List of works - Herman O. Sintim

A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection

scientific article

A noncarbohydrate based approach to polyhydroxylated pyrrolidizines: total syntheses of the natural products hyacinthacine A1 and 1-epiaustraline

scientific article published in September 2005

A pro-drug approach for selective modulation of AI-2-mediated bacterial cell-to-cell communication

scientific article published on 21 March 2012

A rapid assay for affinity and kinetics of molecular interactions with nucleic acids

scientific article published on 30 December 2011

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

scientific article published on 29 April 2008

AI-2 analogs and antibiotics: a synergistic approach to reduce bacterial biofilms.

scientific article published on 4 October 2012

Alkene protection against acid using a bromide substituent: application in a total synthesis of (−)-6,7-dideoxysqualestatin H5

scientific article published on 01 May 2018

Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 2,8-dioxabicyclo[3.2.1]octane core of squalestatins/zaragozic acids

scientific article published on 31 May 2019

Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase.

scientific article

Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues

scientific article published on 30 March 2012

An efficient synthesis of lactacystin beta-lactone

scientific article published in April 2004

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

scientific article published on 30 April 2019

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

scientific article published on 13 October 2009

Biomolecule detection with peroxidase-mimicking DNAzymes; expanding detection modality with fluorogenic compounds

scientific article published on 25 September 2009

Colorimetric split G-quadruplex probes for nucleic acid sensing: improving reconstituted DNAzyme's catalytic efficiency via probe remodeling

scientific article published in July 2009

Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins.

scientific article

Correction to Synthesis of (−)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition–Rearrangement and Cross-electrophile Coupling

scientific article published on 20 August 2018

DNA-based peroxidation catalyst--what is the exact role of topology on catalysis and is there a special binding site for catalysis?

scientific article published on 5 April 2011

Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties

scientific article published on 14 February 2011

Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP.

scientific article

Differential binding of 2'-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins

scientific article

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

scientific article

Discriminating cyclic from linear nucleotides - CRISPR/Cas-related cyclic hexaadenosine monophosphate as a case study

scientific article published on 28 November 2018

Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules

scientific article

Efforts towards the identification of simpler platensimycin analogues--the total synthesis of oxazinidinyl platensimycin

scientific article published in January 2009

Endo-S-c-di-GMP analogues-polymorphism and binding studies with class I riboswitch.

scientific article published on 9 November 2012

Enhanced Base Pairing and Replication Efficiency of Thiothymidines, Expanded-size Variants of Thymidine

scientific article published in 2009

Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine

scientific article published on January 2006

Evidence of link between quorum sensing and sugar metabolism in Escherichia coli revealed via cocrystal structures of LsrK and HPr.

scientific article

Evidence of magnetic isotope effects during thermochemical sulfate reduction

scientific article

Fluorescent analogs of cyclic and linear dinucleotides as phosphodiesterase and oligoribonuclease activity probes

article

Front Cover: Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase (ChemMedChem 12/2018)

scholarly article by Elizabeth A. Larocque et al published 20 June 2018 in ChemMedChem

Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP

scientific article published on 29 December 2021

Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin

article

Inhibition of c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative

article

Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov-Doebner Reactions

scientific article published on 25 September 2019

Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs

scientific article published on June 2012

Interrupting cyclic dinucleotide-cGAS-STING axis with small molecules

scientific article published on 15 August 2019

Investigating the interactions between cations, peroxidation substrates and G-quadruplex topology in DNAzyme peroxidation reactions using statistical testing

scientific article

Isothermal detection of RNA with restriction endonucleases

scientific article

Junction Probes − Sequence Specific Detection of Nucleic Acids via Template Enhanced Hybridization Processes

scientific article published in 2008

Ligand-Based Stability Changes in Duplex DNA Measured with a Microscale Electrochemical Platform

scientific article published on 12 April 2019

Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors of S. aureus and E. faecalis Growth and Biofilm Formation

scientific article published on 12 May 2020

Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry

article

Multiple ways to kill bacteria via inhibiting novel cell wall or membrane targets

scientific article published on 15 June 2020

N -(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria

scientific article published on 15 June 2018

Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy

scientific article published on 02 August 2012

Nicotinamide-Ponatinib Analogues as Potent Anti-CML and Anti-AML Compounds

scientific article published on 04 February 2020

Nonpolar nucleoside mimics as active substrates for human thymidine kinases

scientific article

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis.

scientific article published on 28 September 2012

On the ozonolysis of unsaturated tosylhydrazones as a direct approach to diazocarbonyl compounds

scientific article published on 01 April 2018

Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules

scientific article

Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors

scientific article published on 29 June 2019

Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways

scientific article published on 01 October 2018

Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics

scientific article published on 25 April 2019

Quorum Sensing Autoinducer-3 Finally Yields to Structural Elucidation

scientific article published on 12 February 2020

Quorum-sensing molecule dihydroxy-2,3-pentanedione and its analogs as regulators of epithelial integrity.

scientific article published on 17 January 2018

RNAs synthesized using photocleavable biotinylated nucleotides have dramatically improved catalytic efficiency

scientific article

Rapid nucleic acid melting analyses using a microfabricated electrochemical platform

scientific article

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides

scientific article published on 27 November 2018

Remarkable sensitivity to DNA base shape in the DNA polymerase active site

scientific article published in March 2006

Remote C-H functionalization: using the N-O moiety as an atom-economical tether to obtain 1,5- and the rare 1,7-C-H insertions

scientific article

Signal-on electrochemical Y or junction probe detection of nucleic acid

scientific article published on 26 June 2012

Synthesis of (−)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition–Rearrangement and Cross-electrophile Coupling

scientific article published on 20 June 2017

Synthetic analogs tailor native AI-2 signaling across bacterial species

scientific article published on August 2010

Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor

The difluorotoluene debate--a decade later

scientific article published on 7 July 2006

Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule

scientific article published on 8 March 2011

Utility of the ammonia-free Birch reduction of electron-deficient pyrroles: total synthesis of the 20s proteasome inhibitor, clasto-lactacystin beta-lactone

scientific article published in July 2005

c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators

article published in 2011

List of works by Herman O. Sintim

A C-di-GMP-proflavine-hemin supramolecular complex has peroxidase activity--implication for a simple colorimetric detection

A noncarbohydrate based approach to polyhydroxylated pyrrolidizines: total syntheses of the natural products hyacinthacine A1 and 1-epiaustraline

A pro-drug approach for selective modulation of AI-2-mediated bacterial cell-to-cell communication

A rapid assay for affinity and kinetics of molecular interactions with nucleic acids

A simple solid-phase synthesis of the ubiquitous bacterial signaling molecule, c-di-GMP and analogues

AI-2 analogs and antibiotics: a synergistic approach to reduce bacterial biofilms.

Alkene protection against acid using a bromide substituent: application in a total synthesis of (−)-6,7-dideoxysqualestatin H5

Alkylation of lithiated dimethyl tartrate acetonide with unactivated alkyl halides and application to an asymmetric synthesis of the 2,8-dioxabicyclo[3.2.1]octane core of squalestatins/zaragozic acids

Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase.

Altering the communication networks of multispecies microbial systems using a diverse toolbox of AI-2 analogues

An efficient synthesis of lactacystin beta-lactone

Antibacterial Small Molecules That Potently Inhibit Staphylococcus aureus Lipoteichoic Acid Biosynthesis

Biological screening of a diverse set of AI-2 analogues in Vibrio harveyi suggests that receptors which are involved in synergistic agonism of AI-2 and analogues are promiscuous

Biomolecule detection with peroxidase-mimicking DNAzymes; expanding detection modality with fluorogenic compounds

Colorimetric split G-quadruplex probes for nucleic acid sensing: improving reconstituted DNAzyme's catalytic efficiency via probe remodeling

Conservative change to the phosphate moiety of cyclic diguanylic monophosphate remarkably affects its polymorphism and ability to bind DGC, PDE, and PilZ proteins.

Correction to Synthesis of (−)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition–Rearrangement and Cross-electrophile Coupling

DNA-based peroxidation catalyst--what is the exact role of topology on catalysis and is there a special binding site for catalysis?

Dialkylamino-2,4-dihydroxybenzoic acids as easily synthesized analogues of platensimycin and platencin with comparable antibacterial properties

Diamidinium and iminium aromatics as new aggregators of the bacterial signaling molecule, c-di-GMP.

Differential binding of 2'-biotinylated analogs of c-di-GMP with c-di-GMP riboswitches and binding proteins

Differential radial capillary action of ligand assay for high-throughput detection of protein-metabolite interactions

Discriminating cyclic from linear nucleotides - CRISPR/Cas-related cyclic hexaadenosine monophosphate as a case study

Effects on membrane lateral pressure suggest permeation mechanisms for bacterial quorum signaling molecules

Efforts towards the identification of simpler platensimycin analogues--the total synthesis of oxazinidinyl platensimycin

Endo-S-c-di-GMP analogues-polymorphism and binding studies with class I riboswitch.

Enhanced Base Pairing and Replication Efficiency of Thiothymidines, Expanded-size Variants of Thymidine

Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine

Evidence of link between quorum sensing and sugar metabolism in Escherichia coli revealed via cocrystal structures of LsrK and HPr.

Evidence of magnetic isotope effects during thermochemical sulfate reduction

Fluorescent analogs of cyclic and linear dinucleotides as phosphodiesterase and oligoribonuclease activity probes

Front Cover: Alkynylnicotinamide-Based Compounds as ABL1 Inhibitors with Potent Activities against Drug-Resistant CML Harboring ABL1(T315I) Mutant Kinase (ChemMedChem 12/2018)

Global proteomics of fibroblast cells treated with bacterial cyclic dinucleotides, c-di-GMP and c-di-AMP

Hydroxybenzylidene-indolinones, c-di-AMP synthase inhibitors, have antibacterial and anti-biofilm activities and also re-sensitize resistant bacteria to methicillin and vancomycin

Inhibition of c-di-GMP phosphodiesterase RocR and swarming motility by a benzoisothiazolinone derivative

Inhibitors of Intracellular Gram-Positive Bacterial Growth Synthesized via Povarov-Doebner Reactions

Inhibitors of fatty acid synthesis in prokaryotes and eukaryotes as anti-infective, anticancer and anti-obesity drugs

Interrupting cyclic dinucleotide-cGAS-STING axis with small molecules

Investigating the interactions between cations, peroxidation substrates and G-quadruplex topology in DNAzyme peroxidation reactions using statistical testing

Isothermal detection of RNA with restriction endonucleases

Junction Probes − Sequence Specific Detection of Nucleic Acids via Template Enhanced Hybridization Processes

Ligand-Based Stability Changes in Duplex DNA Measured with a Microscale Electrochemical Platform

Lipoteichoic Acid Biosynthesis Inhibitors as Potent Inhibitors of S. aureus and E. faecalis Growth and Biofilm Formation

Molecular Fluorescence, Phosphorescence, and Chemiluminescence Spectrometry

Multiple ways to kill bacteria via inhibiting novel cell wall or membrane targets

N -(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria

Nanomolar fluorescent detection of c-di-GMP using a modular aptamer strategy

Nicotinamide-Ponatinib Analogues as Potent Anti-CML and Anti-AML Compounds

Nonpolar nucleoside mimics as active substrates for human thymidine kinases

Nucleotide, c-di-GMP, c-di-AMP, cGMP, cAMP, (p)ppGpp signaling in bacteria and implications in pathogenesis.

On the ozonolysis of unsaturated tosylhydrazones as a direct approach to diazocarbonyl compounds

Paradigm shift in discovering next-generation anti-infective agents: targeting quorum sensing, c-di-GMP signaling and biofilm formation in bacteria with small molecules

Potently inhibiting cancer cell migration with novel 3H-pyrazolo[4,3-f]quinoline boronic acid ROCK inhibitors

Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways

Proteomic analysis of bacterial response to a 4-hydroxybenzylidene indolinone compound, which re-sensitizes bacteria to traditional antibiotics

Quorum Sensing Autoinducer-3 Finally Yields to Structural Elucidation

Quorum-sensing molecule dihydroxy-2,3-pentanedione and its analogs as regulators of epithelial integrity.

RNAs synthesized using photocleavable biotinylated nucleotides have dramatically improved catalytic efficiency

Rapid nucleic acid melting analyses using a microfabricated electrochemical platform

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides

Remarkable sensitivity to DNA base shape in the DNA polymerase active site

Remote C-H functionalization: using the N-O moiety as an atom-economical tether to obtain 1,5- and the rare 1,7-C-H insertions

Signal-on electrochemical Y or junction probe detection of nucleic acid

Synthesis of (−)-6,7-Dideoxysqualestatin H5 by Carbonyl Ylide Cycloaddition–Rearrangement and Cross-electrophile Coupling

Synthetic analogs tailor native AI-2 signaling across bacterial species

Tetrahydro-3H-pyrazolo[4,3-a]phenanthridine-based CDK inhibitor

The difluorotoluene debate--a decade later

Thiazole orange-induced c-di-GMP quadruplex formation facilitates a simple fluorescent detection of this ubiquitous biofilm regulating molecule

Utility of the ammonia-free Birch reduction of electron-deficient pyrroles: total synthesis of the 20s proteasome inhibitor, clasto-lactacystin beta-lactone

c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators