List of works - Timothy D Warner

4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor

scientific article published on 06 September 2010

96-well plate-based aggregometry.

scientific article

A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect

scientific article published on 16 December 2020

Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis

scientific article published on 26 October 2006

Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth.

scientific article published on November 2005

Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy

Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy

scientific article

Antiplatelet actions of statins and fibrates are mediated by PPARs

scientific article published on 15 January 2009

Antiplatelet effects of aspirin vary with level of P2Y₁₂ receptor blockade supplied by either ticagrelor or prasugrel.

scientific article published in October 2011

Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2.

scientific article published on 11 January 2008

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2

scholarly article by Serena Lucotti et al published 25 March 2019 in Journal of Clinical Investigation

Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

scientific article published on 15 September 2016

Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test

scientific article published on 21 June 2013

Association of MicroRNAs and YRNAs With Platelet Function

scientific article published on 08 December 2015

Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide

scientific article published on 03 September 2013

COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs

scientific article

COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma

scientific article published on 27 August 2008

COX-2 in cardiovascular disease

scientific article published on 01 May 2006

COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks

scientific article

COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs

scientific article published on January 2008

Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox

scientific article published on 12 September 2019

Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.

scientific article published on 10 February 2005

Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay

scientific article published on 09 January 2014

Circulating microRNAs as novel biomarkers for platelet activation.

scientific article

Clopidogrel withdrawal: is there a "rebound" phenomenon?

scientific article published on 23 November 2010

Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy

scientific article published on 11 April 2020

Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α

scientific article

Cyclo-oxygenase-2 inhibitors and cardiovascular events

scientific article published on 01 November 2002

Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

scientific article

Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension

scientific article published in November 2002

Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?

scientific article

Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues

scientific article

Cyclooxygenases and the cardiovascular system

scientific article published on 05 July 2020

Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic

scientific article published on May 2004

Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies

scientific article published on 11 July 2013

Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy.

scientific article

Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists?

scientific article published on November 2010

Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study

scientific article published on 27 July 2011

Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery.

scientific article published in April 2002

Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation

scientific article

Effects of low-dose aspirin on acute inflammatory responses in humans.

scientific article

Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.

scientific article

Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond)

scientific article published on 19 April 2018

Endogenous epoxygenases are modulators of monocyte/macrophage activity

scientific article

Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis

scientific article published in September 2002

Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers

scientific article published in August 2012

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs

scientific article published on 9 December 2014

Expression and activation of the farnesoid X receptor in the vasculature

scholarly article

Expression of the PlA2 allele of glycoprotein IIIa and its impact on platelet function.

scientific article published on January 2015

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets

scientific article published on 15 June 2017

Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

scientific article published on December 2007

Gases help fuel the vascular debate

scientific article published in January 2008

Gasotransmitters and platelets

scientific article published on 07 July 2011

HIF, stretching to get control of VEGF

scientific article published on 01 October 2003

Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods.

scientific article

High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition

scientific article published on 15 February 2013

Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage

scientific article published on 12 August 2019

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

scientific article

Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia

scientific article published on 09 September 2013

Hypoxia Modulates Platelet Purinergic Signalling Pathways

scientific article published on 13 December 2019

Identification and characterization of a dysfunctional cardiac myocyte phenotype: role of bacteria, Toll-like receptors, and endothelin.

scientific article published in October 2007

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

scientific article published on 16 April 2020

In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation ⬇️

scientific article published on March 1, 2011

Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma.

scientific article published in March 2006

Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2

scientific article (publication date: March 2006)

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

scientific article

Inhibition of profibrotic microRNA-21 affects platelets and their releasate

scientific article published on 02 November 2018

Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27.

scientific article

Interleukin-1beta, but not interleukin-6, enhances renal and systemic endothelin production in vivo

scientific article published on 4 June 2008

Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy

scientific article published on August 2002

Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

scientific article published on 3 January 2018

LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression

scientific article

Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment"

scientific article published on 01 May 2018

Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients

scientific article published on 01 June 2020

Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis

scientific article published in November 2002

Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity

scientific article published on 23 November 2021

Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies.

scientific article

Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets

scientific article (publication date: May 2007)

Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: as easy as ABC?

scientific article

Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry

article

Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction

scientific article

Nucleotide oligomerization domain 1 is a dominant pathway for NOS2 induction in vascular smooth muscle cells: comparison with Toll-like receptor 4 responses in macrophages.

scientific article

Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing

scientific article published on 02 August 2011

Origins of prostaglandin E2: involvements of cyclooxygenase (COX)-1 and COX-2 in human and rat systems

scientific article (publication date: December 2002)

P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation

scientific article

PPARgamma ligands induce prostaglandin production in vascular smooth muscle cells: indomethacin acts as a peroxisome proliferator-activated receptor-gamma antagonist

scientific article published in August 2003

PPARβ/δ Agonists Modulate Platelet Function via a Mechanism Involving PPAR Receptors and Specific Association/Repression of PKCα–Brief Report

scientific article published on 20 August 2009

Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age

scientific article published on 27 April 2020

Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties.

scientific article published on 15 May 2017

Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels.

scientific article published on 3 January 2018

Pregnane X receptor regulates drug metabolism and transport in the vasculature and protects from oxidative stress

scientific article published on 13 December 2011

Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin

scientific article published on 27 June 2020

Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography

scientific article published on 03 March 2015

Prostaglandins and the regulation of tumor growth.

scientific article

Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: monitoring the nasal and systemic immune response using a network biology approach

scientific article

Rapid and accurate method for the von Willebrand factor ristocetin cofactor assay using 96-well microtiter plates.

scientific article published on 30 April 2009

Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy.

scientific article published on 3 December 2009

Reply to Ricciotti et al.: Evidence for vascular COX isoforms

scientific article published on January 2013

Reply to letter regarding article, "evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs"

scientific article published on 01 October 2015

Role for Nuclear Factor-κB and Signal Transducer and Activator of Transcription 1/Interferon Regulatory Factor-1 in Cytokine-Induced Endothelin-1 Release in Human Vascular Smooth Muscle Cells ⬇️

scientific article published on October 1, 2003

Role of Shear Stress in Endothelial Cell Morphology and Expression of Cyclooxygenase Isoforms

scientific article published on 02 December 2010

Role of Toll-like receptors 2 and 4 in the induction of cyclooxygenase-2 in vascular smooth muscle

scientific article

Role of nuclear receptor signaling in platelets: antithrombotic effects of PPARbeta

scientific article published on 20 December 2005

Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts

scientific article published on 20 October 2005

Short thromboelastography and the identification of high platelet reactivity while on and off therapy

scientific article published on 01 May 2012

Smoking, atherothrombosis and clopidogrel

scientific article published on 01 July 2012

Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings ⬇️

scientific article published on 02 August 2011

Stronger inhibition by nonsteroid anti-inflammatory drugs of cyclooxygenase-1 in endothelial cells than platelets offers an explanation for increased risk of thrombotic events

scientific article published on 01 December 2006

The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo

scientific article

The farnesoid X receptor is expressed in breast cancer and regulates apoptosis and aromatase expression

scientific article published on October 2006

The flavonoid quercetin induces apoptosis and inhibits JNK activation in intimal vascular smooth muscle cells

scientific article published on 9 June 2006

The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy

scientific article published in March 2016

Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse

scientific article

Trapping of palindromic ligands within native transthyretin prevents amyloid formation

scientific article

Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness

scientific article published in October 2009

List of works by Timothy D Warner

4-Methylnitrosamino-1-3-pyridyl-1-butanone (NNK) promotes lung cancer cell survival by stimulating thromboxane A2 and its receptor

96-well plate-based aggregometry.

A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect

Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis

Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth.

Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy

Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy

Antiplatelet actions of statins and fibrates are mediated by PPARs

Antiplatelet effects of aspirin vary with level of P2Y₁₂ receptor blockade supplied by either ticagrelor or prasugrel.

Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2.

Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2

Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1.

Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test

Association of MicroRNAs and YRNAs With Platelet Function

Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide

COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs

COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma

COX-2 in cardiovascular disease

COX-2 protects against atherosclerosis independently of local vascular prostacyclin: identification of COX-2 associated pathways implicate Rgl1 and lymphocyte networks

COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs

Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox

Cellular mechanisms of acetaminophen: role of cyclo-oxygenase.

Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay

Circulating microRNAs as novel biomarkers for platelet activation.

Clopidogrel withdrawal: is there a "rebound" phenomenon?

Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy

Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α

Cyclo-oxygenase-2 inhibitors and cardiovascular events

Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system

Cyclooxygenase-2 acts as an endogenous brake on endothelin-1 release by human pulmonary artery smooth muscle cells: implications for pulmonary hypertension

Cyclooxygenase-3 (COX-3): filling in the gaps toward a COX continuum?

Cyclooxygenases 1, 2, and 3 and the production of prostaglandin I2: investigating the activities of acetaminophen and cyclooxygenase-2-selective inhibitors in rat tissues

Cyclooxygenases and the cardiovascular system

Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic

Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies

Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy.

Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists?

Effect of clopidogrel withdrawal on platelet reactivity and vascular inflammatory biomarkers 1 year after drug-eluting stent implantation: results of the prospective, single-centre CESSATION study

Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery.

Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation

Effects of low-dose aspirin on acute inflammatory responses in humans.

Effects of non-steroidal anti-inflammatory drugs on cyclo-oxygenase and lipoxygenase activity in whole blood from aspirin-sensitive asthmatics vs healthy donors.

Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond)

Endogenous epoxygenases are modulators of monocyte/macrophage activity

Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis

Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers

Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs

Expression and activation of the farnesoid X receptor in the vasculature

Expression of the PlA2 allele of glycoprotein IIIa and its impact on platelet function.

Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets

Farnesoid x receptor ligands inhibit vascular smooth muscle cell inflammation and migration

Gases help fuel the vascular debate

Gasotransmitters and platelets

HIF, stretching to get control of VEGF

Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods.

High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition

Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage

Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid

Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia

Hypoxia Modulates Platelet Purinergic Signalling Pathways

Identification and characterization of a dysfunctional cardiac myocyte phenotype: role of bacteria, Toll-like receptors, and endothelin.

Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function

In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation ⬇️

Increased thromboxane B(2) levels are associated with lipid peroxidation and Bcl-2 expression in human lung carcinoma.

Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2

Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation.

Inhibition of profibrotic microRNA-21 affects platelets and their releasate

Inhibition of thromboxane synthase induces lung cancer cell death via increasing the nuclear p27.

Interleukin-1beta, but not interleukin-6, enhances renal and systemic endothelin production in vivo

Intimal smooth muscle cells as a target for peroxisome proliferator-activated receptor-gamma ligand therapy

Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M.

LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression

Letter by Mitchell et al Regarding Article, "Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment"

Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients

Modulation by colony stimulating factors of human epithelial colon cancer cell apoptosis

Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity

Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies.

Nongenomic signaling of the retinoid X receptor through binding and inhibiting Gq in human platelets

Nonsteroidal antiinflammatory drugs inhibiting prostanoid efflux: as easy as ABC?