List of works - Mohane S. Coumar

2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

scientific article published in January 2006

3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes

scientific article published on 12 December 2006

3D-QSAR-assisted drug design: identification of a potent quinazoline-based Aurora kinase inhibitor.

scientific article published on 22 November 2012

Advances in Aurora kinase inhibitor patents

scientific article published on March 2009

Anti-influenza drug discovery: identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization.

scientific article

Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.

scientific article

Apoptosis induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through intrinsic and extrinsic pathways.

scientific article published in December 2014

Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold

scientific article

Aurora kinase inhibitor patents and agents in clinical testing: an update (2009-10).

scientific article published on June 2011

Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 - 2013).

scientific article published on 26 June 2014

Aurora kinase inhibitors in preclinical and clinical testing

scientific article published on 01 April 2009

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

scientific article

BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF-κB pathway--A comparative study with curcumin.

scientific article published on 15 August 2015

BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells

scientific article published on 15 October 2019

BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

scientific article

Characterization of a new rat urinary metabolite of piperine by LC/NMR/MS studies.

scientific article published in August 2003

Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli

scientific article published on 17 April 2019

Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: a molecular dynamics study

scientific article published on 17 November 2018

Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists

scientific article

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

scientific article published on October 2010

Design of a potent anticancer lead inspired by natural products from traditional Indian medicine

scientific article published on 17 September 2019

Design of novel ROCK inhibitors using fragment-based de novo drug design approach

scientific article published on 22 August 2020

Discovery of non-glycoside sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening

scientific article published on 19 November 2010

Ensemble-based virtual screening: identification of a potential allosteric inhibitor of Bcr-Abl

scientific article

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification

scientific article

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

scientific article published in July 2009

Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification.

scientific article published on 29 June 2015

Identification of a novel leukemic-specific splice variant of DNMT3B and its stability

scientific article published on 20 July 2017

Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity.

scientific article published on 26 October 2014

Impact of Genetic Variations in HIV-1 Tat on LTR-Mediated Transcription via TAR RNA Interaction

scientific article

In Silico Investigations of Chemical Constituents of Clerodendrum colebrookianum in the Anti-Hypertensive Drug Targets: ROCK, ACE, and PDE5.

scientific article published on 16 June 2017

In-silico and in-vitro anti-cancer potential of a curcumin analogue (1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-dione.

scientific article published on 23 November 2016

Investigation of Alpinia calcarata constituent interactions with molecular targets of rheumatoid arthritis: docking, molecular dynamics, and network approach

scientific article published on 05 January 2021

Ligand efficiency based approach for efficient virtual screening of compound libraries.

scientific article

Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin--an in vitro and in silico approach

scientific article

Multi-objective Genetic Algorithm for De Novo Drug Design

scientific article published on 20 June 2020

Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.

scientific article

Overcoming vincristine resistance in cancer: computational design and discovery of piperine inspired P-glycoprotein inhibitors

scientific article published on 07 July 2020

P-Glycoprotein Mediated Multidrug Resistance Reversal by Phytochemicals: A Review of SAR & Future Perspective for Drug Design.

scientific article published on 12 February 2016

PRMT7 Interacts with ASS1 and Citrullinemia Mutations Disrupt the Interaction

scientific article published on 3 June 2017

Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors ⬇️

scientific article published on May 10, 2013

Reversible Testicular Toxicity of Piperine on Male Albino Rats

scientific article published on 26 July 2017

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

scientific article published on 24 March 2011

Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists

scientific article published on October 2010

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity

scientific article

Study of beta-adrenoreceptor antagonistic activity of DPJ 904 in rats.

scientific article published on 20 December 2004

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors

scientific article published on 11 April 2006

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers.

scientific article published on 03 July 2009

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

scientific article published in August 2009

Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.

scientific article

Synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethoxy-1-oxo-isoindoline)-substituted phenoxypropanolamines and their beta1-, beta2-adrenergic receptor binding studies

scientific article published in August 2005

Synthesis, beta-adrenergic blocking activity and beta-receptor binding affinities of 1-substituted-3-(2-isopropyl-5-methyl-phenoxy)-propan-2-ol oxalates

scientific journal article

Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer.

scientific article published on 11 August 2017

Therapeutic polymeric nanoparticles and the methods of making and using thereof: a patent evaluation of WO2015036792.

scientific article

Treat cancers by targeting survivin: just a dream or future reality?

scientific article published on 28 February 2013

Virtual screening of traditional Chinese medicine (TCM) database: identification of fragment-like lead molecules for filariasis target asparaginyl-tRNA synthetase.

scientific article published on 20 May 2014

List of works by Mohane S. Coumar

2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

3-[2-((2S)-2-cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogues as selective DPP-IV inhibitors for the treatment of type-II diabetes

3D-QSAR-assisted drug design: identification of a potent quinazoline-based Aurora kinase inhibitor.

Advances in Aurora kinase inhibitor patents

Anti-influenza drug discovery: identification of an orally bioavailable quinoline derivative through activity- and property-guided lead optimization.

Anti-influenza drug discovery: structure-activity relationship and mechanistic insight into novel angelicin derivatives.

Apoptosis induction by an analog of curcumin (BDMC-A) in human laryngeal carcinoma cells through intrinsic and extrinsic pathways.

Aurora kinase A inhibitors: identification, SAR exploration and molecular modeling of 6,7-dihydro-4H-pyrazolo-[1,5-a]pyrrolo[3,4-d]pyrimidine-5,8-dione scaffold

Aurora kinase inhibitor patents and agents in clinical testing: an update (2009-10).

Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 - 2013).

Aurora kinase inhibitors in preclinical and clinical testing

Aurora kinase inhibitors reveal mechanisms of HURP in nucleation of centrosomal and kinetochore microtubules

BDMC-A, an analog of curcumin, inhibits markers of invasion, angiogenesis, and metastasis in breast cancer cells via NF-κB pathway--A comparative study with curcumin.

BIRC5/Survivin is a novel ATG12-ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast cells

BPR1K653, a novel Aurora kinase inhibitor, exhibits potent anti-proliferative activity in MDR1 (P-gp170)-mediated multidrug-resistant cancer cells

Characterization of a new rat urinary metabolite of piperine by LC/NMR/MS studies.

Cloning, expression, and purification of the recombinant pro-apoptotic dominant-negative survivin T34A-C84A protein in Escherichia coli

Delineating the active site architecture of G9a lysine methyltransferase through substrate and inhibitor binding mode analysis: a molecular dynamics study

Design and structural analysis of novel pharmacophores for potent and selective peroxisome proliferator-activated receptor gamma agonists

Design and synthesis of tetrahydropyridothieno[2,3-d]pyrimidine scaffold based epidermal growth factor receptor (EGFR) kinase inhibitors: the role of side chain chirality and Michael acceptor group for maximal potency.

Design of a potent anticancer lead inspired by natural products from traditional Indian medicine

Design of novel ROCK inhibitors using fragment-based de novo drug design approach

Discovery of non-glycoside sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening

Ensemble-based virtual screening: identification of a potential allosteric inhibitor of Bcr-Abl

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification.

Identification of a novel leukemic-specific splice variant of DNMT3B and its stability

Identification of ligand efficient, fragment-like hits from an HTS library: structure-based virtual screening and docking investigations of 2H- and 3H-pyrazolo tautomers for Aurora kinase A selectivity.

Impact of Genetic Variations in HIV-1 Tat on LTR-Mediated Transcription via TAR RNA Interaction

In Silico Investigations of Chemical Constituents of Clerodendrum colebrookianum in the Anti-Hypertensive Drug Targets: ROCK, ACE, and PDE5.

In-silico and in-vitro anti-cancer potential of a curcumin analogue (1E, 6E)-1, 7-di (1H-indol-3-yl) hepta-1, 6-diene-3, 5-dione.

Investigation of Alpinia calcarata constituent interactions with molecular targets of rheumatoid arthritis: docking, molecular dynamics, and network approach

Ligand efficiency based approach for efficient virtual screening of compound libraries.

Mechanism of apoptotic induction in human breast cancer cell, MCF-7, by an analog of curcumin in comparison with curcumin--an in vitro and in silico approach

Multi-objective Genetic Algorithm for De Novo Drug Design

Optimization of ligand and lipophilic efficiency to identify an in vivo active furano-pyrimidine Aurora kinase inhibitor.

Overcoming vincristine resistance in cancer: computational design and discovery of piperine inspired P-glycoprotein inhibitors

P-Glycoprotein Mediated Multidrug Resistance Reversal by Phytochemicals: A Review of SAR & Future Perspective for Drug Design.

PRMT7 Interacts with ASS1 and Citrullinemia Mutations Disrupt the Interaction

Protein Kinase Inhibitor Design by Targeting the Asp-Phe-Gly (DFG) Motif: The Role of the DFG Motif in the Design of Epidermal Growth Factor Receptor Inhibitors ⬇️

Reversible Testicular Toxicity of Piperine on Male Albino Rats

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

Structural basis for the improved potency of peroxisome proliferator-activated receptor (PPAR) agonists

Structure-based drug design of novel Aurora kinase A inhibitors: structural basis for potency and specificity

Study of beta-adrenoreceptor antagonistic activity of DPJ 904 in rats.

Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors

Survivin counteracts the therapeutic effect of microtubule de-stabilizers by stabilizing tubulin polymers.

Synthesis and evaluation of 3-aroylindoles as anticancer agents: metabolite approach.

Synthesis and structure-activity relationships of 2-amino-1-aroylnaphthalene and 2-hydroxy-1-aroylnaphthalenes as potent antitubulin agents.

Synthesis of 4-(1-oxo-isoindoline) and 4-(5,6-dimethoxy-1-oxo-isoindoline)-substituted phenoxypropanolamines and their beta1-, beta2-adrenergic receptor binding studies

Synthesis, beta-adrenergic blocking activity and beta-receptor binding affinities of 1-substituted-3-(2-isopropyl-5-methyl-phenoxy)-propan-2-ol oxalates

Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer.

Therapeutic polymeric nanoparticles and the methods of making and using thereof: a patent evaluation of WO2015036792.

Treat cancers by targeting survivin: just a dream or future reality?

Virtual screening of traditional Chinese medicine (TCM) database: identification of fragment-like lead molecules for filariasis target asparaginyl-tRNA synthetase.