List of works - John Schwabe

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

scientific article

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements

scientific article

Mechanism of corepressor binding and release from nuclear hormone receptors.

scientific article

Structural basis for the activation of PPARgamma by oxidized fatty acids

scientific article

STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells

scientific article

Solution structure of the DNA-binding domain of the oestrogen receptor

scientific article

Zinc mining for protein domains

scientific article published on June 1, 1994

A mutation in the thyroid hormone receptor alpha gene

scientific article published on 14 December 2011

Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb

scientific article

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

scientific article published on 15 November 2010

St John's wort, a herbal antidepressant, activates the steroid X receptor.

scientific article

International Union of Pharmacology. LXVI. Orphan nuclear receptors

scientific article

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling

scientific article

Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance

scientific article published on October 2006

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

scientific article

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

scientific article published on 16 January 2011

A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease

scientific article

Nuclear hormone receptor co-repressors: structure and function.

scientific article published on 08 September 2011

The role of water in protein-DNA interactions

scientific article published on 01 February 1997

Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors.

scientific article

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

scientific article published on 23 June 2014

The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation

scientific article

DNA recognition by the oestrogen receptor: from solution to the crystal

scientific article published in November 1993

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

scientific article

Coexpression of nuclear receptor partners increases their solubility and biological activities.

scientific article

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

scientific article published on 4 January 2018

Targeting Class I Histone Deacetylases in a "Complex" Environment

scientific article published on 27 January 2017

An evolving understanding of nuclear receptor coregulator proteins.

scientific article

NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1

scientific article published on 24 February 2012

BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis

scientific article published on 10 October 2013

The structure of the core NuRD repression complex provides insights into its interaction with chromatin.

scientific article published on 21 April 2016

Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy. A zinc-finger structure with a third strand of beta-sheet

scientific article published on November 20, 1992

Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.

scientific article

Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.

scientific article published on 4 December 2003

Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6)

scientific article published on 04 September 2013

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

scientific article published on 13 September 2018

Limbs are moving: where are they going?

scientific article published in June 1998

Towards an understanding of the structure and function of MTA1

scientific article

Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting

scientific article

Mutations in TBL1X Are Associated With Central Hypothyroidism.

scientific article published on 07 September 2016

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

scientific article

Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth

scientific article published on October 1, 1998

Recombinant protein expression for structural biology in HEK 293F suspension cells: a novel and accessible approach.

scientific article published on 16 October 2014

Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains

scientific article published in April 2006

A specific mutation in TBL1XR1 causes Pierpont syndrome.

scientific article

Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex

scientific article published on 8 June 2015

Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor.

scientific article published on 12 August 2003

Linkers made to measure

scientific article published on 01 September 1997

Transient expression in HEK 293 cells: an alternative to E. coli for the production of secreted and intracellular mammalian proteins.

scientific article

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins

scientific article published on 4 May 2017

List of works by John Schwabe

Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements

Mechanism of corepressor binding and release from nuclear hormone receptors.

Structural basis for the activation of PPARgamma by oxidized fatty acids

STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells

Solution structure of the DNA-binding domain of the oestrogen receptor

Zinc mining for protein domains

A mutation in the thyroid hormone receptor alpha gene

Radical fringe positions the apical ectodermal ridge at the dorsoventral boundary of the vertebrate limb

Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

St John's wort, a herbal antidepressant, activates the steroid X receptor.

International Union of Pharmacology. LXVI. Orphan nuclear receptors

A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling

Non-DNA binding, dominant-negative, human PPARgamma mutations cause lipodystrophic insulin resistance

Co-operative and Hierarchical Binding of c-FLIP and Caspase-8: A Unified Model Defines How c-FLIP Isoforms Differentially Control Cell Fate

Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery

A dynamic mechanism of nuclear receptor activation and its perturbation in a human disease

Nuclear hormone receptor co-repressors: structure and function.

The role of water in protein-DNA interactions

Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors.

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

The oestrogen receptor recognizes an imperfectly palindromic response element through an alternative side-chain conformation

DNA recognition by the oestrogen receptor: from solution to the crystal

Insights into the activation mechanism of class I HDAC complexes by inositol phosphates

Coexpression of nuclear receptor partners increases their solubility and biological activities.

Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors

Targeting Class I Histone Deacetylases in a "Complex" Environment

An evolving understanding of nuclear receptor coregulator proteins.

NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1

BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis

The structure of the core NuRD repression complex provides insights into its interaction with chromatin.

Solution structures of two zinc-finger domains from SWI5 obtained using two-dimensional 1H nuclear magnetic resonance spectroscopy. A zinc-finger structure with a third strand of beta-sheet

Identification of a novel co-regulator interaction surface on the ligand binding domain of Nurr1 using NMR footprinting.

Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor gamma.

Mzt1/Tam4, a fission yeast MOZART1 homologue, is an essential component of the γ-tubulin complex and directly interacts with GCP3(Alp6)

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

Limbs are moving: where are they going?

Towards an understanding of the structure and function of MTA1

Structural and functional characterization of a cell cycle associated HDAC1/2 complex reveals the structural basis for complex assembly and nucleosome targeting

Mutations in TBL1X Are Associated With Central Hypothyroidism.

Disruption of the Class IIa HDAC Corepressor Complex Increases Energy Expenditure and Lipid Oxidation

Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth

Recombinant protein expression for structural biology in HEK 293F suspension cells: a novel and accessible approach.

Human androgen receptor gene ligand-binding-domain mutations leading to disrupted interaction between the N- and C-terminal domains

A specific mutation in TBL1XR1 causes Pierpont syndrome.

Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT/NCoR Transcriptional Repression Complex

Molecular determinants of the balance between co-repressor and co-activator recruitment to the retinoic acid receptor.

Linkers made to measure

Transient expression in HEK 293 cells: an alternative to E. coli for the production of secreted and intracellular mammalian proteins.

Contrasting Phenotypes in Resistance to Thyroid Hormone Alpha Correlate with Divergent Properties of Thyroid Hormone Receptor α1 Mutant Proteins