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List of works by Darren R. Tyson

A Predictive Mathematical Modeling Approach for the Study of Doxorubicin Treatment in Triple Negative Breast Cancer

scientific article

A drift-diffusion checkpoint model predicts a highly variable and growth-factor-sensitive portion of the cell cycle G1 phase.

scientific article published on 12 February 2018

Abstract 302: ECM/Integrin signaling promotes resistance to the combination of HER2 and PI3K inhibitors in HER2+, PIK3CA-mutant breast cancer

Altered TGF-α/β signaling drives cooperation between breast cancer cell populations.

scientific article published on 6 July 2016

An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability

scientific article published on 01 June 2021

An unbiased metric of antiproliferative drug effect in vitro

scientific article

Annexin A2 positively contributes to the malignant phenotype and secretion of IL-6 in DU145 prostate cancer cells.

scientific article published on January 2009

Beyond genetics in personalized cancer treatment: assessing dynamics and heterogeneity of tumor responses.

scientific article published on May 2013

Bone marrow stem cells for urologic tissue engineering

scientific article published on 25 July 2008

Composite thin film and electrospun biomaterials for urologic tissue reconstruction

scientific article published in January 2011

Culture requirements of prostatic epithelial cell lines for acinar morphogenesis and lumen formation in vitro: role of extracellular calcium.

scientific article published on November 2007

Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition.

scientific article published on 16 February 2017

Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer

scientific article published on 10 April 2017

Fractional proliferation: a method to deconvolve cell population dynamics from single-cell data

scientific article

Human embryonic kidney cells (HEK-293 cells): characterization and dose-response relationship for modulated release of nerve growth factor for nerve regeneration.

scientific article published on February 2004

Increased osteoblastic c-fos expression by parathyroid hormone requires protein kinase A phosphorylation of the cyclic adenosine 3',5'-monophosphate response element-binding protein at serine 133.

scientific article published on March 1999

Induction of transcriptional activity of the cyclic adenosine monophosphate response element binding protein by parathyroid hormone and epidermal growth factor in osteoblastic cells.

scientific article published on August 2002

Inhibition of phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model.

scientific article

Long-term impact of a robot assisted laparoscopic prostatectomy mini fellowship training program on postgraduate urological practice patterns

scientific article

Loss of annexin A1 disrupts normal prostate glandular structure by inducing autocrine IL-6 signaling.

scientific article published on 07 April 2009

Network Analysis of the Focal Adhesion to Invadopodia Transition Identifies a PI3K-PKCα Invasive Signaling Axis ⬇️

scientific article published on September 11, 2012

Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness

scientific article published on 15 August 2009

Proteomics for the identification of new prostate cancer biomarkers

scientific article

Proteomics of cancer of hormone-dependent tissues.

scientific article published on January 2008

Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation

scientific article

Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies

scientific article

Role of GATA motifs in tissue factor pathway inhibitor gene expression in malignant cells.

scientific article published on February 2001

Systems-level network modeling of Small Cell Lung Cancer subtypes identifies master regulators and destabilizers

scientific article published on 31 October 2019

The contribution of age structure to cell population responses to targeted therapeutics.

scientific article published on 11 July 2012

The impact of altered annexin I protein levels on apoptosis and signal transduction pathways in prostate cancer cells.

scientific article published on September 2006

Trait variability of cancer cells quantified by high-content automated microscopy of single cells.

scientific article

Utilizing Three-Dimensional Culture Methods to Improve High-Throughput Drug Screening in Anaplastic Thyroid Carcinoma

scientific article published on 07 April 2022

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