List of works by Yasushi Hirota

A Potential Role for Endoplasmic Reticulum Stress in Progesterone Deficiency in Obese Women

scientific article published on 25 November 2016

A case of hemorrhagic shock occurred during dienogest therapy for uterine adenomyosis

scientific article published on 08 October 2020

A gene network of uterine luminal epithelium organizes mouse blastocyst implantation

scientific article published on 05 January 2022

A potential role of endoplasmic reticulum stress in development of ovarian hyperstimulation syndrome.

scientific article published on 28 March 2016

A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan

scientific article published on 30 October 2019

A survey of public attitudes towards third-party reproduction in Japan in 2014

scientific article published in PLoS ONE

Accumulation of advanced glycation end products in follicles is associated with poor oocyte developmental competence

scientific article published on 01 November 2019

Activation of Endoplasmic Reticulum Stress in Granulosa Cells from Patients with Polycystic Ovary Syndrome Contributes to Ovarian Fibrosis.

scientific article published on 7 September 2017

Activation of Nrf2 might reduce oxidative stress in human granulosa cells

scientific article

Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary

article

Activation of endoplasmic reticulum stress mediates oxidative stress-induced apoptosis of granulosa cells in ovaries affected by endometrioma

scientific article published on 01 January 2020

Activation of protease-activated receptor 2 stimulates proliferation and interleukin (IL)-6 and IL-8 secretion of endometriotic stromal cells

scientific article published on 11 August 2005

Activin-A is induced by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma

scientific article published on 2 June 2011

Akt as a possible intracellular mediator for decidualization in human endometrial stromal cells

scientific article published in May 2003

Androgens Increase Accumulation of Advanced Glycation End Products in Granulosa Cells by Activating ER Stress in PCOS

scientific article published on 01 February 2020

Application of detergents or high hydrostatic pressure as decellularization processes in uterine tissues and their subsequent effects on in vivo uterine regeneration in murine models

scientific article

Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways

scientific article

Basic and translational research on proteinase-activated receptors: proteinase-activated receptors in female reproductive tissues and endometriosis.

scientific article published in December 2008

Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells.

scientific article published on 10 September 2013

Bone morphogenetic protein-2 (BMP-2) increases gene expression of FSH receptor and aromatase and decreases gene expression of LH receptor and StAR in human granulosa cells.

scientific article published on 6 September 2010

Bone morphogenetic protein-6 stimulates gene expression of follicle-stimulating hormone receptor, inhibin/activin beta subunits, and anti-Müllerian hormone in human granulosa cells

scientific article published on 21 June 2009

Changes in plasma coagulation markers with prophylactic treatment of low molecular weight heparin after cesarean section

scientific article published in June 2005

Characteristic images of deeply infiltrating rectosigmoid endometriosis on transvaginal and transrectal ultrasonography.

scientific article

Clinical aspects and management of inguinal endometriosis: A case series of 20 patients

scientific article published on 05 August 2019

Combinatory approaches prevent preterm birth profoundly exacerbated by gene-environment interactions.

scientific article published on 27 August 2013

Concentration of adiponectin in peritoneal fluid is decreased in women with endometriosis

scientific article published on 01 October 2005

Concentration of osteoprotegerin (OPG) in peritoneal fluid is increased in women with endometriosis

scientific article published on 8 July 2004

Concentrations of interferon-gamma-induced protein-10 (IP-10), an antiangiogenic substance, are decreased in peritoneal fluid of women with advanced endometriosis

scientific article published on 01 July 2003

Conditional deletion of Msx homeobox genes in the uterus inhibits blastocyst implantation by altering uterine receptivity.

scientific article published on 17 November 2011

Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice

scientific article

Contralateral ovarian endometrioma recurrence after unilateral salpingo-oophorectomy

scientific article published on 02 May 2019

Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinase-1 in human uterine smooth muscle cells

scientific article published on 17 December 2012

Cyclic stretch augments production of neutrophil chemokines and matrix metalloproteinases-1 (MMP-1) from human decidual cells, and the production was reduced by progesterone

scientific article published on 19 February 2013

Cyclic stretch augments production of neutrophil chemokines, matrix metalloproteinases, and activin a in human endometrial stromal cells

scientific article published on 21 January 2015

Deficiency of immunophilin FKBP52 promotes endometriosis

scientific article

Development of an experimental model of endometriosis using mice that ubiquitously express green fluorescent protein

scientific article published on 14 April 2005

Development of ovarian cancer after excision of endometrioma.

scientific article published on 17 August 2016

Dienogest inhibits BrdU uptake with G0/G1 arrest in cultured endometriotic stromal cells

scientific article published on 23 May 2007

Dienogest reduces proliferation, NGF expression and nerve fiber density in human adenomyosis

scientific article published on 8 November 2016

Dienogest reduces proliferation, aromatase expression and angiogenesis, and increases apoptosis in human endometriosis

scientific article published on 07 May 2014

Dienogest suppresses cellular proliferation status of endometrial polyps and acts differently depending on the morphological type

scientific article published on 01 January 2020

Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells.

scientific article published on 29 April 2015

Drospirenone reduces inflammatory cytokines, vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) expression in human endometriotic stromal cells

scientific article published on 29 December 2016

Effects of 1,25-Dihydroxy Vitamin D3 on Endometriosis.

scientific article published in April 2016

Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study

scientific article published on 06 June 2014

Elevated Serum Soluble Vascular Endothelial Growth Factor Receptor 1 (sVEGFR-1) Levels in Women with Preeclampsia

scientific article published on 01 May 2003

Elevated interleukin-16 levels in the peritoneal fluid of women with endometriosis may be a mechanism for inflammatory reactions associated with endometriosis

scientific article published on 01 April 2005

Elevated serum soluble fms-like tyrosine kinase 1 (sFlt1) level in women with hydatidiform mole.

scientific article published on 9 March 2009

Endometrial stromal cells undergoing decidualization down-regulate their properties to produce proinflammatory cytokines in response to interleukin-1 beta via reduced p38 mitogen-activated protein kinase phosphorylation.

scientific article published in May 2003

Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway

scientific article published on 01 November 2019

Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS

scientific article published on 01 January 2019

Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention

scientific article published on 01 May 2019

Estrogen-dependent uterine secretion of osteopontin activates blastocyst adhesion competence

scientific article

Evidence for the presence of angiogenin in human testis

scientific article published in May 2004

Evidence for the presence of protease-activated receptor 2 and its possible implication in remodeling of human endometrium

scientific article published on 7 December 2004

Evidence for the presence of toll-like receptor 4 system in the human endometrium

scientific article published on 27 October 2004

Evidence of the activation of unfolded protein response in granulosa and cumulus cells during follicular growth and maturation.

scientific article

Expression and possible implication of growth hormone-releasing hormone receptor splice variant 1 in endometriosis

scientific article

Expression of ALDH1A Isozymes in Human Endometrium with and without Endometriosis and in Ovarian Endometrioma

scientific article published on 01 January 2020

Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis

article

Expression of adiponectin receptors and its possible implication in the human endometrium

scientific article published on 06 April 2006

Expression of toll-like receptors 2, 3, 4, and 9 genes in the human endometrium during the menstrual cycle

scientific article published on 12 February 2007

F4/80+ Macrophages Contribute to Clearance of Senescent Cells in the Mouse Postpartum Uterus.

scientific article published on 18 May 2017

FR 167653, a p38 mitogen-activated protein kinase inhibitor, suppresses the development of endometriosis in a murine model

scientific article published on 04 August 2006

Follistatin is induced by IL-1β and TNF-α in stromal cells from endometrioma.

scientific article published on 19 November 2012

Four Cases of Postoperative Pneumothorax Among 2814 Consecutive Laparoscopic Gynecologic Surgeries: A Possible Correlation Between Postoperative Pneumothorax and Endometriosis.

scientific article published on 30 April 2015

Galectin-1 markedly reduces the incidence of resorptions in mice missing immunophilin FKBP52

scientific article published on 13 March 2012

GnRH II as a possible cytostatic regulator in the development of endometriosis

scientific article published on 21 July 2005

HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment

scientific article published on 18 June 2018

High mobility group box 1 (HMGB1) levels in the placenta and in serum in preeclampsia

scientific article published on 18 January 2011

IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis

scientific article published on 21 February 2019

IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis

scientific article published on 20 May 2020

IL-1β increases expression of tryptophan 2,3-dioxygenase and stimulates tryptophan catabolism in endometrioma stromal cells

scientific article published on 26 June 2014

Interleukin (IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell proliferation of endometriotic stromal cells

scientific article published on 13 December 2007

Interleukin (IL)-1beta stimulates migration and survival of first-trimester villous cytotrophoblast cells through endometrial epithelial cell-derived IL-8.

scientific article published on 11 September 2008

Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene-α (Gro-α) from endometrioma stromal cells.

scientific article

Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis

scientific article published on 20 May 2011

Interleukin-1β stimulates the secretion of thymic stromal lymphopoietin (TSLP) from endometrioma stromal cells: possible involvement of TSLP in endometriosis.

scientific article

Interleukin-4 and prostaglandin E2 synergistically up-regulate 3β-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells

scientific article published on 28 February 2013

Interleukin-4 induces expression of eotaxin in endometriotic stromal cells.

scientific article

Interleukin-4 stimulates proliferation of endometriotic stromal cells

scientific article published on 3 July 2008

Levonorgestrel Inhibits Embryo Attachment by Eliminating Uterine Induction of Leukemia Inhibitory Factor

scientific article published on 01 February 2020

Long-term dienogest administration in patients with symptomatic adenomyosis

scientific article published on 29 May 2018

Lymphocytes in endometriosis.

scientific article published on January 2011

Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M

scientific article published on 27 June 2019

Mannose receptor is highly expressed by peritoneal dendritic cells in endometriosis.

scientific article published on 25 October 2016

Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality

scientific article published on 27 September 2018

Mechanical stretch stimulates interleukin-8 production in endometrial stromal cells: possible implications in endometrium-related events.

scientific article published on 7 December 2004

Mechanical stretch upregulates IGFBP-1 secretion from decidualized endometrial stromal cells

scientific article published on 23 August 2005

Metformin suppresses interleukin (IL)-1beta-induced IL-8 production, aromatase activation, and proliferation of endometriotic stromal cells

scientific article published on 15 May 2007

MicroRNA-200a locally attenuates progesterone signaling in the cervix, preventing embryo implantation.

scientific article

Muscle Segment Homeobox Genes Direct Embryonic Diapause by Limiting Inflammation in the Uterus

scientific article published on 30 April 2015

Neutrophil depletion reduces endometriotic lesion formation in mice.

scientific article published on 19 July 2016

Nomenclature of primary amenorrhea: A proposal document of the Japan Society of Obstetrics and Gynecology committee for the redefinition of primary amenorrhea.

scientific article

Oil-Soluble Contrast Medium (OSCM) for Hysterosalpingography Modulates Dendritic Cell and Regulatory T Cell Profiles in the Peritoneal Cavity: A Possible Mechanism by Which OSCM Enhances Fertility.

scientific article published on 28 April 2017

PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis

scientific article published on 14 February 2019

PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis

scientific article published on 19 May 2020

Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia

scientific article published on 16 August 2019

Possible implication of midkine in the development of endometriosis.

scientific article published on 25 February 2005

Possible involvement of thrombin/protease-activated receptor 1 system in the pathogenesis of endometriosis.

scientific article published on 8 March 2005

Possible pathophysiological roles of mitogen-activated protein kinases (MAPKs) in endometriosis.

scientific article published in November 2004

Possible roles of thrombin-induced activation of protease-activated receptor 1 in human luteinized granulosa cells.

scientific article

Post-operative oral contraceptive use reduces the risk of ovarian endometrioma recurrence after laparoscopic excision.

scientific article

Preoperative assessment of factors associated with difficulty in performing total laparoscopic hysterectomy.

scientific article

Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells.

scientific article published on 18 January 2010

Progesterone governs endometrial proliferation-differentiation switching and blastocyst implantation

scientific article published on 08 January 2019

Proteinase-activated receptors in the endometrium and endometriosis

scientific article published on 01 January 2012

Proteinase-activated receptors in the endometrium and endometriosis.

scientific article published on June 2012

Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1 beta-, TNF-alpha-, and IL-17A-stimulated endometriotic stromal cells.

scientific article

Recurrence of ovarian endometrioma after laparoscopic excision

scientific article published on 27 April 2006

Reduced homeobox protein MSX1 in human endometrial tissue is linked to infertility

scientific article published on 16 June 2016

Resveratrol Enhances Apoptosis in Endometriotic Stromal Cells.

scientific article published on 19 January 2016

Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion

scientific article published on 05 January 2021

Revisiting reproduction: Prematurity and the puzzle of progesterone resistance

scientific article

Role of oxidative stress in follicular fluid on embryos of patients undergoing assisted reproductive technology treatment

scientific article published on 01 July 2019

STAT3 accelerates uterine epithelial regeneration in a mouse model of decellularized uterine matrix transplantation.

scientific article published on June 2016

Sciatic endometriosis diagnosed by computerized tomography-guided biopsy and CD10 immunohistochemical staining.

scientific article published in November 2005

Selective increase in high molecular weight adiponectin concentration in serum of women with preeclampsia

scientific article published on 24 July 2006

Sensing senescence in preterm birth.

scientific article published on 15 January 2012

Serum adiponectin concentrations are decreased in women with endometriosis

scientific article

Simultaneous Detection and Evaluation of Four Subsets of CD4+ T Lymphocyte in Lesions and Peripheral Blood in Endometriosis

scientific article published on 20 September 2015

TGF-β1 induces proteinase-activated receptor 2 (PAR2) expression in endometriotic stromal cells and stimulates PAR2 activation-induced secretion of IL-6.

scientific article

The EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion

scientific article published in 2023

The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages

scientific article published on 21 February 2020

The efficacy of non-assisted reproductive technology treatment might be limited in infertile patients with advanced endometriosis in their 30s

article

The expression and possible roles of chemokine CXCL11 and its receptor CXCR3 in the human endometrium

scientific article published on 01 December 2006

The impact of elevated thyroid stimulating hormone on female subfertility

scientific article published on 13 August 2015

The localization and regulation of proprotein convertase subtilisin/kexin (PCSK) 6 in human ovary

scientific article published on 31 August 2012

The presence of midkine and its possible implication in human ovarian follicles

scientific article published on 01 October 2007

The role of bone morphogenetic protein 6 in accumulation and regulation of neutrophils in the human ovary

scientific article

Thoracic endometriosis syndrome: Comparison between catamenial pneumothorax or endometriosis-related pneumothorax and catamenial hemoptysis

scientific article published on 20 April 2018

Thrombin enhances soluble Fms-like tyrosine kinase 1 expression in trophoblasts; possible involvement in the pathogenesis of preeclampsia

scientific article

Toll-like receptor-3 ligation-induced indoleamine 2, 3-dioxygenase expression in human trophoblasts

scientific article published on 27 September 2011

Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells

scientific article

Upregulation of interleukin-8 by hypoxia in human ovaries.

scientific article published in October 2003

Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages

scientific article published on 03 December 2020

Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress

scientific article

Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations

scientific article published on 19 December 2019

Uterine deletion of Trp53 compromises antioxidant responses in the mouse decidua

scientific article

Uterine receptivity and embryo-uterine interactions in embryo implantation: lessons from mice.

scientific article published in June 2013

Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation

scientific article published on 24 May 2019

Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice.

scientific article

p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

scientific article published on 25 July 2016