List of works - Ester Ballana

A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19

scientific article published on 24 November 2020

A recessive Mendelian model to predict carrier probabilities of DFNB1 for nonsyndromic deafness

scientific article

ADAR1 affects HCV infection by modulating innate immune response

scientific article published in 2018

ADS-J1 inhibits HIV-1 entry by interacting with gp120 and does not block fusion-active gp41 core formation

scientific article

An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss

scientific article

Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026.

scientific article published on 8 January 2008

Antiretroviral agents effectively block HIV replication after cell-to-cell transfer

scientific article

BMS-663068, a safe and effective HIV-1 attachment inhibitor.

scientific article published on 2 September 2015

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

scientific article published in Nature Communications

Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages

scientific article

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

scientific article

Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events

article

Characterization of the influence of mediator complex in HIV-1 transcription

scientific article

Cochlear alterations in deaf and unaffected subjects carrying the deafness-associated A1555G mutation in the mitochondrial 12S rRNA gene

scientific article published on 30 March 2006

Compensatory mutations rescue the virus replicative capacity of VIRIP-resistant HIV-1.

scientific article

Coxsackie adenovirus receptor and alpha nu beta3/alpha nu beta5 integrins in adenovirus gene transfer of rat cochlea.

scientific article published on 3 August 2006

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages

scientific article

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

scientific article

Detection of unrecognized low-level mtDNA heteroplasmy may explain the variable phenotypic expressivity of apparently homoplasmic mtDNA mutations

scientific article published in February 2008

Development of resistance to VIR-353 with cross-resistance to the natural HIV-1 entry virus inhibitory peptide (VIRIP).

scientific article

Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5.

scientific article

Differential prevalence of the HLA-C −35 CC genotype among viremic long term non-progressor and elite controller HIV+ individuals

article

Efficient and specific transduction of cochlear supporting cells by adeno-associated virus serotype 5.

scientific article published on 26 June 2008

Endocytosis of HIV: anything goes

scientific article

Evaluation of the anti-HIV activity of natalizumab, an antibody against integrin alpha4.

scientific article

Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1.

scientific article

HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection

scientific article published on 5 April 2009

HIV-1 infection andCCR5Δ32homozygosis

article

HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.

scientific article published on 28 June 2012

Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial

scientific article published on 16 July 2020

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers

scientific article published on 25 July 2014

Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1

scientific article

Insights from host genomics into HIV infection and disease: Identification of host targets for drug development

scientific article published on 29 September 2013

Long-term HIV-1 infection induces an antiviral state in primary macrophages

scientific article published on 7 August 2016

MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene

scientific article

Mitochondrial 12S rRNA gene mutations affect RNA secondary structure and lead to variable penetrance in hearing impairment

scientific article

Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations

scientific article

Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4)

scientific article

Nucleotide embargo by SAMHD1: A strategy to block retroviral infection ⬇️

scientific article published on December 21, 2012

Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

scientific article published on September 2014

Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo

scientific article published on February 2013

Prevalence and evolutionary origins of the del(GJB6-D13S1830) mutation in the DFNB1 locus in hearing-impaired subjects: a multicenter study

scientific article

Rare LEDGF/p75 genetic variants in white long-term nonprogressor HIV+ individuals.

scientific article published in February 2012

Reply to correspondence by Abreu-Silva et al. regarding Ballana et al.: Mutation T1291C in the mitochondrial 12S rRNA gene involved in deafness in a Cuban family belongs to the macrohaplogroup L1 of African origin

article

Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

article

SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors

scientific article

SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction.

scientific article published on 10 September 2015

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells

scientific article

The cortical actin determines different susceptibility of naïve and memory CD4+ T cells to HIV-1 cell-to-cell transmission and infection

scientific article

The thioacetate-ω(γ-lactam carboxamide) HDAC inhibitor ST7612AA1 as HIV-1 latency reactivation agent

scientific article published on 5 September 2015

Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells

scientific article

ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression

scientific article

Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration

scientific article

p21 regulates the HIV-1 restriction factor SAMHD1.

scientific article published on 7 March 2014

β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication

scientific article

List of works by Ester Ballana

A Cluster-Randomized Trial of Hydroxychloroquine for Prevention of Covid-19

A recessive Mendelian model to predict carrier probabilities of DFNB1 for nonsyndromic deafness

ADAR1 affects HCV infection by modulating innate immune response

ADS-J1 inhibits HIV-1 entry by interacting with gp120 and does not block fusion-active gp41 core formation

An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss

Anti-HIV activity and resistance profile of the CXC chemokine receptor 4 antagonist POL3026.

Antiretroviral agents effectively block HIV replication after cell-to-cell transfer

BMS-663068, a safe and effective HIV-1 attachment inhibitor.

CD32 expression is associated to T-cell activation and is not a marker of the HIV-1 reservoir

Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages

Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells

Characterization and evolution of the novel gene family FAM90A in primates originated by multiple duplication and rearrangement events

Characterization of the influence of mediator complex in HIV-1 transcription

Cochlear alterations in deaf and unaffected subjects carrying the deafness-associated A1555G mutation in the mitochondrial 12S rRNA gene

Compensatory mutations rescue the virus replicative capacity of VIRIP-resistant HIV-1.

Coxsackie adenovirus receptor and alpha nu beta3/alpha nu beta5 integrins in adenovirus gene transfer of rat cochlea.

Cyclin D3-dependent control of the dNTP pool and HIV-1 replication in human macrophages

Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis

Detection of unrecognized low-level mtDNA heteroplasmy may explain the variable phenotypic expressivity of apparently homoplasmic mtDNA mutations

Development of resistance to VIR-353 with cross-resistance to the natural HIV-1 entry virus inhibitory peptide (VIRIP).

Different selection patterns of resistance and cross-resistance to HIV-1 agents targeting CCR5.

Differential prevalence of the HLA-C −35 CC genotype among viremic long term non-progressor and elite controller HIV+ individuals

Efficient and specific transduction of cochlear supporting cells by adeno-associated virus serotype 5.

Endocytosis of HIV: anything goes

Evaluation of the anti-HIV activity of natalizumab, an antibody against integrin alpha4.

Gene editing using a zinc-finger nuclease mimicking the CCR5Δ32 mutation induces resistance to CCR5-using HIV-1.

HIV endocytosis after dendritic cell to T cell viral transfer leads to productive virus infection

HIV-1 infection andCCR5Δ32homozygosis

HLA class I protective alleles in an HIV-1-infected subject homozygous for CCR5-Δ32/Δ32.

Hydroxychloroquine for Early Treatment of Adults with Mild Covid-19: A Randomized-Controlled Trial

Increased expression of SAMHD1 in a subset of HIV-1 elite controllers

Inhibition of herpes simplex virus type 1 by the CDK6 inhibitor PD-0332991 (palbociclib) through the control of SAMHD1

Insights from host genomics into HIV infection and disease: Identification of host targets for drug development

Long-term HIV-1 infection induces an antiviral state in primary macrophages

MRPS18CP2 alleles and DEFA3 absence as putative chromosome 8p23.1 modifiers of hearing loss due to mtDNA mutation A1555G in the 12S rRNA gene

Mitochondrial 12S rRNA gene mutations affect RNA secondary structure and lead to variable penetrance in hearing impairment

Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations

Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4)

Nucleotide embargo by SAMHD1: A strategy to block retroviral infection ⬇️

Palbociclib, a selective inhibitor of cyclin-dependent kinase4/6, blocks HIV-1 reverse transcription through the control of sterile α motif and HD domain-containing protein-1 (SAMHD1) activity

Polymorphic LEDGF/p75 variants support efficient HIV-1 infection ex vivo

Prevalence and evolutionary origins of the del(GJB6-D13S1830) mutation in the DFNB1 locus in hearing-impaired subjects: a multicenter study

Rare LEDGF/p75 genetic variants in white long-term nonprogressor HIV+ individuals.

Reply to correspondence by Abreu-Silva et al. regarding Ballana et al.: Mutation T1291C in the mitochondrial 12S rRNA gene involved in deafness in a Cuban family belongs to the macrohaplogroup L1 of African origin

Restriction of HIV-1 Replication in Primary Macrophages by IL-12 and IL-18 through the Upregulation of SAMHD1

SAMHD1 specifically affects the antiviral potency of thymidine analog HIV reverse transcriptase inhibitors

SAMHD1: at the crossroads of cell proliferation, immune responses, and virus restriction.

The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells

The cortical actin determines different susceptibility of naïve and memory CD4+ T cells to HIV-1 cell-to-cell transmission and infection

The thioacetate-ω(γ-lactam carboxamide) HDAC inhibitor ST7612AA1 as HIV-1 latency reactivation agent

Trans-infection but not infection from within endosomal compartments after cell-to-cell HIV-1 transfer to CD4+ T cells

ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression

Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration

p21 regulates the HIV-1 restriction factor SAMHD1.

β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication