Search filters

List of works by Eric T MacKenzie

2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo

scientific article published in October 2004

A Transforming Growth Factor-β Antagonist Unmasks the Neuroprotective Role of This Endogenous Cytokine in Excitotoxic and Ischemic Brain Injury

scientific article published on 01 December 1999

A potential role for erythropoietin in focal permanent cerebral ischemia in mice.

scientific article published on June 1999

Acetylcholine and vasoactive intestinal peptide in cerebral blood vessels: effect of extirpation of the sphenopalatine ganglion

scientific article published on 01 April 1989

Akt-dependent expression of NAIP-1 protects neurons against amyloid-{beta} toxicity

scientific article published on 29 March 2005

Amine mechanisms in the cerebral circulation ⬇️

scientific article published on December 1, 1976

Anaesthesia for studies of the cerebral circulation: a comparison of phencyclidine and althesin in the baboon

scientific article published on October 1, 1978

Angiopoietin-1-induced PI3-kinase activation prevents neuronal apoptosis.

scientific article

Angiopoietin-2 is vasoprotective in the acute phase of cerebral ischemia

scientific article published on 5 December 2012

Apoptotic death in cortical neurons of mice subjected to focal ischemia

scientific article published on 01 October 1996

Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling

scientific article published on 23 September 2004

Autoradiographic mapping of cerebral blood flow responses to cholinergic stimulation of the rat substantia innominata: modulatory effect of galanin

scientific article published in April 1998

Basal forebrain control of cortical blood flow and tissue gases in conscious aged rats

scientific article published on 01 October 1994

Brain ischaemia, calcium and calcium antagonists.

scientific article published in May 1982

Brain kinetics and specific binding of [11C]PK 11195 to omega 3 sites in baboons: positron emission tomography study.

scientific article published in August 1991

Calcium antagonists: effects on cerebral blood flow and blood-brain barrier permeability in the rat.

scientific article published on May 1983

Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models.

scientific article

Central serotonergic nerves project to the pial vessels of the brain.

scientific article published in November 1983

Cerebral circulation and norepinephrine: relevance of the blood-brain barrier.

scientific article

Cerebral circulatory and metabolic effects of 5-hydroxytryptamine in anesthetized baboons ⬇️

scientific article published on October 1, 1977

Cerebral circulatory and metabolic effects of perivascular neurotransmitters.

scientific article published on January 1987

Cerebral venous pressure during actively induced hypertension and hypercapnia in cats

scientific article published on 01 March 1980

Cerebro-circulatory effects of so-called 'vasodilators' in the anaesthetised rat.

scientific article published in January 1983

Cerebrovascular actions of serotonin

scientific article published on January 1, 1978

Cerebrovascular effects of sodium nitroprusside in the anaesthetized baboon: a positron emission tomographic study

scientific article published in April 2005

Cerebrovascular evidence for a GABAergic modulation of the cholinergic vasodilatatory basalocortical system in the rat.

scientific article

Cerebrovascular nerve fibers immunoreactive for tryptophan-5-hydroxylase in the rat: distribution, putative origin and comparison with sympathetic noradrenergic nerves.

scientific article published on December 1992

Cerebrovascular responses to haemorrhagic hypotension in anaesthetized cats. Effects of alpha-adrenoceptor antagonists

scientific article

Changes in ouabain affinity of Na+, K+-ATPase during focal cerebral ischaemia in the mouse

scientific article published in November 1997

Cholinergic and vasoactive intestinal polypeptidergic innervation of the cerebral arteries.

scientific article published on January 1995

Cholinergic innervation of small pial vessels: specific uptake and release processes

scientific article published in January 1986

Choroidal and cerebral blood flow in baboons measured by the external monitoring of radioactive inert gases

scientific article published on 01 June 1977

Chronic arterial hypertension impedes glioma growth: a multiparametric MRI study in the rat.

scientific article published on 18 June 2015

Concentrations of putative neurovascular transmitters in major cerebral arteries and small pial vessels of various species

scientific article published in August 1987

Correlation of local blood flow, glucose consumption and probability of necrosis following a middle cerebral artery occlusion in the cat

scientific article published on 01 January 1981

Cortical blood flow increases induced by stimulation of the substantia innominata in the unanesthetized rat

scientific article published on 01 July 1989

Cortical hypometabolism and its recovery following nucleus basalis lesions in baboons: a PET study.

scientific article

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat.

scientific article

Detection of glioblastoma response to temozolomide combined with bevacizumab based on μMRI and μPET imaging reveals [18F]-fluoro-L-thymidine as an early and robust predictive marker for treatment efficacy

scientific article published on 31 October 2012

Determination of 18F-fluoro-2-deoxy-D-glucose rate constants in the anesthetized baboon brain with dynamic positron tomography.

scientific article published in December 1993

Differential effects of electrical stimulation of the dorsal raphe nucleus and of cervical sympathectomy on serotonin and noradrenaline concentrations in major cerebral arteries and pial vessels in the rat

scientific article published on 01 January 1990

Differential time-course decreases in nonselective, mu-, delta-, and kappa-opioid receptors after focal cerebral ischemia in mice.

scientific article published in June 1999

Direct vascular effects of agents used in the pharmacotherapy of cerebrovascular disease on isolated cerebral vessels

scientific article published on 01 January 1981

Dual action of serotonin on pial arterioles in situ and the effect of propranolol on the response

scientific article published on 01 January 1977

Early reperfusion in the anesthetized baboon reduces brain damage following middle cerebral artery occlusion: a quantitative analysis of infarction volume

scientific article

Editorial: Hypertension and the cerebral circulation

scientific article published on July 1, 1976

Effect of adenosine triphosphate and some derivatives on cerebral blood flow and metabolism ⬇️

scientific article published on November 1, 1979

Effect of exogenous noradrenaline on local cerebral blood flow after osmotic opening of the blood-brain barrier in the rat.

scientific article published in January 1978

Effect of halothane on the autoregulation of cerebral blood flow in chronically hypertensive baboons

scientific article published on January 1, 1977

Effect of serotonin on cerebral function, metabolism and circulation

scientific article published on January 1, 1977

Effect of stimulation of the sphenopalatine ganglion on cortical blood flow in the rat

scientific article published on 01 December 1988

Effects of acutely induced hypertension in cats on pial arteriolar caliber, local cerebral blood flow, and the blood-brain barrier

scientific article published on July 1, 1976

Effects of agents used in the pharmacotherapy of cerebrovascular disease on the oxygen consumption of isolated cerebral mitochondria

scientific article

Effects of decreasing arterial blood pressure on cerebral blood flow in the baboon. Influence of the sympathetic nervous system ⬇️

scientific article published on November 1, 1975

Effects of dorsal raphe nucleus stimulation on cerebral blood flow and flow-metabolism coupling in the conscious rat.

scientific article published in July 1993

Effects of dorsal raphe stimulation on cerebral glucose utilization in the anaesthetized rat.

scientific article published in December 1991

Effects of haemorrhagic hypotension on the cerebral circulation

scientific article published on January 1, 1977

Effects of hemorrhagic hypotension on the cerebral circulation. I. Cerebral blood flow and pial arteriolar caliber.

scientific article published in November 1979

Effects of hemorrhagic hypotension on the cerebral circulation. II. Electrocortical function ⬇️

scientific article published on November 1, 1979

Effects of hemorrhagic hypotension on the cerebral circulation. III. Neuropathology

scientific article published on November 1, 1979

Effects of hypotension induced by halothane, on the cerebral circulation in baboons with experimental renovascular hypertension ⬇️

scientific article published on February 1, 1978

Effects of indomethacin on cerebral blood flow and oxygen metabolism: a positron emission tomographic investigation in the anaesthetized baboon

scientific article published in December 1996

Effects of intracarotid adenosine triphosphate infusions on cerebral blood flow and metabolism in the anaesthetized baboon

scientific article published in August 1975

Effects of intraventricular 6-hydroxydopamine on cerebrovascular CO2 reactivity in anesthetized rats

scientific article published on 01 September 1977

Effects of nifedipine of pial arteriolar calibre: an in vivo study

scientific article published on 01 November 1979

Effects of the GABA receptor agonist, progabide, upon local cerebral glucose utilization

scientific article published in October 1987

Effects of unilateral lesion of the nucleus basalis of Meynert on brain glucose utilization in callosotomized baboons: a PET study

scientific article published in September 1990

Effects of urotensin-II on cerebral blood flow and ischemia in anesthetized rats

scientific article

Evaluation of the ratio of cerebral blood flow to cerebral blood volume as an index of local cerebral perfusion pressure.

scientific article published in July 1998

Evidence against cerebral vasospasm during acutely induced hypertension

scientific article published on March 5, 1976

Evidence of type I and type II transforming growth factor-beta receptors in central nervous tissues: changes induced by focal cerebral ischemia.

scientific article published in June 1998

Exofocal alterations in opioidergic receptor densities following focal cerebral ischemia in the mouse

scientific article published on 01 August 2000

Expression of Receptors for Complement Anaphylatoxins C3a and C5a Following Permanent Focal Cerebral Ischemia in the Mouse

scientific article published on 01 January 2000

Focal cerebral ischaemia induces a decrease in activity and a shift in ouabain affinity of Na+, K+-ATPase isoforms without modifications in mRNA and protein expression

scientific article

Functional mapping of the effects of lesions of the habenular nuclei and their afferents in the rat.

scientific article published in November 1986

Galanin inhibits the vasodilatatory basalocortical cholinergic system in the anaesthetized rat.

scientific article published in October 1995

Glial responses, clusterin, and complement in permanent focal cerebral ischemia in the mouse

article

Haemodynamic correlates of penumbral depolarization following focal cerebral ischaemia

scientific article published on 01 October 2000

Heterogeneous vasomotor responses of anatomically distinct feline cerebral arteries.

scientific article published on June 1988

Histofluorescence study on monoamine entry into the brain before and after opening of the blood-brain barrier by various mechanisms

scientific article published on 01 July 1979

Hypoxia induces macrophage polarization and re-education toward an M2 phenotype in U87 and U251 glioblastoma models

scientific article published on 5 June 2015

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.

scientific article

Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.

scientific article

Imaging Modalities to Assess Oxygen Status in Glioblastoma

scientific article

Imaging of human brain lesions with an omega 3 site radioligand.

scientific article published in December 1988

Immersion and perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) compared to mitochondrial enzymes 6 hours after MCA-occlusion in primates.

scientific article published in June 1994

In vivo binding, pharmacokinetics and metabolism of the selective M2 muscarinic antagonists [3H]AF-DX 116 and [3H]AF-DX 384 in the anesthetized rat.

scientific article published in February 1996

In vivo mapping of brain benzodiazepine receptor changes by positron emission tomography after focal ischemia in the anesthetized baboon

scientific article published on 01 December 1993

Increased expression of transforming growth factor-beta after cerebral ischemia in the baboon: an endogenous marker of neuronal stress?

scientific article published in July 2001

Indoleaminergic mechanisms in brain vessels; localization, concentration, uptake and in vitro responses of 5-hydroxytryptamine

scientific article published in July 1984

Influence of ascending serotonergic pathways on glucose use in the conscious rat brain. II. Effects of electrical stimulation of the rostral raphé nuclei

scientific article

Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.

scientific article

Intraluminal thread model of focal stroke in the non-human primate

scientific article published on 14 November 2007

Is tissue-type plasminogen activator a neuromodulator?

scientific article published on April 2004

Ischaemic brain damage induced by rapid lowering of arterial pressure in hypertension.

scientific article published in June 1984

Ischemia-Induced Interleukin-6 as a Potential Endogenous Neuroprotective Cytokine against NMDA Receptor-Mediated Excitoxicity in the Brain

scientific article published on 01 June 2000

Letter: Acute hypertensive encephalopathy

scientific article

Long-term alterations in mu, delta and kappa opioidergic receptors following middle cerebral artery occlusion in mice

scientific article published on 04 August 2007

Matching gene expression with hypometabolism after cerebral ischemia in the nonhuman primate

scientific article published in October 2002

Maximal densities of mu, delta, and kappa receptors are differentially altered by focal cerebral ischaemia in the mouse

scientific article published in March 1998

Migraine and the blood-brain barrier ⬇️

scientific article published on May 14, 1977

Multimodal imaging based on MRI and PET reveals [(18)F]FLT PET as a specific and early indicator of treatment efficacy in a preclinical model of recurrent glioblastoma.

scientific article published on 5 November 2015

NADH fluorescence in vivo: changes in cerebral oxidative metabolism and perfusion induced by pentobarbital, indomethacin, and salicylate

scientific article published in June 1987

NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

scientific article

Neurochemical studies on the existence, origin and characteristics of the serotonergic innervation of small pial vessels

scientific article published in October 1985

Neuronal versus endothelial origin of vasoactive acetylcholine in pial vessels.

scientific article

Neuroprotection after focal cerebral ischaemia in hyperglycaemic and diabetic rats

scientific article published on 01 September 1995

Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway.

scientific article published on May 2001

Neurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosis

scientific article

Noninvasive assessment of hypoxia with 3-[18F]-fluoro-1-(2-nitro-1-imidazolyl)-2-propanol ([18F]-FMISO): a PET study in two experimental models of human glioma

scientific article published on April 2013

Normobaric hypoxia induces tolerance to focal permanent cerebral ischemia in association with an increased expression of hypoxia-inducible factor-1 and its target genes, erythropoietin and VEGF, in the adult mouse brain

scientific article published in April 2002

Osmotic opening of the blood-brain barrier: value in pharmacological studies on the cerebral circulation ⬇️

scientific article published on February 11, 1977

PET studies of [18F]methyl-MK-801, a potential NMDA receptor complex radioligand

scientific article published on 01 January 1991

Pharmacological properties of the receptor(s) involved in the 5-hydroxytryptamine-induced contraction of the feline middle cerebral artery

scientific article published on 01 June 1989

Positron emission tomographic studies of [11C]MDL 72222, a potential 5-HT3 receptor radioligand: distribution, kinetics and binding in the brain of the baboon

scientific article published in January 1993

Postischemic nitrous oxide alone versus intraischemic nitrous oxide in the presence of isoflurane: what it may change for neuroprotection against cerebral stroke in the rat.

scientific article published in August 2005

Potential use of early alterations in mu and delta opioid receptors as a predictive index for delayed brain ischemic damage.

scientific article

Proceedings: Autoregulation of cerebral blood flow in chronically hypertensive baboons.

scientific article published in August 1976

Proceedings: The upper limit of 'autoregulation' of cerebral blood flow in the baboon.

scientific article published in October 1973

Progressive impairment of brain oxidative metabolism reversed by reperfusion following middle cerebral artery occlusion in anaesthetized baboons

scientific article published in August 1997

Prostaglandin-induced effects in the primate cerebral circulation ⬇️

scientific article published on June 15, 1977

Receptors involved in the 5-hydroxytryptamine-induced contraction of isolated cerebral arteries

scientific article published on 01 January 1986

Recording of heart movements from the oesophagus.

scientific article published in November 1974

Reduction of ischemic brain damage by nitrous oxide and xenon.

scientific article published in October 2003

Regional brain uptake of noradrenaline following mechanical or osmotic opening of the blood-brain barrier

scientific article published in November 1977

Regional cerebral blood flow responses to neurochemical stimulation of the substantia innominata in the anaesthetized rat.

scientific article published on May 1995

Relationships between high oxygen extraction fraction in the acute stage and final infarction in reversible middle cerebral artery occlusion: an investigation in anesthetized baboons with positron emission tomography.

scientific article

Response of the cerebral circulation in baboons to changing perfusion pressure after indomethacin ⬇️

scientific article published on February 1, 1977

Responses of the cerebral circulation to hypercapnia and hypoxia after 7th cranial nerve transection in baboons

scientific article published on March 1, 1977

Role of the endothelium in the pial artery responses to several vasoactive peptides

scientific article published on 01 January 1986

Selective age-related changes in neuronal markers and smooth muscle reactivity in cerebrovascular beds of Fischer 344 rats

scientific article

Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat.

scientific article

Selective neuronal vulnerability and specific glial reactions in hippocampal and neocortical organotypic cultures submitted to ischemia.

scientific article published in March 1998

Sequential studies of severely hypometabolic tissue volumes after permanent middle cerebral artery occlusion. A positron emission tomographic investigation in anesthetized baboons

scientific article published on 01 November 1995

Serotonergic innervation of the cerebral vasculature: relevance to migraine and ischaemia

article

Serotonergic neuron stimulation modulates thalamocortical glucose use in the conscious rat.

scientific article published in August 1987

Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis

scientific article

Small pial vessels, but not choroid plexus, exhibit specific biochemical correlates of functional cholinergic innervation

scientific article published in May 1990

Sp1 and Smad transcription factors co-operate to mediate TGF-beta-dependent activation of amyloid-beta precursor protein gene transcription.

scientific article published on October 2004

Spontaneously hypertensive rats are highly vulnerable to AMPA-induced brain lesions

scientific article published on 27 September 2007

Studies on the cerebral circulation of the baboon in acutely induced hypertension.

scientific article

Synthesis and in vitro characterisation of ifenprodil-based fluorescein conjugates as GluN1/GluN2B N-Methyl-D-aspartate receptor antagonists.

scientific article

TIME COURSE OF EFFECTS OF UNILATERAL LESIONS OF THE NUCLEUS BASALIS OF MEYNERT ON GLUCOSE UTILIZATION BY THE CEREBRAL CORTEX

scientific article published on 01 April 1989

Temporal effects of habenular lesions on glucose utilization in the anterior raphé nuclei of the rat.

scientific article published in June 1986

Temporal evolution of regional energy metabolism following focal cerebral ischemia in the rat

scientific article published on 01 August 1988

The nature of penumbral depolarizations following focal cerebral ischemia in the rat.

scientific article published in September 1999

The pharmacotherapy of focal cortical ischaemia in the mouse

scientific article published in July 1990

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

scientific article

The quantification of brain lesions with an omega 3 site ligand: a critical analysis of animal models of cerebral ischaemia and neurodegeneration

scientific article published in July 1990

The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age.

scientific article

The response of the choroidal and cerebral circulations to changing arterial PCO2 and acetazolamide in the baboon

scientific article published on 01 June 1977

The sausage-string pattern in the pial vessels in acute, angiotensin-induced hypertension--vasospasm or vasodilatation?

scientific article published in January 1976

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis

scientific article published on 25 April 2005

Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.

scientific article

Transforming growth factor-beta 1 potentiates amyloid-beta generation in astrocytes and in transgenic mice

scientific article published on 7 March 2003

Transforming growth factor-beta and ischemic brain injury ⬇️

scientific article published on October 1, 2003

Transforming growth factor-beta1-modulated cerebral gene expression

scientific article published in September 2002

Unilateral eyeball enucleation differentially alters AMPA-, NMDA- and kainate glutamate receptor binding in the newborn rat brain.

scientific article

Up-regulation of a serine protease inhibitor in astrocytes mediates the neuroprotective activity of transforming growth factor beta1.

scientific article published in December 1998

Upper limit of autoregulation of cerebral blood flow in the baboon

scientific article published in April 1974

VEGF-Induced BBB Permeability is Associated with an MMP-9 Activity Increase in Cerebral ischemia: Both Effects Decreased by ANG-1

scientific article published on 01 November 2005

Various indices of brain metabolism and activity in a model of chronic neurological dysfunction: triethyl tin intoxication in the rat

scientific article published on 01 January 1981

Paulina is supported by:

About Paulina

Help