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List of works by Joan Massagué Solé

A CXCL1 paracrine network links cancer chemoresistance and metastasis

scientific article

A Poised Chromatin Platform for TGF-β Access to Master Regulators

scientific article

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

scientific article

A Smad transcriptional corepressor

scientific article (publication date: 2 April 1999)

A helping hand from proteoglycans

scientific article published on 01 April 1991

A multigenic program mediating breast cancer metastasis to bone

scientific article (publication date: June 2003)

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

scientific article

A structural basis for mutational inactivation of the tumour suppressor Smad4 ⬇️

scientific article published on July 3, 1997

A surface component on GH3 pituitary cells that recognizes transforming growth factor-beta, activin, and inhibin

scientific article published on 01 November 1988

A unique proteolytic cleavage site on the beta subunit of the insulin receptor

scientific article published on 01 April 1981

A very private TGF-beta receptor embrace

scientific article published on 01 February 2008

Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

scientific article published in April 1997

Absence of TGF-beta receptors and growth inhibitory responses in retinoblastoma cells

scientific article published on 01 April 1988

Activation of signalling by the activin receptor complex

scientific article

Adapting a transforming growth factor beta-related tumor protection strategy to enhance antitumor immunity.

scientific article

Affinity labeling of a nerve growth factor receptor component on rat pheochromocytoma (PC12) cells

scientific article published on 01 December 1982

Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor.

scientific article

Affinity labeling of multiplication stimulating activity receptors in membranes from rat and human tissues

scientific article published on 01 March 1981

Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S

scientific article

Arresting supporters: targeting neutrophils in metastasis.

scientific article published on 29 January 2016

BF-1 interferes with transforming growth factor beta signaling by associating with Smad partners

scientific article

BM-06MECHANISTIC INVESTIGATIONS OF LEPTOMENINGEAL METASTASIS FROM SOLID TUMORS.

scientific article published in November 2014

BMET-03SOLID TUMORS EXPLOIT INNATE IMMUNITY TO GENERATE LEPTOMENINGEAL METASTASES.

scientific article

BMP signaling and vertebrate limb development

scientific article published on 01 January 1997

Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

scientific article published on 01 February 2007

Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites

scientific article

Betaglycan presents ligand to the TGF beta signaling receptor.

scientific article published on July 1993

Beyond tumorigenesis: cancer stem cells in metastasis

scientific article

Binding of two growth factor families to separate domains of the proteoglycan betaglycan

scientific article

Breast cancer banishes p27 from nucleus

scientific article published on 01 October 2002

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

scientific article

Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs

scientific article

Breast cancer methylomes establish an epigenomic foundation for metastasis

scientific article

Breast cancer tumor size, nodal status, and prognosis: biology trumps anatomy

scientific article published on 23 May 2011

C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells

scientific article published in September 2006

Cancer metastasis: building a framework

scientific article (publication date: 17 November 2006)

Carboxy-terminally truncated Gli3 proteins associate with Smads

scientific article published on 01 December 1998

Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

scientific article published on 18 May 2016

Cell adhesion protein receptors as targets for transforming growth factor-beta action

scientific article published on 01 October 1987

Cell cycle 1995: constructing cell physiology with molecular building blocks

scientific article published on 01 December 1995

Cell regulation

scientific article published on 3 April 2008

Cell-cell adhesion mediated by binding of membrane-anchored transforming growth factor alpha to epidermal growth factor receptors promotes cell proliferation

scientific article

Cell-cycle inhibition by independent CDK and PCNA binding domains in p21Cip1

scientific article published in Nature

Characterization and relationship of Dpp receptors encoded by the saxophone and thick veins genes in Drosophila.

scientific article

Clinical implications of cancer self-seeding

scientific article published on 26 April 2011

Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis

scientific article published in March 2017

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

scientific article published in January 1996

Concomitant loss of transforming growth factor (TGF)-beta receptor types I and II in TGF-beta-resistant cell mutants implicates both receptor types in signal transduction.

scientific article published on October 1990

Contextual determinants of TGFβ action in development, immunity and cancer

scientific article published on 11 April 2018

Controlling TGF-beta signaling

scientific article (publication date: 15 March 2000)

Corrigendum: Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer.

scientific article published on 29 March 2017

Crossing receptor boundaries

scientific article published in Nature

Crystal Structure of a Phosphorylated Smad2

article

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

scientific article

Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

scientific article

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation.

scientific article published in November 1994

Cyclin-dependent kinase inhibitor p57KIP2 in soft tissue sarcomas and Wilms'tumors.

scientific article published in March 1996

Cyclin-dependent kinase inhibitors uncouple cell cycle progression from mitochondrial apoptotic functions in DNA-damaged cancer cells.

scientific article published on 6 July 2005

Cyclins, Cdks, and cyclin kinase inhibitors.

scientific article

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

scientific article (publication date: November 2003)

Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis initiation

scientific article published on November 2012

Dephosphorylation of the linker regions of Smad1 and Smad2/3 by small C-terminal domain phosphatases has distinct outcomes for bone morphogenetic protein and transforming growth factor-beta pathways.

scientific article

Determinants of specificity in TGF-beta signal transduction.

scientific article

Differential interaction of the cyclin-dependent kinase (Cdk) inhibitor p27Kip1 with cyclin A-Cdk2 and cyclin D2-Cdk4.

scientific article published on October 1997

Direct Binding of Smad1 and Smad4 to Two Distinct Motifs Mediates Bone Morphogenetic Protein-specific Transcriptional Activation ofId1 Gene ⬇️

scientific article published on November 7, 2001

Disruption of transforming growth factor beta signaling by a mutation that prevents transphosphorylation within the receptor complex.

scientific article published on March 1995

Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma

scientific article published on 01 September 1998

Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import.

scientific article published on 13 August 2003

Distinct roles of type I bone morphogenetic protein receptors in the formation and differentiation of cartilage ⬇️

scientific article published on September 1, 1997

Distinct transforming growth factor-beta (TGF-beta) receptor subsets as determinants of cellular responsiveness to three TGF-beta isoforms.

scientific article published on November 1990

Diverse cell surface protein ectodomains are shed by a system sensitive to metalloprotease inhibitors.

scientific article published on May 1996

Drosophila Dpp signaling is mediated by the punt gene product: A dual ligand-binding type II receptor of the TGFβ receptor family ⬇️

scientific article published on March 24, 1995

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

scientific article

E2F and histone deacetylase mediate transforming growth factor beta repression of cdc25A during keratinocyte cell cycle arrest

scientific article

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

scientific article (publication date: 12 July 2002)

Endogenous human microRNAs that suppress breast cancer metastasis

scientific article (publication date: 10 January 2008)

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells ⬇️

scientific article published on September 25, 1992

Engagement of bone morphogenetic protein type IB receptor and Smad1 signaling by anti-Müllerian hormone and its type II receptor.

scientific article

Epidermal growth factor-like transforming growth factor. II. Interaction with epidermal growth factor receptors in human placenta membranes and A431 cells ⬇️

scientific article published on November 25, 1983

Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer.

scientific article published on 9 December 2012

Extracellular matrix players in metastatic niches ⬇️

scientific article published on December 16, 2011

Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding

scientific article

Field Cancerization: Something New Under the Sun

scientific article published on 01 June 2012

Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

scientific article published on 26 March 2019

Genes that mediate breast cancer metastasis to the brain

scientific article

Genome-scale screens identify JNK-JUN signaling as a barrier for pluripotency exit and endoderm differentiation

scientific article published on 20 May 2019

HER2 silences tumor suppression in breast cancer cells by switching expression of C/EBPß isoforms ⬇️

scientific article published on November 23, 2010

Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway

scientific article (publication date: 2 June 2006)

Human platelet-derived transforming growth factor-beta stimulates parameters of bone growth in fetal rat calvariae

scientific article published on 01 November 1986

Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs

scientific article

Hypoxia signaling--license to metastasize

scientific article published on October 2013

Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions

scientific article

Identification of a Drosophila activin receptor

scientific article published on October 1993

Identification of a nerve growth factor receptor protein in sympathetic ganglia membranes by affinity labeling

scientific article published on 01 September 1981

Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors

scientific article

Identification of receptor proteins for type-alpha transforming growth factor

scientific article published on 01 January 1987

Identification of receptors for type-beta transforming growth factor

scientific article published on 01 January 1987

Identifying site-specific metastasis genes and functions.

scientific article published on January 2005

Immunostaining Protocol: P-Stat3 (Xenograft and Mice).

scientific article published in May 2014

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

scientific article published on February 1999

Insulin action rapidly modulates the apparent affinity of the insulin-like growth factor II receptor

scientific article published on 01 April 1983

Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose

scientific article published on October 15, 1977

Insulin counteraction of α-adrenergic effects on liver glycogen metabolism ⬇️

scientific article published on October 3, 1978

Integral membrane glycoprotein properties of the prohormone pro-transforming growth factor-α

scientific article published in Nature

Integration of Smad and MAPK pathways: a link and a linker revisited

scientific article published on 01 December 2003

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

scientific journal article

Interrelationships among receptor structures for insulin and peptide growth factors

scientific article published on 01 June 1983

Intracerebral infusion of the bispecific targeted toxin DTATEGF in a mouse xenograft model of a human metastatic non-small cell lung cancer.

scientific article published on 14 June 2012

Is cancer a disease of self-seeding?

Juxtacrine cell signaling molecules ⬇️

scientific article published on October 1, 1993

Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta

scientific article published on 01 August 1995

L1CAM defines the regenerative origin of metastasis-initiating cells in colorectal cancer

scientific article published on 13 January 2020

Latent bone metastasis in breast cancer tied to Src-dependent survival signals

scientific article

Loss of receptors for transforming growth factor beta in human T-cell malignancies.

scientific article published on June 1994

Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer.

scientific article

Lung metastasis genes couple breast tumor size and metastatic spread.

scholarly article

Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs.

scientific article published on October 2011

Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression.

scientific article

Mammalian antiproliferative signals and their targets.

scientific article published on February 1995

Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex

scientific article

Mechanism of TGFβ receptor inhibition by FKBP12 ⬇️

scientific article published on July 1, 1997

Mechanisms in TGF-β Action ⬇️

scientific article published on January 1, 1991

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

scientific article (publication date: 13 June 2003)

Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta

scientific article

Membrane-anchored growth factors.

scientific article published on January 1993

Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations

scientific article published on 24 July 2015

Metastatic colonization by circulating tumour cells

scientific article

Metastatic stem cells: sources, niches, and vital pathways

scientific article published on March 2014

MicroRNA-335 inhibits tumor reinitiation and is silenced through genetic and epigenetic mechanisms in human breast cancer

scientific article

Modeling metastasis in the mouse

scientific article published on 01 July 2010

Modulation of type alpha transforming growth factor receptors by a phorbol ester tumor promoter.

scientific article published in January 1985

Molecular basis of metastasis.

scientific article

Molecular pathways: VCAM-1 as a potential therapeutic target in metastasis.

scientific article

Multimodality imaging of TGFbeta signaling in breast cancer metastases

scientific article published on 26 March 2009

Multiple modes of repression by the Smad transcriptional corepressor TGIF

scientific article published on 01 December 1999

Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination

scientific article (publication date: June 2000)

Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 ⬇️

scientific article published on July 3, 1997

Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

scientific article

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

scientific article published in Nature

Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-beta.

scientific article published on April 1993

Negative regulators of growth ⬇️

scientific article published on February 1, 1992

Networks of tumor suppressors. Workshop: tumor suppressor networks

scientific article

New concepts in tissue-specific metastases

scientific article published on 01 October 2003

Novel activin receptors: distinct genes and alternative mRNA splicing generate a repertoire of serine/threonine kinase receptors

scientific article published on January 10, 1992

Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways

scientific article

Nucleocytoplasmic shuttling of signal transducers.

scientific article published on March 2004

Off-target effects dominate a large-scale RNAi screen for modulators of the TGF-β pathway and reveal microRNA regulation of TGFBR2

scientific article (publication date: 14 March 2011)

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1 ⬇️

scientific article published on October 9, 1997

Origins of metastatic traits

scientific article published on October 2013

Parallel decreases in the expression of receptors for insulin and insulin-like growth factor I in a mutant human fibroblast line

scientific article published on 01 June 1983

Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways.

scientific article published on October 1996

Phase II trial of saracatinib (AZD0530), an oral SRC-inhibitor for the treatment of patients with hormone receptor-negative metastatic breast cancer

scientific article published on 3 May 2011

Physical and functional interaction of SMADs and p300/CBP

scientific article published on 01 September 1998

Publisher Correction: Contextual determinants of TGFβ action in development, immunity and cancer

scientific article published on 01 July 2018

Purification of the transforming growth factor-beta (TGF-beta) binding proteoglycan betaglycan ⬇️

scientific article published on December 5, 1991

RARRES3 suppresses breast cancer lung metastasis by regulating adhesion and differentiation

scientific article

Rapamycin resistance tied to defective regulation of p27Kip1.

scientific article published on December 1996

Receptors for nerve growth factor in responsive peripheral neurons.

scientific article

Receptors for the TGF-β family ⬇️

scientific article (publication date: 26 June 1992)

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

scientific article published on 10 February 2020

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta

scientific article published on 01 May 1987

Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

scientific article (publication date: 22 May 1997)

Responsiveness to transforming growth factor-beta (TGF-beta) restored by genetic complementation between cells defective in TGF-beta receptors I and II ⬇️

scientific article published on May 15, 1991

Role of disulfides in the subunit structure of the insulin receptor. Reduction of class I disulfides does not impair transmembrane signalling.

scientific article

Role of the Juxtamembrane Domains of the Transforming Growth Factor-α Precursor and the β-Amyloid Precursor Protein in Regulated Ectodomain Shedding

scientific article published in Journal of Biological Chemistry

Role of transforming growth factor-beta in chondrogenic pattern formation in the embryonic limb: stimulation of mesenchymal condensation and fibronectin gene expression by exogenenous TGF-beta and evidence for endogenous TGF-beta-like activity.

scientific article published on May 1991

SMADs: mediators and regulators of TGF-β signaling ⬇️

scientific article published on February 1, 1998

Selection of bone metastasis seeds by mesenchymal signals in the primary tumor stroma.

scientific article published on August 2013

Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer

scientific article

Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals.

scientific article

Serpins promote cancer cell survival and vascular co-option in brain metastasis

scientific article

Signaling activity of homologous and heterologous transforming growth factor-beta receptor kinase complexes.

scientific article published on March 1995

Signalling change: signal transduction through the decades

scientific article published on 02 May 2013

Smad transcriptional corepressors in TGF beta family signaling.

scientific article

Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus

scientific article

Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells.

scientific article

Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor ⬇️

scientific article published on January 15, 1998

Sorting out breast-cancer gene signatures

scientific article published on 01 January 2007

Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors

scientific article published on 12 December 2017

Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways

scientific article

Structural determinants of Smad function in TGF-β signaling.

scientific article published on 29 April 2015

Structural features of the insulin effector system: relation to hexose transport activation

scientific article published on 01 January 1980

Subunit structure and dynamics of the insulin receptor

scientific article published on 01 September 1982

Subunit structure of a high-affinity receptor for type beta-transforming growth factor. Evidence for a disulfide-linked glycosylated receptor complex

scientific article published on 01 June 1985

Synthesis of glycogen from fructose in the presence of elevated levels of glycogen phosphorylase a in rat hepatocytes

scientific article published on 01 March 1980

TGF beta signals through a heteromeric protein kinase receptor complex

scientific article published on December 11, 1992

TGF-beta signal transduction

scientific article

TGF-beta signaling and cancer: structural and functional consequences of mutations in Smads.

scientific article published in June 1998

TGF-β Inhibition and Immunotherapy: Checkmate

scientific article published on 01 April 2018

TGF-β Tumor Suppression through a Lethal EMT.

scientific article

TGF-β control of stem cell differentiation genes

scientific article

TGF-β signaling in development and disease

scientific article published on 28 May 2012

TGF-β-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition

scientific article published on December 2013

TGFbeta in Cancer

scientific article

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

scientific article

TGFbeta signaling in growth control, cancer, and heritable disorders

scientific article (publication date: 13 October 2000)

TGFbeta signaling: receptors, transducers, and Mad proteins.

scientific article published on June 1996

TGFβ signalling in context

scientific article

TbetaR-I(6A) is a candidate tumor susceptibility allele

scientific article published on 01 November 1999

The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors.

scientific article published on February 1998

The Smad transcriptional corepressor TGIF recruits mSin3

scientific article (publication date: September 2001)

The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction

scientific article published on 01 February 1989

The TGF-beta family and its composite receptors

scientific article published on 01 May 1994

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

scientific journal article

The TGF-beta family of growth and differentiation factors.

scientific article published in May 1987

The actions of insulin-like growth factors I and II on cultured Sertoli cells

scientific article published on 01 January 1984

The brain-specific activator p35 allows Cdk5 to escape inhibition by p27Kip1 in neurons.

scientific article published on April 1996

The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGF alpha into soluble growth factor

scientific article published on 01 December 1992

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

scientific article

The high affinity insulin receptor mediates growth stimulation in rat hepatoma cells

scientific article published on 01 December 1982

The logic of TGFbeta signaling.

scientific article

The nuclear import function of Smad2 is masked by SARA and unmasked by TGFbeta-dependent phosphorylation.

scientific article published in August 2000

The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor

scientific article published on 01 May 1982

The type II TGF-beta receptor signals diverse responses in cooperation with the type I receptor

scientific article published on January 1, 1992

Therapy-induced tumour secretomes promote resistance and tumour progression

scientific article published on 25 March 2015

Tissue factor-specific ultra-bright SERRS nanostars for Raman detection of pulmonary micrometastases

scientific article

Transcriptional control by the TGF-beta/Smad signaling system

scientific article (publication date: 17 April 2000)

Transforming growth factor beta induces myoblast differentiation in the presence of mitogens ⬇️

scientific article published on June 1, 1992

Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans.

scientific article published in February 1988

Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

scientific article

Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

scholarly article

Transforming growth factor-alpha and beta-amyloid precursor protein share a secretory mechanism.

scientific article published on February 1995

Transforming growth factor-alpha. A model for membrane-anchored growth factors.

scientific article published on December 1990

Transforming growth factor-beta (TGF-beta) receptor proteoglycan. Cell surface expression and ligand binding in the absence of glycosaminoglycan chains

scientific article published on 01 July 1989

Transforming growth factor-beta receptors and binding proteoglycans.

scientific article published on January 1990

Transforming growth factor-beta.

scientific article

Tumor self-seeding by circulating cancer cells

scientific article

Two forms of transforming growth factor-β distinguished by multipotential haematopoietic progenitor cells

scientific article published in Nature

Type I receptors specify growth-inhibitory and transcriptional responses to transforming growth factor beta and activin

scientific article

Type I transforming growth factor beta receptor maps to 9q22 and exhibits a polymorphism and a rare variant within a polyalanine tract.

scientific article published in July 1998

Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

scientific article

Ubiquitin removal in the TGF-β pathway

scientific article published on 29 June 2012

Ubiquitin-dependent degradation of TGF-beta-activated smad2.

scientific article

Understanding the molecular mechanisms driving metastasis

scientific article published on January 2017

Unique players in the BMP pathway: small C-terminal domain phosphatases dephosphorylate Smad1 to attenuate BMP signaling.

scholarly article

WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis

scientific article

Wounding Smad

scientific article published on 01 September 1999

XTrR-I is a TGFbeta receptor and overexpression of truncated form of the receptor inhibits axis formation and dorsalising activity.

scientific article published in July 1998

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest

scientific article

p27Kip1: chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors

scientific article published on 01 March 1995

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