List of works - Fabien Lecaille

Active site labeling of cysteine cathepsins by a straightforward diazomethylketone probe derived from the N-terminus of human cystatin C.

scientific article

Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development ⬇️

scientific article

Antimicrobial Peptide LL-37 Is Both a Substrate of Cathepsins S and K and a Selective Inhibitor of Cathepsin L.

scientific article

Antimicrobial proteins and peptides in human lung diseases: A friend and foe partnership with host proteases.

scientific article published on 02 September 2015

Binding of chondroitin 4-sulfate to cathepsin S regulates its enzymatic activity

scientific article published on 4 September 2013

Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD

scientific article published on 25 September 2019

Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners

scientific article

Congopain from Trypanosoma congolense: drug target and vaccine candidate.

scientific article

Cysteine cathepsins and caspases in silicosis.

scientific article published on July 2006

Cysteine cathepsins and cystatins: from ancillary tasks to prominent status in lung diseases.

scientific article published on February 2015

Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins.

scientific article

Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis

scientific article

Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis.

scientific article published on 22 September 2016

Eimeripain, a cathepsin B-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella

scientific article

Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide.

scientific article

Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

scientific article

Human cystatin C: a new biomarker of idiopathic pulmonary fibrosis?

scientific article published on 25 November 2013

Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis

scientific article

Inhibition of a cathepsin L-like cysteine protease by a chimeric propeptide-derived inhibitor

scientific article published in August 2005

Inhibition of trypanosomal cysteine proteinases by their propeptides.

scientific article

Lung cysteine cathepsins: intruders or unorthodox contributors to the kallikrein-kinin system?

scientific article

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

scientific article published on 25 September 2019

Procongopain from Trypanosoma congolense is processed at basic pH: an unusual feature among cathepsin L-like cysteine proteases.

scientific article published in June 2003

Proteinases participating in the processing and activation of prolegumain in primary cultured rat macrophages

scientific article published in June 2004

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.

scientific article

Regulation of cathepsin K activity by hydrogen peroxide

scientific article

Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants

scientific article published on 12 March 2020

Revisiting the S2 specificity of papain by structural analogs of Phe

scientific article published on 01 February 1999

Selective inhibition of human cathepsin S by 2,4,6-trisubstituted 1,3,5-triazine analogs

scientific article published on 19 July 2018

Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties

scientific article published on 22 May 2013

Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S.

scientific article published on 6 May 2016

Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions

scientific article

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

scientific article

Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.

scientific article

The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity

scientific article

The role of basic amino acid surface clusters on the collagenase activity of cathepsin K

scientific article

Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells.

scientific article published on 28 January 2009

List of works by Fabien Lecaille

Active site labeling of cysteine cathepsins by a straightforward diazomethylketone probe derived from the N-terminus of human cystatin C.

Aminopeptidase N1 (EtAPN1), an M1 metalloprotease of the apicomplexan parasite Eimeria tenella, participates in parasite development ⬇️

Antimicrobial Peptide LL-37 Is Both a Substrate of Cathepsins S and K and a Selective Inhibitor of Cathepsin L.

Antimicrobial proteins and peptides in human lung diseases: A friend and foe partnership with host proteases.

Binding of chondroitin 4-sulfate to cathepsin S regulates its enzymatic activity

Cigarette smoke induces overexpression of active human cathepsin S in lungs from current smokers with or without COPD

Cleavage of nidogen-1 by cathepsin S impairs its binding to basement membrane partners

Congopain from Trypanosoma congolense: drug target and vaccine candidate.

Cysteine cathepsins and caspases in silicosis.

Cysteine cathepsins and cystatins: from ancillary tasks to prominent status in lung diseases.

Degradation of apolipoprotein B-100 by lysosomal cysteine cathepsins.

Differential expression of cathepsins K, S and V between young and aged Caucasian women skin epidermis

Discordance in cathepsin B and cystatin C expressions in bronchoalveolar fluids between murine bleomycin-induced fibrosis and human idiopathic fibrosis.

Eimeripain, a cathepsin B-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella

Extracellular catalase activity protects cysteine cathepsins from inactivation by hydrogen peroxide.

Human and parasitic papain-like cysteine proteases: their role in physiology and pathology and recent developments in inhibitor design.

Human cystatin C: a new biomarker of idiopathic pulmonary fibrosis?

Human cysteine cathepsins are not reliable markers of infection by Pseudomonas aeruginosa in cystic fibrosis

Inhibition of a cathepsin L-like cysteine protease by a chimeric propeptide-derived inhibitor

Inhibition of trypanosomal cysteine proteinases by their propeptides.

Lung cysteine cathepsins: intruders or unorthodox contributors to the kallikrein-kinin system?

Processing and Maturation of Cathepsin C Zymogen: A Biochemical and Molecular Modeling Analysis

Procongopain from Trypanosoma congolense is processed at basic pH: an unusual feature among cathepsin L-like cysteine proteases.

Proteinases participating in the processing and activation of prolegumain in primary cultured rat macrophages

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.

Regulation of cathepsin K activity by hydrogen peroxide

Regulation of the Proteolytic Activity of Cysteine Cathepsins by Oxidants

Revisiting the S2 specificity of papain by structural analogs of Phe

Selective inhibition of human cathepsin S by 2,4,6-trisubstituted 1,3,5-triazine analogs

Specific cleavage of the lung surfactant protein A by human cathepsin S may impair its antibacterial properties

Straightforward synthesis of 2,4,6-trisubstituted 1,3,5-triazine compounds targeting cysteine cathepsins K and S.

Structure-Activity Analysis of Cathepsin K/Chondroitin 4-Sulfate Interactions

Substrate profiling of cysteine proteases using a combinatorial peptide library identifies functionally unique specificities

Synthesis of a biologically active triazole-containing analogue of cystatin A through successive peptidomimetic alkyne-azide ligations.

The Unusual Resistance of Avian Defensin AvBD7 to Proteolytic Enzymes Preserves Its Antibacterial Activity

The role of basic amino acid surface clusters on the collagenase activity of cathepsin K

Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells.