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List of works by Aidong Wen

A Network Pharmacology Technique to Investigate the Synergistic Mechanisms of Salvia miltiorrhiza and Radix puerariae in Treatment of Cardio-Cerebral Vascular Diseases

scientific article published on 05 October 2020

A new flavonoid glycoside (APG) isolated from Clematis tangutica attenuates myocardial ischemia/reperfusion injury via activating PKCε signaling.

scientific article published on 23 December 2016

A new synthetic Cu(II) compound, [Cu3(p-3-bmb)2Cl4·(CH3OH)2]n, inhibits tumor growth in vivo and in vitro.

scientific article published on 21 December 2013

A novel animal model of impaired glucose tolerance induced by the interaction of vitamin E deficiency and (60)Co radiation.

scientific article published on 14 April 2015

A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of hydroxysafflor yellow A in human plasma: application to a pharmacokinetic study

scientific article published on 14 October 2008

A sensitive LC-MS/MS method for determination of levamisole in human plasma: application to pharmacokinetic study

scientific article published on 09 December 2010

Absorption and metabolism characteristics of rutin in Caco-2 cells

scientific article published on 02 October 2013

Acetyl-11-Keto-β-Boswellic Acid Attenuates Prooxidant and Profibrotic Mechanisms Involving Transforming Growth Factor-β1, and Improves Vascular Remodeling in Spontaneously Hypertensive Rats.

scientific article published on 23 December 2016

Alpha-boswellic acid protects against ethanol-induced gastric injury in rats: involvement of nuclear factor erythroid-2-related factor 2/heme oxygenase-1 pathway

scientific article published on 14 March 2016

An improved LC-MS/MS method for quantitative determination of metolazone in human plasma and its application to a pharmacokinetic study.

scientific article

Analgesic effect of coumarins from Radix angelicae pubescentis is mediated by inflammatory factors and TRPV1 in a spared nerve injury model of neuropathic pain

scientific article published on 30 November 2016

Analysis of sofalcone in human plasma by high performance liquid chromatography

scientific article published on 26 May 2007

Anti-inflammatory effect of protocatechuic aldehyde on myocardial ischemia/reperfusion injury in vivo and in vitro

scientific article

Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats

scientific article published on 11 February 2014

Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats.

scientific article published on 20 April 2016

Application of a liquid chromatographic/tandem mass spectrometric method to a kinetic study of derivative glucosamine in healthy human urine

scientific article published on 22 January 2011

Application of a liquid chromatographic/tandem mass spectrometric method to a urinary excretion study of rabeprazole and two of its metabolites in healthy human urine

scientific article published on 23 January 2015

Application of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method to the pharmacokinetics, tissue distribution and excretion studies of felotaxel (SHR110008) in tumor-bearing mice

scientific article

Application of a liquid chromatography-tandem mass spectrometry method to the pharmacokinetics, tissue distribution and excretion studies of brazilin in rats

scientific article published on 28 May 2013

Application of a sensitive liquid chromatographic/tandem mass spectrometric method to a pharmacokinetic study of allylestrenol in healthy Chinese female volunteers

scientific article

Application of a sensitive liquid chromatographic/tandem mass spectrometric method to pharmacokinetic study of nalmefene in humans

scientific article published on 15 February 2007

Application of liquid chromatographic/tandem mass spectrometric method to a urinary excretion study of subutinib and active metabolite in human urine.

scientific article published on 18 August 2015

Aralia taibaiensis Protects Cardiac Myocytes against High Glucose-Induced Oxidative Stress and Apoptosis

scientific article published in January 2015

Aralia taibaiensis Protects against I/R-Induced Brain Cell Injury through the Akt/SIRT1/FOXO3a Pathway.

scientific article published on 12 May 2019

Autophagy facilitates the Lapatinib resistance of HER2 positive breast cancer cells

scientific article

Autophagy is a therapeutic target in anticancer drug resistance.

scientific article published on 13 July 2010

Brazilin exerts protective effects against renal ischemia-reperfusion injury by inhibiting the NF-κB signaling pathway

scientific article published on 31 May 2016

Cardioprotective effect of Danshensu against myocardial ischemia/reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation ⬇️

scientific article published on November 29, 2012

Chikusetsu Saponin IVa Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice via Adiponectin-Mediated AMPK/GSK-3β Pathway In Vivo and In Vitro

scientific article published on 31 January 2015

Chikusetsu saponin IVa confers cardioprotection via SIRT1/ERK1/2 and Homer1a pathway.

scientific article

Chikusetsu saponin IVa regulates glucose uptake and fatty acid oxidation: implications in antihyperglycemic and hypolipidemic effects

scientific article

Cognitive behavior therapy for older patients with generalized anxiety disorder

scientific article published on 01 August 2009

Combined cancer therapy with non-conventional drugs: all roads lead to AMPK.

scientific article

Comparison of the anti-inflammatory and analgesic effects of Gentiana macrophylla Pall. and Gentiana straminea Maxim., and identification of their active constituents

scientific article

Cytotoxic asterosaponins capable of promoting polymerization of tubulin from the starfish Culcita novaeguineae.

scientific article published in February 2009

DRUGS System Improving the Effects of Clinical Pathways: A Systematic Study.

scientific article published on 10 December 2015

DRUGS system enhancing adherence of Chinese surgeons to antibiotic use guidelines during perioperative period

scientific article

Determination of azatadine in human plasma by liquid chromatography/tandem mass spectrometry

scientific article published on 12 June 2011

Determination of cefcapene acid by LC-MS and their application to a pharmacokinetic study in healthy Chinese volunteers

scientific article published on 7 October 2012

Determination of ipriflavone in human plasma by LC-MS and its application in a pharmacokinetic study.

scientific article

Determination of sinomenine sustained-release capsules in healthy Chinese volunteers by liquid chromatography-tandem mass spectrometry.

scientific article

Determination of venlafaxine in human plasma by high-performance liquid chromatography using cloud-point extraction and spectrofluorimetric detection.

scientific article published on 6 July 2008

Development and validation of a robust LC-MS-MS with atmospheric pressure chemical ionization for quantitation of carbazochrome sodium sulfonate in human plasma: application to a pharmacokinetic study

scientific article

Development of an LC-MS/MS method for the simultaneous quantification of aripiprazole and dehydroaripiprazole in human plasma

scientific article

Dietary ellagic acid improves oxidant-induced endothelial dysfunction and atherosclerosis: role of Nrf2 activation

scientific article published on 02 July 2014

Dissection of mechanisms of a chinese medicinal formula: danhong injection therapy for myocardial ischemia/reperfusion injury in vivo and in vitro.

scientific article published on 03 June 2013

Effect of Food on the Single-dose Pharmacokinetics and Tolerability of Subutinib and its Active Metabolite in Chinese Healthy Volunteers

scientific article published in September 2015

Effect of food on the pharmacokinetics of triflusal and its major active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid, in healthy subjects

scientific article published in March 2015

Effect of food on the single-dose pharmacokinetics and tolerability of clinofibrate tablets in Chinese healthy volunteers

scientific article published in August 2013

Effect of niacin on lipids and glucose in patients with type 2 diabetes: A meta-analysis of randomized, controlled clinical trials

scientific article published on 28 September 2014

Effects and Mechanism of Combination of Rhein and Danshensu in the Treatment of Chronic Kidney Disease

scientific article published on 27 October 2015

Effects of amlodipine on the oral bioavailability of cephalexin and cefuroxime axetil in healthy volunteers.

scientific article published on 24 January 2013

Enhanced Neuroprotection of Acetyl-11-Keto-β-Boswellic Acid (AKBA)-Loaded O-Carboxymethyl Chitosan Nanoparticles Through Antioxidant and Anti-Inflammatory Pathways

scientific article published on 11 July 2015

Epigallocatechin-3-gallate ameliorates insulin resistance in hepatocytes

scientific article

Evaluation of body weight-based vancomycin therapy and the incidence of nephrotoxicity: a retrospective study in the northwest of China

scientific article published on 6 July 2015

Facile access to unnatural dipeptide-alcohols based on cis-2,5-disubstituted pyrrolidines

scientific article published on 11 February 2015

Ginsenoside-Rd improves outcome of acute ischaemic stroke - a randomized, double-blind, placebo-controlled, multicenter trial

scientific article published on 10 January 2012

High performance liquid chromatographic method for the determination of cinepazide maleate and its application to a pharmacokinetic study in rats

scientific article published on 04 March 2014

Histone deacetylase 1 is required for Carbamazepine-induced CYP3A4 expression.

scientific article published on 22 September 2011

Huangqi-Honghua combination and its main components ameliorate cerebral infarction with Qi deficiency and blood stasis syndrome by antioxidant action in rats

scientific article published on 21 June 2014

Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition

scientific article

Hydroxysafflor yellow A promotes neovascularization and cardiac function recovery through HO-1/VEGF-A/SDF-1α cascade

scientific article published on 22 January 2017

Identification of AMPK activator from twelve pure compounds isolated from Aralia Taibaiensis: implication in antihyperglycemic and hypolipidemic activities.

scientific article

Identification of genes and pathways potentially related to PHF20 by gene expression profile analysis of glioblastoma U87 cell line

scientific article published on 4 October 2017

Impact of pharmacist interventions on rational prophylactic antibiotic use and cost saving in elective cesarean section

scientific article published on August 2015

Impact on L‐carnitine Homeostasis of Short‐term Treatment with the Pivalate Prodrug Tenofovir Dipivoxil ⬇️

scientific article published on August 20, 2013

In vitro assessment of cytochrome P450 inhibition and induction potential of felotaxel (SHR110008)

scientific article published on 17 February 2012

Insulin-secretagogue activity of eleven plant extracts and twelve pure compounds isolated from Aralia taibaiensis ⬇️

scientific article published on November 28, 2012

Insulinotropic effect of Chikusetsu saponin IVa in diabetic rats and pancreatic β-cells

scientific article

Iridoid glycosides from the flowers of Gentiana macrophylla Pall. ameliorate collagen-induced arthritis in rats

scientific article

Liquid chromatography/electrospray ionization mass spectrometry method for the determination of the active metabolite M-1 of suplatast tosilate in human plasma

scientific article

Liquid chromatography/electrospray ionization tandem mass spectrometry for the quantification of mitiglinide in human plasma: validation and its application to pharmacokinetic studies

scientific article

Magnesium lithospermate B improves myocardial function and prevents simulated ischemia/reperfusion injury-induced H9c2 cardiomyocytes apoptosis through Akt-dependent pathway.

scientific article published on December 2013

Magnesium lithospermate B reduces myocardial ischemia/reperfusion injury in rats via regulating the inflammation response.

scientific article

Mechanistic prediction of food effects for Compound A tablet using PBPK model.

scientific article published on 11 February 2017

Neuroprotection by acetyl-11-keto-β-Boswellic acid, in ischemic brain injury involves the Nrf2/HO-1 defense pathway

scientific article

Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats

scientific article published on 19 December 2014

Neuroprotective effect of calycosin on cerebral ischemia and reperfusion injury in rats

scientific article

Pharmacokinetic comparisons of hydroxysafflower yellow A in normal and blood stasis syndrome rats.

scientific article published on 4 March 2010

Pharmacokinetic properties of hydroxysafflor yellow A in healthy Chinese female volunteers

scientific article published on 4 March 2009

Pharmacokinetic properties of lansoprazole (30-mg enteric-coated capsules) and its metabolites: A single-dose, open-label study in healthy Chinese male subjects.

scientific article published on June 2009

Pharmacokinetic study of inosiplex tablets in healthy Chinese volunteers by hyphenated HPLC and tandem MS techniques.

scientific article published on 20 March 2013

Pharmacokinetics and Pharmacodynamics of Henagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, in Chinese Patients with Type 2 Diabetes Mellitus

scientific article published on 01 March 2016

Pharmacokinetics and bioavailability in healthy Chinese volunteers of a novel rabeprazole sterile powder formulation for injection

scientific article published on 01 June 2016

Pharmacokinetics and food interaction of a novel prodrug of tenofovir, tenofovir dipivoxil fumarate, in healthy volunteers.

scientific article

Pharmacokinetics of metronidazole, tetracycline and bismuth in healthy volunteers after oral administration of compound tablets containing a combination of metronidazole, tetracycline hydrochloride and bismuth oxide

scientific article published on 24 April 2014

Posttreatment with 11-Keto-β-Boswellic Acid Ameliorates Cerebral Ischemia-Reperfusion Injury: Nrf2/HO-1 Pathway as a Potential Mechanism

scientific article published on 28 October 2014

Preclinical pharmacokinetic analysis of felotaxel (SHR110008), a novel derivative of docetaxel, in rats and its protein binding ability in vitro

scientific article published on 30 December 2011

Precolumn derivatization LC-MS/MS method for the determination and pharmacokinetic study of glucosamine in human plasma and urine.

scientific article published on 24 October 2011

Pretreatment with β-Boswellic Acid Improves Blood Stasis Induced Endothelial Dysfunction: Role of eNOS Activation.

scientific article

Propofol Regulates the Surface Expression of GABAA Receptors: Implications in Synaptic Inhibition

scientific article

Protection against Helicobacter pylori infection by a trivalent fusion vaccine based on a fragment of urease B-UreB414

scientific article published on 01 April 2010

Protective autophagy promotes the resistance of HER2-positive breast cancer cells to lapatinib

scientific article published on 14 September 2015

Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: involvement of the AMPK/GSK-3β/Nrf2 signaling pathway

scientific article published on 27 January 2017

Protective effect of crocetin against burn-induced intestinal injury

scientific article published on 03 June 2015

Protective effect of wedelolactone against CCl4-induced acute liver injury in mice.

scientific article

Protective effects of Lycium barbarum polysaccharide on 6-OHDA-induced apoptosis in PC12 cells through the ROS-NO pathway.

scientific article published on 24 December 2014

Protocatechualdehyde Protects Against Cerebral Ischemia-Reperfusion-Induced Oxidative Injury Via Protein Kinase Cε/Nrf2/HO-1 Pathway

scientific article published on 16 January 2016

Regulatory mechanisms of annexin-induced chemotherapy resistance in cisplatin resistant lung adenocarcinoma

scientific article

Relative bioavailability study of a novel prodrug of tenofovir, tenofovir dipivoxil fumarate, in healthy male fasted volunteers.

scientific article published on May 2012

Resveratrol sensitizes tamoxifen in antiestrogen-resistant breast cancer cells with epithelial-mesenchymal transition features

scientific article published on 26 July 2013

Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro ⬇️

scientific article published on February 11, 2013

Safflower yellow B suppresses HepG2 cell injury induced by oxidative stress through the AKT/Nrf2 pathway.

scientific article published on 21 January 2016

Shen-Kang protects 5/6 nephrectomized rats against renal injury by reducing oxidative stress through the MAPK signaling pathways

scientific article

ShenKang injection suppresses kidney fibrosis and oxidative stress via transforming growth factor-β/Smad3 signalling pathway in vivo and in vitro.

scientific article

Simple LC-MS/MS methods for simultaneous determination of pitavastatin and its lactone metabolite in human plasma and urine involving a procedure for inhibiting the conversion of pitavastatin lactone to pitavastatin in plasma and its application to

scientific article published on 29 September 2012

Simultaneous determination of amoxicillin and ambroxol in human plasma by LC-MS/MS: validation and application to pharmacokinetic study

scientific article published on 7 July 2008

Simultaneous determination of lansoprazole and its metabolites 5'-hydroxy lansoprazole and lansoprazole sulphone in human plasma by LC-MS/MS: application to a pharmacokinetic study in healthy volunteers

scientific article

Simultaneous determination of subutinib and its active metabolite in human plasma by LC-MS/MS: Application to pharmacokinetic study

scientific article

Synergistic analgesic effect of propofol-alfentanil combination through detecting the inhibition of cAMP signal pathway

scientific article published on 23 June 2016

Synergistic antinociception of propofol-alfentanil combination in mice

scientific article published on 12 October 2013

Synergistic antinociceptive effects of alfentanil and propofol in the formalin test

scientific article published on 7 February 2017

Synergistic antinociceptive interactions between fospropofol and alfentanil in mice

scientific article

Synergistic efficacy of meropenem and rifampicin in a murine model of sepsis caused by multidrug-resistant Acinetobacter baumannii

scientific article published on 21 February 2014

Synthesis and characterization of novel polar-embedded silica stationary phases for use in reversed-phase high-performance liquid chromatography.

scientific article

The effect of Madopar on the pharmacokinetics of ropinirole in healthy Chinese volunteers

scientific article published on 19 October 2006

The effect of lansoprazole, an OCT inhibitor, on metformin pharmacokinetics in healthy subjects.

scientific article published on 30 October 2013

The effect of staggered administration of zinc sulfate on the pharmacokinetics of oral cephalexin.

scientific article

The effect of transcatheter arterial chemoembolization on phase II drug metabolism enzymes in patients with hepatocellular carcinoma.

scientific article

The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl(4)-model rats

scientific article published on 14 January 2012

Therapeutic time window and underlying therapeutic mechanism of breviscapine injection against cerebral ischemia/reperfusion injury in rats

scientific article published on 26 November 2013

Total saponins from Aralia taibaiensis protect against myocardial ischemia/reperfusion injury through AMPK pathway.

scientific article published on 23 October 2015

Trillium tschonoskii steroidal saponins suppress the growth of colorectal Cancer cells in vitro and in vivo.

scientific article

Triterpenoid saponins from Ardisia pusilla and their cytotoxic activity.

scientific article

Triterpenoid saponins from Clematis tangutica and their cardioprotective activities ⬇️

scientific article published on December 22, 2012

Triterpenoid saponins from the roots of Clematis argentilucida and their cytotoxic activity.

scientific article

miR-592/WSB1/HIF-1α axis inhibits glycolytic metabolism to decrease hepatocellular carcinoma growth.

scientific article published on 02 May 2016

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