Search filters

List of works by Clare E. Hughes

ADAMTS-4_v1 is a splice variant of ADAMTS-4 that is expressed as a protein in human synovium and cleaves aggrecan at the interglobular domain

scientific article published on November 2013

ADAMTS4

ADAMTS5

Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.

scientific article published in November 1999

Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processing

scientific article published on 8 December 2003

Altered proteolytic activity and expression of MMPs and aggrecanases and their inhibitors in Kashin-Beck disease

An alternative spliced transcript of ADAMTS4 is present in human synovium from OA patients

scientific article published on 6 April 2006

Antibodies and immunohistochemistry in extracellular matrix research

scientific article

Articular cartilage metabolism in patients with Kashin-Beck Disease: an endemic osteoarthropathy in China

scientific article published on 22 October 2007

Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism.

scientific article

Binding and localization of recombinant lubricin to articular cartilage surfaces

scientific article published in March 2007

Catabolism of aggrecan, decorin and biglycan in tendon.

scientific article

Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease.

scientific article

Chondroitin sulfate sulfation motifs as putative biomarkers for isolation of articular cartilage progenitor cells

scientific article

Chondroitin sulphate and heparan sulphate sulphation motifs and their proteoglycans are involved in articular cartilage formation during human foetal knee joint development

scientific article published on 23 May 2012

Cyclosporin A inhibition of aggrecanase-mediated proteoglycan catabolism in articular cartilage

scientific article published in January 2002

Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration.

scientific article published on February 2005

Cytokine-induced cartilage proteoglycan degradation is mediated by aggrecanase

scientific article

Dietary fatty acids and arthritis.

scientific article published in March 2010

Differential Expression of Aggrecanase and Matrix Metalloproteinase Activity in Chondrocytes Isolated from Bovine and Porcine Articular Cartilage

scientific article published in Journal of Biological Chemistry

Differential expression of the keratan sulphate proteoglycan, keratocan, during chick corneal embryogenesis

scientific article

Differential relative sulfation of Keratan sulfate glycosaminoglycan in the chick cornea during embryonic development

scientific article published on 8 October 2009

Effects of culture conditions and exposure to catabolic stimulators (IL-1 and retinoic acid) on the expression of matrix metalloproteinases (MMPs) and disintegrin metalloproteinases (ADAMs) by articular cartilage chondrocytes

scientific article published in June 1999

Effects of n-3 fatty acids on cartilage metabolism

article

Effects of n-3 fatty acids on cartilage metabolism

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

scientific article published on 14 July 2008

Generation of anti-complement "prodrugs": cleavable reagents for specific delivery of complement regulators to disease sites

scientific article published on 3 July 2003

Glucosamine Hydrochloride but Not Chondroitin Sulfate Prevents Cartilage Degradation and Inflammation Induced by Interleukin-1α in Bovine Cartilage Explants

scientific article

Histopathology of chondronecrosis development in knee articular cartilage in a rat model of Kashin-Beck disease using T-2 toxin and selenium deficiency conditions

scientific article published on 19 January 2012

Immunochemical localization of keratan sulfate proteoglycans in cornea, sclera, and limbus using a keratanase-generated neoepitope monoclonal antibody

scientific article published in June 2008

Immunodetection and partial cDNA sequence of the proteoglycan, superficial zone protein, synthesized by cells lining synovial joints.

scientific article

Immunolocalisation and expression of keratocan in tendon

scientific article published on 31 August 2008

Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon

scientific article

Increased expression of chondroitin sulphate proteoglycans in rat hepatocellular carcinoma tissues ⬇️

scientific article published on August 14, 2012

Low molecular weight isoforms of the aggrecanases are responsible for the cytokine-induced proteolysis of aggrecan in a porcine chondrocyte culture system

scientific article published in September 2007

Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation

scientific article

Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase

scholarly article

Measurement of aggrecanase-generated interglobular domain catabolites in the medium and extracts of cartilage explants using Western blot analysis

scientific article

Modification of palm oil for anti-inflammatory nutraceutical properties.

scientific article published on 16 May 2009

Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.

scientific article

Phosphate prodrugs derived from N-acetylglucosamine have enhanced chondroprotective activity in explant cultures and represent a new lead in antiosteoarthritis drug discovery

scientific article

Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early- and late-stage osteoarthritis

scientific article published on 01 October 2005

Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect

scientific article

Proteoglycan metabolism, cell death and Kashin-Beck disease

scientific article

Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

scientific article

Relative efficacies of omega-3 polyunsaturated fatty acids in reducing expression of key proteins in a model system for studying osteoarthritis.

scientific article published on 13 January 2009

TIMP-3 inhibits aggrecanase-mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors

scientific article published on December 2003

The CS Sulfation Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify Stem Cell Populations and Their Niches, Activated Progenitor Cells and Transitional Areas of Tissue Development in the Fetal Human Elbow

scientific article published on 5 May 2016

The effect of beta-xylosides on the chondrogenic differentiation of mesenchymal stem cells

scientific article published on 23 August 2012

The influence of link protein stabilization on the viscometric properties of proteoglycan aggregate solutions

scientific article published on 01 August 1989

The ovine newborn and human foetal intervertebral disc contain perlecan and aggrecan variably substituted with native 7D4 CS sulphation motif: spatiotemporal immunolocalisation and co-distribution with Notch-1 in the human foetal disc

scientific article published on 13 June 2013

The role of human HtrA1 in arthritic disease

scientific article

The role of synovial macrophages and macrophage-produced cytokines in driving aggrecanases, matrix metalloproteinases, and other destructive and inflammatory responses in osteoarthritis

scientific article published on January 2006

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

scientific article published on March 2010

Utilization of a Recombinant Substrate rAgg1 to Study the Biochemical Properties of Aggrecanase in Cell Culture Systems

scientific article published in Journal of Biological Chemistry

Vascular dimorphism ensured by regulated proteoglycan dynamics favors rapid umbilical artery closure at birth

scientific article published on 10 September 2020

Paulina is supported by:

About Paulina

Help