1,1,1-Trichloro-4,4-diethoxy-3-buten-2-one and its Trichloroacetylacetate Derivatives: Synthesis and Applications in Regiospecific Preparation of Azoles

1,1-Difluoro-3-aryl(heteroaryl)-1H-pyrido[1,2-c][1,3,5,2]oxadiazaborinin-9-ium-1-uides: synthesis; structure; and photophysical, electrochemical, and BSA-binding studies

13C NMR Chemical Shift Substituent Effects: Empirical Substituent Effects in β-Alcoxyvinyl Halomethylketones

13C NMR Chemical Shifts Substituent Effects of (E)- and (Z)-N-ethyl-N-Methylamides

13C NMR Chemical Shifts of β-Alkoxyvinyl Ketones: III✠-Empirical Substituent Effects in 1-Alkylamino-6-Ethoxy-1,5-Hexadien-3,4-Diones and 1,6-bis(Alkylamino)-1,5-Hexadien-3,4-diones

15N NMR spectroscopy of 3-substituted 5-trichloromethyl-1,2-dimethyl-1H-pyrazolium chlorides

1H and13C NMR Chemical Shifts and N-Substituent Effects of Some Unsymmetrically N,N-Disubstituted Acetamides

2-Trifluoroacetyl-1-methoxycycloalkenes: A convenient precursor for the synthesis of geminated polymethylene trifluoromethyl substituted heterocycles

4-Alkoxy-1,1,1-Trichloro-3-Alken-2-ones: Preparation and Applications in Heterocyclic Synthesis

5-Halomethyl-5-Hydroxy-4,5-Dihydroisoxazoles: Synthesis and 13C, 17O,15N, 19F NMR Spectroscopy

5-Trifluoromethyl-1,2-dimethyl-1H-pyrazolium chlorides: synthesis and , , and NMR chemical shifts

A CONVENIENT SYNTHESIS OF 4-TRICHLOROMETHYL-PYRIMIDIN-2-YLAMINE DERIVATIVES

A Convenient Method to Obtain 4,5-Dihydro-1H-Methylpyrazoles by A Ring Transformation Reaction

A Convenient Preparation of 4-Methyl- and 4-Phenylseleno-1,1,1-trihalo-3-alken-2-ones and their Usefulness in the Synthesis of 3-Trihalomethylisoselenazoles

article published in 2002

A Convenient Synthesis of 5- and 6-Substituted 2-Phenyl-3H-pyrimidin-4-ones

A convenient method for the synthesis of 2-trichloromethyl-4-p-substituted-phenyl-3h-1,5-benzodiazepines

A convenient one-pot synthesis of 5-carboxyisoxazoles: trichloromethyl group as a carboxyl group precursor

article published in 2000

A convenient two-step synthesis of 6-methylenesubstituted-4-trichloromethyl-2-methylsulfanyl pyrimidines

article by Nilo Zanatta et al published January 2006 in Tetrahedron Letters

A novel, potent, oral active and safe antinociceptive pyrazole targeting kappa opioid receptors.

scientific article

A pyrazolyl-thiazole derivative causes antinociception in mice

scientific article published on 2 June 2006

A simple one-pot synthesis of 3-alkoxy-3-cyanocarboxylic acids: a rapid entry to new GABA derivatives

A solvent-free synthesis of beta-enamino trihalomethyl ketones

A telescoped protocol for the synthesis of new pyrrolo [3,4-d]pyridazinones by cascade reactions

ANRORC rearrangement in tetrahydro-2H-chromenones. Synthesis and structural assignment by NMR, MS, X-ray and DFT calculations of 2-[3(5)-trifluoromethyl-1H-pyrazol-4-yl)arylmethyl]cyclohexenones and derivatives

Activity of 4,5-dihydro-1H-pyrazoles against Mycobacterium tuberculosis and nontuberculous mycobacteria

scientific article published on 16 March 2014

Alpha 2-adrenoceptors and 5-HT receptors mediate the antinociceptive effect of new pyrazolines, but not of dipyrone

scientific article

An E-factor minimized solvent-free protocol for the preparation of 4,5-dihydro-5-(trifluoromethyl)-1H-pyrazoles

An Efficient Synthesis of Oxa- and Aza-Condensed Tetrahydropyridines from Cyclic Enones

An Efficient Two-Step Synthesis of New 5-Substituted-1H-tetrazoles of Biological Interest

An efficient and regioselective synthesis of 1,1′-oxalylbis[3-(alkyl/aryl/heteroaryl)-5-(trihalomethyl)-1H-pyrazoles] from 4-alkoxy-1,1,1-trihaloalk-3-en-2-ones

An efficient solvent-free synthesis of NH-pyrazoles from β-dimethylaminovinylketones and hydrazine on grinding

An efficient synthesis of 1-cyanoacetyl-5-halomethyl-4,5-dihydro-1H-pyrazoles in ionic liquid

An ionic liquid as reaction medium for the synthesis of halo-containing β-enaminones at room temperature

Antidepressant-like effect of the novel MAO inhibitor 2-(3,4-dimethoxy-phenyl)-4,5-dihydro-1H-imidazole (2-DMPI) in mice

scientific article published on 17 April 2012

Antimalarial activity of 4-(5-trifluoromethyl-1H-pyrazol-1-yl)-chloroquine analogues

scientific article published on 27 October 2005

Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4, 5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice.

scientific article

Antinociceptive effect of 3-(4-fluorophenyl)-5-trifluoromethyl-1H-1-tosylpyrazole. A Celecoxib structural analog in models of pathological pain

scientific article published on 16 July 2014

Antinociceptive effect of a novel tosylpyrazole compound in mice.

scientific article published on 18 December 2008

Antinociceptive effect of novel pyrazolines in mice.

scientific article published on 22 September 2004

Antinociceptive effect of novel trihalomethyl-substituted pyrazoline methyl esters in formalin and hot-plate tests in mice.

scientific article

Antioxidant potential of new pyrazoline derivatives to prevent oxidative damage

scientific article published on 18 December 2008

Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats.

scientific article published on 3 December 2010

Antitumoral activity of a trichloromethyl pyrimidine analogue: molecular cross-talk between intrinsic and extrinsic apoptosis

scientific article published on 3 June 2014

Anxiolytic-like effects of 4-phenyl-2-trichloromethyl-3H-1, 5-benzodiazepine hydrogen sulfate in mice

scientific article

Application of 4-Alkoxy-1,1,1-trifluoro[chloro]alk-3-en-2-ones as Selective Protecting Groups of Amino Acids

Brominated Trihalomethylenones as Versatile Precursors to 3-Ethoxy, -Formyl, -Azidomethyl, -Triazolyl, and 3-Aminomethyl Pyrazoles

Chelating effect of novel pyrimidines in a model of aluminum intoxication

scientific article published in September 2005

Chemo- and regioselective reactions of 5-bromo enones/enaminones with pyrazoles

scientific article published on 01 February 2019

Chemoselective Synthesis of 1-Substituted 4-Amino-2-(trifluoromethyl)-1H-pyrroles through the Heterocyclization Reaction of 4-Methoxy-5-bromo-1,1,1-trifluoropent-3-en-2-ones with Amines

scientific article published on 30 November 2015

Chemoselective fluorination of 2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones using DAST

Comparative Study of the Chemoselectivity and Yields of the Synthesis ofN-Alkyl-4-(trihalomethyl)-1H-pyrimidin-2-ones

article published in 2008

Comparative Study of the Regioselectivity and Reaction Media for the Synthesis of 1-tert-Butyl-3(5)-trifluoromethyl-1H-pyrazoles

Competition between the donor and acceptor hydrogen bonds of the threads in the formation of [2]rotaxanes by clipping reaction

article

Conformer Distribution in Rotaxanes Containing Nonsymmetric Threads: A Systematic Approach

Convenient One-Pot Synthesis of N-Substituted 3-Trifluoroacetyl Pyrroles

Convenient synthesis of 3-aminomethylenedihydrofuran-2-ones

Convenient synthesis of furan-3-carboxylic acid and derivatives

Convergent procedure for the synthesis of trifluoromethyl-containing N-(pyridinyl-triazolyl)pyrimidin-2-amines

Convergent synthesis and cruzain inhibitory activity of novel 2-(N'-benzylidenehydrazino)-4-trifluoromethyl-pyrimidines

scientific article published on 25 October 2008

Correction to Antitumoral Activity of a Trichloromethyl Pyrimidine Analogue: Molecular Cross-Talk between Intrinsic and Extrinsic Apoptosis

article

Cover Feature: Conformer Distribution in Rotaxanes Containing Nonsymmetric Threads: A Systematic Approach (Eur. J. Org. Chem. 36/2018)

Cyanoacetylazoles and salicylic aldehydes promoting the synthesis of new trifluoromethyl-substituted azolecarbonyl-2H-chromen-2-ones through the Knoevenagel condensation reaction

Cycloaromatization Reaction of 4-Alkoxy-1,1,1-trifluoroalk-3-en-2-ones with 2,6-Diaminotoluene: The Unexpected Regioselective Synthesis of 2,4,7,8-Tetrasubstituted Quinolines

DAST promotes the synthesis of new 5-(trifluoromethyl)-3-(1,1-difluoroethan-2-yl)-1H-pyrazoles

Deep eutectic solvent mediated synthesis of thiomethyltriazolo[1,5- a ]pyrimidines

Design and Synthesis of Novel TrichloromethylatedN-Azolylmethyl-1H-pyrimidin-2-ones and RelatedN-Methylenaminones

Design and microwave-assisted synthesis of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles: novel agents with analgesic and anti-inflammatory properties

scientific article published on 15 August 2007

Eco-friendly synthesis and antioxidant activity of new trifluoromethyl-substituted N-(pyrimidin-2-yl)benzo[d]thiazol-2-amines and some N-derivatives

Effect of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles on chronic inflammatory pain model in rats

scientific article

Effect of carbonyl substituents on the barrier to rotation inN-ethyl-N-methylamides

Effect of slight structural changes on the gelation properties of N-phenylstearamide supramolecular gels

scientific article published on 01 August 2018

Effects per se of organic solvents in the cerebral acetylcholinesterase of rats

scientific article published in March 2005

Efficient Syntheses of Ethyl 2-Methylthio- and Ethyl 2-Benzylthio-6-methyl(aryl)pyrimidine-4-carboxylates and Their Carboxylic Acid Derivatives

Efficient Synthesis of (1,2,3-Triazol-1-yl)methylpyrimidines from 5-Bromo-1,1,1-trifluoro-4-methoxypent-3-en-2-one

Efficient and highly regioselective synthesis of ethyl 1-(2,4-dichlorophenyl)-1H-pyrazole-3-carboxylates under ultrasound irradiation

scientific article published on 30 June 2010

Efficient entry to trifluoromethyl substituted chromanes from oxidative aromatization of tetrahydro-2H-chromen-5(6H)-ones using iodine/alcohol with conventional and microwave methods

article published in 2012

Efficient microwave-assisted synthesis of 1-aryl-4-dimethylamino methyleno-pyrrolidine-2,3,5-triones

Efficient synthesis and dehydration reaction of trichloromethylated 2-(3-phenyl-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl)-4-aryl-5-alkylthiazoles

Efficient synthesis of new 1-[Alkyl(aryl)]-5-(3,3,3-trihalo-2-oxopropylidene)pyrrolidin-2-ones

Efficient synthetic access to novel N-(Pyrimidinyl)-N-(1H-benzo[d]imidazolyl)amines in an aqueous medium

Energetic and topological approach for characterization of supramolecular clusters in organic crystals

scholarly article in RSC Advances, vol. 4 no. 84, 2014

Enol ethers and acetals: acylation with dichloroacetyl, acetyl and benzoyl chloride in ionic liquid medium

Evaluation of the synthesis of 1-(pentafluorophenyl)-4,5-dihydro-1H-pyrazoles using green metrics

Experimental and calculated structural parameters of 5-trihalomethyl-4,5-dihydro-1H-pyrazole derivatives, novel analgesic agents

Facile Synthesis and Structural Characterization by NMR, ESI-MS/MS and DFT Calculations of New (E)-6-[2-Ferrocenylalkylidenehydrazino]nicotinic Hydrazides and Their (E)-Ferrocenyl-pyrazolyl-pyridine Heterocyclic System

General method for dehydration, intramolecular cyclization, and fluorination of trifluoromethyl-1H-pyrazoles using DAST

General pathway for a convenient one-pot synthesis of trifluoromethyl-containing 2-amino-7-alkyl(aryl/heteroaryl)-1,8-naphthyridines and fused cycloalkane analogues

HALOACETYLATED ENOL ETHERS. XVII.1* A CONVENIENT SYNTHESIS OF 5-TRICHLOROMETHYL-1,2-DIMETHYL- 1H-PYRAZOLIUM CHLORIDES

Haloacetylated Compounds: Solvent Effects on the 17O Nmr Chemical Shifts of 1,1,1-Trichloro-4-Methoxy-3-Alken-2-Ones

Haloacetylated Enol Ethers, 19: Synthesis of 3-(2-Thienyl)- and 3-(2-Furyl)-5-trihalomethyl Substituted Azoles

Haloacetylated enol ethers 10. Condensation of β-alkoxyvinyl trifluoromethyl ketones with thiosemicarbazide. Synthesis of new trifluoromethyl 4,5-dihydro-1H-1-pyrazolethiocarboxyamides

Haloacetylated enol ethers: 12 [18]. Regiospecific synthesis and structural determination of stable 5-hydroxy-1H-pyrazolines

Haloacetylated enol ethers: 18

Highly Chemoselective Synthesis of 6-Alkoxy-1-alkyl(aryl)-3-trifluoroacetyl-1,4,5,6-tetrahydropyridines and 1-Alkyl(aryl)-6-amino-3-trifluoroacetyl-1,4,5,6-tetrahydropyridines

Highly Regioselective Synthesis of 3,6-Disubstituted 2-(Methylsulfanyl)pyrimidin-4(3H)-ones

Highly regioselective synthesis of novel 1,4'-bipyrazoles

How Mechanical and Chemical Features Affect the Green Synthesis of 1H-Pyrazoles in a Ball Mill

Hypothermic and antipyretic effects of 3-methyl- and 3-phenyl-5-hydroxy-5-trichloromethyl-4,5-dihydro-1H-pyrazole-1-carboxyamides in mice

scientific article published on September 2002

Improved One-Pot Synthesis of 1-Aryl-3-trifluoroacetyl-1H-pyrroles under Swern Oxidation

Indium(III) bromide catalyzed one-pot synthesis of trichloromethylated tetrahydropyrimidinones

Influence of bulky and halogen substituents on crystal packing of pyrazolo[1,5-a]pyrimidines

Inhibitory effect of novel pyrimidines on ATP and ADP hydrolysis in synaptosomes from rat cerebral cortex

scientific article published in November 2003

Insights on conformation in the solid state: a case study – s-cis and/or s-trans crystallization of 5(3)-aryl-3(5)-carboxyethyl-1-tert-butylpyrazoles

Intramolecular cyclization of N-propargylic β-enaminones catalyzed by silver

Ionic Liquids Promoted the C-Acylation of Acetals in Solvent-free Conditions

Ionic Liquids in Heterocyclic Synthesis

scientific article published on 01 June 2008

Ionic liquid and Lewis acid combination in the synthesis of novel (E)-1-(benzylideneamino)-3-cyano-6-(trifluoromethyl)-1H-2-pyridones

Ionic liquid as catalyst in the synthesis of N-alkyl trifluoromethyl pyrazoles

Ionic liquid effects on the reaction of β-enaminones and tert-butylhydrazine and applications for the synthesis of pyrazoles

Ionic liquid promoted cyclocondensation reactions to the formation of isoxazoles, pyrazoles and pyrimidines

Ionic liquid/HCl catalyzed synthesis of 4-(trifluoromethyl)-2(1H)-pyrimidinones

MOLECULAR STRUCTURE OF HETEROCYCLES:17O NMR CHEMICAL SHIFTS: TORSION ANGLE RELATIONSHIPS IN 3-ALKYL SUBSTITUTED 4,5-DIHYDROISOXAZOLES AND ISOXAZOLES†

Microwave assisted synthesis of 5-hydroxy-5-trichloromethyl-4,5-dihydroisoxazoles

Microwave-Assisted Regiospecific Synthesis of 2-Trifluoromethyl-7- Trihalomethylated Pyrazolo[1,5-a]Pyrimidines

Microwave-assisted synthesis and antimicrobial activity of 5-trihalomethyl-3-arylisoxazoles

Microwave-assisted synthesis of 5-trichloromethyl substituted 1-phenyl-1H-pyrazoles and 1,2-dimethylpyrazolium chlorides

Microwave-assisted synthesis of novel 5-trichloromethyl-4,5-dihydro-1H-1-pyrazole methyl esters under solvent free conditions

Molecular Structure of Heterocycles: 2#NMR Spectroscopy, X- ray Diffraction, and Semiempirical MO Calculations of 5-Bromo-4, 6-dimethoxy-4-trichloromethyl-hexahydropyrimidin-2-one

Molecular Structure of Heterocycles: 4# NMR Spectroscopy, X-Ray Diffraction, and Semiempirical Mo Calculations of 3-Phenyl-5-Hydroxy- 5-Trichloromethyl-4,5-Dihydro-FH-Pyrazole-1-Carboxyamide

N- and C-Acylation in β-Enamino Ketones: Structural Effects on Regiocontrol

New 2-(aryl/heteroaryl)-6-(morpholin-4-yl/pyrrolidin-1-yl)-(4-trifluoromethyl)quinolines: synthesis via Buchwald–Hartwig amination, photophysics, and biomolecular binding properties

New 4-fluoroalkyl substituted N-phenylpyrazoles: Synthesis promoted by DAST and multinuclear NMR analysis

New Pyrazolyl-Nicotinic Acids, Methyl Esters, and 1,3,4-Oxadiazolyl-pyrazolyl-pyridine Tricyclic Scaffold Derivatives from 6-Hydrazinylnicotinic Acid Hydrazide Hydrate

New benzodiazepines alter acetylcholinesterase and ATPDase activities

scientific article

New one-pot, efficient, and regioselective method for the synthesis of 3-Trifluoromethyl-1H-1-phenylpyrazoles and alkyl 3-carboxylate analogs

New regioselective synthesis of polyfunctionalized 3-ferrocenyl-1 H -pyrroles under microwave irradiation

New solventless and metal-free synthesis of the antiepileptic drug 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide (Rufinamide) and analogues

New strategy for the regioselective synthesis of 1-phenyl-3-trifluoromethyl-1H-pyrazoles

New succinyl-spaced pyrazoles: Regioselective synthesis of 1,4-bis[5-(trichloromethyl)-1H-pyrazol-1-yl]butane-1,4-diones

New trifluoromethyl-containing (E)-N′-arylidene-[3-alkyl(aryl/heteroaryl)-4,5-dihydro-1H-pyrazol-1-yl]carbohydrazides: Synthesis, crystal structure and antimicrobial/antioxidant activity

Ni and Cu-catalyzed one pot synthesis of unsymmetrical 1,3-di(hetero)aryl-1H-indazoles from hydrazine, o-chloro (hetero)benzophenones, and (hetero)aryl bromides

scientific article published in June 2017

One-Pot Synthesis of a New Series of 3-Alkoxy-5-hydroxy-5-trifluoromethylpyrrolidin-2-ones from 1,1,1-Trifluoro-4-alkoxyalk-3-en-2-ones

One-pot synthesis of aryl and heteroaroyl-substituted hydroxypyrazolines from the reactions of β-alkoxyvinyl trichloromethyl ketones with heteroarylhydrazides

One‐Pot Synthesis of Pyrazole‐5(3)‐carboxyamides

Organoallylaluminum reagents promote easy access to trihalomethyl triazolyl homoallylic alcohols analogous to rufinamide

article by Helio G Bonacorso et al published April 2014 in Tetrahedron Letters

Polymorphism in an 18-membered macrocycle: an energetic and topological approach to understand the supramolecular structure

Preparation and crystal structure determination of adducts of copper(II) chloride with 3-aryl-1-(imino-pyridin-2-yl-methyl)-5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-pyrazoles

Promotion of 1,3-dipolar cycloaddition between azides and β-enaminones by deep eutectic solvents

Proposal for crystallization of 3-amino-4-halo-5-methylisoxazoles: an energetic and topological approach

article published in 2015

Pyrazole synthesis under microwave irradiation and solvent-free conditions

article published in 2010

REACTIONS OF β-ALKOXYVINYL TRIFLUOROMETHYL KETONES. THE SYNTHESIS OFN-[1-ARYL-3-OXO-4,4,4-TRIFLUORO-1-BUTEN-1-YL]-o-PHENYLENEDIAMINES AND 4-ARYL-2-TRIFLUOROMETHYL-3H-1,5-BENZODIAZEPINES

Reaction of β-alkoxyvinyl halomethyl ketones with cyanoacetohydrazide

Reactions of β-methoxyvinyl trifluoromethyl ketones with 2-pyridinecarboxamidrazone

Regiochemistry of cyclocondensation reactions in the synthesis of polyazaheterocycles.

scientific article published on 10 February 2017

Regioselective synthesis and characterization of new 3-aryl-7-trifluoromethyl-[1,2,4]triazolo[4,3-a]pyrimidines

Regioselective synthesis and through-space 13C–19F spin–spin coupling NMR of new tetracyclic 3-(trifluoromethyl)-spiro(chromen[4,3-c]pyrazole-4,1′-cycloalkanes)

Regioselective synthesis, biological evaluation, and molecular docking of dihydropyrimidin-4-ols as acetylcholinesterase inhibitors.

scientific article published on 5 June 2017

Regioselectively Controlled Synthesis of N-Substituted (Trifluoromethyl)pyrimidin-2(1H)-ones

scientific article published on 21 April 2016

Regioselectively controlled synthesis of 3(5)-(trifluoromethyl)pyrazolylbenzenesulfonamides and their effects on a pathological pain model in mice

scientific article published on 23 July 2015

Regiospecific Allylic Mono- and Dibromination of 4-Methoxy-1,1,1-trihalo-3-alken-2-ones and 5-Methoxy-1,1,1,2,2-pentafluoro-4-hexen-2-one, and their Applications to the Synthesis of Heterocycles

Regiospecific Bromination of 2-Phenyl-3H-pyrimidin-4-ones

Regiospecific Synthesis of 4-Alkoxy and 4-Amino Substituted 2-Trifluoromethyl Pyrroles

scientific article published on 01 September 2006

Regiospecific acylation of acetals. A convenient method to obtain β-methoxyvinyl trichloromethyl ketones

Regiospecific synthesis of 1,2-bis(azolyl)ethanes

Regiospecific synthesis of 3H-pyrido[2,3-b][1,4]diazepin-4(5H)-onesviahaloform reaction with the isolation ofN3-[3-oxo-4,4,4-trichloroalk-1-en-1-yl]-2,3-diaminopyridine intermediates

Regiospecific synthesis of new non-condensed heteropolycyclic systems from beta-heteroaryl-beta-methoxyvinyl trihalomethyl ketones

Regiospecific synthesis of polyfluorinated heterocycles

Resourceful synthesis of pyrazolo[1,5-a]pyrimidines under ultrasound irradiation

scientific article published on 6 March 2013

SYNTHESIS OF 3-METHYLISOXAZOLE- 5-CARBOXAMIDES AND 5-[(1H-PYRAZOL-1-YL)CARBONYL]- 3-METHYLISOXAZOLES

SYNTHESIS OF SOME N-[1-ALKYL(ARYL)- 3-OXO-4,4,4-TRICHLORO(TRIFLUORO)- 1-BUTEN-1-YL]-o-AMINOPHENOLS AND o-PHENYLENEDIAMINES AS POTENTIAL ANTICANCER AGENTS

Sequential one-pot three-step synthesis of polysubstituted 4-(5-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-1,2,3-triazole systems

scholarly article in RSC Advances, vol. 7 no. 69, 2017

Simplified Approach to the Regiospecific Synthesis of Trichloromethylpyrazolines Using Microwave Irradiation

Solvent effects on the 17O NMR chemical shifts of 4-dimethylsulfoximide-1,1,1-trifluoro-3-alken-2-ones

Solvent-free route to β-enamino dichloromethyl ketones and application in the synthesis of novel 5-dichloromethyl-1H-pyrazoles

Sonochemical heating profile for solvents and ionic liquid doped solvents, and their application in the N -alkylation of pyrazoles

scientific article published on 15 March 2016

Straightforward and Regiospecific Synthesis of Pyrazole-5-carboxylates from Unsymmetrical Enaminodiketones

Straightforward method for regioselective reduction of 3-acyl-substituted 2-(trifluoromethyl)-2H-chromen-5-one and chromane scaffolds in NaBH4/ethanol medium

Straightforward microwave-assisted synthesis of 1-carboxymethyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoles under solvent-free conditions

Structural investigations of 5-hydroxy-4,5-dihydroisoxazoles

Succinic acid dihydrazide: a convenient N,N-double block for the synthesis of symmetrical and non-symmetrical succinyl-bis[5-trifluoro(chloro)methyl-1H-pyrazoles]

Supramolecular structure of enaminones in solid-state

Synergic Effects of Ionic Liquid and Microwave Irradiation in Promoting Trifluoromethylpyrazole Synthesis

Synthesis and Characterization of Some Novel 2-(Trifluoromethyl)pyrimido[1,2-a]benzimidazoles and Pyrimido[1,2-a]benzimidazol-2H)-ones of Biological Interest

Synthesis and antimicrobial activity of new (4,4,4-trihalo-3-oxo-but-1-enyl)-carbamic acid ethyl esters, (4,4,4-trihalo-3-hydroxy-butyl)-carbamic acid ethyl esters, and 2-oxo-6-trihalomethyl-[1,3]oxazinane-3-carboxylic acid ethyl esters

scientific article published on 18 January 2006

Synthesis and antinociceptive activity of new 2-substituted 4-(trifluoromethyl)-5,6-dihydrobenzo[ h ]quinazolines

scientific article published on 10 August 2016

Synthesis and cytotoxic activity evaluation of some novel 1-(3-(aryl-4,5-dihydroisoxazol-5-yl)methyl)-4-trihalomethyl-1H-pyrimidin-2-ones in human cancer cells

scientific article published on 24 June 2015

Synthesis and in vitro antimycobacterial activity of 3-substituted 5-hydroxy-5-trifluoro[chloro]methyl-4,5-dihydro-1H-1-(isonicotinoyl) pyrazoles

scientific article published on 20 June 2008

Synthesis and structural study of N-methyl-2-methylthiopyrimidine derivatives from trihalomethylated enones

Synthesis of 1,1,1-trichloro[fluoro]-3-alken-2-ones using ionic liquids

Synthesis of 1-Arylethyl-2-arylethylamino-5-trifluoroacetyl-1,2,3,4-tetrahydropyridines and Related Compounds with Potential Cell Efflux Pump Inhibition

Synthesis of 1H-1,2,3-triazoles—Rufinamide analogs by 1,3-dipolar cycloaddition and eletrocyclization reactions of trifluoroacetyl enolethers under thermal solventless conditions

Synthesis of Alkyl-, Aryl- and Heteroaryl-Substituted 2-[3-Oxo-2,3-dihydro-1H-pyrazol-2-yl]-6(4)-trifluoromethylpyrimidines from β-Alkoxyvinyl Trifluoromethyl Ketones

Synthesis of Ethyl Pyrimidine-4-carboxylates from Unsymmetrical Enamino Diketones and Their Application in the First Synthesis of Pyrimido[4,5-d]pyridazin-8(7H)-ones

Synthesis of N-Pyrrolyl(furanyl)-Substituted Piperazines, 1,4-Dizepanes, and 1,4-Diazocanes

scientific article published on 01 July 2019

Synthesis of N-substituted 6-trifluoromethyl-1,3-oxazinanes

Synthesis of New Fluorine-Containing 1,2,3,4-Tetrahydroacridines

Synthesis of Novel 3-Amino-5-trifluoromethylazoles: A Convenient Method of Obtaining N-(Azol-3-yl)amines

Synthesis of Tetrahydro‐2(1H)quinazolinones, Cyclopenta[d]‐2(1H)pyrimidinones, and Their Thioxo Analogs from 2‐Trifluoroacetyl‐1‐methoxycycloalkenes

Synthesis of new 1,1′-carbonyl-bis[3-aryl(heteroaryl)-5-(trihalomethyl)-1H-pyrazoles] and trifluoromethyl derivatives through ring-opening reactions

Synthesis of new fluorine-containing dihydrobenzo[c]acridines from trifluoroacetyl dihydronaphthalene and substituted anilines

Synthesis of new halo-containing acetylenes and their application to the synthesis of azoles

Synthesis of novel trifluoromethylated β-acetal-diols and their application to the synthesis of 3-ethoxy-5-hydroxy-5-trifluoromethyl-pyrrolidin-2-one

Synthesis of pyrazolo[1,5-a]quinoxalin-4(5H)-ones via one-pot amidation/N-arylation reactions under transition metal-free conditions

scientific article published on 01 September 2016

Synthesis of tetra-substituted 5-trifluoromethylpyrazoles via sequential halogenation/palladium-catalyzed C–C and C–N cross-coupling

scientific article published on 26 January 2016

Synthesis of the omega-brominated alpha-trifluoroacetylcycloalkanones and their isoxazole derivatives

Synthesis of β-enaminones by ionic liquid catalysis: A one-pot condensation under solvent-free conditions

Synthesis, 11B- and 19F NMR spectroscopy, and optical and electrochemical properties of novel 9-aryl-3-(aryl/heteroaryl)-1,1-difluoro-7-(trifluoromethyl)-1H-[1,3,5,2]oxadiazaborinino[3,4-a][1,8]naphthyridin-11-ium-1-uide complexes

Synthesis, 17O NMR spectroscopy and structure of 2-trifluoroacetyl-1-methoxycycloalkenes

Synthesis, Crystal Structure, and Supramolecular Understanding of 1,3,5-Tris(1-phenyl-1H-pyrazol-5-yl)benzenes.

scientific article published on 22 December 2017

Synthesis, Structure Elucidation, Antioxidant and Antimicrobial Activity of Novel 2-(5-Trifluoromethyl-1H-pyrazol-1-yl)-5-(5-trihalomethyl-1H-pyrazol-1-yl-1-carbonyl)pyridines

Synthesis, antimicrobial activity, and QSAR studies of furan-3-carboxamides

scientific article published on 04 January 2007

Synthesis, biological evaluation and molecular docking study of 7-amine-spiro[chromeno[4,3-b]quinoline-6,1′-cycloalkanes] as new tacrine hybrids

Synthesis, effect of substituents on the regiochemistry and equilibrium studies of tetrazolo[1,5-a]pyrimidine/2-azidopyrimidines

scientific article published on 10 November 2017

Synthesis, screening for antiacetylcholinesterase activity and binding mode prediction of a new series of [3-(disubstituted-phosphate)-4,4,4-trifluoro-butyl]-carbamic acid ethyl esters

The Efficient One-Step Synthesis of Protected 6-Alkyl(aryl)-2-acetylamino-4(3H)-pyrimidinones

The antinociceptive effect of reversible monoamine oxidase-A inhibitors in a mouse neuropathic pain model

scientific article published on 15 February 2013

The first application of 4-alkoxy-1,1,1-trifluoroalk-3-en-2-ones in a three-component condensation protocol for the synthesis of 3-acyl-4-aryl-2-(trifluoromethyl)-2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones

The first synthesis of dihydro-3H-pyrido[2,3-b][1,4]diazepinols and a new alternative approach for diazepinone analogues

The regiospecific ω-bromination of 2-trichloroacetylcycloalkanones

The unexpected cyclization routes of N,N′-bis(oxotrifluoroalkenyl)-1,3-phenylenediamines in polyphosphoric acid medium

Trifluoroacetylation of unsymmetrical ketone acetals. A convenient route to obtain alkyl side chain trifluoromethylated heterocycles

Trifluoromethyl-containing pyrazolinyl (p-tolyl) sulfones: The synthesis and structure of promising antimicrobial agents

Two-photon absorption properties of BODIPY-like compounds based on BF2-naphthyridine complexes

scientific article published on 11 March 2019

Ultrasound irradiation promotes the synthesis of new 1,2,4-triazolo[1,5-a]pyrimidine

scientific article

Ultrasound promoted synthesis of 2-imidazolines in water: a greener approach toward monoamine oxidase inhibitors

scientific article published on 6 March 2008

Ultrasound promoted synthesis of 5-hydroxy-5-trihalomethyl-4,5-dihydroisoxazoles and β-enamino trihalomethyl ketones in water

scientific article published on 12 July 2005

Ultrasound promoted the synthesis of N-propargylic β-enaminones

scientific article published on 02 July 2011

Unexpected Metal-Free Fluorination and Oxidation at the C-4 Position of Pyrazoles Promoted by Selectfluor

Update 1 of: Ionic Liquids in Heterocyclic Synthesis

scientific article published on 16 September 2014

X-ray structure, semi-empirical MO calculations and π-electron delocalization of 1-cyanoacetyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazoles

β-Alkoxyvinyl trichloromethyl ketones as N-heterocyclic acylating agent. A new access to 5H-thiazolo[3,2-a]pyrimidin-5-ones