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List of works by James E. Dunford

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

scientific article published on 12 February 2019

Activation of multiple protein kinases by interleukin-1.

scientific article

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.

scientific article published on 16 November 2013

Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming

scientific article published on 08 April 2019

CMT3 alters mitochondrial function in murine osteoclast lineage cells.

scientific article published on 26 November 2007

Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells

scientific article published on 21 March 2011

Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes

scientific article published in September 2007

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

scientific article published on 07 December 2018

Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism.

scientific article published on 21 October 2008

Differences between bisphosphonates in binding affinities for hydroxyapatite.

scientific article published in January 2010

Differential display analysis of gene expression indicates that age-related changes are restricted to a small cohort of genes

scientific article published in March 1998

Discovery of Orally Bioavailable, Quinoline-based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.

scientific article published on 16 May 2018

Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine

scientific article published on 08 December 2015

Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types

scientific article published on 24 September 2018

GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates.

scientific article published in May 2017

Identification of a novel phosphonocarboxylate inhibitor of Rab geranylgeranyl transferase that specifically prevents Rab prenylation in osteoclasts and macrophages.

scientific article

Identification of biphenylcarboxylic acid derivatives as a novel class of bone resorption inhibitors.

scientific article published in October 2004

Inhibition of protein prenylation by bisphosphonates causes sustained activation of Rac, Cdc42, and Rho GTPases.

scientific article published on May 2006

Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.

scientific article published on 29 November 2017

Modulation of osteoclastogenesis by fatty acids

scientific article published on 10 July 2008

Molecular Characterization of a Novel Geranylgeranyl Pyrophosphate Synthase from Plasmodium Parasites

scientific article

Molecular targets of the nitrogen containing bisphosphonates: the molecular pharmacology of prenyl synthase inhibition.

scientific article published on January 2010

Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases

scientific article

Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.

scientific article published on 8 March 2008

Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates.

scientific article

Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.

scientific article

Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid.

scientific article published on May 2010

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

scientific article

The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate).

scientific article published on 24 March 2017

The crystal structure of human geranylgeranyl pyrophosphate synthase reveals a novel hexameric arrangement and inhibitory product binding

scientific article (publication date: 4 August 2006)

The fungal metabolite chaetocin is a sensitizer for pro-apoptotic therapies in glioblastoma

scientific article published on 26 November 2019

The inhibition of human farnesyl pyrophosphate synthase by nitrogen-containing bisphosphonates. Elucidating the role of active site threonine 201 and tyrosine 204 residues using enzyme mutants

scientific article published on 28 August 2015

The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs

scholarly article

The relationship between the chemistry and biological activity of the bisphosphonates.

scientific article published on 09 April 2011

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