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List of works by Joseph A. Trapani

A 3.5 kilobase taq I restriction fragment of genomic DNA segregates with HLA-B27

scientific article published on 01 January 1985

A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

scientific article published on 12 January 2017

A Renaissance in Understanding the Multiple and Diverse Functions of Granzymes?

scientific article published on 01 November 2008

A central role for Bid in granzyme B-induced apoptosis

scientific article published in December 2004

A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death

scientific article

A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl

scientific article

A common fold mediates vertebrate defense and bacterial attack

scientific article

A critical role for granzymes in antigen cross-presentation through regulating phagocytosis of killed tumor cells.

scientific article published on 27 June 2011

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

scientific article

A direct comparison of cytolytic T-lymphocyte responses to Melan-A peptides in vitro: differential immunogenicity of Melan-A27-35 and Melan-A26-35.

scientific article published in February 2000

A fresh look at tumor immunosurveillance and immunotherapy.

scientific article

A functional analysis of the putative polymorphisms A91V and N252S and 22 missense perforin mutations associated with familial hemophagocytic lymphohistiocytosis.

scientific article published on 8 March 2005

A functional genomics screen identifies PCAF and ADA3 as regulators of human granzyme B-mediated apoptosis and Bid cleavage.

scientific article published on 24 January 2014

A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells

scientific article published on May 2004

A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity.

scientific article published on 12 February 2016

A method for detecting intracellular perforin in mouse lymphocytes

scientific article published on 27 October 2014

A natural genetic variant of granzyme B confers lethality to a common viral infection

scientific article (publication date: December 2014)

A new family of 10 murine ovalbumin serpins includes two homologs of proteinase inhibitor 8 and two homologs of the granzyme B inhibitor (proteinase inhibitor 9).

scientific article published on June 1997

A new intracellular serine protease inhibitor expressed in the rat pituitary gland complexes with granzyme B.

scientific article

A new quantitative assay for cytochrome c release in apoptotic cells.

scientific article

A novel c-Jun-dependent signal transduction pathway necessary for the transcriptional activation of interferon gamma response genes

scientific article published on 14 November 2006

A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-gamma in myeloid cells

scientific article published on January 1, 1992

A novel role for granzymes in anti-tumor immunity.

scientific article published on March 2012

A novel substrate-binding pocket interaction restricts the specificity of the human NK cell-specific serine protease, Met-ase-1.

scientific article

A radio-resistant perforin-expressing lymphoid population controls allogeneic T cell engraftment, activation, and onset of graft-versus-host disease in mice

scientific article published on 12 November 2014

A role for granzyme M in TLR4-driven inflammation and endotoxicosis.

scientific article published on 28 June 2010

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

scientific article published on 02 May 2016

A serum-free culture model for studying the differentiation of human dendritic cells from adult CD34+ progenitor cells

article

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

scientific article published on 27 March 2008

Activated Mouse B Cells Lack Expression of Granzyme B

scientific article published on 16 March 2012

Activated T Cells Express a Non-HLA-ABC Class I Gene that Is Inducible with Gamma-Interferon

article

Activation of cytotoxic cells in hyperplastic lymph nodes from HIV-infected patients

article

Adaptive reprogramming of NK cells in X-linked lymphoproliferative syndrome.

scientific article

Addressing the mysteries of perforin function.

scientific article published in February 2006

Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

scholarly article

Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection

scientific article published on 19 July 2005

Adoptive transfer: The role of perforin in mouse cytotoxic T lymphocyte rejection of human tumor xenografts in vivo

scientific article published on 01 May 1998

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

scientific article published on 19 September 2017

Analysis of Perforin Assembly by Quartz Crystal Microbalance Reveals a Role for Cholesterol and Calcium-independent Membrane Binding

scientific article

Antibiotic-associated colitis due to Clostridium difficile: double-blind comparison of vancomycin with bacitracin

scientific article

Apoptosis induced by the lymphocyte effector molecule perforin

scientific article

Assaying cytochrome C translocation during apoptosis

scientific article

B cell-derived circulating granzyme B is a feature of acute infectious mononucleosis

scientific article published on 26 June 2015

B-CLL cells acquire APC- and CTL-like phenotypic characteristics after stimulation with CpG ODN and IL-21

scientific article

Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes

scientific article published on 01 June 1997

Benzenesulphonamide inhibitors of the cytolytic protein perforin.

scientific article published on 23 December 2016

Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2.

scientific article

Blocking granule-mediated death by primary human NK cells requires both protection of mitochondria and inhibition of caspase activity.

scientific article

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

scientific article

CAR-T cells are serial killers

scientific article

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

scientific article published on 16 August 2017

CTL: Caspases Terminate Life, but that's not the whole story.

scientific article

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

scientific article

Caspase activation by granzyme B is indirect, and caspase autoprocessing requires the release of proapoptotic mitochondrial factors.

scientific article published on March 2003

Cathepsin C limits acute viral infection independently of NK cell and CD8+ T-cell cytolytic function.

scientific article published on 26 October 2010

Cathepsin H is an additional convertase of pro-granzyme B

scientific article

Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells

scientific article

Characterization of Partially Purified Natural Killer Cytotoxic Factor

Chimeric (mouse/human) anti-colon cancer antibody c30.6 inhibits the growth of human colorectal cancer xenografts in scid/scid mice.

scientific article published on December 1994

Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma

scientific article

Cloning and characterisation of Ifi206: a new murine HIN-200 family member

scientific article

Cloning and characterising an unusual perforin from chicken (Gallus gallus) ⬇️

scientific article published on May 13, 2013

Conformational changes during pore formation by the perforin-related protein pleurotolysin

scientific article (publication date: February 2015)

Control of lytic function by mitogen-activated protein kinase/extracellular regulatory kinase 2 (ERK2) in a human natural killer cell line: identification of perforin and granzyme B mobilization by functional ERK2.

scientific article

Controversies in granzyme biology.

scientific article published on December 2012

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis

scientific article published in April 2006

Cytotoxic T-Cells From T-Cell Receptor Transgenic NOD8.3 Mice Destroy β-Cells via the Perforin and Fas Pathways

scientific article published on 01 September 2006

Cytotoxic activity of the lymphocyte toxin granzyme B.

scientific article

Cytotoxic cell granule-mediated apoptosis: perforin delivers granzyme B-serglycin complexes into target cells without plasma membrane pore formation

scientific article

Cytotoxic lymphocytes: redirecting the cell-mediated immune response for the therapy of cancer

scientific article published on June 1995

Cytotoxic lymphocytes; instigators of dramatic target cell death.

scientific article published in September 2004

Defining the interaction of perforin with calcium and the phospholipid membrane

scientific article

Dependence of granzyme B-mediated cell death on a pathway regulated by Bcl-2 or its viral homolog, BHRF1

scientific article published on 01 October 2000

Description of a mouse monoclonal anti-HLA-B27 antibody HLA-ABC-m3

scientific article published on 01 August 1983

Diarylthiophenes as inhibitors of the pore-forming protein perforin

scientific article published on 7 December 2015

Differential tumor surveillance by natural killer (NK) and NKT cells.

scientific article

Dihydrofuro[3,4-c]pyridinones as inhibitors of the cytolytic effects of the pore-forming glycoprotein perforin

scientific article

Discordant regulation of granzyme H and granzyme B expression in human lymphocytes

scientific article published on 6 April 2004

Dissecting the apoptotic mechanisms of chemotherapeutic drugs and lymphocytes to design effective anticancer therapies

Distinct granzyme expression in human CD3- CD56+ large granular- and CD3- CD56+ small high density-lymphocytes displaying non-MHC-restricted cytolytic activity

scientific article published on 01 January 1995

Dual mechanisms of apoptosis induction by cytotoxic lymphocytes.

scientific article published on January 1998

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

scientific article published on 13 December 2016

EMBO workshop on cytotoxicity, cell death and the immune system

scientific article published on 01 May 2009

Efficient Nuclear Targeting of Granzyme B and the Nuclear Consequences of Apoptosis Induced by Granzyme B and Perforin Are Caspase-dependent, but Cell Death Is Caspase-independent

scientific article published in Journal of Biological Chemistry

Endolysosomal proteases and their inhibitors in immunity.

scientific article published on December 2009

Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells

scientific article published on 22 July 2020

Epigenetic control of mitochondrial cell death through PACS1-mediated regulation of BAX/BAK oligomerization

scientific article

Eprenetapopt triggers ferroptosis, inhibits NFS1 cysteine desulfurase, and synergizes with serine and glycine dietary restriction

scientific article published in 2022

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype.

scientific article published on 29 April 2010

Exploration of a series of 5-arylidene-2-thioxoimidazolidin-4-ones as inhibitors of the cytolytic protein perforin

scientific article

Expression in cytotoxic T lymphocytes of a single-chain anti-carcinoembryonic antigen antibody. Redirected Fas ligand-mediated lysis of colon carcinoma

scientific article published on May 1998

Expression of IFI 16 in epithelial cells and lymphoid tissues.

scientific article published on 20 December 2002

Expression of human perforin in a mouse cytotoxic T lymphocyte cell line: evidence for perturbation of granule-mediated cytotoxicity.

scientific article published on December 1993

Expression of recombinant human Met-ase-1: a NK cell-specific granzyme.

scientific article published on December 1995

Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.

scientific article

Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.

scientific article

Familial haemophagocytic lymphohistiocytosis: Australian experience and perspectives

scientific article published in August 2014

Fas-ligand-mediated lysis of erbB-2-expressing tumour cells by redirected cytotoxic T lymphocytes

scientific article published on January 1999

Fatal immune dysregulation due to a gain of glycosylation mutation in lymphocyte perforin

scientific article published on 20 December 2011

Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

scientific article published in Journal of Biological Chemistry

Functional crosstalk between type I and II interferon through the regulated expression of STAT1.

scientific article

Functional dissection of the granzyme family: cell death and inflammation.

scientific article published on May 2010

Functional dissociation of DeltaPsim and cytochrome c release defines the contribution of mitochondria upstream of caspase activation during granzyme B-induced apoptosis

scientific article published in April 2006

Functional role of phosphatidylinositol 3-kinase in direct tumor lysis by human natural killer cells.

scientific article

Functional significance of the perforin/granzyme cell death pathway

scientific article

Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer

scientific article

Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen.

scientific article published on 4 March 2010

Genomic organization and chromosomal assignment for a serine protease gene (CSPB) expressed by human cytotoxic lymphocytes

scientific article

Genomic organization of IFI16, an interferon-inducible gene whose expression is associated with human myeloid cell differentiation: correlation of predicted protein domains with exon organization

scientific article (publication date: 1994)

Granule-mediated death by cytotoxic lymphocytes does not require mitochondrial polarization toward the immunologic synapse in target cells

scientific article published on 01 February 2009

Granzyme A Deficiency Breaks Immune Tolerance and Promotes Autoimmune Diabetes Through a Type I Interferon-Dependent Pathway

scientific article published on 21 July 2017

Granzyme B (GraB) autonomously crosses the cell membrane and perforin initiates apoptosis and GraB nuclear localization.

scientific article

Granzyme B encoded by the commonly occurring human RAH allele retains pro-apoptotic activity.

scientific article published on 29 January 2004

Granzyme B is dispensable in the development of diabetes in non-obese diabetic mice

scientific article

Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737

scientific article

Granzyme B: pro-apoptotic, antiviral and antitumor functions

scientific article

Granzyme H is a novel protease expressed by human mast cells

scientific article

Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice

scientific article published in September 2008

Granzyme M mediates a novel form of perforin-dependent cell death

scientific article

Granzymes, cytotoxic granules and cell death: the early work of Dr. Jurg Tschopp.

scientific article published on 18 November 2011

Granzymes: a family of lymphocyte granule serine proteases

scientific article

Granzymes: a variety of serine protease specificities encoded by genetically distinct subfamilies

scientific article

Granzymes: exogenous proteinases that induce target cell apoptosis.

scientific article published on April 1995

H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells

scientific article

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors

scientific article

HIN-200: a novel family of IFN-inducible nuclear proteins expressed in leukocytes.

scientific article published on September 1996

HYPOTHESIS: CYTOTOXIC LYMPHOCYTE GRANULE SERINE PROTEASES ACTIVATE TARGET CELL ENDONUCLEASES TO TRIGGER APOPTOSIS

scientific article published on 01 January 1994

Heterozygosity for the common perforin mutation, p.A91V, impairs the cytotoxicity of primary natural killer cells from healthy individuals

Homeostatic defects in interleukin 18-deficient mice contribute to protection against the lethal effects of endotoxin

scientific article

Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L.

scientific article

Human perforin mutations and susceptibility to multiple primary cancers

scientific article

IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukaemia cell lines

scientific article

Immunotherapy of cancer

article from 2017

In memoriam: Prof Christopher J Froelich (1951-2015)

scientific article published on January 2016

In vitro and in vivo antitumor activity of a chimeric anti-CD19 antibody

scientific article published on 01 July 1995

Incentives: encouraging adventurous ideas

scientific article published in January 2010

Induction of potent NK cell-dependent anti-myeloma cytotoxic T cells in response to combined mapatumumab and bortezomib

scientific article

Infective, neoplastic, and homeostatic sequelae of the loss of perforin function in humans

scientific article

Inhibition of the cellular function of perforin by 1-amino-2,4-dicyanopyrido[1,2-a]benzimidazoles.

scientific article published on 18 May 2011

Inhibition of the pore-forming protein perforin by a series of aryl-substituted isobenzofuran-1(3H)-ones ⬇️

scientific article published on December 22, 2011

Initiation of apoptosis by granzyme B requires direct cleavage of bid, but not direct granzyme B-mediated caspase activation.

scientific article

Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9.

scientific article

Interleukin-1 beta-converting enzyme-like protease cleaves DNA-dependent protein kinase in cytotoxic T cell killing.

scientific article published in August 1996

Isolation and characterization of cDNA clones for mouse Ly-9 ⬇️

scientific article published on September 1, 1992

Isolation and expression of a cDNA clone encoding HLA-Cw6: unique characteristics of HLA-C encoded gene products

scientific article

Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene

scientific article

Isotypic variants of the interferon-inducible transcriptional repressor IFI 16 arise through differential mRNA splicing

scientific article

Lack of apoptosis of Sézary cells in the circulation following oral bexarotene therapy

scientific article published in June 2005

Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D.

scientific article published on 9 August 2017

Ligation of the cell surface receptor, CD46, alters T cell polarity and response to antigen presentation

scholarly article

Lymphocyte granule-mediated cell death.

scientific article published on January 1998

Lymphocyte-Mediated Cytolysis Role of Granule Mediators

Lymphocyte-Mediated Cytolysis: Dual Apoptotic Mechanisms with Overlapping Cytoplasmic and Nuclear Signalling Pathways

Lymphocyte-mediated immunosurveillance of epithelial cancers?

scientific article published on 01 August 2001

Measuring cell death mediated by cytotoxic lymphocytes or their granule effector molecules.

scientific article published on March 2008

Mechanisms of interferon mediated anti-viral resistance

scientific article

Missense mutations in the perforin (PRF1) gene as a cause of hereditary cancer predisposition

scientific article published on 2 June 2016

Molecular cloning and partial nucleotide sequence of a 3.5 kb HLA-B27-associated fragment of genomic DNA.

scientific article published in January 1985

Monoclonal antibodies detecting discrete epitopes of human perforin

scientific article published on 01 May 1990

Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis

scientific article

NK cell intrinsic regulation of MIP-1α by granzyme M

scientific article published on 13 March 2014

Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.

scientific article published in August 2003

Novel properties of the protein kinase CK2-site-regulated nuclear- localization sequence of the interferon-induced nuclear factor IFI 16

scientific article

Nuclear targeting of the serine protease granzyme A (fragmentin-1) ⬇️

scientific article published on September 1, 1998

Nuclear transport of granzyme B (fragmentin-2). Dependence of perforin in vivo and cytosolic factors in vitro.

scientific article published on November 1996

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function

scientific article

Perforin and Fas induced by IFNγ and TNFα mediate beta cell death by OT-I CTL

scientific article published on 30 March 2006

Perforin and granzymes: function, dysfunction and human pathology

scientific article published on June 2015

Perforin evolved from a gene duplication of MPEG1, followed by a complex pattern of gene gain and loss within Euteleostomi

scientific article

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack

scientific article published in February 2013

Perforin-dependent cytotoxicity: 'Kiss of death' or prolonged embrace with darker elocation-idnseque11es?

scientific article published on 14 April 2015

Perforin-dependent nuclear targeting of granzymes: A central role in the nuclear events of granule-exocytosis-mediated apoptosis?

scientific article

Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction

scientific article (publication date: December 2001)

Perforin-mediated suppression of B-cell lymphoma

scholarly article

Perforin-mediated target-cell death and immune homeostasis

scientific article

Perforin: structure, function, and role in human immunopathology

scientific article

Perforinopathy: a spectrum of human immune disease caused by defective perforin delivery or function.

scientific article published on 12 December 2013

Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia

scientific article published on 08 July 2013

Proapoptotic functions of cytotoxic lymphocyte granule constituents in vitro and in vivo.

scientific article

Production of anti-breast cancer monoclonal antibodies using a glutathione-S-transferase-MUC1 bacterial fusion protein ⬇️

scientific article published on April 1, 1993

Proteases in lymphocyte killer function: redundancy, polymorphism and questions remaining.

scientific article published on August 2010

Protecting a serial killer: pathways for perforin trafficking and self-defence ensure sequential target cell death

scientific article published on 18 May 2012

Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes

scientific article published on 9 June 2011

Proteolytic activation of the cytotoxic phenotype during human NK cell development.

scientific article published in July 2009

Purification of natural killer cell cytotoxic granules for assaying target cell apoptosis.

scientific article published on May 2003

Rapid and unidirectional perforin pore delivery at the cytotoxic immune synapse.

scientific article published on 24 July 2013

Real-time visualization of perforin nanopore assembly.

scientific article published on 6 February 2017

Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C.

scientific article published on 6 July 2016

Redirected Perforin-Dependent Lysis of Colon Carcinoma by Ex Vivo Genetically Engineered CTL

scientific article published on 01 April 2000

Redirected cytotoxic effector function. Requirements for expression of chimeric single chain high affinity immunoglobulin e receptors.

scientific article

Regulation of perforin activation and pre-synaptic toxicity through C-terminal glycosylation

scientific article published on 14 August 2017

Rejection of Syngeneic Colon Carcinoma by CTLs Expressing Single-Chain Antibody Receptors Codelivering CD28 Costimulation

scientific article published on 01 November 2002

Report on apoptosis and immunity, 31 May-3 June 2005, Palm Cove, Queensland, Australia

scientific article

Residual active granzyme B in cathepsin C-null lymphocytes is sufficient for perforin-dependent target cell apoptosis

scientific article

Role of Bid-induced mitochondrial outer membrane permeabilization in granzyme B-induced apoptosis

scientific article

Serglycin determines secretory granule repertoire and regulates natural killer cell and cytotoxic T lymphocyte cytotoxicity.

scientific article published on 12 January 2016

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

scientific article published on November 2002

Spontaneous T cell responses to melanoma differentiation antigens from melanoma patients and healthy subjects

article

Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes

scientific article

Substituted arylsulphonamides as inhibitors of perforin-mediated lysis

scientific article published on 26 May 2017

Suppression of lymphoma and epithelial malignancies effected by interferon gamma

scientific article published in July 2002

Surprisingly variable "dangers, toils, and snares" faced by humans and mice.

scientific article published in January 2013

Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells

scientific article published in December 2007

TRAIL+ NK cells control CD4+ T cell responses during chronic viral infection to limit autoimmunity.

scientific article published on October 2014

Target cell apoptosis induced by cytotoxic T cells and natural killer cells involves synergy between the pore-forming protein, perforin, and the serine protease, granzyme B.

scientific article

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

scientific article

Temperature sensitivity of human perforin mutants unmasks subtotal loss of cytotoxicity, delayed FHL, and a predisposition to cancer

scholarly article

The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

scientific article

The IFN-inducible nucleoprotein IFI 16 is expressed in cells of the monocyte lineage, but is rapidly and markedly down-regulated in other myeloid precursor populations

scientific article

The Interferon Inducible Autoantigen, IFI 16: Localization to the Nucleolus and Identification of a DNA-Binding Domain

scientific article published on 01 September 1995

The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum

scientific article

The MACPF/CDC family of pore-forming toxins

scientific article

The Relative Role of Lymphocyte Granule Exocytosis versus Death Receptor-Mediated Cytotoxicity in Viral Pathophysiology ⬇️

scientific article published on January 1, 1998

The Role of p202 in Regulating Hematopoietic Cell Proliferation and Differentiation

scientific article published on 01 January 2008

The battlefield of perforin/granzyme cell death pathways.

scientific article

The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression

scientific article

The complex issue of regulating perforin expression.

scientific article published on 27 April 2007

The dual adverse effects of TGF-beta secretion on tumor progression.

scientific article published on November 2005

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene

scientific article

The granzyme B gene is highly polymorphic in wild mice but essentially invariant in common inbred laboratory strains.

scientific article

The human interferon-inducible protein, IFI 16, is a repressor of transcription

scientific article

The immunostimulatory effect of lenalidomide on NK-cell function is profoundly inhibited by concurrent dexamethasone therapy

scientific article published on 26 October 2010

The major human and mouse granzymes are structurally and functionally divergent

scientific article

The molecular basis for perforin oligomerization and transmembrane pore assembly

scientific article

The peptide loop consisting of amino acids 139–157 of human granzyme B (fragmentin 2) contains an immunodominant epitope recognized by the mouse

scientific article published on 01 August 1995

The perforin pore facilitates the delivery of cationic cargos

scientific article published on 20 February 2014

The preclinical pharmacokinetic disposition of a series of perforin-inhibitors as potential immunosuppressive agents

scientific article published on 26 August 2014

The production and preclinical characterization of a chimeric anti-breast-cancer antibody, cBC2

scientific article published on April 1, 1994

The role of perforin and granzymes in diabetes.

scientific article

The structural basis for membrane binding and pore formation by lymphocyte perforin

scientific article

The structure and function of mammalian membrane-attack complex/perforin-like proteins.

scientific article published on 22 September 2010

The use of chimeric human Fc(epsilon) receptor I to redirect cytotoxic T lymphocytes to tumors

scientific article

Tumor ablation by gene-modified T cells in the absence of autoimmunity.

scientific article published on 23 November 2010

Tumor-mediated apoptosis of cancer-specific T lymphocytes--reversing the "kiss of death"?

scientific article

Tumor-specific IgE-mediated inhibition of human colorectal carcinoma xenograft growth.

scientific article published in January 1998

Type I IFNs enhance the terminal differentiation of dendritic cells

scientific article published on 01 August 1998

Use of the 5'-flanking region of the mouse perforin gene to express human Fc gamma receptor I in cytotoxic T lymphocytes

scientific article published on April 1994

Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing.

scientific article published on 9 January 2009

XENOSPECIFIC CYTOTOXIC T LYMPHOCYTES

scientific article published on 01 April 1997

Xenospecific cytotoxic T lymphocytes use perforin- and Fas-mediated lytic pathways

scientific article published on November 1996

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

scientific article (publication date: 18 December 2003)

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