List of works - Marcus Groettrup

A cytomegalovirus inhibitor of gamma interferon signaling controls immunoproteasome induction

scientific article published on February 2004

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

scientific article

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

scientific article

Activating the ubiquitin family: UBA6 challenges the field

scientific article

Advances in prostate cancer immunotherapies

scientific article published on January 2007

An altered T cell repertoire in MECL-1-deficient mice

scientific article published on June 2006

An artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinoma

scientific article published on 15 November 2011

Analgesia in mice with experimental meningitis reduces pain without altering immune parameters

scientific article published on 24 March 2015

Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells

scientific article

Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress

scientific article published on 23 October 2010

CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2 ⬇️

scientific article published on October 30, 2003

Chaperone BAG6 is dispensable for MHC class I antigen processing and presentation

scientific article published on 17 November 2015

Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma

scientific article published on 27 April 2017

Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice

scientific article

Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation

scientific article

Cross-presentation of the long-lived lymphocytic choriomeningitis virus nucleoprotein does not require neosynthesis and is enhanced via heat shock proteins

scientific article published on July 2005

Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease.

scientific article

Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L.

scientific article published on 21 January 2009

Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro

scientific article

Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells

scientific article published on 25 October 2005

Endosomal trafficking of open Major Histocompatibility Class I conformers--implications for presentation of endocytosed antigens

scientific article

FAT10, a ubiquitin-independent signal for proteasomal degradation

scientific article

FAT10ylation as a signal for proteasomal degradation

scientific article published on 18 January 2013

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity

scientific article

Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation

scientific article published on 14 September 2012

Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

scientific article published on 11 November 2010

Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus

scientific journal article

Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice

scientific article published on 7 February 2017

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

scientific article published on 16 January 2014

Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1

scientific article

Long-lived signal peptide of lymphocytic choriomeningitis virus glycoprotein pGP-C.

scientific article

Microencapsulation of inorganic nanocrystals into PLGA microsphere vaccines enables their intracellular localization in dendritic cells by electron and fluorescence microscopy

scientific article

NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation

scientific article

NUB1 modulation of GSK3β reduces tau aggregation

scientific article published on 10 September 2012

No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes

scientific article published on April 2007

PLGA microspheres for improved antigen delivery to dendritic cells as cellular vaccines

scientific article

Phenotype and functional analysis of human monocyte-derived dendritic cells loaded with biodegradable poly(lactide-co-glycolide) microspheres for immunotherapy

scientific article

Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

scientific article

Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells

scientific article

Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit

scientific article published on 14 September 2012

Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells

scientific article

Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors

scientific article

Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice

scientific article published on 29 September 2010

Stable antigen is most effective for eliciting CD8+ T-cell responses after DNA vaccination and infection with recombinant vaccinia virus in vivo

scientific article

Subunit specific inhibitors of proteasomes and their potential for immunomodulation

scientific article

TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses

scientific article

The STEAP1(262-270) peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice--A new approach to immunotherapy against prostate carcinoma

scientific article

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10

scientific article

The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection

scientific article published on 23 September 2015

The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA.

scientific article published on 22 March 2010

The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD: evidence from a randomized controlled trial

scientific article published on 27 March 2014

The immunoproteasome in antigen processing and other immunological functions

scientific article

The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathway

scientific article

The non-peptidic HIV protease inhibitor tipranavir and two synthetic peptidomimetics (TS98 and TS102) modulate Pneumocystis carinii growth and proteasome activity of HEL299 cell line

scientific article published on January 2006

The preservation of phenotype and functionality of dendritic cells upon phagocytosis of polyelectrolyte-coated PLGA microparticles

scientific article

The proteasome inhibitor bortezomib enhances the susceptibility to viral infection

scientific article

The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice

scientific article published on 30 September 2014

The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense

scientific article published on 13 May 2015

The ubiquitin-like modifier FAT10 in cancer development

scientific article

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

scientific article

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells

scientific article published on 27 July 2015

The unique functions of tissue-specific proteasomes

scientific article

Tumor eradication by immunotherapy with biodegradable PLGA microspheres--an alternative to incomplete Freund's adjuvant

scientific article published on 28 March 2011

UBE1L2, a novel E1 enzyme specific for ubiquitin

scientific article

USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis ⬇️

scientific article published on May 4, 2010

Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration

scientific article

Using protease inhibitors in antigen presentation assays

scientific article published on January 2013

List of works by Marcus Groettrup

A cytomegalovirus inhibitor of gamma interferon signaling controls immunoproteasome induction

A novel cytosolic class I antigen-processing pathway for endoplasmic-reticulum-targeted proteins

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

Activating the ubiquitin family: UBA6 challenges the field

Advances in prostate cancer immunotherapies

An altered T cell repertoire in MECL-1-deficient mice

An artificial PAP gene breaks self-tolerance and promotes tumor regression in the TRAMP model for prostate carcinoma

Analgesia in mice with experimental meningitis reduces pain without altering immune parameters

Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells

Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress

CCL19/CCL21-triggered signal transduction and migration of dendritic cells requires prostaglandin E2 ⬇️

Chaperone BAG6 is dispensable for MHC class I antigen processing and presentation

Chronic stress suppresses anti-tumor TCD8+ responses and tumor regression following cancer immunotherapy in a mouse model of melanoma

Coencapsulation of tumor lysate and CpG-ODN in PLGA-microspheres enables successful immunotherapy of prostate carcinoma in TRAMP mice

Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation

Cross-presentation of the long-lived lymphocytic choriomeningitis virus nucleoprotein does not require neosynthesis and is enhanced via heat shock proteins

Cytotoxic T cell vaccination with PLGA microspheres interferes with influenza A virus replication in the lung and suppresses the infectious disease.

Degradation of FAT10 by the 26S proteasome is independent of ubiquitylation but relies on NUB1L.

Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro

Encapsulation of proteins and peptides into biodegradable poly(D,L-lactide-co-glycolide) microspheres prolongs and enhances antigen presentation by human dendritic cells

Endosomal trafficking of open Major Histocompatibility Class I conformers--implications for presentation of endocytosed antigens

FAT10, a ubiquitin-independent signal for proteasomal degradation

FAT10ylation as a signal for proteasomal degradation

Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity

Immunoproteasome subunit LMP7 deficiency and inhibition suppresses Th1 and Th17 but enhances regulatory T cell differentiation

Immunoproteasomes are essential for survival and expansion of T cells in virus-infected mice

Immunoproteasomes down-regulate presentation of a subdominant T cell epitope from lymphocytic choriomeningitis virus

Inhibition and deficiency of the immunoproteasome subunit LMP7 suppress the development and progression of colorectal carcinoma in mice

Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis

Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1

Long-lived signal peptide of lymphocytic choriomeningitis virus glycoprotein pGP-C.

Microencapsulation of inorganic nanocrystals into PLGA microsphere vaccines enables their intracellular localization in dendritic cells by electron and fluorescence microscopy

NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation

NUB1 modulation of GSK3β reduces tau aggregation

No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes

PLGA microspheres for improved antigen delivery to dendritic cells as cellular vaccines

Phenotype and functional analysis of human monocyte-derived dendritic cells loaded with biodegradable poly(lactide-co-glycolide) microspheres for immunotherapy

Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

Prostaglandin E(2) enhances T-cell proliferation by inducing the costimulatory molecules OX40L, CD70, and 4-1BBL on dendritic cells

Prostaglandin E2 inhibits IL-23 and IL-12 production by human monocytes through down-regulation of their common p40 subunit

Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells

Prostaglandin E2 is generally required for human dendritic cell migration and exerts its effect via EP2 and EP4 receptors

Reduced immunoproteasome formation and accumulation of immunoproteasomal precursors in the brains of lymphocytic choriomeningitis virus-infected mice

Stable antigen is most effective for eliciting CD8+ T-cell responses after DNA vaccination and infection with recombinant vaccinia virus in vivo

Subunit specific inhibitors of proteasomes and their potential for immunomodulation

TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses

The STEAP1(262-270) peptide encapsulated into PLGA microspheres elicits strong cytotoxic T cell immunity in HLA-A*0201 transgenic mice--A new approach to immunotherapy against prostate carcinoma

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10

The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection

The combination of TLR-9 adjuvantation and electroporation-mediated delivery enhances in vivo antitumor responses after vaccination with HPV-16 E7 encoding DNA.

The effect of trauma-focused therapy on the altered T cell distribution in individuals with PTSD: evidence from a randomized controlled trial

The immunoproteasome in antigen processing and other immunological functions

The inherited blindness protein AIPL1 regulates the ubiquitin-like FAT10 pathway

The non-peptidic HIV protease inhibitor tipranavir and two synthetic peptidomimetics (TS98 and TS102) modulate Pneumocystis carinii growth and proteasome activity of HEL299 cell line

The preservation of phenotype and functionality of dendritic cells upon phagocytosis of polyelectrolyte-coated PLGA microparticles

The proteasome inhibitor bortezomib enhances the susceptibility to viral infection

The ubiquitin-like modifier FAT10 decorates autophagy-targeted Salmonella and contributes to Salmonella resistance in mice

The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense

The ubiquitin-like modifier FAT10 in cancer development

The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition

The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells

The unique functions of tissue-specific proteasomes

Tumor eradication by immunotherapy with biodegradable PLGA microspheres--an alternative to incomplete Freund's adjuvant

UBE1L2, a novel E1 enzyme specific for ubiquitin

USE1 is a bispecific conjugating enzyme for ubiquitin and FAT10, which FAT10ylates itself in cis ⬇️

Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration

Using protease inhibitors in antigen presentation assays