List of works - Anna Sparatore

2-(4-R-phenoxy/phenylthio)alkanoic esters of l-lupinine

scientific article published in March 2001

2-[4-[3-(4-aryl/heteroaryl-1-piperazinyl)propoxy]phenyl]-2H- benzotriazoles and their N-oxides as ligands for serotonin and dopamine receptors

scientific article

ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function.

scientific article

ACS84, a novel hydrogen sulfide-releasing compound, protects against amyloid β-induced cell cytotoxicity

scientific article published on 12 February 2011

Activity of a new hydrogen sulfide-releasing aspirin (ACS14) on pathological cardiovascular alterations induced by glutathione depletion in rats.

scientific article

Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent.

scientific article published on 14 March 2014

Atovaquone-statine "double-drugs" with high antiplasmodial activity.

scientific article published in March 2008

Benzimidazole derivatives endowed with potent antileishmanial activity.

scientific article published in December 2018

Detection and mass spectrometric characterization of the major urinary and fecal metabolites of 9-methyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]-quinolizine in the rat

scientific article published on 01 April 1995

Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity

scientific article

Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

scientific article published on 23 July 2009

Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.

scientific article

Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice.

scientific article

Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation

scientific article

Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.

scientific article published on 13 May 2007

Effect of hydrogen sulphide-donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats.

scientific article published on 26 March 2009

Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson disease.

scientific article published on 5 April 2010

Effects of some rigid analogues of imipramine and amitriptyline on the uptake of noradrenaline, serotonin and choline in rat brain synaptosomes

scientific article published on 01 March 1982

Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity

scientific article

Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells

scientific article published on 7 May 2008

Glutamate oxidative injury to RGC-5 cells in culture is necrostatin sensitive and blunted by a hydrogen sulfide (H2S)-releasing derivative of aspirin (ACS14) ⬇️

scientific article published on January 28, 2012

H(2)S-Releasing Aspirin Protects against Aspirin-Induced Gastric Injury via Reducing Oxidative Stress ⬇️

scientific article published on September 28, 2012

H2S releasing aspirin protects amyloid beta induced cell toxicity in BV-2 microglial cells ⬇️

scientific article published on July 18, 2011

H2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G

scientific article published on September 2008

High antiplasmodial activity of novel plasmepsins I and II inhibitors.

scientific article published on December 2006

Hydrogen sulfide inhibits human platelet aggregation in vitro in part by interfering gap junction channels: effects of ACS14, a hydrogen sulfide-releasing aspirin

scientific article published on 24 June 2014

Hydrogen sulfide releasing aspirin, ACS14, attenuates high glucose-induced increased methylglyoxal and oxidative stress in cultured vascular smooth muscle cells

scientific article (publication date: 2014)

Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation.

scientific article published in January 2010

Hydrogen sulfide-releasing aspirin derivative ACS14 exerts strong antithrombotic effects in vitro and in vivo

scientific article published on 27 September 2012

Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo

scientific article

In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial

scientific article

MZe786 Rescues Cardiac Mitochondrial Activity in High sFlt-1 and Low HO-1 Environment

scientific article published on 09 July 2020

Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain

scientific article published on December 2017

Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

scientific article published on 12 March 2007

Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β-Amyloid (Aβ) Aggregation

scientific article published on 29 April 2015

N-homolupinanoyl and N-(omega-lupinylthio)alkanoyl derivatives of some tricyclic systems as ligands for muscarinic M1 and M2 receptor subtypes

scientific article published in September 2003

New aryldithiolethione derivatives as potent histone deacetylase inhibitors.

scientific article published on 7 May 2010

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma.

scientific article published on 8 February 2008

New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-κB transcription factors.

scientific article

New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity

scientific article

Novel Hydrophilic Riminophenazines as Potent Antiprotozoal Agents

scientific article published on 05 November 2019

Novel amodiaquine congeners as potent antimalarial agents

scientific article published on 16 June 2008

Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes.

scientific article published on 3 August 2009

Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.

scientific article published on 10 March 2009

Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation

scientific article published in June 2010

Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity

scientific article published in October 2012

Quinolizidine-Derived Lucanthone and Amitriptyline Analogues Endowed with Potent Antileishmanial Activity

scientific article published on 25 October 2020

Quinolizidinyl derivatives of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid and 1-homolupinanoyl benzimidazolones as ligands for 5-HT3 and 5-HT4 receptors

scientific article published in April 1999

Quinolizidinyl derivatives of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one as ligands for muscarinic receptors

scientific article published on 01 October 1999

Reply to Savolainen: High Toxicity of Hydrogen Sulfide by the Inhibition of Mitochondrial Respiration.

scientific article published in June 2010

Role of paraoxonase-1 in the protection of hydrogen sulfide-donating sildenafil (ACS6) against homocysteine-induced neurotoxicity

scientific article published on July 29, 2012

S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling

scientific article

Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains

scientific article published on 24 July 2015

Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline

scientific article published on 2 August 2012

Synthesis and evaluation of the antiplasmodial activity of novel indeno[2,1-c]quinoline derivatives

scientific article published on 10 October 2014

Synthesis and pharmacological investigation of 9-methyl-1,2,3,4,6,7,12,12b-octahydro-7-oxo-indolo[2,3-a]quinolizine

scientific article published on 01 July 1999

Synthesis and preliminary pharmacological investigation of some 2-[4-(dialkylaminoalkoxy)phenyl]benzotriazoles and their N-oxides

scientific article published in February 1998

Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines ⬇️

scientific article published on August 6, 2010

Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors.

scientific article

The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart.

scientific article

The new HS-releasing compound ACS94 exerts protective effects through the modulation of thiol homoeostasis

scholarly article by Daniela Giustarini et al published December 2018 in Journal of Enzyme Inhibition and Medicinal Chemistry

Therapeutic effect of hydrogen sulfide-releasing L-Dopa derivative ACS84 on 6-OHDA-induced Parkinson's disease rat model

scientific article

Therapeutic potential of new hydrogen sulfide-releasing hybrids.

scientific article published on January 2011

Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injury

scientific article published on 01 January 2008

[4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs).

scientific article published on April 2006

List of works by Anna Sparatore

2-(4-R-phenoxy/phenylthio)alkanoic esters of l-lupinine

2-[4-[3-(4-aryl/heteroaryl-1-piperazinyl)propoxy]phenyl]-2H- benzotriazoles and their N-oxides as ligands for serotonin and dopamine receptors

ACS6, a Hydrogen sulfide-donating derivative of sildenafil, inhibits homocysteine-induced apoptosis by preservation of mitochondrial function.

ACS84, a novel hydrogen sulfide-releasing compound, protects against amyloid β-induced cell cytotoxicity

Activity of a new hydrogen sulfide-releasing aspirin (ACS14) on pathological cardiovascular alterations induced by glutathione depletion in rats.

Anethole dithiolethione lowers the homocysteine and raises the glutathione levels in solid tissues and plasma of rats: a novel non-vitamin homocysteine-lowering agent.

Atovaquone-statine "double-drugs" with high antiplasmodial activity.

Benzimidazole derivatives endowed with potent antileishmanial activity.

Detection and mass spectrometric characterization of the major urinary and fecal metabolites of 9-methyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]-quinolizine in the rat

Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity

Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer.

Effect of S-aspirin, a novel hydrogen-sulfide-releasing aspirin (ACS14), on atherosclerosis in apoE-deficient mice.

Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation

Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative, on carrageenan-induced hindpaw oedema formation in the rat.

Effect of hydrogen sulphide-donating sildenafil (ACS6) on erectile function and oxidative stress in rabbit isolated corpus cavernosum and in hypertensive rats.

Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson disease.

Effects of some rigid analogues of imipramine and amitriptyline on the uptake of noradrenaline, serotonin and choline in rat brain synaptosomes

Efficacy of novel acridine derivatives in the inhibition of hPrP90-231 prion protein fragment toxicity

Exogenous hydrogen sulfide inhibits superoxide formation, NOX-1 expression and Rac1 activity in human vascular smooth muscle cells

Glutamate oxidative injury to RGC-5 cells in culture is necrostatin sensitive and blunted by a hydrogen sulfide (H2S)-releasing derivative of aspirin (ACS14) ⬇️

H(2)S-Releasing Aspirin Protects against Aspirin-Induced Gastric Injury via Reducing Oxidative Stress ⬇️

H2S releasing aspirin protects amyloid beta induced cell toxicity in BV-2 microglial cells ⬇️

H2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G

High antiplasmodial activity of novel plasmepsins I and II inhibitors.

Hydrogen sulfide inhibits human platelet aggregation in vitro in part by interfering gap junction channels: effects of ACS14, a hydrogen sulfide-releasing aspirin

Hydrogen sulfide releasing aspirin, ACS14, attenuates high glucose-induced increased methylglyoxal and oxidative stress in cultured vascular smooth muscle cells

Hydrogen sulfide-releasing NSAIDs attenuate neuroinflammation induced by microglial and astrocytic activation.

Hydrogen sulfide-releasing aspirin derivative ACS14 exerts strong antithrombotic effects in vitro and in vivo

Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo

In Vivo and In Vitro Activities and ADME-Tox Profile of a Quinolizidine-Modified 4-Aminoquinoline: A Potent Anti-P. falciparum and Anti-P. vivax Blood-Stage Antimalarial

MZe786 Rescues Cardiac Mitochondrial Activity in High sFlt-1 and Low HO-1 Environment

Methanethiosulfonate derivatives as ligands of the STAT3-SH2 domain

Modulation of angiogenesis by dithiolethione-modified NSAIDs and valproic acid.

Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi- and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β-Amyloid (Aβ) Aggregation

N-homolupinanoyl and N-(omega-lupinylthio)alkanoyl derivatives of some tricyclic systems as ligands for muscarinic M1 and M2 receptor subtypes

New aryldithiolethione derivatives as potent histone deacetylase inhibitors.

New histone deacetylase inhibitors as potential therapeutic tools for advanced prostate carcinoma.

New sulfurated derivatives of cinnamic acids and rosmaricine as inhibitors of STAT3 and NF-κB transcription factors.

New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity

Novel Hydrophilic Riminophenazines as Potent Antiprotozoal Agents

Novel amodiaquine congeners as potent antimalarial agents

Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes.

Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells.

Novel quinolizidinyl derivatives as antiarrhythmic agents: 2. Further investigation

Organosulfur derivatives of the HDAC inhibitor valproic acid sensitize human lung cancer cell lines to apoptosis and to cisplatin cytotoxicity

Quinolizidine-Derived Lucanthone and Amitriptyline Analogues Endowed with Potent Antileishmanial Activity

Quinolizidinyl derivatives of 2,3-dihydro-2-oxo-1H-benzimidazole-1-carboxylic acid and 1-homolupinanoyl benzimidazolones as ligands for 5-HT3 and 5-HT4 receptors

Quinolizidinyl derivatives of 5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one as ligands for muscarinic receptors

Reply to Savolainen: High Toxicity of Hydrogen Sulfide by the Inhibition of Mitochondrial Respiration.

Role of paraoxonase-1 in the protection of hydrogen sulfide-donating sildenafil (ACS6) against homocysteine-induced neurotoxicity

S-diclofenac protects against doxorubicin-induced cardiomyopathy in mice via ameliorating cardiac gap junction remodeling

Synthesis and Antiplasmodial Activity of Novel Chloroquine Analogues with Bulky Basic Side Chains

Synthesis and antiplasmodial activity of new heteroaryl derivatives of 7-chloro-4-aminoquinoline

Synthesis and evaluation of the antiplasmodial activity of novel indeno[2,1-c]quinoline derivatives

Synthesis and pharmacological investigation of 9-methyl-1,2,3,4,6,7,12,12b-octahydro-7-oxo-indolo[2,3-a]quinolizine

Synthesis and preliminary pharmacological investigation of some 2-[4-(dialkylaminoalkoxy)phenyl]benzotriazoles and their N-oxides

Synthesis, antimalarial activity, and cellular toxicity of new arylpyrrolylaminoquinolines ⬇️

Targeting the plasmepsin 4 orthologs of Plasmodium sp. with "double drug" inhibitors.

The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart.

The new HS-releasing compound ACS94 exerts protective effects through the modulation of thiol homoeostasis

Therapeutic effect of hydrogen sulfide-releasing L-Dopa derivative ACS84 on 6-OHDA-induced Parkinson's disease rat model

Therapeutic potential of new hydrogen sulfide-releasing hybrids.

Treatment with H2S-releasing diclofenac protects mice against acute pancreatitis-associated lung injury

[4-(2H-1,2,3-benzotriazol-2-yl)phenoxy]alkanoic acids as agonists of peroxisome proliferator-activated receptors (PPARs).