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List of works by Pekka T. Männistö

2(S)-(Cycloalk-1-enecarbonyl)-1-(4-phenyl-butanoyl)pyrrolidines and 2(S)-(aroyl)-1-(4-phenylbutanoyl)pyrrolidines as prolyl oligopeptidase inhibitors

scientific article

4-Phenylbutanoyl-2(S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2(S)-acylpyrrolidines as prolyl oligopeptidase inhibitors.

scientific article published in July 2002

7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety.

scientific article published in June 1997

A 6-month dermal toxicity test with dithranol and butantrone in miniature swine

article

A prolyl oligopeptidase inhibitor, Z-Pro-Prolinal, inhibits glyceraldehyde-3-phosphate dehydrogenase translocation and production of reactive oxygen species in CV1-P cells exposed to 6-hydroxydopamine.

scientific article published on 14 July 2006

A transient inhibition and permanent lack of catechol-O-methyltransferase have minor effects on feeding pattern of female rodents

scientific article published on 28 September 2011

AMINE UPTAKE AND THYROTROPIN-RELEASING HORMONE

scientific article published in The Lancet

Absorption of rifampin from various preparations and pharmaceutic forms ⬇️

scientific article published on March 1, 1977

Activation of 5-HT2A receptors impairs response control of rats in a five-choice serial reaction time task

scientific article published in January 2000

Acute Toxicity of Three New Selective COMT Inhibitors in Mice with Special Emphasis on Interactions with Drugs Increasing Catecholaminergic Neurotransmission

article

Adrenalectomy modifies the effect of intracerebral histamine on the cold-stimulated TSH secretion in male rats

scientific article published in August 1986

Advanced brain dopamine transporter imaging in mice using small-animal SPECT/CT.

scientific article

Alteration of prolyl oligopeptidase and activated α-2-macroglobulin in multiple sclerosis subtypes and in the clinically isolated syndrome.

scientific article published on 30 April 2013

Ampicillin concentrations in serum and bronchial mucosa after ampicillin and bacampicillin

scientific article published on March 1, 1979

An acute i.c.v. infusion of leptin has no effect on hypothalamic histamine and tele-methylhistamine contents in Wistar rats

scientific article published on 01 April 2000

An introduction of a pyridine group into the structure of prolyl oligopeptidase inhibitors

scientific article published on 17 August 2006

Anesthetics and thyrotropin secretion in the rat.

scientific article published in September 1976

Antidiabetic effects of lithium

scientific article

Apomorphine-induced behavioural sensitization in rats: individual differences, role of dopamine and NMDA receptors

scientific article published on 01 December 1999

Ara-C induces apoptosis in monkey fibroblast cells.

scientific article

Are Transglutaminase 2 Inhibitors Able to Reduce Gliadin-Induced Toxicity Related to Celiac Disease? A Proof-of-Concept Study

article

Are genetic variants of COMT associated with addiction? ⬇️

scientific article published on December 1, 2010

Association of prolyl oligopeptidase with conventional neurotransmitters in the brain.

scientific article published on May 2011

Atipamezole, an alpha2-adrenoceptor antagonist, augments the effects of L-DOPA on evoked dopamine release in rat striatum.

scientific article published in February 2003

Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine-treated rats

scientific article

Beneficial effects of co-administration of catechol-O-methyltransferase inhibitors and L-dihydroxyphenylalanine in rat models of depression.

scientific article published on February 1995

Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors.

scientific article

Biochemistry and pharmacology of catechol-O-methyltransferase inhibitors.

scientific article published on January 2010

Biogenic amine metabolites in the CSF of patients with late onset and alcoholic ataxias

scientific article published on 01 April 1993

COMT gene locus: new functional variants

scientific article published on 23 July 2015

Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats

scientific article published in January 1997

Catechol-O-methyltransferase (COMT) protein expression and activity after dopaminergic and noradrenergic lesions of the rat brain

scientific article published on 16 April 2013

Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis

scientific article published on September 2012

Catecholamine metabolism in the brain by membrane-bound and soluble catechol-o-methyltransferase (COMT) estimated by enzyme kinetic values.

scientific article published in November 2001

Cellular and subcellular distribution of rat brain prolyl oligopeptidase and its association with specific neuronal neurotransmitters

scientific article published in April 2008

Central and peripheral type benzodiazepine ligands displace [3H][3-ME-HIS2]TRH from its binding sites in the brain and the anterior pituitary and antagonize the effect of TRH in the rat duodenum

scientific article published in July 1991

Characterization of membrane-bound prolyl endopeptidase from brain.

scientific article published on 24 July 2008

Cholecystokinin2 receptor-deficient mice display altered function of brain dopaminergic system.

scientific article published in November 2001

Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease.

scientific article published on 24 December 2010

Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain.

scientific article

Comparative bacterial mutagenicity studies with 8-methoxypsoralen and 4,5',8-trimethylpsoralen in the presence of near-ultraviolet light and in the dark

scientific article published in February 1983

Comparison of motor performance, brain biochemistry and histology of two A30P α-synuclein transgenic mouse strains.

scientific article

Comparison of pharmacokinetics of sulphadiazine and sulphamethoxazole after intravenous infusion

scientific article published on 01 June 1982

Comparison of the Effects of Intraventricular Taurine, GABA and Homotaurine on Serum Prolactin Levels in Male Rats

scientific article published on 01 August 1989

Comparison of the effects of deramciclane, ritanserin and buspirone on extracellular dopamine and its metabolites in striatum and nucleus accumbens of freely moving rats.

scientific article published on 25 October 2007

Comparison of two new inhibitors of catechol O-methylation on striatal dopamine metabolism: a microdialysis study in rats.

scientific article published on May 1994

Complex actions of serotonergic agonists on cold-stimulated TSH secretion in male rats

scientific article published on 01 May 1990

Concentrations of metronidazole and tinidazole in female reproductive organs after a single intravenous infusion and after repeated oral administration

scientific article published on 01 May 1984

Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors.

scientific article published in August 2003

Constitutive Ret signaling is protective for dopaminergic cell bodies but not for axonal terminals.

scientific article published on 20 September 2009

Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis

scientific article

Cross-over study of ten tetracycline preparations

scientific article published in June 1973

Deficiency of prolyl oligopeptidase in mice disturbs synaptic plasticity and reduces anxiety-like behaviour, body weight, and brain volume.

scientific article published on 27 February 2016

Deficient activity of mammalian prolyl oligopeptidase on the immunoactive peptide digestion in coeliac disease

scientific article published on 01 May 2007

Degradation of coeliac disease-inducing rye secalin by germinating cereal enzymes: diminishing toxic effects in intestinal epithelial cells.

scientific article

Delayed O-methylation of l-DOPA in MB-COMT-deficient mice after oral administration of l-DOPA and carbidopa

scientific article published on 21 April 2017

Deramciclane, a putative anxiolytic drug, is a serotonin 5-HT 2C receptor inverse agonist but fails to induce 5-HT 2C receptor down-regulation ⬇️

scientific article published on March 1, 1998

Determination of catechol-O-methyltransferase activity by high-performance liquid chromatography with electrochemical detection.

scientific article

Development of tolerance to the hormonal effects of morphine without changes in the aminergic functions in the brain of the rat.

scientific article published in August 1992

Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions.

scientific article published in July 2005

Dicarboxylic acid bis(L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors.

scientific article published in September 2002

Different in vivo properties of three new inhibitors of catechol O-methyltransferase in the rat ⬇️

scientific article published on March 1, 1992

Different interactions of prolyl oligopeptidase and neurotensin in dopaminergic function of the rat nigrostriatal and mesolimbic pathways

scientific article published on 23 June 2012

Different renal effects of two inhibitors of catechol-O-methylation in the rat: Entacapone and CGP 28014

scientific article published on 01 April 1998

Different synergistic roles of small polyethylenimine and Dosper in gene delivery.

scientific article published in February 2003

Different viabilities and toxicity types after 6-OHDA and Ara-C exposure evaluated by four assays in five cell lines.

scientific article published on 26 July 2007

Differential disappearance of tolerance to thermal, hormonal and locomotor effects of morphine in the male rat

scientific article published on 01 October 1995

Differential effect of tetracaine and bupivacaine on catecholamine and 5-hydroxytryptamine turnover

scientific article published in May 1987

Distribution of immunoreactive prolyl oligopeptidase in human and rat brain

scientific article published on 31 March 2007

Distribution of prolyl oligopeptidase in human peripheral tissues and in ovarian and colorectal tumors

scientific article

Distribution of prolyl oligopeptidase in the mouse whole-body sections and peripheral tissues.

scientific article published on 11 July 2008

Diurnal variations of medial basal and anterior hypothalamic thyroliberin [TRH] and serum thyrotropin [TSH] concentrations in male rats ⬇️

scientific article published on October 2, 1978

Dopaminergic transmission in the rat striatum in vivo in conditions of pharmacological modulation.

scientific article

Dual action of morphine on cold-stimulated thyrotropin secretion in male rats

scientific article published in September 1984

Effect of Enzyme Induction and Inhibition on the Fate of Metronidazole and Tinidazole in the Rat

scientific article published on 01 January 1987

Effect of S-COMT deficiency on behavior and extracellular brain dopamine concentrations in mice

scientific article published on 9 July 2010

Effect of acute levodopa on brain catecholamines after selective MAO and COMT inhibition in male rats

scientific article published on 01 January 1990

Effect of cell-surface glycosaminoglycans on cationic carrier combined with low-MW PEI-mediated gene transfection.

scientific article published in October 2004

Effect of dopamine uptake inhibition on brain catecholamine levels and locomotion in catechol-O-methyltransferase-disrupted mice.

scientific article published in December 2002

Effect of erythromycin acistrate and erythromycin stearate on human colonic microflora.

scientific article

Effect of forced chronic oral nicotine exposure on intravenous self-administration and rewarding properties of acute nicotine

scientific article published on 27 June 2008

Effect of genetic modifications in the synaptic dopamine clearance systems on addiction-like behaviour in mice.

scientific article

Effect of high single doses of levodopa and carbidopa on brain dopamine and its metabolites: modulation by selective inhibitors of monoamine oxidase and/or catechol-O-methyltransferase in the male rat.

scientific article published in October 1991

Effect of modified brain histamine contents on prolactin and thyrotropin secretion in male rats

scientific article published in February 1996

Effect of stress and dexamethasone on immunoreactive beta-endorphin levels in rat hypothalamus and pineal

scientific article published in April 1982

Effect of tolcapone, a catechol-O-methyltransferase inhibitor, on striatal dopaminergic transmission during blockade of dopamine uptake

scientific article

Effects of Central and Peripheral Type Benzodiazepine Ligands on Growth Hormone and Gonadotropin Secretion in Male Rats

scientific article published on 01 July 1992

Effects of Cysteamine Pretreatment and Hypothalamic Periventricular Nucleus Lesion on the Cold-Stimulated Thyrotropin Responses to Intracerebroventricular 5-Hydroxytryptamine in Male Rats

article

Effects of acute hypotension and hypertension on serum TSH concentrations in male rats

scientific article published on October 1, 1979

Effects of bilateral cholinotoxin infusions on the behavior and brain biochemistry of the rats

scientific article published in September 1994

Effects of central and peripheral type benzodiazepine ligands on thyrotropin and prolactin secretion

scientific article published in March 1992

Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase

scientific article published on 6 September 2010

Effects of histamine H3-ligands on the levodopa-induced turning behavior of hemiparkinsonian rats

scientific article published on 01 July 2000

Effects of intraventricular taurine, homotaurine and GABA on serum prolactin and thyrotropin levels in female and in male rats

scientific article published on 01 January 1993

Effects of selective catechol-O-methyltransferase inhibitors on single-trial passive avoidance retention in male rats

scientific article published in June 1997

Effects of systemic carbidopa on dopamine synthesis in rat hypothalamus and striatum

scientific article published in January 1992

Effects of three types of catechol O-methylation inhibitors on L-3,4-dihydroxyphenylalanine-induced circling behaviour in rats

scientific article published on 01 November 1993

Efficient Transfection of Novel Bovine Papillomavirus 1 Expression Plasmids ⬇️

scientific article published on November 1, 2001

Entacapone protects from angiotensin II-induced inflammation and renal injury.

scientific article

Enzymatic detoxification of gluten by germinating wheat proteases: implications for new treatment of celiac disease.

scientific article

Epistasis between polymorphisms in COMT, ESR1, and GCH1 influences COMT enzyme activity and pain

scientific article

Epithelial transport and deamidation of gliadin peptides: a role for coeliac disease patient immunoglobulin A.

scientific article published on 14 January 2011

Evidence for an Additive Neurorestorative Effect of Simultaneously Administered CDNF and GDNF in Hemiparkinsonian Rats: Implications for Different Mechanism of Action.

scientific article published on January 2017

Evolutionary relationships of the prolyl oligopeptidase family enzymes.

scientific article

Failure of FK506 (tacrolimus) to alleviate apomorphine-induced circling in rat Parkinson model in spite of some cytoprotective effects in SH-SY5Y dopaminergic cells.

scientific article published on March 2005

Four day inhibition of prolyl oligopeptidase causes significant changes in the peptidome of rat brain, liver and kidney.

scientific article published on 21 April 2012

Further studies of serotonergic activity in the regulation of the cold stimulated thyrotropin secretion in male rats.

scientific article published in August 1988

Further studies on properties of renin granules isolated from rat kidney cortex

scientific article published on 01 August 1981

Further studies on the role of cholecystokinin-A and B receptors in secretion of anterior pituitary hormones in male rats

scientific article published on 01 January 1995

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease

scientific article published on 14 January 2013

Heparin-binding determinants of GDNF reduce its tissue distribution but are beneficial for the protection of nigral dopaminergic neurons

scientific article

High correlation between in vivo [123I]β-CIT SPECT/CT imaging and post-mortem immunohistochemical findings in the evaluation of lesions induced by 6-OHDA in rats

scientific article published on 10 June 2013

Hypothalamic histamine, growth rate, plasma prolactin and growth hormone levels in rats with long-term portacaval anastomosis

scientific article published in February 1999

Hypothalamus-adenohypophysis-thyroid axis in spontaneously hypertensive rats (SHR)

scientific article published on 01 January 1981

Impairing effect of food on ketoconazole absorption

scientific article published on May 1982

Improved assay of reaction products to quantitate catechol-O-methyltransferase activity by high-performance liquid chromatography with electrochemical detection

scientific article published on 01 January 1995

Increase of catechol-O-methyltransferase activity in rat brain microglia after intrastriatal infusion of fluorocitrate, a glial toxin.

scientific article published in July 1997

Influence of various diets on the bioavailability of isoniazid

scientific article published in November 1982

Inhibitors of catechol-O-methyltransferase sensitize mice to pain

scientific article published on December 2010

Intracerebroventricular antisense knockdown of G alpha i2 results in ciliary stasis and ventricular dilatation in the rat.

scientific article

Isolation of Renin Granules from Rat Kidney Cortex by Isotonic or Hyperosmotic Metrizamide-Sucrose Gradients

scientific article published on 01 January 1980

L-Arginine abolishes the anxiolytic-like effect of diazepam in the elevated plus-maze test in rats.

scientific article published in June 1998

L-dopa-induced desensitization depends on 5-hydroxytryptamine imbalance in hemiparkinsonian rats.

scientific article published in February 2009

Lack of increased oxidative stress in catechol-O-methyltransferase (COMT)-deficient mice.

scientific article published on 17 September 2004

Localization of prolyl oligopeptidase in the thalamic and cortical projection neurons: a retrograde neurotracing study in the rat brain.

scientific article published on 21 November 2008

Locomotor activity and evoked dopamine release are reduced in mice overexpressing A30P-mutated human alpha-synuclein

scientific article published in November 2005

Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases: Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?

scientific article published on 14 February 2017

Minocycline protects SH-SY5Y cells from 6-hydroxydopamine by inhibiting both caspase-dependent and -independent programmed cell death

scientific article

Minor effect of tolcapone, a catechol-O-methyltransferase inhibitor, on extracellular dopamine levels modified by amphetamine or pargyline: a microdialysis study in anaesthetized rats

scientific article published in June 1996

Modulation of rat brain endogenous dopamine metabolism by new inhibitors of catechol O-methyltransferase

scientific article published in August 1993

Molecular dynamics study of prolyl oligopeptidase with inhibitor in binding cavity.

scientific article

Molecular dynamics, crystallography and mutagenesis studies on the substrate gating mechanism of prolyl oligopeptidase

scientific article

Morphine withdrawal alters anterior pituitary hormone secretion, brain endopeptidase activity and brain monoamine metabolism in the rat.

scientific article published in March 1996

N-Nitro-L-arginine attenuates development of tolerance to antinociceptive but not to hormonal effects of morphine

article

Neurochemical mediators of anxiety have inconsistent effects on hypothalamic self-stimulation in rats

scientific article published in May 1996

Neurotransmission and secretion of thyroid-stimulating hormone

scientific article published in September 1973

Neurotransmitter control of thyrotropin secretion in the rat ⬇️

scientific article published on February 1, 1975

New Prolyl Oligopeptidase Inhibitors Developed from Dicarboxylic Acid Bis(l-prolyl-pyrrolidine) Amides ⬇️

scientific article published on October 9, 2003

Nitecapone reduces development and symptoms of neuropathic pain after spinal nerve ligation in rats

scientific article

Nitric oxide mediates caeruleininduced suppression of locomotor activity

scientific article published on 01 August 1996

Nitrofurantoin is highly bound to plasma protein

scientific article published on 01 April 1982

No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthetized rats

scientific article published in September 1998

On-line radiochemical assay for monoamine oxidase utilizing high-performance liquid chromatography

scientific article published in December 1984

Ondansetron, an antagonist of 5-HT3 receptors, antagonizes the anti-exploratory effect of caerulein, an agonist of CCK receptors, in the elevated plus-maze

scientific article published in January 1993

Opposite effects mediated by CCKA and CCKB receptors in behavioural and hormonal studies in rats

scientific article published on 01 May 1994

Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice

scientific article

Overflow of noradrenaline and dopamine in frontal cortex after [N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine] (DSP-4) treatment: in vivo microdialysis study in anaesthetized rats

scientific article published on 01 February 1997

Pain relief and sputum prostaglandins in adults treated with pethidine, tilidine and indomethacin after tonsillectomy: a double-blind study.

scientific article published on April 1980

Pharmacodynamic response of entacapone in rats after administration of entacapone formulations and prodrugs with varying bioavailabilities.

scientific article published in June 2002

Pharmacokinetic interactions of timolol with vasodilating drugs, food and phenobarbitone in healthy human volunteers

scientific article published in January 1983

Pharmacokinetics of methenamine in healthy volunteers

scientific article published on 01 March 1982

Pharmacokinetics of pipemidic` acid in healthy middle-aged volunteers and elderly patients with renal insufficiency

scientific article published on 01 April 1984

Pharmacokinetics of slow-release diltiazem and its effect on atrioventricular conduction in healthy volunteers

scientific article published on 01 January 1986

Pharmacokinetics of sustained-release verapamil after a single administration and at steady state

scientific article published on 01 April 1985

Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cgamma signaling pathways in mouse brain

scientific article published on 21 February 2007

Plasma Renin Activity andin vitroSynthesis of Aldosterone by the Adrenal Glands of Rats with Spontaneous, Renal, or Pinealectomy-Induced Hypertension ⬇️

scientific article published on June 1, 1975

Possible involvement of nigrostriatal dopamine system in the inhibition of thyrotropin secretion in the rat.

scientific article published in December 1981

Possible role of cholecystokinin-A receptors in regulation of thyrotropin (TSH) secretion in male rats

scientific article published on 01 December 1992

Potentiation of central effects of L-dopa by an inhibitor of catechol-O-methyltransferase

scientific article published on 01 January 1987

Production of functional recombinant tyrosine hydroxylase by the BPV-1 expression plasmids in the cell cultures

scientific article published in November 2003

Prolyl oligopeptidase colocalizes with α-synuclein, β-amyloid, tau protein and astroglia in the post-mortem brain samples with Parkinson's and Alzheimer's diseases.

scientific article

Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner.

scientific article

Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice

scientific article

Rat plasma and hypothalamic beta-endorphin levels fluctuate concomitantly with plasma corticosteroids during the day.

scientific article published in August 1982

Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease.

scientific article published on May 1990

Relation of exploratory behavior of rats in elevated plus-maze to brain receptor binding properties and serum growth hormone levels

scientific article published in November 1997

Role of N-methyl-D-aspartic acid and cholecystokinin receptors in apomorphine-induced aggressive behaviour in rats.

scientific article published on April 1995

Sample purification improves the analysis of nonviral in vivo gene transfection.

scientific article published on 19 September 2009

Selective cardiorespiratory activity of an iodinated analog of thyrotropin-releasing hormone (TRH).

scientific article published in September 1990

Sequential expression, activity and nuclear localization of prolyl oligopeptidase protein in the developing rat brain

scientific article published on 14 December 2010

Serotonergic activation after 2-week intrastriatal infusion of L-dopa and slow recovery of circling in rats with unilateral nigral lesions

scientific article published on 31 October 2007

Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum

scientific article

Skin irritation by dithranol (anthralin) and its 10-acyl analogues in 3 animal models.

scientific article

Social isolation of rats increases the density of cholecystokinin receptors in the frontal cortex and abolishes the anti-exploratory effect of caerulein

scientific article published in July 1993

Somatostatin, neuropeptide Y, GABA and cholinergic enzymes in brain of pentylenetetrazol-kindled rats

scientific article published on 01 October 1989

Spatial association of prolyl oligopeptidase, inositol 1,4,5-triphosphate type 1 receptor, substance P and its neurokinin-1 receptor in the rat brain: an immunohistochemical colocalization study.

scientific article published on 4 March 2008

Stress-induced analgesia and morphine responses are changed in catechol-O-methyltransferase-deficient male mice

scientific article published in October 2008

Striatal membrane-bound and soluble catechol-O-methyl-transferase after selective neuronal lesions in the rat

scientific article published on 01 January 1987

Strong preferences of dopamine and l-dopa towards lipid head group: importance of lipid composition and implication for neurotransmitter metabolism

article

Studies on the mechanism of the enhanced cold-induced TSH secretion in spontaneously hypertensive rats

scientific article published on 01 April 1983

Subdiaphragmatic vagotomy does not prevent the anti-exploratory effect of caerulein in the elevated plus-maze

scientific article published in January 1994

Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819.

scientific article published in August 2002

Synthesis and biological evaluation of novel 123I-labeled 4-(4-iodophenyl)butanoyl-l-prolyl-(2S)-pyrrolidines for imaging prolyl oligopeptidase in vivo

scientific article published on 12 April 2014

Synthesis and characterization of the novel fluorescent prolyl oligopeptidase inhibitor 4-fluoresceinthiocarbamoyl-6-aminocaproyl-L-prolyl-2(S)-(hydroxyacetyl)pyrrolidine

scientific article published in November 2005

Synthesis and in vitro pharmacology of a series of new chiral histamine H3-receptor ligands: 2-(R and S)-Amino-3-(1H-imidazol-4(5)-yl)propyl ether derivatives.

scientific article published in April 1999

Synthesis and in vitro/in vivo evaluation of novel oral N-alkyl- and N,N-dialkyl-carbamate esters of entacapone

scientific article published on 01 January 2000

Synthesis and in-vitro/in-vivo evaluation of orally administered entacapone prodrugs.

scientific article published in November 2001

Target tissue morphology and serum biochemistry following 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in a TCDD-susceptible and a TCDD-resistant rat strain.

scientific article

The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse.

scientific article published on 16 April 2014

The cold-induced TSH secretion is resistant to alterations in the physicochemical properties of the intracerebral infusions

scientific article published in June 1983

The effects of diazepam or diphenhydramine on healthy human subjects

scientific article published on 01 January 1971

The multiple faces of quercetin in neuroprotection.

scientific article published on July 2009

The role of PEI structure and size in the PEI/liposome-mediated synergism of gene transfection

scientific article published on 5 October 2008

The role of dopamine-metabolizing enzymes in the regulation of renal sodium excretion in the rat.

scientific article published in July 2001

The roles of dopamine transporter and Bcl-2 protein in the protection of CV1-P cells from 6-OHDA-induced toxicity.

scientific article

The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell cultures

scientific article

Time course of the antibacterial activity of erythromycin stearate and erythromycin acistrate against two Staphylococcus aureus strains in vitro.

scientific article

Time-dependent protective and harmful effects of quercetin on 6-OHDA-induced toxicity in neuronal SH-SY5Y cells

scientific article

Toxicological studies with dithranol and its 10-acyl analogues

scientific article published in October 1986

Transcriptional profiling of C57 and DBA strains of mice in the absence and presence of morphine.

scientific article

Tumor-producing and skin-irritating activity of dithranol (anthralin) and its 10-acyl analogues in SENCAR mice

scientific article published on 01 October 1986

Unpredictable rotational responses to L-dopa in the rat model of Parkinson's disease: the role of L-dopa pharmacokinetics and striatal dopamine depletion.

scientific article published on 13 September 2011

Validation of assay of catechol-O-methyltransferase activity in human erythrocytes

Variation in tolerance to the antinociceptive, hormonal and thermal effects of morphine after a 5-day pre-treatment of male rats with increasing doses of morphine

scientific article

Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo.

scientific article

mu- and delta-opioid receptor antisense oligodeoxynucleotides antagonize morphine-induced growth hormone secretion in rats.

scientific article

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