List of works - Paul A. Keller

A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines

scientific article published on 21 February 2008

A new methodology for the simulation of flexible protein-ligand interactions

scientific article published on 21 November 2006

A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain

scientific article published on 9 October 2013

A twist of nature--the significance of atropisomers in biological systems

scientific article published on 18 August 2015

Alkaloids from the root of Indonesian Annona muricata L

scientific article published on 08 July 2019

An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: Textual understanding and the current practices

scientific article published on 24 April 2013

An improved synthesis of pyrido[2,3-d]pyrimidin-4(1H)-ones and their antimicrobial activity

scientific article published on 01 May 2018

Anilinopyrimidines as novel antituberculosis agents.

scientific article published on May 2003

Antarctic Moss Biflavonoids Show High Antioxidant and Ultraviolet-Screening Activity

scientific article

Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities

scientific article published on 03 December 2019

Anti-cancer Evaluation of Depsides Isolated from Indonesian Folious Lichens: Physcia millegrana, Parmelia dilatata and Parmelia aurulenta

scientific article published on 08 October 2020

Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia

scientific article

Atroposelective synthesis of axially chiral biaryl compounds

scientific article

Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities.

scientific article published on 18 April 2009

Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria.

scientific article published on 22 April 2015

Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations.

scientific article

Binaphthyl-based dicationic peptoids with therapeutic potential.

scientific article published in January 2010

Bioactive Discovery in the New Millennium--A Joint RACI, JMGM, FACS and MM2003 Conference. 5-9 February 2003, Lorne, Australia

scientific article published on 01 April 2003

Bioactive glycosides from the African medicinal plant Boerhavia erecta L.

scientific article published on 20 February 2015

Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro-oxazocinodiindoles

scientific article published on 01 August 2018

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation and an in vivo C. difficile infection model

scientific article published on 01 March 2019

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies

scientific article published on 13 February 2019

Chikungunya virus: emerging targets and new opportunities for medicinal chemistry

scientific article

Combining structure-based drug design and pharmacophores

scientific article published on 01 April 2005

Control of hepatitis C: a medicinal chemistry perspective

scientific article

Current and Ongoing Developments in Targeting Clostridioides difficile Infection and Recurrence

scientific article published on 15 June 2024

Cyclic Phosphine Oxides and Phosphinamides from Di-Grignard Reagents and Phosphonic Dichlorides: Modular Access to Annulated Phospholanes

scientific article published on 30 September 2015

Dengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis.

scientific article published on 26 October 2012

Desymmetrization Reactions of Indigo with Grignard Reagents for the Synthesis of Selective Antiplasmodial [1H,3'H]-3-Aryl-2,2'-diindol-3'-ones

scientific article published on 15 August 2019

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

scientific article published on 20 February 2020

Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus

scientific article published on 23 April 2014

Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis. ⬇️

scientific article published on 4 August 2015

Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia

scientific article

Enantiopure Trans-4,5-Disubstituted 2-Imidazolidinones via Copper(I)-Catalyzed Ring Opening of 1,1'-DiBoc-2,2'-Biaziridine with Grignard Reagents

scientific article published on 7 May 2015

Ethnobotanical authentication and identification of Khrog-sman (Lower Elevation Medicinal Plants) of Bhutan

scientific article

Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.

scientific article published on 28 June 2011

Facile Synthesis and Preliminary Structure-Activity Analysis of New Sulfonamides Against Trypanosoma brucei

scientific article

Fullerene Van der Waals Oligomers as Electron Traps

scientific article published on 24 July 2014

Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo

scientific article published on 15 April 2015

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile

scientific article published on September 2013

Identification of chikungunya virus nsP2 protease inhibitors using structure-base approaches

scientific article published on 12 January 2015

Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants.

scientific article published on 12 June 2013

Major Transitions in Cuticular Hydrocarbon Expression Coincide with Sexual Maturity in a Blowfly (Diptera: Calliphoridae)

scientific article published on 15 July 2020

Mining the Chemical Abstracts database with pharmacophore-based queries

scientific article

Molecular Docking Studies to Explore Potential Binding Pockets and Inhibitors for Chikungunya Virus Envelope Glycoproteins

scientific article

New anti-malarial compounds from database searching

scientific article published in February 2002

Novel pharmacophore-based methods reveal gossypol as a reverse transcriptase inhibitor

scientific article published in March 2003

Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile.

scientific article published on July 2014

Photoprotection enhanced by red cell wall pigments in three East Antarctic mosses

scientific article published on 21 November 2018

Phytochemical Studies on Two Australian Anigozanthos Plant Species

scientific article published on 6 July 2017

Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa

scientific article published on May 1, 2012

Phytochemical studies on the Australian native plant species Acacia pycnantha and Jacaranda mimosifolia D.Don

scientific article published on 11 June 2018

Rapid cascade synthesis of poly-heterocyclic architectures from indigo

scientific article published on 18 July 2013

Revealing indigenous Indonesian traditional medicine: anti-infective agents

scientific article published on December 1, 2011

Ring-opening and -expansion of 2,2'-biaziridine: access to diverse enantiopure linear and bicyclic vicinal diamines

scientific article published on 07 August 2014

Structural reassignment of the mono- and bis-addition products from the addition reactions of N-(Diphenylmethylene)glycinate esters to [60]fullerene under Bingel conditions

scientific article

Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins

scientific article

Synthesis and Density Functional Theory Studies of Azirinyl and Oxiranyl Functionalized Isoindigo and (3Z,3'Z)-3,3'-(ethane-1,2-diylidene)bis(indolin-2-one) Derivatives

scientific article published on 10 October 2019

Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives

scientific article published on 25 June 2011

Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid

scientific article published on 14 April 2011

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1.

scientific article published on 23 February 2010

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2.

scientific article published on 2 June 2010

Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics

scientific article published on 9 September 2015

Synthesis and characterization of mono- and bis-methano[60]fullerenyl amino acid derivatives and their reductive ring-opening retro-bingel reactions.

scientific article

Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites

scientific article published on 15 February 2006

Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands

scientific article published on 5 December 2013

Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials.

scientific article published on 9 July 2008

Synthesis of reaction-ready 6,6'-biindole and 6,6'-biisatin via palladium(II)-catalysed intramolecular C-H functionalisation

scientific article published on 23 March 2010

Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists.

scientific article

The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction.

scientific article

The first syntheses of enantiopure 2,2'-biindoline

scientific article published on November 2010

The medicinal chemistry of dengue fever

scientific article published on December 2009

The role of the HPA axis in psychiatric disorders and CRF antagonists as potential treatments.

scientific article published on July 2006

The synthesis and testing of arenearylpyrimidylmethanes as antimalarial agents

scientific article published on 01 July 2006

Vascular Epiphytic Medicinal Plants as Sources of Therapeutic Agents: Their Ethnopharmacological Uses, Chemical Composition, and Biological Activities

scientific article published on 24 January 2020

List of works by Paul A. Keller

A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines

A new methodology for the simulation of flexible protein-ligand interactions

A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain

A twist of nature--the significance of atropisomers in biological systems

Alkaloids from the root of Indonesian Annona muricata L

An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: Textual understanding and the current practices

An improved synthesis of pyrido[2,3-d]pyrimidin-4(1H)-ones and their antimicrobial activity

Anilinopyrimidines as novel antituberculosis agents.

Antarctic Moss Biflavonoids Show High Antioxidant and Ultraviolet-Screening Activity

Anti-Infective and Anti-Cancer Properties of the Annona Species: Their Ethnomedicinal Uses, Alkaloid Diversity, and Pharmacological Activities

Anti-cancer Evaluation of Depsides Isolated from Indonesian Folious Lichens: Physcia millegrana, Parmelia dilatata and Parmelia aurulenta

Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia

Atroposelective synthesis of axially chiral biaryl compounds

Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities.

Binaphthyl-1,2,3-triazole peptidomimetics with activity against Clostridium difficile and other pathogenic bacteria.

Binaphthyl-anchored antibacterial tripeptide derivatives with hydrophobic C-terminal amino acid variations.

Binaphthyl-based dicationic peptoids with therapeutic potential.

Bioactive Discovery in the New Millennium--A Joint RACI, JMGM, FACS and MM2003 Conference. 5-9 February 2003, Lorne, Australia

Bioactive glycosides from the African medicinal plant Boerhavia erecta L.

Cascade reactions of indigo with oxiranes and aziridines: efficient access to dihydropyrazinodiindoles and spiro-oxazocinodiindoles

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles targeting Clostridioides (Clostridium) difficile: Synthesis, antibacterial evaluation and an in vivo C. difficile infection model

Cationic biaryl 1,2,3-triazolyl peptidomimetic amphiphiles: synthesis, antibacterial evaluation and preliminary mechanism of action studies

Chikungunya virus: emerging targets and new opportunities for medicinal chemistry

Combining structure-based drug design and pharmacophores

Control of hepatitis C: a medicinal chemistry perspective

Current and Ongoing Developments in Targeting Clostridioides difficile Infection and Recurrence

Cyclic Phosphine Oxides and Phosphinamides from Di-Grignard Reagents and Phosphonic Dichlorides: Modular Access to Annulated Phospholanes

Dengue virus therapeutic intervention strategies based on viral, vector and host factors involved in disease pathogenesis.

Desymmetrization Reactions of Indigo with Grignard Reagents for the Synthesis of Selective Antiplasmodial [1H,3'H]-3-Aryl-2,2'-diindol-3'-ones

Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action

Discovery of in silico hits targeting the nsP3 macro domain of chikungunya virus

Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis. ⬇️

Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia

Enantiopure Trans-4,5-Disubstituted 2-Imidazolidinones via Copper(I)-Catalyzed Ring Opening of 1,1'-DiBoc-2,2'-Biaziridine with Grignard Reagents

Ethnobotanical authentication and identification of Khrog-sman (Lower Elevation Medicinal Plants) of Bhutan

Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.

Facile Synthesis and Preliminary Structure-Activity Analysis of New Sulfonamides Against Trypanosoma brucei

Fullerene Van der Waals Oligomers as Electron Traps

Further exploration of the heterocyclic diversity accessible from the allylation chemistry of indigo

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile

Identification of chikungunya virus nsP2 protease inhibitors using structure-base approaches

Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants.

Major Transitions in Cuticular Hydrocarbon Expression Coincide with Sexual Maturity in a Blowfly (Diptera: Calliphoridae)

Mining the Chemical Abstracts database with pharmacophore-based queries

Molecular Docking Studies to Explore Potential Binding Pockets and Inhibitors for Chikungunya Virus Envelope Glycoproteins

New anti-malarial compounds from database searching

Novel pharmacophore-based methods reveal gossypol as a reverse transcriptase inhibitor

Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile.

Photoprotection enhanced by red cell wall pigments in three East Antarctic mosses

Phytochemical Studies on Two Australian Anigozanthos Plant Species

Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa

Phytochemical studies on the Australian native plant species Acacia pycnantha and Jacaranda mimosifolia D.Don

Rapid cascade synthesis of poly-heterocyclic architectures from indigo

Revealing indigenous Indonesian traditional medicine: anti-infective agents

Ring-opening and -expansion of 2,2'-biaziridine: access to diverse enantiopure linear and bicyclic vicinal diamines

Structural reassignment of the mono- and bis-addition products from the addition reactions of N-(Diphenylmethylene)glycinate esters to [60]fullerene under Bingel conditions

Structure based design towards the identification of novel binding sites and inhibitors for the chikungunya virus envelope proteins

Synthesis and Density Functional Theory Studies of Azirinyl and Oxiranyl Functionalized Isoindigo and (3Z,3'Z)-3,3'-(ethane-1,2-diylidene)bis(indolin-2-one) Derivatives

Synthesis and antibacterial activity of C2-symmetric binaphthyl scaffolded amino acid derivatives

Synthesis and antibacterial activity of some binaphthyl-supported macrocycles containing a cationic amino acid

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 1.

Synthesis and antibacterial studies of binaphthyl-based tripeptoids. Part 2.

Synthesis and antimicrobial activity of binaphthyl-based, functionalized oxazole and thiazole peptidomimetics

Synthesis and characterization of mono- and bis-methano[60]fullerenyl amino acid derivatives and their reductive ring-opening retro-bingel reactions.

Synthesis and in vitro binding of N,N-dialkyl-2-phenylindol-3-yl-glyoxylamides for the peripheral benzodiazepine binding sites

Synthesis and in vitro evaluation of tetrahydroisoquinolines with pendent aromatics as sigma-2 (σ2) selective ligands

Synthesis of novel N-protected hydrophobic phenylalanines and their application in potential antibacterials.

Synthesis of reaction-ready 6,6'-biindole and 6,6'-biisatin via palladium(II)-catalysed intramolecular C-H functionalisation

Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists.

The discovery of allyltyrosine based tripeptides as selective inhibitors of the HIV-1 integrase strand-transfer reaction.

The first syntheses of enantiopure 2,2'-biindoline

The medicinal chemistry of dengue fever

The role of the HPA axis in psychiatric disorders and CRF antagonists as potential treatments.

The synthesis and testing of arenearylpyrimidylmethanes as antimalarial agents

Vascular Epiphytic Medicinal Plants as Sources of Therapeutic Agents: Their Ethnopharmacological Uses, Chemical Composition, and Biological Activities