis validated for individualized clinical applications.

scientific article published on 28 January 2014

A randomized placebo-controlled trial of alphacalcidol on the preservation of beta cell function in children with recent onset type 1 diabetes

scientific article published on 26 January 2013

Activated brown adipose tissue releases exosomes containing mitochondrial methylene tetrahydrofolate dehydrogenase (NADP dependent) 1-like protein (MTHFD1L)

scientific article published on 01 May 2022

Acute dysautonomia: a rare manifestation of diabetic autonomic neuropathy masquerading as pheochromocytoma

scientific article published on 01 December 2005

Adefovir-induced Fanconi syndrome: diagnostic pearls and perils of late or missed diagnosis.

scientific article published on 14 March 2014

Adipocyte Long Noncoding RNA Transcriptome Analysis of Obese Mice Identified Lnc-leptin Which Regulates Leptin

scientific article published on 8 March 2018

Analysis via Markov decision process to evaluate glycemic control strategies of a large retrospective cohort with type 2 diabetes: the ameliorate study

scientific article published on 21 February 2020

Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis

scientific article published on 23 June 2017

Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes

scientific article published on 30 April 2015

Apelin attenuates oxidative stress in human adipocytes.

scientific article published on 20 December 2013

Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.

scientific article

Association Between Early Life Weight Gain and Abdominal Fat Partitioning at 4.5 Years is Sex, Ethnicity, and Age Dependent

scientific article published on 01 February 2019

Association between Serum Vitamin D Metabolites and Metabolic Function in Healthy Asian Adults

scientific article published on 30 November 2020

Associations of physical activity levels and screen time with oral glucose tolerance test profiles in Singaporean women of reproductive age actively trying to conceive: the S-PRESTO study

scientific article published on 07 April 2019

Automated segmentation of visceral and subcutaneous (deep and superficial) adipose tissues in normal and overweight men.

scientific article

Body Composition and Acquired Functional Impairment in Survivors of Pediatric Critical Illness

scientific article published on 01 June 2019

Brown Adipose Tissue: Multimodality Evaluation by PET, MRI, Infrared Thermography, and Whole-Body Calorimetry (TACTICAL-II)

scientific article published on 13 July 2019

Brown fat activity determined by infrared thermography and thermogenesis measurement using whole body calorimetry (BRIGHT Study)

scientific article published on 19 December 2019

Brown fat detection by infrared thermography—An invaluable research methodology with noteworthy uncertainties confirmed by a mathematical proof

scientific article published in 2022

Calcinosis cutis with siliconomas complicated by hypercalcemia

scientific article

Can the Sequence of Food Presentation Influence Postprandial Glycaemia? (P10-072-19)

Catecholamine and metanephrine excess in intracerebral haemorrhage: revisiting an obscure yet common "pseudophaeochromocytoma"

scientific article published on May 2007

Central diabetes insipidus unmasked by corticosteroid therapy for cerebral metastases: beware the case with pituitary involvement and hypopituitarism

scientific article published in September 2017

Characterization of the Asian Phenotype - An Emerging Paradigm with Clinicopathological and Human Research Implications

scientific article

Clarifying the controversial risk-benefit profile of soluble ACE2 in COVID-19

scientific article published on 06 July 2020

Combination of soya protein and polydextrose reduces energy intake and glycaemic response via modulation of gastric emptying rate, ghrelin and glucagon-like peptide-1 in Chinese.

scientific article published in June 2016

Configuration of the hemoglobin oxygen dissociation curve demystified: a basic mathematical proof for medical and biological sciences undergraduates

scientific article published in June 2007

Correlating Cell Line Studies With Tissue Distribution of DPP4/TMPRSS2 and Human Biological Samples May Better Define the Viral Tropism of MERS-CoV ⬇️

scientific article published on July 21, 2013

Decline of thyroid hormones following preoperative therapeutic plasma exchange for stabilization of thyrotoxicosis ⬇️

scientific article published on August 30, 2010

Demethylation and re-methylation dynamics in transgenerational epigenetic inheritance

scientific article

Depletion interaction forces contribute to erythrocyte-endothelial adhesion in diabetes

scientific article published on 11 June 2019

Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice

scientific article published on 11 February 2016

Design of an online-tuned model based compound controller for a fully automated artificial pancreas

scientific article published on 20 March 2019

Determinants of Health-Related Quality of Life (HRQoL) in the Multiethnic Singapore Population - A National Cohort Study

scientific article

Determinants of intramyocellular lipid accumulation in early childhood

scientific article published on 28 August 2019

Differential Effects of Monounsaturated and Polyunsaturated Fats on Satiety and Gut Hormone Responses in Healthy Subjects

scientific article published on 03 December 2019

Differential cell adhesion of breast cancer stem cells on biomaterial substrate with nanotopographical cues

scientific article published on 21 April 2015

Do thyroid-stimulating hormone, body weight, or body mass index serve as adequate markers to guide levothyroxine dose titration?

scientific article published in October 2013

Dose-Dependent Effects of Exercise and Diet on Insulin Sensitivity and Secretion

scientific article published on 01 October 2019

Ectopic fat and aerobic fitness are key determinants of glucose homeostasis in nonobese Asians

scientific article published on 25 February 2019

Effect of chicken, fat and vegetable on glycaemia and insulinaemia to a white rice-based meal in healthy adults

scientific article published on 10 May 2014

Environmental origins of hypertension: phylogeny, ontogeny and epigenetics

scientific article

Erratum: Author Correction: Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis

scientific article published on 19 April 2018

Ethnic Differences in the Role of Adipocytokines Linking Abdominal Adiposity and Insulin Sensitivity Among Asians.

scientific article published on 26 August 2015

Ethnic differences in the association of fat and lean mass with bone mineral density in the Singapore population.

scientific article

Ethnic differences translate to inadequacy of high-risk screening for gestational diabetes mellitus in an Asian population: a cohort study

scientific article

Ethnic variation in the correlation between fasting glucose concentration and glycated hemoglobin (HbA1c).

scientific article published on September 2013

Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore

scientific article published on 01 February 2019

Exploring Extracellular Vesicles Biogenesis in Hypothalamic Cells through a Heavy Isotope Pulse/Trace Proteomic Approach

scientific article published on 25 May 2020

Fatal thyroid crisis years after two thyroidectomies for graves' disease: is thyroid tissue autotransplantation for postthyroidectomy hypothyroidism worthwhile?

scientific article published on 01 September 2002

Fibroblast Growth Factor-21, Leptin, and Adiponectin Responses to Acute Cold-Induced Brown Adipose Tissue Activation

scientific article published on 01 March 2020

Functional Outcomes and Physical Impairments in Pediatric Critical Care Survivors: A Scoping Review.

scientific article published on 30 March 2016

General error analysis in the relationship between free thyroxine and thyrotropin and its clinical relevance

scientific article published on 08 September 2013

Giant phaeochromocytoma presenting with an acute stroke: reappraising phaeochromocytoma surveillance for the neurofibromatosis type 1 phakomatosis.

scientific article published on 3 November 2017

Glycated Hemoglobin (HbA1c): Clinical Applications of a Mathematical Concept.

scientific article

High iodine (substrate) turnover Graves' disease: the intriguing 'rapid responder' variant of thyrotoxicosis.

scientific article

Human Immunodeficiency Virus/Highly Active Antiretroviral Therapy-Associated Metabolic Syndrome: Clinical Presentation, Pathophysiology, and Therapeutic Strategies ⬇️

scientific article published on May 1, 2003

Hyperparathyroidism due to eutopic PTH secretion from an ectopic intrathymic parathyroid cyst

scientific article published on 13 July 2011

Hyperthyroidism in the personalized medicine era: the rise of mathematical optimization

scientific article published on 26 June 2019

Hypocortisolism in survivors of severe acute respiratory syndrome (SARS).

scientific article published in August 2005

Hypothalamus-pituitary-thyroid feedback control: implications of mathematical modeling and consequences for thyrotropin (TSH) and free thyroxine (FT4) reference ranges

scientific article published in May 2014

Immune manipulation for Graves' disease: re-exploring an unfulfilled promise with modern translational research.

scientific article published on 09 August 2012

Impact of preloading either dairy or soy milk on postprandial glycemia, insulinemia and gastric emptying in healthy adults.

scientific article published on 6 October 2015

Iodine-131 therapy for hyperthyroidism prescribed by endocrinologist - our preliminary experience

scientific article published on 03 December 2008

Isolated adrenal mass in cachectic patients-don't forget malignant pheochromocytoma

scientific article

Letter to the Editor: The Ultimate Proof of the Log-linear Nature of TSH-Free T4 Relationship by Intraindividual Analysis of a Large Population

scientific article published on 01 May 2016

Lipoprotein Subclass Profile after Progressive Energy Deficits Induced by Calorie Restriction or Exercise

scientific article published on 21 November 2018

Low subjective socioeconomic status stimulates orexigenic hormone ghrelin - A randomised trial

scientific article published on 12 January 2018

Low-Dose Levothyroxine Reduces Intrahepatic Lipid Content in Patients With Type 2 Diabetes Mellitus and NAFLD

scientific article published on 01 July 2018

Mastication effects on the glycaemic index: impact on variability and practical implications.

scientific article

Minor perturbations of thyroid homeostasis and major cardiovascular endpoints–Physiological mechanisms and clinical evidence

scientific article published on 15 August 2022

Mitochondrial oxidative capacity and NAD+ biosynthesis are reduced in human sarcopenia across ethnicities

scientific article published on 20 December 2019

Molecular pathways linking the pheochromocytoma susceptibility genes

scientific article published on 01 December 2007

Morbidity and Mortality Risks of Premature Enteral Nutrition During the Recovery of Myxedema Coma (A Response to the Article Entitled "Pediatric Patient With Altered Mental Status and Hypoxemia").

scientific article published on September 2016

Multiple endocrinopathies associated with lithium therapy.

scientific article

New measure of insulin sensitivity predicts cardiovascular disease better than HOMA estimated insulin resistance

scientific article (publication date: 2013)

Non‐steroidal anti‐inflammatory drugs (NSAIDS) for trigger finger

Obstructive sleep apnoea and the orexigenic pathway in type 2 diabetes

scientific article published on 8 May 2010

Oncogenic osteomalacia presenting as a crippling illness in a young man.

scientific article

Oxytocin in metabolic homeostasis: implications for obesity and diabetes management

scientific article published on 25 September 2018

PPARβ/δ Agonism Upregulates Forkhead Box A2 to Reduce Inflammation in C2C12 Myoblasts and in Skeletal Muscle

scientific article published on 04 March 2020

PTENHaploinsufficiency, Obesity, and Insulin Sensitivity ⬇️

scientific article published on December 20, 2012

Personalized glucose-insulin model based on signal analysis.

scientific article published on 27 December 2016

Pituitary abscess: our experience with a case and a review of the literature.

scientific article

Polyphenol-rich curry made with mixed spices and vegetables benefits glucose homeostasis in Chinese males (Polyspice Study): a dose-response randomized controlled crossover trial

scientific article published on 13 December 2017

Postprandial changes in cardiometabolic disease risk in young Chinese men following isocaloric high or low protein diets, stratified by either high or low meal frequency - a randomized controlled crossover trial

scientific article published on 15 March 2016

Postprandial glucose, insulin and incretin responses differ by test meal macronutrient ingestion sequence (PATTERN study)

scientific article published on 27 April 2019

Pre-operative serum alkaline phosphatase as a predictor for hypocalcemia post-parathyroid adenectomy

scientific article

Predictors of cardiovascular complication in patients with diabetes mellitus: a 5-year follow-up study in a multiethnic population of Singapore: CREDENCE II study

scientific article published on 7 September 2013

Profiling retrospective thyroid function data in complete thyroidectomy patients to investigate the HPT axis set point (PREDICT-IT)

scientific article published on 17 August 2020

Psychometric analysis of an eating behaviour questionnaire for an overweight and obese Chinese population in Singapore.

scientific article published on 2 March 2016

Quality of life and psychological status in survivors of severe acute respiratory syndrome at 3 months postdischarge

scientific article published in May 2006

RNA Binding Protein, Ybx2, Regulates RNA Stability During Cold-Induced Brown Fat Activation.

scientific article published on 29 September 2017

Retraction: Pid1 Induces Insulin Resistance in Both Human and Mouse Skeletal Muscle during Obesity ⬇️

scientific article published on August 8, 2013

Segmentation and characterization of interscapular brown adipose tissue in rats by multi-parametric magnetic resonance imaging.

scientific article published on 8 January 2016

Sex Differences in Glucose and Fatty Acid Metabolism in Asians Who Are Nonobese

scientific article published on 01 January 2019

Skeletal Muscle Ultrasonography in Nutrition and Functional Outcome Assessment of Critically Ill Children: Experience and Insights From Pediatric Disease and Adult Critical Care Studies [Formula: see text].

scientific article published in December 2016

Smaller size of high metabolic rate organs explains lower resting energy expenditure in Asian-Indian Than Chinese men.

scientific article published on 16 November 2015

Smartphone apps for calculating insulin dose: a systematic assessment.

scientific article

The TSH–free thyroxine relationship: logarithmic-linear or error function? ⬇️

scientific article published on July 29, 2010

The enigmatic duality of high-density lipoprotein-cardioprotective yet potentially atherogenic: comment on the article by McMahon et al

scientific article published on 01 February 2007

The haptoglobin 2-2 genotype is associated with inflammation and carotid artery intima-media thickness.

scientific article published on 16 May 2016

The homeostatic set point of the hypothalamus-pituitary-thyroid axis--maximum curvature theory for personalized euthyroid targets.

scientific article

The influence of the menstrual cycle on energy balance and taste preference in Asian Chinese women

scientific article published on 14 December 2014

Therapeutic plasma exchange for control of thyroid storm

scientific article published on 21 August 2020

Under-recognised paradox of neuropathy from rapid glycaemic control.

scientific article

VIPoma in a 37-year-old man.

scientific article published in August 2013

Validation of prediction equations for resting energy expenditure in Singaporean Chinese men.

scientific article published in May 2014

Visceral adipose tissue tracks more closely with metabolic dysfunction than intrahepatic triglyceride in lean Asians without diabetes

scientific article published on 10 May 2018

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