List of works - John Farrell

Abs No: HLA-A*31:01 positive hypersensitive patient

scientific article

Activation of T cells by carbamazepine and carbamazepine metabolites

scientific article

Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base

scientific article published on 4 October 2007

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives

scientific article

Activation of human dendritic cells by p-phenylenediamine.

scientific article published on 15 November 2006

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury.

scientific article published on 23 July 2015

Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis.

scientific article

Characterization of drug-specific T cells in lamotrigine hypersensitivity

scientific article published on June 2003

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury

article

Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans

scientific article published on 3 April 2003

Characterization of the T-cell response in a patient with phenindione hypersensitivity

scientific article (publication date: June 2005)

Characterization of the TCR V repertoire of piperacillin-specific T-cells.

scientific article

Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis

scientific article

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

scientific article published in September 2002

Cutaneous immunopathology of long-standing complex regional pain syndrome

scientific article

Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients

scientific article

Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism.

scientific article

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis

scientific article published on 26 February 2011

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.

scientific article published on 22 February 2007

HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient

article by Maike Lichtenfels et al published 31 January 2014 in Chemical Research in Toxicology

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury.

scientific article

IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers ⬇️

scientific article published on September 12, 2012

Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse

scientific article published on 24 December 2008

Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals

scientific article published in January 2010

Metabolic and chemical origins of cross-reactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives.

scientific article published in January 2010

Partial mitigation of gold nanoparticle interactions with human lymphocytes by surface functionalization with a ‘mixed matrix’

article by Neill J Liptrott et al published November 2014 in Nanomedicine

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

scientific article

Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan.

scientific article

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms

scientific article published on 12 April 2013

The Generation, Detection, and Effects of Reactive Drug Metabolites ⬇️

scientific article published on October 22, 2012

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation

scientific article published on 13 September 2015

Trimethoprim stimulates T-cells through metabolism-dependent and -independent pathways

scientific article published on 3 May 2011

β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis

scientific article published on 23 May 2013

List of works by John Farrell

Abs No: HLA-A*31:01 positive hypersensitive patient

Activation of T cells by carbamazepine and carbamazepine metabolites

Activation of T-cells from allergic patients and volunteers by p-phenylenediamine and Bandrowski's base

Activation of carbamazepine-responsive T-cell clones with metabolically inert halogenated derivatives

Activation of human dendritic cells by p-phenylenediamine.

Characterization of amoxicillin- and clavulanic acid-specific T cells in patients with amoxicillin-clavulanate-induced liver injury.

Characterization of anti-drug antibodies and drug-responsive B-lymphocytes in piperacillin hypersensitive patients with cystic fibrosis.

Characterization of drug-specific T cells in lamotrigine hypersensitivity

Characterization of drug-specific lymphocyte responses in a patient with drug-induced liver injury

Characterization of sulfamethoxazole and sulfamethoxazole metabolite-specific T-cell responses in animals and humans

Characterization of the T-cell response in a patient with phenindione hypersensitivity

Characterization of the TCR V repertoire of piperacillin-specific T-cells.

Characterization of the antigen specificity of T-cell clones from piperacillin-hypersensitive patients with cystic fibrosis

Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation

Cutaneous immunopathology of long-standing complex regional pain syndrome

Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients

Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism.

Enhanced antigenicity leads to altered immunogenicity in sulfamethoxazole-hypersensitive patients with cystic fibrosis

Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity.

HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient

Human leukocyte antigen (HLA)-B*57:01-restricted activation of drug-specific T cells provides the immunological basis for flucloxacillin-induced liver injury.

IL-8 Release from Human Neutrophils Cultured with Pro-Haptenic Chemical Sensitizers ⬇️

Investigation of the immunogenicity of p-phenylenediamine and Bandrowski's base in the mouse

Measurement of CD4+ and CD8+ T-lymphocyte cytokine secretion and gene expression changes in p-phenylenediamine allergic patients and tolerant individuals

Metabolic and chemical origins of cross-reactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives.

Partial mitigation of gold nanoparticle interactions with human lymphocytes by surface functionalization with a ‘mixed matrix’

Sulfamethoxazole and its metabolite nitroso sulfamethoxazole stimulate dendritic cell costimulatory signaling

Systemic illness with skin eruption, fever and positive lymphocyte transformation test in a patient on irbesartan.

T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms

The Generation, Detection, and Effects of Reactive Drug Metabolites ⬇️

Towards depersonalized abacavir therapy: chemical modification eliminates HLA-B*57 : 01-restricted CD8+ T-cell activation

Trimethoprim stimulates T-cells through metabolism-dependent and -independent pathways

β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis