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List of works by Alan Melcher

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one

scientific article (publication date: November 2016)

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016

scientific article published oln 16 November 2016

A new genetic method to generate and isolate small, short-lived but highly potent dendritic cell-tumor cell hybrid vaccines

scientific article published on 17 August 2003

A phase I study of intravenous oncolytic reovirus type 3 Dearing in patients with advanced cancer

scientific article published on November 2008

A phase-I trial of pre-operative, margin intensive, stereotactic body radiation therapy for pancreatic cancer: the 'SPARC' trial protocol ⬇️

scientific article

A simple method to cure established tumors by inflammatory killing of normal cells

scientific article

APOBEC3 Mediates Resistance to Oncolytic Viral Therapy ⬇️

Activating systemic T-cell immunity against self tumor antigens to support oncolytic virotherapy with vesicular stomatitis virus

scientific article published on 11 April 2011

Adenovirally delivered enzyme prodrug therapy with herpes simplex virus-thymidine kinase in composite tissue free flaps shows therapeutic efficacy in rat models of glioma ⬇️

scientific article

Allogeneic tumor cells expressing fusogenic membrane glycoproteins as a platform for clinical cancer immunotherapy

scientific article published on February 2006

An Intravenous Stimulus Package for Oncolytic Virotherapy ⬇️

scientific article published on November 1, 2011

Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking ⬇️

scientific article published on 31 January 2018

Anti-cancer effects of oncolytic viral therapy combined with photodynamic therapy in human pancreatic cancer cell lines

scientific article published on February 2015

Antiangiogenic cancer therapy combined with oncolytic virotherapy leads to regression of established tumors in mice

scientific article

Antitumor immunity can be uncoupled from autoimmunity following heat shock protein 70-mediated inflammatory killing of normal pancreas

scientific article published on 8 September 2009

Applications of coxsackievirus A21 in oncology

scientific article published on 10 April 2014

Autologous versus allogeneic peptide-pulsed dendritic cells for anti-tumour vaccination: expression of allogeneic MHC supports activation of antigen specific T cells, but impairs early naïve cytotoxic priming and anti-tumour therapy

scientific article published on 04 December 2007

BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress ⬇️

scientific article

Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors

scientific article

CD40-mediated death and cytokine secretion in colorectal cancer: a potential target for inflammatory tumour cell killing

scientific article published on September 2007

Cancer immunotherapy via combining oncolytic virotherapy with chemotherapy: recent advances

scientific article

Cell carriers for oncolytic viruses: Fed Ex for cancer therapy

scientific article published on 18 August 2009

Cell death associated with genetic prodrug activation therapy of colorectal cancer

scientific article

Cell migration in paediatric glioma; characterisation and potential therapeutic targeting ⬇️

scientific article

Clinical grade OK432-activated dendritic cells: in vitro characterization and tracking during intralymphatic delivery

scientific article

Combination Therapy With Reovirus and Anti-PD-1 Blockade Controls Tumor Growth Through Innate and Adaptive Immune Responses ⬇️

scientific article published on 27 August 2015

Combination viroimmunotherapy with checkpoint inhibition to treat glioma, based on location-specific tumor profiling

scientific article published on 26 September 2015

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

scientific article published on 01 March 2020

Cyclophosphamide facilitates antitumor efficacy against subcutaneous tumors following intravenous delivery of reovirus

scientific article published on January 2008

Cytokine conditioning enhances systemic delivery and therapy of an oncolytic virus ⬇️

scientific article published on 24 June 2014

Definitive Management of Oligometastatic Melanoma in a Murine Model Using Combined Ablative Radiation Therapy and Viral Immunotherapy

scientific article published on 26 July 2015

Dendritic cells for the immunotherapy of cancer

scientific article

Detecting and targeting tumor relapse by its resistance to innate effectors at early recurrence

scientific article

Differential effects of Paclitaxel on dendritic cell function ⬇️

scientific article

Enhancing the efficacy of a weak allogeneic melanoma vaccine by viral fusogenic membrane glycoprotein-mediated tumor cell-tumor cell fusion

scientific article published on October 2002

Evidence for Oncolytic Virotherapy: Where Have We Got to and Where Are We Going? ⬇️

scientific article

Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells

scientific article

Expression profiling of single cells and patient cohorts identifies multiple immunosuppressive pathways and an altered NK cell phenotype in glioblastoma

scientific article published on 16 December 2019

Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse

scientific article

Future clinical potential of oncolytic virotherapy for pediatric CNS tumors ⬇️

scientific article published in July 2013

Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues.

scientific article

Immune activation by combination human lymphokine-activated killer and dendritic cell therapy ⬇️

scientific article published on August 16, 2011

Immunogenicity of self tumor associated proteins is enhanced through protein truncation ⬇️

scientific article published on 07 December 2016

Immunosuppressive effects of radiation on human dendritic cells: reduced IL-12 production on activation and impairment of naive T-cell priming ⬇️

scientific article published on April 2005

Improved systemic delivery of oncolytic reovirus to established tumors using preconditioning with cyclophosphamide-mediated Treg modulation and interleukin-2

scientific article

International symposium on CTL and immunostimulation, Pamplona (Spain), October 26th and 27th 2010.

scientific article published on 5 March 2011

Intravenous delivery of oncolytic reovirus to brain tumor patients immunologically primes for subsequent checkpoint blockade. ⬇️

scientific article published in January 2018

Killing of normal melanocytes, combined with heat shock protein 70 and CD40L expression, cures large established melanomas

scientific article published on September 2006

Live viruses to treat cancer

scientific article published on 3 July 2013

Loading of oncolytic vesicular stomatitis virus onto antigen-specific T cells enhances the efficacy of adoptive T-cell therapy of tumors

scientific article published on 28 February 2008

Locoregional intravascular viral therapy of cancer: precision guidance for Paris's arrow?

scientific article published on 06 May 2010

Mutated BRAF Emerges as a Major Effector of Recurrence in a Murine Melanoma Model After Treatment With Immunomodulatory Agents

scientific article published on 29 December 2014

Oncolytic Herpes Simplex Virus Inhibits Pediatric Brain Tumor Migration and Invasion ⬇️

scientific article published on 2 May 2017

Oncolytic Immunotherapy for Bladder Cancer Using Coxsackie A21 Virus. ⬇️

scientific article published on 14 February 2018

Oncolytic Vaccinia virus and radiotherapy in head and neck cancer ⬇️

scientific article published on August 25, 2012

Oncolytic immunotherapy for the treatment of non-muscle invasive bladder cancer using intravesical coxsackievirus A21.

scientific article published on 4 November 2015

Oncolytic viruses: do they have a role in anti-cancer therapy?

scientific article published on 09 February 2008

Oncolytic viruses: time to compare, contrast, and combine? 5th international meeting on replicating oncolytic virus therapeutics. Banff, Alberta, Canada, 18-22 March 2009.

scientific article published on June 2009

Phase I/II Trial of Carboplatin and Paclitaxel Chemotherapy in Combination with Intravenous Oncolytic Reovirus in Patients with Advanced Malignancies ⬇️

scientific article published on February 7, 2012

Phase I/II storm study: Intravenous delivery of a novel oncolytic immunotherapy agent, Coxsackievirus A21, in advanced cancer patients.

scientific article published on 4 November 2015

Potent selection of antigen loss variants of B16 melanoma following inflammatory killing of melanocytes in vivo

scientific article

Precise scheduling of chemotherapy primes VEGF-producing tumors for successful systemic oncolytic virotherapy

scientific article

Preoperative radiotherapy combined with 5 days per week capecitabine chemotherapy in locally advanced rectal cancer

scientific article published on 6 November 2007

Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy ⬇️

scientific article

Pro-inflammatory cytokine/chemokine production by reovirus treated melanoma cells is PKR/NF-κB mediated and supports innate and adaptive anti-tumour immune priming

scientific article published on 21 February 2011

REO-10: a phase I study of intravenous reovirus and docetaxel in patients with advanced cancer

scientific article published on 06 October 2010

Reovirus activates human dendritic cells to promote innate antitumor immunity

scientific article

Reovirus exerts potent oncolytic effects in head and neck cancer cell lines that are independent of signalling in the EGFR pathway ⬇️

scientific article published on August 24, 2012

Reovirus-associated reduction of microRNA-let-7d is related to the increased apoptotic death of cancer cells in clinical samples

scientific article

Reovirus: viral therapy for cancer 'as nature intended'.

scientific article published on 25 June 2008

Short-course radiotherapy, with elective delay prior to surgery, in patients with unresectable rectal cancer who have poor performance status or significant co-morbidity

scientific article published on 4 May 2009

Single-cycle viral gene expression, rather than progressive replication and oncolysis, is required for VSV therapy of B16 melanoma ⬇️

scientific article published on 17 December 2009

Subversion of NK-cell and TNFα Immune Surveillance Drives Tumor Recurrence ⬇️

scientific article published on 15 October 2017

Synergistic antitumour effects of rapamycin and oncolytic reovirus

scientific article published on 3 May 2018

Synergistic cytotoxicity of oncolytic reovirus in combination with cisplatin–paclitaxel doublet chemotherapy ⬇️

scientific article published on August 16, 2012

Synergistic effects of oncolytic reovirus and cisplatin chemotherapy in murine malignant melanoma

scientific article

Synergistic effects of oncolytic reovirus and docetaxel chemotherapy in prostate cancer

scientific article

Talimogene laherparepvec in the treatment of melanoma

scientific article

The biology of the sodium iodide symporter and its potential for targeted gene delivery

scientific article published on March 2010

The effect of cell cycle synchronization on tumor sensitivity to reovirus oncolysis

scientific article published on 14 September 2010

The hitchhiker's guide to virotherapy ⬇️

scientific article published on August 2012

The profile of tumor antigens which can be targeted by immunotherapy depends upon the tumor's anatomical site

scientific article

Thunder and lightning: immunotherapy and oncolytic viruses collide

scientific article

Treg depletion-enhanced IL-2 treatment facilitates therapy of established tumors using systemically delivered oncolytic virus

scientific article published on 22 April 2008

Type III IFN interleukin-28 mediates the antitumor efficacy of oncolytic virus VSV in immune-competent mouse models of cancer

scientific article published on 18 May 2010

Use of biological therapy to enhance both virotherapy and adoptive T-cell therapy for cancer

scientific article published on 30 September 2008

Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma

scientific article

VSV Oncolytic Virotherapy in the B16 Model Depends Upon Intact MyD88 Signaling ⬇️

scientific article published on October 19, 2010

Vaccination of colorectal cancer patients with modified vaccinia ankara encoding the tumor antigen 5T4 (TroVax) given alongside chemotherapy induces potent immune responses

scientific article published in August 2007

Vesicular stomatitis virus-induced immune suppressor cells generate antagonism between intratumoral oncolytic virus and cyclophosphamide

scientific article

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