List of works - Nathalie Janel

A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase.

scientific article published on 25 December 2013

Altered gene expression in liver from a murine model of hyperhomocysteinemia.

scientific article

Assessment of the expression of candidate human plasma membrane phospholipid scramblase in Scott syndrome cells

scientific article published on 01 February 1999

BDNF and DYRK1A are variable and inversely correlated in lymphoblastoid cell lines from Down syndrome patients

scientific article

Cadmium Alters the Biotransformation of Carcinogenic Aromatic Amines by Arylamine N -Acetyltransferase Xenobiotic-Metabolizing Enzymes: Molecular, Cellular, and in Vivo Studies ⬇️

scientific article (publication date: December 2010)

Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer's disease.

scientific article published on 20 June 2017

Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis

scientific article

Cystathionine beta synthase deficiency affects mouse endochondral ossification

scientific journal article

Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver

scientific journal article

Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver.

scientific article published in May 2005

DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.

scientific article published on 9 December 2014

DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels

scientific article

DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase

scientific article

Development of DANDYs, new 3,5-diaryl-7-azaindoles demonstrating potent DYRK1A kinase inhibitory activity

scientific article

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

scientific article published on 28 May 2014

Dyrk1A, a Serine/Threonine Kinase, is Involved in ERK and Akt Activation in the Brain of Hyperhomocysteinemic Mice ⬇️

scientific article published on August 26, 2012

Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism.

scientific article

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

scientific article published on 30 January 2014

Early reduction of circulating homocysteine levels in Goto–Kakizaki rat, a spontaneous nonobese model of type 2 diabetes

scientific article published on 05 April 2011

Effect of cadmium administration in hyperhomocysteinemic mice due to cystathionine beta synthase deficiency.

scientific article

Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice

scientific article published on 17 August 2012

Effect of lyophilized prune extract on hyperhomocysteinemia in mice

scientific article published on 10 March 2017

Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice

scientific article published on 28 April 2011

Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice

scientific article published on 02 February 2007

Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice

scientific article published on 3 August 2008

Elevated plasma von Willebrand factor in a murine model of severe hyperhomocysteinemia

scientific article published on 01 August 2003

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

scientific article published on 14 September 2013

Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A

scientific article published on 05 June 2020

Ets transcription factors bind and transactivate the core promoter of the von Willebrand factor gene.

scientific article

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

scientific article published on 4 May 2014

Expression of the cystathionine beta synthase (CBS) gene during mouse development and immunolocalization in adult brain.

scientific article published in March 2003

Functional characterization of bovine von Willebrand factor gene promoter in bovine endothelial cells demonstrates species-specific properties.

scientific article published on October 1997

Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice ⬇️

scientific article published on February 18, 2013

Hepatoprotective effects of lycopene on liver enzymes involved in methionine and xenobiotic metabolism in hyperhomocysteinemic rats

scientific article published on 27 May 2016

Homocysteine threshold value based on cystathionine beta synthase and paraoxonase 1 activities in mice

scientific article published on 30 October 2007

Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto–Kakizaki (GK) rat

scientific article published on 10 July 2011

Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice

scientific article published on 22 September 2006

Hyperkeratosis in cystathionine beta synthase-deficient mice: an animal model of hyperhomocysteinemia.

scientific article published in October 2004

Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: molecular and cellular mechanisms of inhibition

scientific article published on 29 February 2008

Impact of Dyrk1A level on alcohol metabolism

scientific article published on 20 May 2016

Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome.

scientific article published on 25 September 2017

Inhibition of Extracellular Signal–Regulated Kinase in Liver of Hyperhomocysteinemic Mice

scientific article published on 01 July 2006

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat

scientific article

LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice.

scientific article

Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway

scientific article published on 11 June 2007

Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain

scientific article published on 15 June 2012

Mice lacking cystathionine beta synthase have lung fibrosis and air space enlargement

scientific article published on 06 May 2007

Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise

scientific article published on 13 May 2014

Mouse liver paraoxonase-1 gene expression is downregulated in hyperhomocysteinemia

article

Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats

scientific article published on 12 October 2010

Oct-1 is involved in the transcriptional repression of the von willebrand factor gene promoter.

scientific article published in August 1998

Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues.

scientific article

Paraoxonase-1 expression is up-regulated in Down syndrome fetal liver.

scientific article

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models.

scientific article

Plasma DYRK1A as a novel risk factor for Alzheimer's disease.

scientific article

Plasma homocysteine levels are not increased in murine models of Alzheimer's disease

scientific article

Plasma nitrate levels are increased in adult Down syndrome patients

scientific article published on 29 April 2013

Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.

scientific article published on January 2014

Primary structure of the propeptide and factor VIII-binding domain of bovine von Willebrand factor

scientific article published in April 1997

Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice

scientific article published on 24 December 2010

Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus

scientific journal article

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.

scientific article

Silver nanoparticle array structures that produce remarkably narrow plasmon lineshapes

scientific article published on 01 June 2004

The iron component of particulate matter is antiapoptotic: A clue to the development of lung cancer after exposure to atmospheric pollutants?

scientific article

The localization of the von Willebrand factor gene on cattle, sheep and goat chromosomes illustrates karyotype evolution in mammals

article

The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia

scientific journal article

Thiol compounds metabolism in mice, rats and humans: Comparative study and potential explanation of rodents protection against vascular diseases

scientific article published on 07 April 2006

List of works by Nathalie Janel

A high-performance liquid chromatography assay for Dyrk1a, a Down syndrome-associated kinase.

Altered gene expression in liver from a murine model of hyperhomocysteinemia.

Assessment of the expression of candidate human plasma membrane phospholipid scramblase in Scott syndrome cells

BDNF and DYRK1A are variable and inversely correlated in lymphoblastoid cell lines from Down syndrome patients

Cadmium Alters the Biotransformation of Carcinogenic Aromatic Amines by Arylamine N -Acetyltransferase Xenobiotic-Metabolizing Enzymes: Molecular, Cellular, and in Vivo Studies ⬇️

Combined assessment of DYRK1A, BDNF and homocysteine levels as diagnostic marker for Alzheimer's disease.

Connexin30 deficiency causes instrastrial fluid-blood barrier disruption within the cochlear stria vascularis

Cystathionine beta synthase deficiency affects mouse endochondral ossification

Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver

Cystathionine beta synthase deficiency promotes oxidative stress, fibrosis, and steatosis in mice liver.

DYRK1A BAC transgenic mouse: a new model of thyroid dysgenesis in Down syndrome.

DYRK1A overexpression decreases plasma lecithin:cholesterol acyltransferase activity and apolipoprotein A-I levels

DYRK1A, a novel determinant of the methionine-homocysteine cycle in different mouse models overexpressing this Down-syndrome-associated kinase

Development of DANDYs, new 3,5-diaryl-7-azaindoles demonstrating potent DYRK1A kinase inhibitory activity

Dyrk1A induces pancreatic β cell mass expansion and improves glucose tolerance.

Dyrk1A, a Serine/Threonine Kinase, is Involved in ERK and Akt Activation in the Brain of Hyperhomocysteinemic Mice ⬇️

Dyrk1a activates antioxidant NQO1 expression through an ERK1/2-Nrf2 dependent mechanism.

Dyrk1a haploinsufficiency induces diabetes in mice through decreased pancreatic beta cell mass

Early reduction of circulating homocysteine levels in Goto–Kakizaki rat, a spontaneous nonobese model of type 2 diabetes

Effect of cadmium administration in hyperhomocysteinemic mice due to cystathionine beta synthase deficiency.

Effect of catechin/epicatechin dietary intake on endothelial dysfunction biomarkers and proinflammatory cytokines in aorta of hyperhomocysteinemic mice

Effect of lyophilized prune extract on hyperhomocysteinemia in mice

Effect of red wine polyphenol dietary supplementation on two phase II enzymes in liver of hyperhomocysteinemic mice

Effects of catechin on homocysteine metabolism in hyperhomocysteinemic mice

Effects of red wine polyphenolic compounds on paraoxonase-1 and lectin-like oxidized low-density lipoprotein receptor-1 in hyperhomocysteinemic mice

Elevated plasma von Willebrand factor in a murine model of severe hyperhomocysteinemia

Epigallocatechin-3-gallate, a DYRK1A inhibitor, rescues cognitive deficits in Down syndrome mouse models and in humans

Ethanol-Induced Changes in Brain of Transgenic Mice Overexpressing DYRK1A

Ets transcription factors bind and transactivate the core promoter of the von Willebrand factor gene.

Excitation/inhibition balance and learning are modified by Dyrk1a gene dosage

Expression of the cystathionine beta synthase (CBS) gene during mouse development and immunolocalization in adult brain.

Functional characterization of bovine von Willebrand factor gene promoter in bovine endothelial cells demonstrates species-specific properties.

Hepatocyte-specific Dyrk1a gene transfer rescues plasma apolipoprotein A-I levels and aortic Akt/GSK3 pathways in hyperhomocysteinemic mice ⬇️

Hepatoprotective effects of lycopene on liver enzymes involved in methionine and xenobiotic metabolism in hyperhomocysteinemic rats

Homocysteine threshold value based on cystathionine beta synthase and paraoxonase 1 activities in mice

Hypercholesterolaemia, signs of islet microangiopathy and altered angiogenesis precede onset of type 2 diabetes in the Goto–Kakizaki (GK) rat

Hyperhomocysteinemia due to cystathionine beta synthase deficiency induces dysregulation of genes involved in hepatic lipid homeostasis in mice

Hyperkeratosis in cystathionine beta synthase-deficient mice: an animal model of hyperhomocysteinemia.

Identification of the xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 as a new target of cisplatin in breast cancer cells: molecular and cellular mechanisms of inhibition

Impact of Dyrk1A level on alcohol metabolism

Increased levels of inflammatory plasma markers and obesity risk in a mouse model of Down syndrome.

Inhibition of Extracellular Signal–Regulated Kinase in Liver of Hyperhomocysteinemic Mice

Islet endothelial activation and oxidative stress gene expression is reduced by IL-1Ra treatment in the type 2 diabetic GK rat

LPS-Induced Inflammation Abolishes the Effect of DYRK1A on IkB Stability in the Brain of Mice.

Mice deficient in cystathionine beta synthase display altered homocysteine remethylation pathway

Mice deficient in cystathionine beta synthase display increased Dyrk1A and SAHH activities in brain

Mice lacking cystathionine beta synthase have lung fibrosis and air space enlargement

Molecular rescue of DYRK1A overexpression in cystathionine beta synthase-deficient mouse brain by enriched environment combined with voluntary exercise

Mouse liver paraoxonase-1 gene expression is downregulated in hyperhomocysteinemia

Myocardial fibrosis and TGFB expression in hyperhomocysteinemic rats

Oct-1 is involved in the transcriptional repression of the von willebrand factor gene promoter.

Overexpression of the DYRK1A Gene (Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A) Induces Alterations of the Serotoninergic and Dopaminergic Processing in Murine Brain Tissues.

Paraoxonase-1 expression is up-regulated in Down syndrome fetal liver.

Pharmacological correction of excitation/inhibition imbalance in Down syndrome mouse models.

Plasma DYRK1A as a novel risk factor for Alzheimer's disease.

Plasma homocysteine levels are not increased in murine models of Alzheimer's disease

Plasma nitrate levels are increased in adult Down syndrome patients

Prefrontal deficits in a murine model overexpressing the down syndrome candidate gene dyrk1a.

Primary structure of the propeptide and factor VIII-binding domain of bovine von Willebrand factor

Protection and reversal of hepatic fibrosis by red wine polyphenols in hyperhomocysteinemic mice

Regulation of extracellular signal-regulated kinase by homocysteine in hippocampus

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial.

Silver nanoparticle array structures that produce remarkably narrow plasmon lineshapes

The iron component of particulate matter is antiapoptotic: A clue to the development of lung cancer after exposure to atmospheric pollutants?

The localization of the von Willebrand factor gene on cattle, sheep and goat chromosomes illustrates karyotype evolution in mammals

The neuronal SAPK/JNK pathway is altered in a murine model of hyperhomocysteinemia

Thiol compounds metabolism in mice, rats and humans: Comparative study and potential explanation of rodents protection against vascular diseases