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List of works by Monika E Hegi

-OMICS AND PROGNOSTIC MARKERS

scientific article published on 21 October 2011

A novel volume-age-KPS (VAK) glioblastoma classification identifies a prognostic cognate microRNA-gene signature

scientific article

A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306)

scientific article

Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients

scientific article published on December 12, 2011

Alkylpurine–DNA–N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients.

scientific article

Allelotype analysis of mouse lung carcinomas reveals frequent allelic losses on chromosome 4 and an association between allelic imbalances on chromosome 6 and K-ras activation.

scientific article published in December 1994

Analysis of activated protooncogenes in B6C3F1 mouse liver tumors induced by ciprofibrate, a potent peroxisome proliferator.

scientific article published on January 1993

Anoxia induces macrophage inhibitory cytokine-1 (MIC-1) in glioblastoma cells independently of p53 and HIF-1.

scientific article published on June 2002

Anti-O6-methylguanine-methyltransferase (MGMT) immunohistochemistry in glioblastoma multiforme: observer variability and lack of association with patient survival impede its use as clinical biomarker

scientific article published on 8 April 2008

Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22

scientific article published on November 13, 1992

Brain cancer in 2012: Molecular characterization leads the way.

scientific article published on 08 January 2013

CSIG-05THE UBIQUITIN SPECIFIC PEPTIDASE 15 (USP15) SUPPRESSES PROLIFERATION OF HUMAN GLIOBLASTOMA CELL LINES VIA STABILIZATION OF HECTD1 E3 LIGASE.

scientific article

Characterization of p53 mutations in methylene chloride-induced lung tumors from B6C3F1 mice.

scientific article published in May 1993

Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are associated with expression of a stem cell related HOX-signature in glioblastoma

scientific article

Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial

scientific article

Cilengitide in newly diagnosed glioblastoma: biomarker expression and outcome

scientific article published on 22 February 2016

Classification of human astrocytic gliomas on the basis of gene expression: a correlated group of genes with angiogenic activity emerges as a strong predictor of subtypes.

scientific article published on October 2003

Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide

scientific article published on March 2004

Combining chromosomal arm status and significantly aberrant genomic locations reveals new cancer subtypes

scientific article published on 12 March 2009

Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains.

scientific article

Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity

scientific article published on September 2008

Correlation of immune phenotype with IDH mutation in diffuse glioma.

scientific article published on 20 May 2017

Correlative studies in neuro-oncology trials: should they influence treatment?

scientific article

Current concepts and management of glioblastoma

scientific article published on July 2011

Current management of low-grade gliomas

scientific article published on 26 September 2016

DNA fingerprinting of glioma cell lines and considerations on similarity measurements.

scientific article

Determination of p53 mutations, EGFR overexpression, and loss of p16 expression in pediatric glioblastomas.

scientific article published in July 1997

Does Valproic Acid or Levetiracetam Improve Survival in Glioblastoma? A Pooled Analysis of Prospective Clinical Trials in Newly Diagnosed Glioblastoma

scientific article published on 19 January 2016

Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial

scientific article published on 07 October 2013

EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood

scientific article published on 08 December 2020

EG-05COMBINATION OF GENE COPY GAIN AND EPIGENETIC DEREGULATION ARE ASSOCIATED WITH THE ABERRANT EXPRESSION OF A STEM CELL RELATED HOX-SIGNATURE IN GLIOBLASTOMA.

scientific article published in November 2014

EORTC 26083 phase I/II trial of dasatinib in combination with CCNU in patients with recurrent glioblastoma

scientific article

Early detection of human glioma sphere xenografts in mouse brain using diffusion MRI at 14.1 T.

scientific article published on 15 September 2016

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma: A Randomized Clinical Trial

scientific article published in December 2017

Elevated levels of MIC-1/GDF15 in the cerebrospinal fluid of patients are associated with glioblastoma and worse outcome

scientific article

Endothelin receptor type B counteracts tenascin-C-induced endothelin receptor type A-dependent focal adhesion and actin stress fiber disorganization.

scientific article

Epidermal growth factor receptor inhibitors in neuro-oncology: hopes and disappointments

scientific article published on February 2008

Erratum to: MGMT methylation analysis of glioblastoma on the Infinium methylation BeadChip identifies two distinct CpG regions associated with gene silencing and outcome, yielding a prediction model for comparisons across datasets, tumor grades, and

article

European Association for Neuro-Oncology (EANO) guideline on the diagnosis and treatment of adult astrocytic and oligodendroglial gliomas.

scientific article published on 5 May 2017

Evidence-based management of adult patients with diffuse glioma - Authors' reply

scientific article

Expression of O⁶-methylguanine-DNA methyltransferase in childhood medulloblastoma.

scientific article

Expression-based intrinsic glioma subtypes are prognostic in low-grade gliomas of the EORTC22033-26033 clinical trial.

scientific article

Extent and patterns of MGMT promoter methylation in glioblastoma- and respective glioblastoma-derived spheres.

scientific article

Familial Brain Tumour Syndrome Associated with a p53 Germline Deletion of Codon 236

scientific article published in January 1995

GENETIC AND EPIGENETIC DEREGULATION ARE ASSOCIATED WITH THE ABERRANT EXPRESSION OF A STEM CELL RELATED HOX GENE SIGNATURE IN GLIOBLASTOMA.

scientific article published in July 2014

Genetic alterations in brain tumors following 1,3-butadiene exposure in B6C3F1 mice

scientific article published in January 2005

Genome-wide DNA methylation detection by MethylCap-seq and Infinium HumanMethylation450 BeadChips: an independent large-scale comparison

scientific article

Glioma epigenetics: From subclassification to novel treatment options

scientific article published on 20 November 2017

Growth promoting signaling by tenascin-C [corrected].

scientific article

Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.

scientific article published in September 1997

Hepatic and pulmonary carcinogenicity of methylene chloride in mice: a search for mechanisms.

scientific article published on September 1995

Histopathologic assessment of hot-spot microvessel density and vascular patterns in glioblastoma: Poor observer agreement limits clinical utility as prognostic factors: a translational research project of the European Organization for Research and T

scientific article published in July 2006

INK4a/Arf is required for suppression of EGFR/DeltaEGFR(2-7)-dependent ERK activation in mouse astrocytes and glioma.

scientific article

Identical mutations of the p53 tumor suppressor gene in the gliomatous and the sarcomatous components of gliosarcomas suggest a common origin from glial cells.

scientific article published in September 1995

Improving survival in molecularly selected glioblastoma

scientific article published on 14 February 2019

In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice

scientific article published in September 1993

In vivo characterization of brain metabolism by 1 H MRS, 13 C MRS and 18 FDG PET reveals significant glucose oxidation of invasively growing glioma cells

scientific article published on 8 February 2018

In-vitro assays to detect alkylating and mutagenic activities of dietary components nitrosated in situ

scientific article published in January 1987

Individualized targeted therapy for glioblastoma: fact or fiction?

scientific article published on January 2012

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

scientific article published on 23 May 2020

Is more better? The impact of extended adjuvant temozolomide in newly diagnosed glioblastoma: a secondary analysis of EORTC and NRG Oncology/RTOG.

scientific article

Light-induced cell death of retinal photoreceptors in the absence of p53

scientific article published in April 1998

MGMT gene silencing and benefit from temozolomide in glioblastoma

scientific article

MGMT promoter methylation in malignant gliomas: ready for personalized medicine?

scientific article published on 08 December 2009

MGMT promoter methylation status testing to guide therapy for glioblastoma: refining the approach based on emerging evidence and current challenges

scientific article published on 01 February 2019

MGMT testing--the challenges for biomarker-based glioma treatment

scientific article

Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for Glioblastoma: A Randomized Clinical Trial

scientific article

Marker-independent identification of glioma-initiating cells

scientific article published on 21 February 2010

Mechanisms of Resistance to EGFR Inhibition Reveal Metabolic Vulnerabilities in Human GBM

scientific article published on 03 July 2019

Methylguanine methyltransferase testing in glioblastoma: when and how?

scientific article

Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact

scientific article

Modulation of angiogenic and inflammatory response in glioblastoma by hypoxia

scientific article

Molecular diagnostics of gliomas: the clinical perspective

scientific article published on 23 September 2010

Molecular insights into brain tumors: ready for translation into novel treatment strategies?

scientific article

Molecular neuro-oncology in clinical practice: a new horizon

scientific article published on August 2013

Neuro-oncology: in search of molecular markers of glioma in elderly patients.

scientific article

Neuro-oncology: oligodendroglioma and molecular markers

scientific article published in January 2007

New prognostic factors and calculators for outcome prediction in patients with recurrent glioblastoma: a pooled analysis of EORTC Brain Tumour Group phase I and II clinical trials.

scientific article published on 28 March 2012

New trends in the medical management of glioblastoma multiforme: the role of temozolomide chemotherapy.

scientific article

No complementation between TP53 or RB-1 and v-src in astrocytomas of GFAP-v-src transgenic mice

scientific article published in October 1999

No measurable increase in thymidine glycol or 8-hydroxydeoxyguanosine in liver DNA of rats treated with nafenopin or choline-devoid low-methionine diet

scientific article published in May 1990

Nomograms for predicting survival of patients with newly diagnosed glioblastoma: prognostic factor analysis of EORTC and NCIC trial 26981-22981/CE.3.

scientific article published on 21 December 2007

Novel, improved grading system(s) for IDH-mutant astrocytic gliomas

scientific article published on 23 April 2018

Optimal role of temozolomide in the treatment of malignant gliomas.

scientific article

Pathway Analysis of Glioblastoma Tissue after Preoperative Treatment with the EGFR Tyrosine Kinase Inhibitor Gefitinib—A Phase II Trial

scientific article published on April 6, 2011

Personalized care in neuro-oncology coming of age: why we need MGMT and 1p/19q testing for malignant glioma patients in clinical practice

scientific article

Phase I/IIa study of cilengitide and temozolomide with concomitant radiotherapy followed by cilengitide and temozolomide maintenance therapy in patients with newly diagnosed glioblastoma

scientific article

Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082).

scientific article

Presence of alternative lengthening of telomeres mechanism in patients with glioblastoma identifies a less aggressive tumor type with longer survival.

scientific article published in July 2010

Presence of an oligodendroglioma-like component in newly diagnosed glioblastoma identifies a pathogenetically heterogeneous subgroup and lacks prognostic value: central pathology review of the EORTC_26981/NCIC_CE.3 trial

scientific article published on 15 January 2012

Prognostic factors for low-grade gliomas.

scientific article published on December 2003

Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma

scientific article published on 29 October 2014

Promoter Methylation Cutoff with Safety Margin for Selecting Glioblastoma Patients into Trials Omitting Temozolomide: A Pooled Analysis of Four Clinical Trials

scientific article published on 04 December 2018

Quantitative real-time PCR does not show selective targeting of p14(ARF) but concomitant inactivation of both p16(INK4A) and p14(ARF) in 105 human primary gliomas.

scientific article published in March 2001

RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma--a phase II study

scientific article published on 2 September 2009

Radiotherapy suppresses angiogenesis in mice through TGF-betaRI/ALK5-dependent inhibition of endothelial cell sprouting

scientific article

Recent developments in the use of chemotherapy in brain tumours.

scientific article published on 20 January 2006

Reduced latency but no increased brain tumor penetrance in mice with astrocyte specific expression of a human p53 mutant.

scientific article published in November 2000

Reply to F. Felix et al and M.F. Fay et al.

scientific article published on 13 June 2016

Reply to M.C. Chamberlain

scientific article published on 21 April 2014

Senescence Is the Main Trait Induced by Temozolomide in Glioblastoma Cells

scientific article published in 2022

Sensitivity Analysis of the MGMT-STP27 Model and Impact of Genetic and Epigenetic Context to Predict the MGMT Methylation Status in Gliomas and Other Tumors.

scientific article

Should biomarkers be used to design personalized medicine for the treatment of glioblastoma?

scientific article published on September 2010

Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma

scientific article

Targeting brain-tumor stem cells

scientific article published in February 2007

Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study

scientific article published on 26 September 2016

Temozolomide versus standard 6-week radiotherapy versus hypofractionated radiotherapy in patients older than 60 years with glioblastoma: the Nordic randomised, phase 3 trial

scientific article

The DNA methylome of DDR genes and benefit from RT or TMZ in IDH mutant low-grade glioma treated in EORTC 22033.

scientific article

The TICking clock of EGFR therapy resistance in glioblastoma: Target Independence or target Compensation

scientific article published on 01 March 2019

The mouse ERG before and after light damage is independent of p53

scientific article published in 1998

Toward methylation-based classification of central nervous system tumors

scientific article published on 9 April 2018

Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study

scientific article published on 11 March 2015

Ubiquitin Specific Peptidase 15 (USP15) suppresses glioblastoma cell growth via stabilization of HECTD1 E3 ligase attenuating WNT pathway activity.

scientific article published on 30 November 2017

Validation of real-time methylation-specific PCR to determine O6-methylguanine-DNA methyltransferase gene promoter methylation in glioma.

scientific article published on 13 June 2008

WIF1 re-expression in glioblastoma inhibits migration through attenuation of non-canonical WNT signaling by downregulating the lncRNA MALAT1.

scientific article

Withholding temozolomide in glioblastoma patients with unmethylated MGMT promoter--still a dilemma?

scientific article published on 15 September 2015

[Role of MGMT and clinical applications in brain tumours].

scientific article published in September 2007

p53 gene mutation and ink4a-arf deletion appear to be two mutually exclusive events in human glioblastoma

scientific article published in August 2000

p53 transdominance but no gain of function in mouse brain tumor model

scientific article published in June 2000

p73 is not mutated in meningiomas as determined with a functional yeast assay but p73 expression increases with tumor grade.

scientific article published in July 2001