List of works - Gerhard Krönke

12/15-Lipoxygenase during the regulation of inflammation, immunity, and self-tolerance ⬇️

scientific article published on September 15, 2012

12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.

scientific article

12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis

scientific article published on 12 August 2009

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

scientific article published on 21 January 2019

A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation.

scientific article

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

scientific article published on 11 March 2014

Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis

scientific article

Anti–citrullinated protein antibody positivity correlates with cartilage damage and proteoglycan levels in patients with rheumatoid arthritis in the hand joints

scientific article

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.

scientific article

Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints.

scientific article published on 19 March 2009

Corrigendum to “Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis” [Osteoarthritis Cartilage 23 (2015) 1221–1225]

scientific article published on 17 November 2016

Development of myeloproliferative disease in 12/15-lipoxygenase deficiency

scientific article

Development of three-dimensional prints of arthritic joints for supporting patients' awareness to structural damage

scientific article

Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility

scientific article

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.

scientific article

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death

scientific article published on 26 March 2019

Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow.

scientific article published on 14 February 2018

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women.

scientific article published on 2 May 2018

Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors

scientific article

Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis

scientific article published on 4 March 2015

Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction.

scientific article

Gegenseitige Beeinflussung von Immunsystem und Knochen

scientific article published on 01 May 2018

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis

scientific article published on 11 July 2018

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

scientific article

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

scientific article published on 01 July 2018

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1.

scientific article

Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis.

scientific article

Inflammation-Associated Changes in Bone Homeostasis ⬇️

scientific article published on June 1, 2012

Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo

scientific article

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

scientific article published on 01 February 2020

Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss

scientific article published on 19 November 2012

Locally renewing resident synovial macrophages provide a protective barrier for the joint

scientific article published on 07 August 2019

Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis.

scientific article published on 5 August 2015

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche.

scientific article published on 16 September 2015

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.

scientific article published on 5 July 2013

Modular Lattice Constructs for Biological Joint Resurfacing

scientific article published on 18 March 2019

NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover

scientific article published on 24 July 2018

Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.

scientific article

Origin and function of synovial macrophage subsets during inflammatory joint disease

scientific article published on 13 September 2019

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

scientific article published on 12 January 2015

Osteoimmunology-IMMUNOBONE : Regulation of bone by inflammation

scientific article published on 24 April 2018

Oxidized Phospholipids Negatively Regulate Dendritic Cell Maturation Induced by TLRs and CD40

scientific article published on 21 June 2005

Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein.

scientific article published on 30 September 2003

Oxidized phospholipids trigger atherogenic inflammation in murine arteries.

scientific article published on 9 December 2004

PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis.

scientific article published on 8 March 2016

PPARβ/δ governs Wnt signaling and bone turnover

scientific article published on 31 March 2013

PPARβ/δ: A master regulator of mesenchymal stem cell functions.

scientific article published on 30 November 2016

Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high resolution computed tomography

scientific article published in 2010

Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity

scientific article published on 03 April 2019

Photooxidation Generates Biologically Active Phospholipids That Induce Heme Oxygenase-1 in Skin Cells

scientific article published in Journal of Biological Chemistry

Platelet-derived serotonin links vascular disease and tissue fibrosis

scientific article

R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway

scientific article published on 6 April 2010

RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection

scientific article published on 01 May 2019

Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature.

scientific article

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease

scientific article

Runx2 mediated Induction of Novel Targets ST2 and Runx3 Leads to Cooperative Regulation of Hypertrophic Differentiation in ATDC5 Chondrocytes.

scientific article published on 20 December 2017

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss.

scientific article published on 4 January 2018

Structural insights into heme binding to IL-36α proinflammatory cytokine

scientific article published on 15 November 2019

TNF-induced structural joint damage is mediated by IL-1.

scholarly article

The -Isoform of p38 MAPK Specifically Regulates Arthritic Bone Loss

scientific article published on 14 October 2009

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis

scientific article

The B cell response to citrullinated antigens in the development of rheumatoid arthritis.

scientific article published on 8 February 2018

The double-edged role of 12/15-lipoxygenase during inflammation and immunity.

scientific article

The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis

scientific article published on 11 July 2018

The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells

scientific article published on 16 April 2014

Tumor necrosis factor α and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis

scientific article published in September 2009

List of works by Gerhard Krönke

12/15-Lipoxygenase during the regulation of inflammation, immunity, and self-tolerance ⬇️

12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function.

12/15-lipoxygenase counteracts inflammation and tissue damage in arthritis

A network of trans-cortical capillaries as mainstay for blood circulation in long bones

A role for 12/15-lipoxygenase-derived proresolving mediators in postoperative ileus: protectin DX-regulated neutrophil extravasation.

Activation of liver X receptors inhibits experimental fibrosis by interfering with interleukin-6 release from macrophages

Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis

Anti–citrullinated protein antibody positivity correlates with cartilage damage and proteoglycan levels in patients with rheumatoid arthritis in the hand joints

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis.

Blockade of Dickkopf (DKK)-1 induces fusion of sacroiliac joints.

Corrigendum to “Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis” [Osteoarthritis Cartilage 23 (2015) 1221–1225]

Development of myeloproliferative disease in 12/15-lipoxygenase deficiency

Development of three-dimensional prints of arthritic joints for supporting patients' awareness to structural damage

Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility

Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease.

Enzymatically oxidized phospholipids assume center stage as essential regulators of innate immunity and cell death

Eosinophils are not essential for maintenance of murine plasma cells in the bone marrow.

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women.

Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors

Fc-gamma receptors are not involved in cartilage damage during experimental osteoarthritis

Full Length Interleukin 33 Aggravates Radiation-Induced Skin Reaction.

Gegenseitige Beeinflussung von Immunsystem und Knochen

Glucocorticoid receptor in stromal cells is essential for glucocorticoid-mediated suppression of inflammation in arthritis

Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss

Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice

IVIg-mediated amelioration of ITP in mice is dependent on sialic acid and SIGNR1.

Induction of osteoclast-associated receptor, a key osteoclast costimulation molecule, in rheumatoid arthritis.

Inflammation-Associated Changes in Bone Homeostasis ⬇️

Inhibition of interleukin-6 receptor directly blocks osteoclast formation in vitro and in vivo

JAK inhibition increases bone mass in steady-state conditions and ameliorates pathological bone loss by stimulating osteoblast function

Liver X receptors orchestrate osteoblast/osteoclast crosstalk and counteract pathologic bone loss

Locally renewing resident synovial macrophages provide a protective barrier for the joint

Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis.

Microbiota from Obese Mice Regulate Hematopoietic Stem Cell Differentiation by Altering the Bone Niche.

Milk fat globule-EGF factor 8 mediates the enhancement of apoptotic cell clearance by glucocorticoids.

Modular Lattice Constructs for Biological Joint Resurfacing

NR4A1 Regulates Motility of Osteoclast Precursors and Serves as Target for the Modulation of Systemic Bone Turnover

Networks of enzymatically oxidized membrane lipids support calcium-dependent coagulation factor binding to maintain hemostasis.

Origin and function of synovial macrophage subsets during inflammatory joint disease

Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis

Osteoimmunology-IMMUNOBONE : Regulation of bone by inflammation

Oxidized Phospholipids Negatively Regulate Dendritic Cell Maturation Induced by TLRs and CD40

Oxidized phospholipids induce expression of human heme oxygenase-1 involving activation of cAMP-responsive element-binding protein.

Oxidized phospholipids trigger atherogenic inflammation in murine arteries.

PPARβ/δ directs the therapeutic potential of mesenchymal stem cells in arthritis.

PPARβ/δ governs Wnt signaling and bone turnover

PPARβ/δ: A master regulator of mesenchymal stem cell functions.

Periarticular bone structure in rheumatoid arthritis patients and healthy individuals assessed by high resolution computed tomography

Phospholipid membranes drive abdominal aortic aneurysm development through stimulating coagulation factor activity

Photooxidation Generates Biologically Active Phospholipids That Induce Heme Oxygenase-1 in Skin Cells

Platelet-derived serotonin links vascular disease and tissue fibrosis

R-spondin 1 protects against inflammatory bone damage during murine arthritis by modulating the Wnt pathway

RELMα-expressing macrophages protect against fatal lung damage and reduce parasite burden during helminth infection

Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature.

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease

Runx2 mediated Induction of Novel Targets ST2 and Runx3 Leads to Cooperative Regulation of Hypertrophic Differentiation in ATDC5 Chondrocytes.

Short-chain fatty acids regulate systemic bone mass and protect from pathological bone loss.

Structural insights into heme binding to IL-36α proinflammatory cytokine

TNF-induced structural joint damage is mediated by IL-1.

The -Isoform of p38 MAPK Specifically Regulates Arthritic Bone Loss

The 12/15-lipoxygenase pathway counteracts fibroblast activation and experimental fibrosis

The B cell response to citrullinated antigens in the development of rheumatoid arthritis.

The double-edged role of 12/15-lipoxygenase during inflammation and immunity.

The involvement of Toll-like receptor 9 in the pathogenesis of erosive autoimmune arthritis

The nuclear receptor Nr4a1 mediates anti-inflammatory effects of apoptotic cells

Tumor necrosis factor α and RANKL blockade cannot halt bony spur formation in experimental inflammatory arthritis