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List of works by A. V. Apkarian

A brain signature for acute pain

scientific article published on 05 June 2013

A central mechanism enhances pain perception of noxious thermal stimulus changes

scientific article

A comparative fMRI study of cortical representations for thermal painful, vibrotactile, and motor performance tasks.

scientific article published on October 1999

A cryogenic device for reversibly blocking transmission through small regions of the spinal cord white matter

scientific article published in August 1989

A dorsolateral spinothalamic pathway in cat.

scientific article published in May 1985

A dorsolateral spinothalamic tract in macaque monkey

scientific article published on 01 June 1989

A dynamic network perspective of chronic pain.

scientific article published on 08 May 2012

A preliminary fMRI study of analgesic treatment in chronic back pain and knee osteoarthritis

scientific article published on 25 October 2008

A randomized placebo-controlled pilot study of the efficacy and safety of D-cycloserine in people with chronic back pain

scientific article

Abnormal brain chemistry in chronic back pain: an in vivo proton magnetic resonance spectroscopy study

scientific article

Abnormalities in hippocampal functioning with persistent pain.

scientific article

Abstract

Abstract

Adaptive alterations in the mesoaccumbal network following peripheral nerve injury

scientific article published on 30 September 2020

Aging alters regional multichemical profile of the human brain: an in vivo 1H-MRS study of young versus middle-aged subjects.

scientific article

Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome

scientific article published on 26 March 2014

Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study

scientific article published on 5 June 2015

Anatomical and functional assemblies of brain BOLD oscillations.

scientific article

Attenuation of neuropathic manifestations by local block of the activities of the ventrolateral orbito-frontal area in the rat.

scientific article published in January 2003

BOLD temporal variability differentiates wakefulness from anesthesia-induced unconsciousness

scientific article published on 6 December 2017

Benchmarking Residual Limb Pain and Phantom Limb Pain in Amputees through a Patient-reported Outcomes Survey

scientific article published on 15 July 2020

Beneficial effects of hematopoietic growth factor therapy in chronic ischemic stroke in rats

scientific article published on 30 August 2007

Beyond feeling: chronic pain hurts the brain, disrupting the default-mode network dynamics.

scientific article

Biotin-dextran: a sensitive anterograde tracer for neuroanatomic studies in rat and monkey

scientific article published in October 1992

Brain Connectivity Predicts Placebo Response across Chronic Pain Clinical Trials

scientific article

Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Neuroimaging Study

scientific article published on 21 February 2015

Brain activity for chronic knee osteoarthritis: dissociating evoked pain from spontaneous pain

scientific article

Brain activity for spontaneous pain of postherpetic neuralgia and its modulation by lidocaine patch therapy

scientific article published on 25 October 2006

Brain activity for tactile allodynia: a longitudinal awake rat functional magnetic resonance imaging study tracking emergence of neuropathic pain

scientific article

Brain and psychological determinants of placebo pill response in chronic pain patients

scientific article published in Nature Communications

Brain chemistry reflects dual states of pain and anxiety in chronic low back pain.

scientific article published in October 2002

Brain dynamics for perception of tactile allodynia (touch-induced pain) in postherpetic neuralgia.

scientific article published on April 2008

Brain functional and anatomical changes in chronic prostatitis/chronic pelvic pain syndrome.

scientific article published on 14 May 2011

Brain grey matter abnormalities in osteoarthritis pain: a cross-sectional evaluation

scientific article published on 04 May 2020

Brain imaging findings in neuropathic pain

scientific article

Brain morphological signatures for chronic pain.

scientific article

Brain networks predicting placebo analgesia in a clinical trial for chronic back pain

scientific article

Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study

scientific article published on 30 June 2017

Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study

scientific article published on December 2016

Brain white matter structural properties predict transition to chronic pain

scientific article published on October 2013

CORRIGENDUM: Resting-state functional reorganization of the rat limbic system following neuropathic injury.

scientific article published on 23 January 2015

Catecholamine varicosities in cat dorsal root ganglion and spinal ventral roots

scientific article published on 01 February 1983

Changes in the effects of stimulation of locus coeruleus and nucleus raphe magnus following dorsal rhizotomy.

scientific article published in December 1983

Chemical heterogeneity of the living human brain: a proton MR spectroscopy study on the effects of sex, age, and brain region

scientific article published on 01 May 2000

Chemical mapping of anxiety in the brain of healthy humans: an in vivo 1H-MRS study on the effects of sex, age, and brain region

scientific article published in December 2000

Chemical network of the living human brain. Evidence of reorganization with aging.

scientific article

Chronic back pain is associated with decreased prefrontal and thalamic gray matter density.

scientific article

Chronic neuropathic pain-like behavior and brain-borne IL-1β.

scientific article published on July 2012

Chronic neuropathic pain-like behavior correlates with IL-1β expression and disrupts cytokine interactions in the hippocampus.

scientific article published on 26 October 2011

Chronic pain and the emotional brain: specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain.

scientific article

Chronic pain patients are impaired on an emotional decision-making task.

scientific article published in March 2004

Chronic pain: the role of learning and brain plasticity.

scientific article published on January 2014

Cortical pathophysiology of chronic pain

scientific article published in January 2004

Cortical representation of pain: functional characterization of nociceptive areas near the lateral sulcus

scientific article

Cortical responses to thermal pain depend on stimulus size: a functional MRI study

scientific article published in May 2000

Corticolimbic anatomical characteristics predetermine risk for chronic pain

scientific article

Corticostriatal functional connectivity predicts transition to chronic back pain.

scientific article

D-cycloserine reduces neuropathic pain behavior through limbic NMDA-mediated circuitry

scientific article published on 20 April 2007

Deconstructing biomarkers for chronic pain: context- and hypothesis-dependent biomarker types in relation to chronic pain

scientific article published on 01 May 2019

Differentiating cortical areas related to pain perception from stimulus identification: temporal analysis of fMRI activity

scientific article

Direct spinal projections to limbic and striatal areas: anterograde transport studies from the upper cervical spinal cord and the cervical enlargement in squirrel monkey and rat.

scientific article published in February 1996

Dissimilarity of functional connectivity uncovers the influence of participant's motion in functional magnetic resonance imaging studies

scientific article published on 20 October 2020

Dissociating anxiety from pain: mapping the neuronal marker N-acetyl aspartate to perception distinguishes closely interrelated characteristics of chronic pain.

scientific article published in May 2001

Dorsolateral pontine inhibition of dorsal horn cell responses to cutaneous stimulation: lack of dependence on catecholaminergic systems in cat.

scientific article published in November 1983

Dynamics of pain: fractal dimension of temporal variability of spontaneous pain differentiates between pain States.

scientific article published on 9 November 2005

Expression of DNA methyltransferases in adult dorsal root ganglia is cell-type specific and up regulated in a rodent model of neuropathic pain.

scientific article published on 8 August 2014

Expression of IL-1beta in supraspinal brain regions in rats with neuropathic pain.

scientific article published on 14 September 2006

Expression of background potassium channels in rat DRG is cell-specific and down-regulated in a neuropathic pain model

scientific article

Factors associated with the development of chronic pain after surgery for breast cancer: a prospective cohort from a tertiary center in the United States.

scientific article published on 13 November 2013

Fingertip representation in the human somatosensory cortex: an fMRI study.

scientific article published in May 1998

Functional reorganization of the default mode network across chronic pain conditions.

scientific article

Funicular course of catecholamine fibers innervating the lumbar spinal cord of the cat.

scientific article

Funicular location of ascending axons of lamina I cells in the cat spinal cord.

scientific article published in May 1985

Global disruption of degree rank order: a hallmark of chronic pain

scientific article

Heat-induced pain diminishes vibrotactile perception: a touch gate

scientific article published on 01 January 1994

Hippocampal morphology mediates biased memories of chronic pain

scientific article published on 25 October 2017

Hippocampus shape deformation: potential diagnostic biomarker for chronic back pain in women

scientific article published on 06 November 2020

How do morphological alterations caused by chronic pain distribute across the brain? A meta-analytic co-alteration study

scientific article published on 21 December 2017

Human brain mechanisms of pain perception and regulation in health and disease.

scientific article

Identification of traits and functional connectivity-based neurotraits of chronic pain

scientific article published on 20 August 2019

Identifying brain nociceptive information transmission in patients with chronic somatic pain

scientific article published on October 2016

Identifying directed links in large scale functional networks: application to brain fMRI.

scientific article

Imaging the pain of low back pain: functional magnetic resonance imaging in combination with monitoring subjective pain perception allows the study of clinical pain states.

scientific article published in February 2001

Immediate reorganization of the rat somatosensory thalamus after partial ligation of sciatic nerve

scientific article published on 01 August 2001

Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome

scientific article published on 14 August 2014

Increased taste intensity perception exhibited by patients with chronic back pain

scientific article published on 19 December 2005

Inferring distinct mechanisms in the absence of subjective differences: Placebo and centrally acting analgesic underlie unique brain adaptations

scientific article published on 7 February 2018

Inflammatory and neuropathic pain animals exhibit distinct responses to innocuous thermal and motoric challenges.

scientific article

Kölliker-Fuse nucleus: the principal source of pontine catecholaminergic cells projecting to the lumbar spinal cord of cat.

scientific article published in May 1982

Lidocaine patch (5%) is no more potent than placebo in treating chronic back pain when tested in a randomised double blind placebo controlled brain imaging study.

scientific article

Linking human brain local activity fluctuations to structural and functional network architectures

scientific article published on 8 February 2013

Locus coeruleus modulation of dorsal horn unit responses to cutaneous stimulation

scientific article published on 01 January 1981

Lumbar dorsal root potentials elicited by stimulation of nucleus locus coeruleus.

scientific article published in July 1984

Mastalgia and breast cancer: a protective association?

article

Medial, intralaminar, and lateral terminations of lumbar spinothalamic tract neurons: a fluorescent double-label study

scientific article published on 01 January 1989

Modulated noisy biological dynamics: Three examples

article

Morphological and functional reorganization of rat medial prefrontal cortex in neuropathic pain

scholarly article

Morphology of subcortical brain nuclei is associated with autonomic function in healthy humans.

scientific article

Morphology of thalamocortical neurons projecting to the primary somatosensory cortex and their relationship to spinothalamic terminals in the squirrel monkey

scientific article published on 01 October 1995

Multi-chemical networking profile of the living human brain: potential relevance to molecular studies of cognition and behavior in normal and diseased brain

scientific article published in January 2002

Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network

scientific article published on 06 January 2016

Neural and Genetic Bases for Human Ability Traits

scientific article published on 16 December 2020

Neural mechanisms of pain and alcohol dependence

scientific article

Neurological effects of chronic pain

scientific article published in January 2007

Nociception, Pain, Consciousness, and Society: A Plea for Constrained Use of Pain-related Terminologies

scientific article published on 08 June 2018

Nociception, Pain, Negative Moods, and Behavior Selection

scientific article

Noise-Induced Tuning Curve Changes in Mechanoreceptors ⬇️

scientific article published on April 1, 1998

Novel method for functional brain imaging in awake minimally restrained rats

scientific article published on 06 April 2016

One more reason why neurons need to be noisy

scholarly article published 5 November 1993

Opioid signaling in mast cells regulates injury responses associated with heterotopic ossification

scientific article published on 11 December 2013

Pain and somatosensory activation

scientific article published in July 1992

Pain and the brain: specificity and plasticity of the brain in clinical chronic pain

scientific article

Pain characteristic differences between subacute and chronic back pain.

scientific article

Pain perception in relation to emotional learning

scientific article published on August 2008

Pancreatic Pain—Knowledge Gaps and Research Opportunities in Children and Adults

scientific article

Parceling human accumbens into putative core and shell dissociates encoding of values for reward and pain.

scientific article

Parsing pain perception between nociceptive representation and magnitude estimation

scientific article

Peripheral and central viewpoints of chronic pain, and translational implications

scientific article published on 29 November 2018

Peripheral inflammation increases the functional coherency of spinal responses to tactile but not nociceptive stimulation

scientific article published on 01 October 2002

Persistent pain inhibits contralateral somatosensory cortical activity in humans

scientific article

Personalized medicine and opioid analgesic prescribing for chronic pain: opportunities and challenges

scientific article

Pharmacotherapy for Pain in a Family With Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling.

scientific article published on 18 April 2016

Predicting placebo response with functional magnetic resonance imaging

scientific article published in June 2017

Predicting transition to chronic pain

scientific article published on August 2013

Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain.

scientific article published on April 2010

Predictive dynamics of human pain perception

scientific article

Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitor

scientific article published on 03 July 2009

Prefrontal cortical hyperactivity in patients with sympathetically mediated chronic pain.

scientific article

Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study

scientific article published on 19 September 2014

Profiles of precentral and postcentral cortical mean thicknesses in individual subjects over acute and subacute time-scales

scientific article published on 13 October 2009

Prognostics for pain in osteoarthritis: Do clinical measures predict pain after total joint replacement?

scientific article published on 08 January 2020

Psychophysical properties of female genital sensation

scientific article

Reduced ΔFosB expression in the rat nucleus accumbens has causal role in the neuropathic pain phenotype

scientific article published on 29 November 2018

Reorganization of functional brain network architecture in chronic osteoarthritis pain

scientific article published on 19 November 2020

Reorganization of hippocampal functional connectivity with transition to chronic back pain

scientific article published on 11 December 2013

Reply

Reproducibility of structural, resting-state BOLD and DTI data between identical scanners

scientific article

Resting-sate functional reorganization of the rat limbic system following neuropathic injury

scientific article published on 2 September 2014

Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study

scientific article published on 17 March 2017

Risky monetary behavior in chronic back pain is associated with altered modular connectivity of the nucleus accumbens

scientific article

Role of adult hippocampal neurogenesis in persistent pain

scientific article

Role of nucleus accumbens in neuropathic pain: linked multi-scale evidence in the rat transitioning to neuropathic pain

scientific article published on 6 March 2014

Scale-Free Brain Functional Networks

scientific article

Segregation of nociceptive and non-nociceptive networks in the squirrel monkey somatosensory thalamus

scientific article published on 01 July 2000

Sex-Specific Pharmacotherapy for Back Pain: A Proof-of-Concept Randomized Trial

scientific article published on 10 August 2021

Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits.

scientific article published on September 2013

Single subject pharmacological-MRI (phMRI) study: modulation of brain activity of psoriatic arthritis pain by cyclooxygenase-2 inhibitor

scientific article

Smoking increases risk of pain chronification through shared corticostriatal circuitry

scientific article published on 12 October 2014

Somatosensory response properties of contralaterally projecting spinothalamic and nonspinothalamic neurons in the second cervical segment of the cat.

scientific article published in July 1991

Sources of the catecholaminergic innervation of the trigeminal nucleus caudalis in cat.

scientific article published in October 1985

Spared nerve injury rats exhibit thermal hyperalgesia on an automated operant dynamic thermal escape task

scientific article

Spinothalamocortical inputs nonpreferentially innervate the superficial and deep cortical layers of SI

scientific article published on 01 October 1993

Spinothalamocortical projections to the secondary somatosensory cortex (SII) in squirrel monkey

scientific article published on 01 December 1993

Spontaneous pain and brain activity in neuropathic pain: functional MRI and pharmacologic functional MRI studies.

scientific article

Squirrel monkey lateral thalamus. I. Somatic nociresponsive neurons and their relation to spinothalamic terminals

scientific article published on 01 November 1994

Squirrel monkey lateral thalamus. II. Viscerosomatic convergent representation of urinary bladder, colon, and esophagus

scientific article published on 01 November 1994

Targeted Muscle Reinnervation Treats Neuroma and Phantom Pain in Major Limb Amputees: A Randomized Clinical Trial

scientific article published on 01 August 2019

Temporal Factors Associated With Opioid Prescriptions for Patients With Pain Conditions in an Urban Emergency Department

scientific article published on 02 March 2020

Thalamically projecting cells of the lateral cervical nucleus in monkey

scientific article published in July 1991

The Brain in Chronic Pain: Clinical Implications ⬇️

scientific article published on November 1, 2011

The Emotional Brain as a Predictor and Amplifier of Chronic Pain

scientific article published on 10 March 2016

The brain in chronic CRPS pain: abnormal gray-white matter interactions in emotional and autonomic regions

scientific article

The characteristics of cyclical and non-cyclical mastalgia: a prospective study using a modified McGill Pain Questionnaire

scientific article published on 01 September 2002

The cortical rhythms of chronic back pain.

scientific article published on September 2011

The effects of stimulus location on the gating of touch by heat- and cold-induced pain

scientific article published on 01 January 2000

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

scientific article published on 21 December 2015

The location of spinothalamic axons within spinal cord white matter in cat and squirrel monkey

scientific article published on 01 January 1991

The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network

scientific article

The role of the dorsal columns in neuropathic behavior: evidence for plasticity and non-specificity.

scientific article published in January 2002

The shadows of pain.

scientific article

Towards a theory of chronic pain.

scientific article published on 05 October 2008

Unique Microstructural Changes in the Brain Associated with Urological Chronic Pelvic Pain Syndrome (UCPPS) Revealed by Diffusion Tensor MRI, Super-Resolution Track Density Imaging, and Statistical Parameter Mapping: A MAPP Network Neuroimaging Stud

scientific article

Ventrolateral and dorsolateral ascending spinal cord pathway influence on thalamic nociception in cat.

scientific article

Viscero-somatic neurons in the primary somatosensory cortex (SI) of the squirrel monkey

scientific article published in May 1997

Viscerosomatic interactions in the thalamic ventral posterolateral nucleus (VPL) of the squirrel monkey.

scientific article published in March 1998

Whole-brain functional network disruption in chronic pain with disk herniation

scientific article published on 01 December 2019

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