List of works - James A Timmons

A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes.

scientific article published on 8 September 2017

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

A dynamic ribosomal biogenesis response is not required for IGF-1-mediated hypertrophy of human primary myotubes.

scientific article published on 3 August 2017

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status

scientific article

A reverse genetics cell-based evaluation of genes linked to healthy human tissue age.

scientific article published on 3 October 2016

A statistical and biological response to an informatics appraisal of healthy aging gene signatures

scientific article published on 02 August 2019

A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype

scientific article published on 7 October 2010

Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.

scientific article published on 21 October 2004

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

scientific article

An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes

scientific article

Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss

scientific article published on 03 August 2016

Chasing the "ghost" of the acetyl group deficit.

scientific article published in January 2005

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

scientific article

Chronic treatment with the beta(2)-adrenoceptor agonist prodrug BRL-47672 impairs rat skeletal muscle function by inducing a comprehensive shift to a faster muscle phenotype

scientific article published on 14 July 2006

Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription

article published in 2008

Considerations when using the significance analysis of microarrays (SAM) algorithm

scientific article

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.

scientific article

Does everything now make (anti)sense?

scientific article published on 01 December 2006

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review.

scientific article

Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness

scientific article published on 2 February 2016

Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes

scientific article published on 02 December 2005

Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

scientific article

Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway ⬇️

scientific article published on May 21, 2013

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

scientific article

Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle

scientific article published in August 2005

High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression.

scientific article published on 28 October 2010

Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia.

scientific article published on February 1996

Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes

scientific article

Integrative pathway analysis of a genome-wide association study of (V)O(2max) response to exercise training.

scientific article published on 29 August 2013

Interaction between aerobic and anaerobic metabolism during intense muscle contraction

scientific article published on 01 January 1998

Is irisin a human exercise gene?

scientific article

Limb proportions show developmental plasticity in response to embryo movement

scientific article published on 06 February 2017

Longevity-related molecular pathways are subject to midlife "switch" in humans

scientific article published on 06 June 2019

Loss of neuronatin promotes "browning" of primary mouse adipocytes while reducing Glut1-mediated glucose disposal.

scientific article

Metabolic adaptations to repeated periods of contraction with reduced blood flow in canine skeletal muscle.

scientific article

Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle

scientific article published on 01 August 1997

Metabolic responses of canine gracilis muscle during contraction with partial ischemia

scientific article published on 01 March 1996

Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans

scientific article

Modulation of microRNAs during exercise and disease in human skeletal muscle

scientific article published on 01 October 2011

Molecular Diagnostics of Ageing and Tackling Age-related Disease

scientific article published on 12 December 2016

Molecular networks of human muscle adaptation to exercise and age

scientific article

Molecular studies of exercise, skeletal muscle, and ageing

scientific article

Multiple sources of bias confound functional enrichment analysis of global -omics data

scientific article

Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise

scientific article published on 01 February 1998

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

scholarly article

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

scientific article published on 20 December 2019

Pyruvate dehydrogenase complex activation status and acetyl group availability as a site of interchange between anaerobic and oxidative metabolism during intense exercise

scientific article published on 01 January 1998

Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues

scientific article published on 9 August 2011

Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction

scientific article published on 01 May 1998

Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks.

scientific article published on 22 April 2013

Single-Gene Genotyping and Personalized Preventive Care

scientific article published on 01 July 2015

Submaximal running economy in run-trained pre-pubertal boys.

scientific article published in March 1996

Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies

scientific article published on 27 March 2012

Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance.

scientific article published on 5 February 2009

The Importance of Brown Adipose Tissue

scientific article published on 01 July 2009

The effect of the beta2-adrenoceptor agonist prodrug BRL-47672 on cardiovascular function, skeletal muscle myosin heavy chain, and MyoD expression in the rat.

scientific article published on 8 July 2004

The experimental type 2 diabetes therapy glycogen phosphorylase inhibition can impair aerobic muscle function during prolonged contraction

scientific article published in June 2006

The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function

scientific article

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist.

scientific article published on 20 May 2008

Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis

scientific article published on 01 October 2012

Using functional genomics to study PINK1 and metabolic physiology.

scientific article

Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans

scientific article

Using systems biology to define the essential biological networks responsible for adaptation to endurance exercise training.

scientific article published on November 2007

Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia

scientific article

VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise

scientific article published on 20 January 2005

Variability in training-induced skeletal muscle adaptation.

scientific article

What happens if you pose the wrong questions?

scientific article published on 01 October 2011

iGEMS: an integrated model for identification of alternative exon usage events

scientific article published on 19 April 2016

List of works by James A Timmons

A Practical and Time-Efficient High-Intensity Interval Training Program Modifies Cardio-Metabolic Risk Factors in Adults with Risk Factors for Type II Diabetes.

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

A dynamic ribosomal biogenesis response is not required for IGF-1-mediated hypertrophy of human primary myotubes.

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status

A reverse genetics cell-based evaluation of genes linked to healthy human tissue age.

A statistical and biological response to an informatics appraisal of healthy aging gene signatures

A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype

Acetyl group availability influences phosphocreatine degradation even during intense muscle contraction.

Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration?

An essential role for Tbx15 in the differentiation of brown and "brite" but not white adipocytes

Biomarkers of browning of white adipose tissue and their regulation during exercise- and diet-induced weight loss

Chasing the "ghost" of the acetyl group deficit.

Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

Chronic treatment with the beta(2)-adrenoceptor agonist prodrug BRL-47672 impairs rat skeletal muscle function by inducing a comprehensive shift to a faster muscle phenotype

Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription

Considerations when using the significance analysis of microarrays (SAM) algorithm

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes.

Does everything now make (anti)sense?

Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review.

Expression of protocadherin gamma in skeletal muscle tissue is associated with age and muscle weakness

Expression profiling following local muscle inactivity in humans provides new perspective on diabetes-related genes

Extremely short duration high intensity interval training substantially improves insulin action in young healthy males

Focal adhesion kinase is required for IGF-I-mediated growth of skeletal muscle cells via a TSC2/mTOR/S6K1-associated pathway ⬇️

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

Glycogen phosphorylase inhibition in type 2 diabetes therapy: a systematic evaluation of metabolic and functional effects in rat skeletal muscle

High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression.

Increased acetyl group availability enhances contractile function of canine skeletal muscle during ischemia.

Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes

Integrative pathway analysis of a genome-wide association study of (V)O(2max) response to exercise training.

Interaction between aerobic and anaerobic metabolism during intense muscle contraction

Is irisin a human exercise gene?

Limb proportions show developmental plasticity in response to embryo movement

Longevity-related molecular pathways are subject to midlife "switch" in humans

Loss of neuronatin promotes "browning" of primary mouse adipocytes while reducing Glut1-mediated glucose disposal.

Metabolic adaptations to repeated periods of contraction with reduced blood flow in canine skeletal muscle.

Metabolic responses from rest to steady state determine contractile function in ischemic skeletal muscle

Metabolic responses of canine gracilis muscle during contraction with partial ischemia

Modulation of extracellular matrix genes reflects the magnitude of physiological adaptation to aerobic exercise training in humans

Modulation of microRNAs during exercise and disease in human skeletal muscle

Molecular Diagnostics of Ageing and Tackling Age-related Disease

Molecular networks of human muscle adaptation to exercise and age

Molecular studies of exercise, skeletal muscle, and ageing

Multiple sources of bias confound functional enrichment analysis of global -omics data

Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise

Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages.

Novel approach reveals genomic landscapes of single-strand DNA breaks with nucleotide resolution in human cells

Pyruvate dehydrogenase complex activation status and acetyl group availability as a site of interchange between anaerobic and oxidative metabolism during intense exercise

Recruited vs. nonrecruited molecular signatures of brown, "brite," and white adipose tissues

Regulation of skeletal muscle carbohydrate oxidation during steady-state contraction

Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks.

Single-Gene Genotyping and Personalized Preventive Care

Submaximal running economy in run-trained pre-pubertal boys.

Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies

Systematic analysis of adaptations in aerobic capacity and submaximal energy metabolism provides a unique insight into determinants of human aerobic performance.

The Importance of Brown Adipose Tissue

The effect of the beta2-adrenoceptor agonist prodrug BRL-47672 on cardiovascular function, skeletal muscle myosin heavy chain, and MyoD expression in the rat.

The experimental type 2 diabetes therapy glycogen phosphorylase inhibition can impair aerobic muscle function during prolonged contraction

The human PINK1 locus is regulated in vivo by a non-coding natural antisense RNA during modulation of mitochondrial function

Thermogenically competent nonadrenergic recruitment in brown preadipocytes by a PPARgamma agonist.

Time-series transcriptional profiling yields new perspectives on susceptibility to murine osteoarthritis

Using functional genomics to study PINK1 and metabolic physiology.

Using molecular classification to predict gains in maximal aerobic capacity following endurance exercise training in humans

Using systems biology to define the essential biological networks responsible for adaptation to endurance exercise training.

Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia

VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise

Variability in training-induced skeletal muscle adaptation.

What happens if you pose the wrong questions?

iGEMS: an integrated model for identification of alternative exon usage events