List of works - Keith A. Stubbs

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases

scientific article

A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance

scientific article published on 21 July 2016

A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem

scientific article published in 2023

A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

scientific article published on 18 January 2006

A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action

scientific article published in 2022

A general method for affinity-based proteomic profiling of exo-α-glycosidases

scientific article

A herbicide structure-activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana

scientific article published on 27 January 2018

A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides

scientific article published on 10 February 2006

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

scientific article published on 04 September 2018

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

scientific article

A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.

scientific article

A simple and robust preparation of N-acetylindoxyls: precursors for indigogenic substrates

scientific article published on 01 January 2015

Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis

scientific article published on 14 March 2017

Activity-based proteomics probes for carbohydrate-processing enzymes: current trends and future outlook.

scientific article published on 04 March 2014

An interactive database to explore herbicide physicochemical properties

scientific article published on 21 April 2015

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

scientific article

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human -GlcNAcase

article

Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

scientific article published on 01 June 2018

Biosynthesis of a Tricyclo[6.2.2.02,7 ]dodecane System by a Berberine Bridge Enzyme-Like Aldolase

scientific article published on 28 October 2019

Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria

scientific article published on 22 November 2017

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance

scientific article published on 28 March 2017

Crystal Structures of a Glycoside Hydrolase Family 20 Lacto-N-biosidase from Bifidobacterium bifidum ⬇️

scientific article published on March 11, 2013

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

scientific article published in February 2018

Development of tools to study lacto-N-biosidase: an important enzyme involved in the breakdown of human milk oligosaccharides

scientific article published on 19 April 2012

East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide

scientific article published on 20 November 2019

Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue

scientific article published on 13 July 2010

Enzyme targets for drug design of new anti-virulence therapeutics

scientific article published on 14 September 2018

Expansion of the tetracycline-dependent regulation toolbox for Helicobacter pylori

scientific article

Exploiting sp2 -Hybridisation in the Development of Potent 1,5-α-l-Arabinanase Inhibitors

scientific article published on 7 March 2017

Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides

scientific article published on 27 June 2017

Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis

scientific article

Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach

scientific article

Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum ⬇️

scientific article published on 20 December 2019

Glycosylation-related Diagnostic and Therapeutic Drug Target Markers in Hepatocellular Carcinoma

scientific article

Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection

scientific article

Herbicidal properties of antimalarial drugs

scientific article published on 31 March 2017

Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system ⬇️

scientific article published on 22 November 2018

Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast.

scientific article

Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses

scientific article

Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase, StrH

scientific article

Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

scientific article

Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

scientific article published on 25 April 2017

Integrating thin film microfluidics in developing a concise synthesis of DGJNAc: A potent inhibitor of α-N-acetylgalctosaminidases

scientific article published on 11 October 2018

Letter to the Glycoforum Transforming Glycoscience: An Australian Perspective

article

Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains

article

Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori

scientific article published on 2 March 2016

Mechanism of the dehydrogenase reaction of DmpFG and analysis of inter-subunit channeling efficiency and thermodynamic parameters in the overall reaction

scientific article published on 3 June 2013

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: INTRACELLULAR -O-LINKED N-GLYCOLYLGLUCOSAMINE (GlcNGc), UDP-GlcNGc, AND THE BIOCHEMICAL AND STRUCTURAL RATIONALE FOR THE SUBSTRATE TOLERANCE OF -O-LINKED -N-ACETYLGLUCOSAMINIDASE

scientific article

Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidases

scientific article published on 01 March 2016

Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase

scientific article

Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum.

scientific article published on 4 April 2017

Multifunctional nanoadditives for the thermodynamic and kinetic stabilization of enzymes

scientific article published on 06 September 2011

NAG-thiazoline is a potent inhibitor of the Vibrio campbellii GH20 β-N-Acetylglucosaminidase

scientific article published on 07 March 2020

Nitrate uptake by p-phosphonic acid or p-(trimethylammonium)methyl calix[8]arene stablized laminar materials

scholarly article in RSC Advances, vol. 4 no. 89, 2014

O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis

scientific article

Perturbation of indole-3-butyric acid homeostasis by the UDP-glucosyltransferase UGT74E2 modulates Arabidopsis architecture and water stress tolerance

scientific article published on 26 August 2010

Phosphonated calix[4]arene-based amphiphiles as scaffolds for fluorescent nano-fibres

scientific article published on 31 May 2011

Photoredox catalysis under shear using thin film vortex microfluidics

scientific article published on 01 July 2015

Potent inhibition of a GH20 exo-β-N-acetylglucosaminidase from marine Vibrio bacteria by reaction intermediate analogues

scientific article published on 03 May 2018

Preliminary studies into the inhibition of the cholesterol alpha-glucosyltransferase from Helicobacter pylori using azasugars

scientific article published on 04 March 2010

Primary antibiotic resistance of Helicobacter pylori among a Chinese Tibetan population

scientific article published on 09 September 2020

Red Algal Molecules - Synthesis of Methyl Neo-β-carrabioside and Its S-Linked Variant via Two Synthetic Routes: A Late Stage Ring Closure and Using a 3,6-Anhydro-d-galactosyl Donor

scientific article published on 12 November 2020

Stereospecific synthesis of resorcin[4]arenes and pyrogallol[4]arenes in dynamic thin films.

scientific article

Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut. ⬇️

scientific article

Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway

scientific article

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

scientific journal article

Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi

scientific article published on 16 October 2020

Structure of a Talaromyces pinophilus GH62 arabinofuranosidase in complex with AraDNJ at 1.25 Å resolution

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

scientific article

Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa

scientific article published on 20 December 2016

Synthesis and use of mechanism-based protein-profiling probes for retaining beta-D-glucosaminidases facilitate identification of Pseudomonas aeruginosa NagZ.

scientific article published on 8 December 2007

Synthesis of 2-amido, 2-amino, and 2-azido derivatives of the nitrogen analogue of the naturally occurring glycosidase inhibitor salacinol and their inhibitory activities against O-GlcNAcase and NagZ enzymes

scientific article

Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors

scientific article published on 18 March 2019

Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance

article

The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams

scientific article

The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors

scientific article published on 25 May 2017

The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

scientific article

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

scientific article

The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc

scientific article published on 15 August 2008

Towards aryl C-N bond formation in dynamic thin films

scientific article published in July 2014

Understanding protein glycosylation pathways in bacteria

scientific article published on 30 September 2016

Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae β-galactosidase, BgaA

scientific article (publication date: September 2014)

Visualizing the reaction coordinate of an O-GlcNAc hydrolase

scientific article

Vortex Fluidic Chemical Transformations

scientific article

Vortex Fluidic-Mediated Fabrication of Fast Gelated Silica Hydrogels with Embedded Laccase Nanoflowers for Real-Time Biosensing under Flow

scientific article published on 05 November 2020

List of works by Keith A. Stubbs

A 1-acetamido derivative of 6-epi-valienamine: an inhibitor of a diverse group of beta-N-acetylglucosaminidases

A Fluorescent Transport Assay Enables Studying AmpG Permeases Involved in Peptidoglycan Recycling and Antibiotic Resistance

A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem

A divergent synthesis of 2-acyl derivatives of PUGNAc yields selective inhibitors of O-GlcNAcase.

A fungal tolerance trait and selective inhibitors proffer HMG-CoA reductase as a herbicide mode-of-action

A general method for affinity-based proteomic profiling of exo-α-glycosidases

A herbicide structure-activity analysis of the antimalarial lead compound MMV007978 against Arabidopsis thaliana

A highly concise preparation of O-deacetylated arylthioglycosides of N-acetyl-D-glucosamine from 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-alpha-D-glucopyranosyl chloride and aryl thiols or disulfides

A mechanism-based GlcNAc-inspired cyclophellitol inactivator of the peptidoglycan recycling enzyme NagZ reverses resistance to β-lactams in Pseudomonas aeruginosa

A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo

A selective inhibitor Gal-PUGNAc of human lysosomal beta-hexosaminidases modulates levels of the ganglioside GM2 in neuroblastoma cells.

A simple and robust preparation of N-acetylindoxyls: precursors for indigogenic substrates

Acquisition of the capsule locus by horizontal gene transfer in Neisseria meningitidis is often accompanied by the loss of UDP-GalNAc synthesis

Activity-based proteomics probes for carbohydrate-processing enzymes: current trends and future outlook.

An interactive database to explore herbicide physicochemical properties

Analysis of PUGNAc and NAG-thiazoline as transition state analogues for human O-GlcNAcase: mechanistic and structural insights into inhibitor selectivity and transition state poise

Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human -GlcNAcase

Angled Vortex Fluidic Mediated Multicomponent Photocatalytic and Transition Metal-Catalyzed Reactions

Biosynthesis of a Tricyclo[6.2.2.02,7 ]dodecane System by a Berberine Bridge Enzyme-Like Aldolase

Carrageenan catabolism is encoded by a complex regulon in marine heterotrophic bacteria

Conformational flexibility of the glycosidase NagZ allows it to bind structurally diverse inhibitors to suppress β-lactam antibiotic resistance

Crystal Structures of a Glycoside Hydrolase Family 20 Lacto-N-biosidase from Bifidobacterium bifidum ⬇️

Developing ciprofloxacin analogues against plant DNA gyrase: a novel herbicide mode of action

Development of tools to study lacto-N-biosidase: an important enzyme involved in the breakdown of human milk oligosaccharides

East-Asian Helicobacter pylori strains synthesize heptan-deficient lipopolysaccharide

Efforts toward elucidating Thalidomide's molecular target: an expedient synthesis of the first Thalidomide biotin analogue

Enzyme targets for drug design of new anti-virulence therapeutics

Expansion of the tetracycline-dependent regulation toolbox for Helicobacter pylori

Exploiting sp2 -Hybridisation in the Development of Potent 1,5-α-l-Arabinanase Inhibitors

Exploiting the Evolutionary Relationship between Malarial Parasites and Plants To Develop New Herbicides

Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis

Gaining insight into the inhibition of glycoside hydrolase family 20 exo-β-N-acetylhexosaminidases using a structural approach

Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum ⬇️

Glycosylation-related Diagnostic and Therapeutic Drug Target Markers in Hepatocellular Carcinoma

Helicobacter pylori gene silencing in vivo demonstrates urease is essential for chronic infection

Herbicidal properties of antimalarial drugs

Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system ⬇️

Heterologous expression of cytotoxic sesquiterpenoids from the medicinal mushroom Lignosus rhinocerotis in yeast.

Inhibition of a bacterial O-GlcNAcase homologue by lactone and lactam derivatives: structural, kinetic and thermodynamic analyses

Inhibition of the family 20 glycoside hydrolase catalytic modules in the Streptococcus pneumoniae exo-β-D-N-acetylglucosaminidase, StrH

Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

Insights from the redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

Integrating thin film microfluidics in developing a concise synthesis of DGJNAc: A potent inhibitor of α-N-acetylgalctosaminidases

Letter to the Glycoforum Transforming Glycoscience: An Australian Perspective

Lipopolysaccharide Structural Differences between Western and Asian Helicobacter pylori Strains

Lipopolysaccharide Structure and Biosynthesis in Helicobacter pylori

Mechanism of the dehydrogenase reaction of DmpFG and analysis of inter-subunit channeling efficiency and thermodynamic parameters in the overall reaction

Metabolism of Vertebrate Amino Sugars with N-Glycolyl Groups: INTRACELLULAR -O-LINKED N-GLYCOLYLGLUCOSAMINE (GlcNGc), UDP-GlcNGc, AND THE BIOCHEMICAL AND STRUCTURAL RATIONALE FOR THE SUBSTRATE TOLERANCE OF -O-LINKED -N-ACETYLGLUCOSAMINIDASE

Modifying the phenyl group of PUGNAc: reactivity tuning to deliver selective inhibitors for N-acetyl-D-glucosaminidases

Molecular Basis of 1,6-Anhydro Bond Cleavage and Phosphoryl Transfer by Pseudomonas aeruginosa 1,6-Anhydro-N-acetylmuramic Acid Kinase

Molecular Insight into Evolution of Symbiosis between Breast-Fed Infants and a Member of the Human Gut Microbiome Bifidobacterium longum.

Multifunctional nanoadditives for the thermodynamic and kinetic stabilization of enzymes

NAG-thiazoline is a potent inhibitor of the Vibrio campbellii GH20 β-N-Acetylglucosaminidase

Nitrate uptake by p-phosphonic acid or p-(trimethylammonium)methyl calix[8]arene stablized laminar materials

O-GlcNAcase catalyzes cleavage of thioglycosides without general acid catalysis

Perturbation of indole-3-butyric acid homeostasis by the UDP-glucosyltransferase UGT74E2 modulates Arabidopsis architecture and water stress tolerance

Phosphonated calix[4]arene-based amphiphiles as scaffolds for fluorescent nano-fibres

Photoredox catalysis under shear using thin film vortex microfluidics

Potent inhibition of a GH20 exo-β-N-acetylglucosaminidase from marine Vibrio bacteria by reaction intermediate analogues

Preliminary studies into the inhibition of the cholesterol alpha-glucosyltransferase from Helicobacter pylori using azasugars

Primary antibiotic resistance of Helicobacter pylori among a Chinese Tibetan population

Red Algal Molecules - Synthesis of Methyl Neo-β-carrabioside and Its S-Linked Variant via Two Synthetic Routes: A Late Stage Ring Closure and Using a 3,6-Anhydro-d-galactosyl Donor

Stereospecific synthesis of resorcin[4]arenes and pyrogallol[4]arenes in dynamic thin films.

Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut. ⬇️

Structural enzymology of Helicobacter pylori methylthioadenosine nucleosidase in the futalosine pathway

Structure and mechanism of a bacterial beta-glucosaminidase having O-GlcNAcase activity

Structure of a GH51 α-L-arabinofuranosidase from Meripilus giganteus: conserved substrate recognition from bacteria to fungi

Structure of a Talaromyces pinophilus GH62 arabinofuranosidase in complex with AraDNJ at 1.25 Å resolution

Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding

Synergistic activity of fosfomycin, β-lactams and peptidoglycan recycling inhibition against Pseudomonas aeruginosa

Synthesis and use of mechanism-based protein-profiling probes for retaining beta-D-glucosaminidases facilitate identification of Pseudomonas aeruginosa NagZ.

Synthesis of 2-amido, 2-amino, and 2-azido derivatives of the nitrogen analogue of the naturally occurring glycosidase inhibitor salacinol and their inhibitory activities against O-GlcNAcase and NagZ enzymes

Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors

Targeting plant DIHYDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance

The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams

The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors

The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains

The role of oxidoreductases in determining the function of the neisserial lipid A phosphoethanolamine transferase required for resistance to polymyxin.

The synthesis and biological evaluation of some carbocyclic analogues of PUGNAc