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List of works by Roger Hunter

4-Aminoquinoline Antimalarials Containing a Benzylmethylpyridylmethylamine Group Are Active against Drug Resistant Plasmodium falciparum and Exhibit Oral Activity in Mice

scientific article published on 29 November 2017

A series of structurally simple chloroquine chemosensitizing dibemethin derivatives that inhibit chloroquine transport by PfCRT.

scientific article published on 22 February 2011

Bifunctional inhibition of human immunodeficiency virus type 1 reverse transcriptase: mechanism and proof-of-concept as a novel therapeutic design strategy

scientific article published on 9 May 2013

C-2-aryl O-substituted HI-236 derivatives as non-nucleoside HIV-1 reverse-transcriptase inhibitors

scientific article

Catalytic enantioselective acyl transfer: the case for 4-PPY with a C-3 carboxamide peptide auxiliary based on synthesis and modelling studies

scientific article published on 4 November 2016

Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with Plasmodium falciparum Multidrug Resistance-Associated Protein and Lipids

scientific article published on 24 September 2018

Chemoselective room temperature E1cB N-N cleavage of oxazolidinone hydrazides from enantioselective aldehyde α-hydrazination: synthesis of (+)-1,4-dideoxyallonojirimycin

scientific article published on 5 January 2016

Current developments in the synthesis and biological activity of HIV-1 double-drug inhibitors.

scientific article published on January 2007

Garlic-derived anticancer agents: structure and biological activity of ajoene.

scientific article published on January 2010

Identification and Mechanistic Evaluation of Hemozoin-Inhibiting Triarylimidazoles Active against Plasmodium falciparum

scientific article published on 24 January 2017

Identification and SAR Evaluation of Hemozoin-Inhibiting Benzamides Active against Plasmodium falciparum.

scientific article published on 14 June 2016

In vitro antimalarial activity, β-haematin inhibition and structure-activity relationships in a series of quinoline triazoles

scientific article published on 12 September 2013

Inclusion of the allicin mimicS-p-tolylt-butylthiosulphinate in β-cyclodextrin

Inexpensive, one-pot synthesis of unsymmetrical disulfides using 1-chlorobenzotriazole

scientific article published in October 2006

Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols

scientific article

Modification, crosslinking and reactive electrospinning of a thermoplastic medical polyurethane for vascular graft applications.

scientific article published on 18 January 2010

Preparation and structure of an air stable sodium cyanoborate salt

Preparation, Thermal Behaviour and Solid-state Structures of Inclusion Complexes of Permethylated-β-cyclodextrin with the Garlic-derived Antithrombotics (E)- and (Z)-Ajoene

Quaternized α,α'-Amino Acids via Curtius Rearrangement of Substituted Malonate-Imidazolidinones

scientific article published on 13 September 2017

Quinoline antimalarials containing a dibemethin group are active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).

scientific article

Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum

scientific article

Solution chemistry of 1,15-bis(N,N-dimethyl)-5,11-dioxo-8-(N-benzyl)-1,4,8,12,15-pentaazapentadecane with metal ions of biological interest-Insights toward active metal ion containing therapeutics and diagnostic agents

scientific article published on 8 June 2006

Stereoselective formation of quaternary stereogenic centers via alkylation of α-substituted malonate-imidazolidinones.

scientific article

Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity.

scientific article published on January 2000

Structure–activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells

scientific article published on February 11, 2012

Synthesis and anti-prion activity evaluation of aminoquinoline analogues

scientific article published on 6 August 2010

Synthesis of (+)-Tacamonine via Stereoselective Radical Cyclization

scientific article published on 24 October 2019

Synthesis of 2-deoxy-2-C-alkylglucosides of myo-inositol as possible inhibitors of a N-deacetylase enzyme in the biosynthesis of mycothiol.

scientific article

Technetium-99m labelling of bis-oxime ligands

scientific article published in May 1994

The Mechanism of the Amidases: MUTATING THE GLUTAMATE ADJACENT TO THE CATALYTIC TRIAD INACTIVATES THE ENZYME DUE TO SUBSTRATE MISPOSITIONING

scientific article

The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS.

scientific article published on 04 April 2016

The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells.

scientific article published on 24 July 2015

Thiolsulfinate allicin from garlic: inspiration for a new antimicrobial agent.

scientific article

Unsymmetrical Organotrisulfide Formation via Low-Temperature Disulfanyl Anion Transfer to an Organothiosulfonate

scientific article published on 18 February 2019

[d4U]-butyne-[HI-236] as a non-cleavable, bifunctional NRTI/NNRTI HIV-1 reverse-transcriptase inhibitor

scientific article published on 4 February 2007

[d4U]-spacer-[HI-236] double-drug inhibitors of HIV-1 reverse-transcriptase.

scientific article