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List of works by David Kirsch

A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma.

scientific article

A Method for Generating Intensity Modulated Radiation Therapy Fields for Small Animal Irradiators Utilizing 3D Printed Compensator Molds

scientific article published on 13 April 2020

A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs

scientific article published on 9 June 2016

A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy

scientific article published on 23 May 2015

A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models

scientific article published on February 2013

A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer.

scientific article published on January 2016

A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer

scientific article

A novel imaging system permits real-time in vivo tumor bed assessment after resection of naturally occurring sarcomas in dogs

scientific article published on March 2013

A precision 3D conformal treatment technique in rats: application to whole brain radiotherapy with hippocampal avoidance.

scientific article published on 24 August 2017

A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins.

scientific article

A spatially and temporally restricted mouse model of soft tissue sarcoma

scientific article published on 5 August 2007

Abstract 4812: p53 acts during total-body irradiation to promote lymphomagenesis

Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma

scientific article

Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway

scientific article

Agreement among RTOG sarcoma radiation oncologists in contouring suspicious peritumoral edema for preoperative radiation therapy of soft tissue sarcoma of the extremity

scientific article published on 6 March 2013

Algorithms for differentiating between images of heterogeneous tissue across fluorescence microscopes.

scientific article published on 12 August 2016

An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis

scientific article published on 21 November 2012

An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control

scientific article published on 16 December 2009

An extra copy of p53 suppresses development of spontaneous Kras-driven but not radiation-induced cancer

scientific article

An intravital window to image the colon in real time

scientific article published on 11 December 2019

Analysis of perioperative radiation therapy in the surgical treatment of primary and recurrent retroperitoneal sarcoma

scientific article published on 4 August 2015

Animal models of soft-tissue sarcoma.

scientific article

Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation

scientific article published on March 2014

Assessing the radiation response of lung cancer with different gene mutations using genetically engineered mice.

scientific article published on 2 April 2013

Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium

scientific article

Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice.

scientific article published on 26 July 2018

Characterizing the potency and impact of carbon ion therapy in a primary mouse model of soft tissue sarcoma.

scientific article published on 7 February 2018

Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage

scientific article published on 21 August 2013

Commissioning a small-field biological irradiator using point, 2D, and 3D dosimetry techniques

scientific article published on December 2011

Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent

scientific article (publication date: 2012)

Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation.

scientific article published on 28 February 2018

Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma

scientific article

Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model

scientific article

Deletion of ATM in tumor but not endothelial cells improves radiation response in a primary mouse model of lung adenocarcinoma

scientific article published on 12 October 2018

Dicer1 functions as a haploinsufficient tumor suppressor

scientific article

Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer

scientific article published on 01 December 2020

Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells.

scientific article published on 14 November 2013

Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy.

scientific article published on 12 February 2018

Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study

scientific article

Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas

scientific article published on November 2012

Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo

scholarly article

Efficacy and safety of low dose iodine plaque brachytherapy for juxtapapillary choroidal melanoma

scientific article published on 30 November 2017

Efficacy of phosphatidylinositol-3 kinase inhibitors in a primary mouse model of undifferentiated pleomorphic sarcoma

scientific article

Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma

scientific article published on July 2009

Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting

scientific article

Epidermal growth factor regulates hematopoietic regeneration after radiation injury

scientific article published on 3 February 2013

Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.

scientific article

Establishing the Impact of Vascular Damage on Tumor Response to High-Dose Radiation Therapy

scientific article published on 19 August 2019

Externally applied high-dose-rate brachytherapy for deeply invasive cutaneous squamous cell carcinoma in an older patient.

scientific article published on 17 November 2015

Future of early detection of lung cancer: the role of mouse models

scientific article

GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy

scientific article published on 22 March 2021

Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma

scientific article

Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice

scientific article published on 22 December 2011

Genetically engineered mouse models for studying radiation biology

scientific article published on 01 July 2017

Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D

scientific article published on 20 November 2019

Genomic status of MET potentiates sensitivity to MET and MEK inhibition in NF1-related malignant peripheral nerve sheath tumors.

scientific article published on 2 May 2018

HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.

scientific article published on 14 May 2015

Hypoxia-dependent modification of collagen networks promotes sarcoma metastasis.

scientific article published on August 2013

Imaging primary lung cancers in mice to study radiation biology.

scientific article

Imaging primary mouse sarcomas after radiation therapy using cathepsin-activatable fluorescent imaging agents

scientific article published on 04 February 2013

In Reply to O'Sullivan et al.

scientific article published in October 2012

In vivo characterization of tumor vasculature using iodine and gold nanoparticles and dual energy micro-CT.

scientific article published on 19 February 2013

Inhibiting Glycogen Synthase Kinase-3 Mitigates the Hematopoietic Acute Radiation Syndrome in a Sex- and Strain- Dependent Manner in Mice

scientific article published on 14 March 2020

Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice

scientific article

Inhibition of vascular endothelial growth factor A and hypoxia-inducible factor 1α maximizes the effects of radiation in sarcoma mouse models through destruction of tumor vasculature

scientific article

Injury promotes sarcoma development in a genetically and temporally restricted manner

scientific article published on 18 October 2018

Insights into pediatric rhabdomyosarcoma research: Challenges and goals

scientific article published on 21 June 2019

Intraoperative detection and removal of microscopic residual sarcoma using wide-field imaging

scientific article

Intravital imaging of mouse embryos

scientific article published on 01 April 2020

Investigating a chimeric anti-mouse PDGFRα antibody as a radiosensitizer in primary mouse sarcomas

Long-term Oncologic Outcomes After Neoadjuvant Radiation Therapy for Retroperitoneal Sarcomas

scientific article

Loss of MST/Hippo Signaling in a Genetically Engineered Mouse Model of Fusion-Positive Rhabdomyosarcoma Accelerates Tumorigenesis

scientific article published on 09 August 2018

Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?

scientific article published on 12 October 2020

Margin reduction from image guided radiation therapy for soft tissue sarcoma: Secondary analysis of Radiation Therapy Oncology Group 0630 results

scientific article published on 17 November 2015

Methods to generate genetically engineered mouse models of soft tissue sarcoma.

scientific article published on January 2015

Mice Lacking RIP3 Kinase are not Protected from Acute Radiation Syndrome.

scientific article published on 10 April 2018

MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma

scientific article published on 4 June 2015

MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma

scientific article published on 01 September 2015

MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes

scientific article published on 01 April 2016

MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.

scientific article

Mutational landscape in genetically engineered, carcinogen-induced, and radiation-induced mouse sarcoma

scientific article published on 11 July 2019

NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition.

scientific article published on 15 July 2013

NF1+/- Hematopoietic Cells Accelerate Malignant Peripheral Nerve Sheath Tumor Development without Altering Chemotherapy Response.

scientific article published on 23 June 2017

Neutrophils promote tumor resistance to radiation therapy

scientific article published on 28 August 2019

Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting

scientific article published on 29 May 2018

Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma

scientific article published on 20 November 2012

Oncogenic NRAS, required for pathogenesis of embryonic rhabdomyosarcoma, relies upon the HMGA2-IGF2BP2 pathway

scientific article published on 27 March 2013

Opportunities for Radiosensitization in the Stereotactic Body Radiation Therapy (SBRT) Era

scientific article published on July 2016

Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma

scientific article

PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma

scientific article (publication date: 2013)

Pathologic complete response of a malignant peripheral nerve sheath tumor in the lung treated with neoadjuvant Ifosfamide and radiation therapy

scientific article published on 06 August 2012

Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas

scientific article

Practical radiation oncology for extremity sarcomas

scientific article published on 13 March 2013

Practice Patterns for the Treatment of Uveal Melanoma with Iodine-125 Plaque Brachytherapy: Ocular Oncology Study Consortium Report 5

scientific article published on 11 December 2019

Preoperative or postoperative radiotherapy versus surgery alone for retroperitoneal sarcoma: a case-control, propensity score-matched analysis of a nationwide clinical oncology database

scientific article

Preoperative radiotherapy for retroperitoneal sarcoma

scientific article published on 01 January 2021

Primary tumor genotype is an important determinant in identification of lung cancer propagating cells

scientific article

Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas

scientific article

Quantitative Segmentation of Fluorescence Microscopy Images of Heterogeneous Tissue: Application to the Detection of Residual Disease in Tumor Margins

scientific article

RAS and ROS in rhabdomyosarcoma

scientific article published on December 2013

RTOG sarcoma radiation oncologists reach consensus on gross tumor volume and clinical target volume on computed tomographic images for preoperative radiotherapy of primary soft tissue sarcoma of extremity in Radiation Therapy Oncology Group studies

scientific article

Radiation Therapy for Soft Tissue Sarcoma: Indications and Controversies for Neoadjuvant Therapy, Adjuvant Therapy, Intraoperative Radiation Therapy, and Brachytherapy

scientific article

Radiation therapy for control of soft-tissue sarcomas resected with positive margins

scientific article published on April 2007

Rationale and emerging strategies for immune checkpoint blockade in soft tissue sarcoma.

scientific article published on 3 May 2018

Reining in radiation injury: HIF2α in the gut

scientific article published on 01 May 2014

Rescuing dicer defects via inhibition of an anti-dicing nuclease.

scientific article

Response to Central Boost Radiation Therapy in an Unresectable Retroperitoneal Sarcoma: A Case Report

scientific article published on 06 June 2020

Restoration of p53 function leads to tumour regression in vivo

scientific article (publication date: 8 February 2007)

Retraction: The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis

scientific article published on December 2016

Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study

scientific article published on 13 October 2019

Role of p53 in regulating tissue response to radiation by mechanisms independent of apoptosis

scientific article published on October 2013

Sensitization of Vascular Endothelial Cells to Ionizing Radiation Promotes the Development of Delayed Intestinal Injury in Mice

scientific article published on 02 July 2019

Significant Reduction of Late Toxicities in Patients With Extremity Sarcoma Treated With Image-Guided Radiation Therapy to a Reduced Target Volume: Results of Radiation Therapy Oncology Group RTOG-0630 Trial

scientific article published on 9 February 2015

Single cell analysis reveals distinct immune landscapes in transplant and primary sarcomas that determine response or resistance to immunotherapy

scientific article published on 17 December 2020

Spectrotemporal CT data acquisition and reconstruction at low dose

scientific article

Structured Illumination Microscopy and a Quantitative Image Analysis for the Detection of Positive Margins in a Pre-Clinical Genetically Engineered Mouse Model of Sarcoma

scientific article published on 22 January 2016

Survival after brain metastases from breast cancer in the trastuzumab era.

scientific article published in March 2005

Tailoring Adjuvant Radiation Therapy by Intraoperative Imaging to Detect Residual Cancer

scientific article published on 14 May 2015

The Fusion Oncogene FUS-CHOP Drives Sarcomagenesis of High-Grade Spindle Cell Sarcomas in Mice

scientific article published on 25 July 2019

The Role of Radiotherapy for Chordoma Patients Managed with Surgery: Analysis of the National Cancer Database

scientific article published on 06 February 2020

The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review

scientific article published on 7 May 2015

The clinical management of chondrosarcoma

scientific article published on 24 February 2009

The effect of neoadjuvant radiation therapy on perioperative outcomes among patients undergoing resection of retroperitoneal sarcomas

scientific article

The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis

retracted scientific article

The long non-coding RNA NEAT1 promotes sarcoma metastasis by regulating RNA splicing pathways

scientific article published on 19 June 2020

The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival

scientific article published on 04 June 2015

Tie2(+) bone marrow endothelial cells regulate hematopoietic stem cell regeneration following radiation injury

scientific article published on February 2013

Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis

scientific article published on 01 September 2019

Treatment Guidelines for Preoperative Radiation Therapy for Retroperitoneal Sarcoma: Preliminary Consensus of an International Expert Panel

scientific article published on July 2015

Treatment and outcome of 82 patients with angiosarcoma

scientific article published on 14 March 2007

Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy

scientific article

Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models

scientific article published on 29 September 2020

Tumor subtype determines therapeutic response to chimeric polypeptide nanoparticle-based chemotherapy in Pten-deleted mouse models of sarcoma

scientific article published on 27 July 2020

Use of gene expression profiling to direct in vivo molecular imaging of lung cancer

scientific article

Uveal melanoma treated with iodine-125 episcleral plaque: an analysis of dose on disease control and visual outcomes

scientific article published on 07 March 2014

Variation in the gross tumor volume and clinical target volume for preoperative radiotherapy of primary large high-grade soft tissue sarcoma of the extremity among RTOG sarcoma radiation oncologists.

scientific article

X-Ray Psoralen Activated Cancer Therapy (X-PACT)

scientific article

p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome.

scientific article

p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis

scientific article

p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice

scientific article

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