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List of works by Scott D. Rychnovsky

A C-glycosidation approach to the central core of amphidinol 3: synthesis of the c39-c52 fragment

scientific article published on 01 April 2005

A concise synthesis of ent-Cholesterol

scientific article published on 13 March 2008

A new in vivo cross-linking mass spectrometry platform to define protein-protein interactions in living cells.

scientific article

A reductive cyclization approach to attenol A

scientific article published on 9 March 2007

A reverse-phase HPLC assay for measuring the interaction of polyene macrolide antifungal agents with sterols

scientific article published on 01 August 1992

A unified approach to polyene macrolides: synthesis of candidin and nystatin polyols

scholarly article

Absolute configuration of lactams and oxazolidinones using kinetic resolution catalysts

scientific article published on 16 January 2013

Allyl transfer to aldehydes and ketones by Brønsted acid activation of allyl and crotyl 1,3,2-dioxazaborolidines.

scientific article published on November 2010

Anti-1,3-diols by Addition of Dialkylzinc Reagents to 4-Acetoxy-1,3-dioxanes.

scientific article

Assignment of absolute configuration to SCH 351448 via total synthesis

scientific article published on 11 June 2008

Axial-selective prins cyclizations by solvolysis of alpha-bromo ethers.

scientific article

Beta-selective glycosylations with masked D-mycosamine precursors

scientific article published on 01 October 2001

Biosynthesis-Inspired Approach to Kujounin A2 Using a Stereoselective Tsuji-Trost Alkylation

scientific article published on 07 September 2018

Carbon-Carbon Bond Formation from Small- and Medium-Ring Lactol Acetates via Radical and Oxonium Ion Intermediates. Synthesis of (+/-)-Laurenan

scientific article

Catalytic Enantioselective Allylations of Acetylenic Aldehydes via 2-Propanol-Mediated Reductive Coupling

scientific article published on 25 June 2018

Concise synthesis of (+)-fastigiatine

scientific article published on 6 October 2015

Cyclization via carbolithiation of alpha-amino alkyllithium reagents.

scientific article published on 14 August 2008

DABO Boronates: Stable Heterocyclic Boronic Acid Complexes for Use in Suzuki-Miyaura Cross-Coupling Reactions.

scientific article published on October 2011

Design of CID-cleavable protein cross-linkers: identical mass modifications for simpler sequence analysis.

scientific article

Determination of absolute configuration of secondary alcohols using thin-layer chromatography

scientific article published on 17 April 2013

Determination of absolute configuration using kinetic resolution catalysts.

scientific article

Determination of the Absolute Configuration of Cyclic Amines with Bode's Chiral Hydroxamic Esters Using the Competing Enantioselective Conversion Method

scientific article published in August 2017

Determination of the Absolute Configuration of β-Chiral Primary Alcohols Using the Competing Enantioselective Conversion Method

scientific article published on 16 May 2017

Developing a Multiplexed Quantitative Cross-Linking Mass Spectrometry Platform for Comparative Structural Analysis of Protein Complexes.

scientific article published on 14 September 2016

Developing an Acidic Residue Reactive and Sulfoxide-Containing MS-Cleavable Homobifunctional Cross-Linker for Probing Protein-Protein Interactions

scientific article published on 14 July 2016

Developing new isotope-coded mass spectrometry-cleavable cross-linkers for elucidating protein structures.

scientific article published on 06 February 2014

Development of a Novel Sulfoxide-Containing MS-Cleavable Homobifunctional Cysteine-Reactive Cross-Linker for Studying Protein-Protein Interactions.

scientific article published on 5 June 2018

Diastereoselective additions of nucleophiles to alpha-acetoxy ethers using the alpha-(trimethylsilyl)benzyl auxiliary

scientific article published on 01 June 2003

Diastereoselective synthesis of the pectenotoxin 2 non-anomeric AB spiroacetal.

scientific article published on February 2007

Direct assignment of the relative configuration in acyclic 1,3-diols by 1H NMR spectroscopy

scientific article published on 01 December 2005

Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis

scientific article published on 9 September 2015

Distinct mechanisms underlying cholesterol protection against alcohol-induced BK channel inhibition and resulting vasoconstriction

scientific article published on 24 August 2016

Dual roles for cholesterol in mammalian cells

scientific article

Empirical model for the molar rotations of syn-2,2-dimethyl-1,3-dioxanes

scientific article published on 01 September 2002

Enantioselective synthesis of the C18-C25 segment of lasonolide A by an oxonia-cope prins cascade

scientific article published on 01 April 2005

Exploring Spacer Arm Structures for Designs of Asymmetric Sulfoxide-Containing MS-Cleavable Cross-Linkers

scientific article published on 31 March 2020

Filipin III: Configuration Assignment and Confirmation by Synthetic Correlation

scientific article

Formal synthesis of (-)-apicularen A

scientific article published on 01 September 2003

Formal synthesis of (-)-kendomycin featuring a Prins-cyclization to construct the macrocycle

scientific article

Formation of highly substituted tetrahydropyranones: application to the total synthesis of cyanolide A

scientific article published on 20 August 2013

Generation and utility of tertiary alpha-aminoorganolithium reagents

scientific article published on 01 August 2004

Generation, Stability, and Utility of Lithium 4,4'-Di-tert-butylbiphenylide (LiDBB).

scientific article published on 27 October 2016

Generation, structure and reactivity of tertiary organolithium reagents.

scientific article

Gln40 deamidation blocks structural reconfiguration and activation of SCF ubiquitin ligase complex by Nedd8.

scientific article

Hedgehog pathway modulation by multiple lipid binding sites on the smoothened effector of signal response.

scientific article published on 15 August 2013

Heteroatom-Directed Acylation of Secondary Alcohols To Assign Absolute Configuration.

scientific article published on 9 February 2018

Kinetic analysis of the HBTM-catalyzed esterification of an enantiopure secondary alcohol.

scientific article

Lewis Acid Promoted Mukaiyama Aldol-Prins (MAP) Cyclizations of Acetals, Ketals, α-Acetoxy Ethers, and Orthoformates ⬇️

scientific article published on February 12, 2008

Mapping the structural topology of the yeast 19S proteasomal regulatory particle using chemical cross-linking and probabilistic modeling

scientific article

Memory of chirality in the transannular cyclization of cyclodecenyl radicals

scientific article published in August 2004

Molecular Details Underlying Dynamic Structures and Regulation of the Human 26S Proteasome.

scientific article

Mukaiyama aldol-Prins cyclization cascade reaction: a formal total synthesis of leucascandrolide A.

scientific article

Nanomole-Scale Assignment and One-Use Kits for Determining the Absolute Configuration of Secondary Alcohols

scientific article published on 14 July 2016

Nanomole-scale assignment of configuration for primary amines using a kinetic resolution strategy.

scientific article

Optically pure alpha-(trimethylsilyl)benzyl alcohol: a practical chiral auxiliary for oxocarbenium ion reactions

scientific article published on 01 January 2002

Origins of Regio- and Stereochemistry in Type 2 Intramolecular N-Acylnitroso Diels–Alder Reactions: A Computational Study of Tether Length and Substituent Effects ⬇️

scientific article published on March 11, 2013

Polyol synthesis with beta-oxyanionic alkyllithium reagents: syntheses of aculeatins A, B, and D.

scientific article published on September 2009

Prins Desymmetrization of a C(2)-Symmetric Diol: Application to the Synthesis of 17-Deoxyroflamycoin.

scientific article

Qualitative and quantitative measurements of hydrogen bond mediated scalar couplings in acyclic 1,3-diols

scientific article published on 01 November 2006

Racemization in Prins cyclization reactions

scientific article published on October 2006

Rapid stereocontrolled assembly of the fully substituted C-aryl glycoside of kendomycin with a Prins cyclization: a formal synthesis.

scientific article published on 2 May 2006

Reductive spiroannulation of nitriles with secondary electrophiles

scientific article published on 01 May 2005

Relative and Absolute Structure Assignments of Alkenes Using Crystalline Osmate Derivatives for X-ray Analysis

scientific article published on 10 December 2019

Role of 2-oxonia Cope rearrangements in Prins cyclization reactions

scientific article published on 01 November 2001

Role of chirality in peptide-induced formation of cholesterol-rich domains.

scientific article published on September 2005

Route to Highly Substituted Pyridines

scientific article published on 31 August 2016

Second-Generation Synthesis of (+)-Fastigiatine Inspired by Conformational Studies

scientific article published on 26 June 2018

Silyl enol ether Prins cyclization: diastereoselective formation of substituted tetrahydropyran-4-ones

scientific article

Solvolysis of a tetrahydropyranyl mesylate: mechanistic implications for the Prins cyclization, 2-oxonia-cope rearrangement, and Grob fragmentation.

scientific article published on May 2006

Specificity of cholesterol and analogs to modulate BK channels points to direct sterol-channel protein interactions ⬇️

scientific article

Specificity of cholesterol and analogs to modulate BK channels points to direct sterol–channel protein interactions.

scientific article published in April 2011

Spiroannulation by alkylation and reductive cyclization of nitriles

scientific article published in February 2003

Stereochemical Outcomes in Reductive Cyclizations To Form Spirocyclic Heterocycles

scientific article published on 19 June 2015

Stereoselection in Intramolecular Diels-Alder Reactions of 2-Cyano-1-azadienes: Indolizidine and Quinolizidine Synthesis

scientific article published on 13 June 2016

Stereoselectivity and regioselectivity in the segment-coupling Prins cyclization.

scientific article published in June 2001

Strategies for the generation of molecularly imprinted polymeric nitroxide catalysts

scientific article published on 01 October 2005

Studies toward the synthesis of palhinine lycopodium alkaloids: a Morita-Baylis-Hillman/intramolecular Diels-Alder approach

scientific article published on 24 January 2014

Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase

scientific journal article

Symmetric macrocycles by a Prins dimerization and macrocyclization strategy.

scientific article

Synthesis and structural reassignment of (+)-epicalyxin F.

scientific article published on 25 October 2007

Synthesis and structure revision of calyxin natural products

scientific article

Synthesis of (-)-centrolobine by Prins cyclizations that avoid racemization

scientific article published on 01 October 2002

Synthesis of rimocidinolide methyl ester, the aglycone of (+)-rimocidin

scientific article

Synthesis of the C1-C52 fragment of amphidinol 3, featuring a beta-alkoxy alkyllithium addition reaction.

scientific article published on 18 October 2007

Synthesis of the C3-C19 segment of phorboxazole B

scientific article published on 01 July 2005

Synthesis of the C31-C67 fragment of amphidinol 3

scientific article published on 01 November 2006

Synthesis of the spirofungin B core by a reductive cyclization strategy

scientific article published on 01 April 2005

Synthesis of two new enrichable and MS-cleavable cross-linkers to define protein-protein interactions by mass spectrometry.

scientific article published on May 2015

Synthesis, Equilibration, and Coupling of 4-Lithio-1,3-dioxanes: Synthons for syn- and anti-1,3-Diols ⬇️

scientific article published on September 3, 1999

TEMPO-Catalyzed Oxidations of Alcohols Using m-CPBA: The Role of Halide Ions ⬇️

scientific article published on January 8, 1999

Tetrahydropyran rings from a Mukaiyama-Michael cascade reaction

scientific article

Total Synthesis and Structure Revision of (-)-Illisimonin A, a Neuroprotective Sesquiterpenoid from the Fruits of Illicium simonsii

scientific article published on 13 August 2019

Total Synthesis of (-)-Himeradine A

scientific article published on 25 September 2019

Total Synthesis of Lepadiformine Alkaloids using N-Boc α-Amino Nitriles as Trianion Synthons ⬇️

scientific article published on March 13, 2012

Total Synthesis of the Cyanolide A Aglycon ⬇️

scientific article published on June 8, 2011

Total synthesis and structure assignment of (+)-hexacyclinol.

scientific article

Trianion synthon approach to spirocyclic heterocycles

scientific article published on 17 April 2013

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis

scientific article published on 02 March 2022

Use of a conformational radical clock for evaluating alkyllithium-mediated cyclization reactions

scientific article published on 01 March 2001

Using the Competing Enantioselective Conversion Method to Assign the Absolute Configuration of Cyclic Amines with Bode's Acylation Reagents

scientific article published on 31 July 2020

Utilization of an oxonia-Cope rearrangement as a mechanistic probe for Prins cyclizations

scientific article

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