List of works - Meritxell Canals

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation

scientific article published on 15 November 2011

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

scientific article published on 28 January 2021

Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

scientific article

Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes

scientific article

Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

scientific article published on 21 August 2003

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

scientific article published on July 2004

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

scientific article published on February 2011

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

scientific article published on 02 August 2013

Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking

scientific article

Allosteric modulation of a chemogenetically modified G protein-coupled receptor.

scientific article published on 29 November 2012

Allostery in GPCRs: 'MWC' revisited.

scientific article published on 14 September 2011

Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor.

scientific article published on 26 May 2015

Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity

scientific article

Cannabinoid Receptor Type 1 Protects against Age- Related Osteoporosis by Regulating Osteoblast and Adipocyte Differentiation in Marrow Stromal Cells

scientific article published on 01 August 2009

Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands

scientific article

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

scientific article (publication date: 17 May 2002)

Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

scientific article published on September 2004

Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors

scientific article

Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1).

scientific article published on 6 March 2012

Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging

scientific article published in January 2015

Detection and quantification of allosteric modulation of endogenous m4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line.

scientific article published on 22 December 2014

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor

scientific article

Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig.

scientific article

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

scientific article published on 30 October 2017

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

scientific article

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

scientific article published in January 2018

G-Protein-Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

scientific article published on 13 February 2019

Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling.

scientific article

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

scientific article published on February 2004

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211.

scientific article published on 30 October 2013

Inflammation-associated changes in DOR expression and function in the mouse colon

Intramembrane receptor-receptor interactions: a novel principle in molecular medicine.

scientific article published on 27 October 2006

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2.

scientific article published on 23 May 2017

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

scientific article published on 12 September 2019

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

scientific article published on 31 March 2020

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.

scientific article

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.

scientific article published on 17 January 2014

Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures

scientific article

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

scientific article published on 17 July 2018

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

scientific article published on May 2017

Novel GPCR paradigms at the μ-opioid receptor

scientific article

Pharmacological Evidence for a Putative Conserved Allosteric Site on Opioid Receptors.

scientific article published on 12 December 2017

Pharmacological characterization of a small‐molecule agonist for the chemokine receptor CXCR3 ⬇️

scientific article published on June 1, 2012

Pharmacological modulation of chemokine receptor function.

scientific article published on March 2012

Phosphoproteomic characterization of the signaling network resulting from activation of chemokine receptor CCR2

scientific article published on 02 April 2020

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

scientific article

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

scientific article

Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors

scientific article published on 03 February 2016

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

article published in the Proceedings of the National Academy of Sciences of the United States of America

Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane

scientific article

Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization.

scientific article published on 6 March 2018

Regulation of G protein-coupled receptors by allosteric ligands

scientific article

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

scientific article published on 01 May 2003

Sequential Conformational Rearrangements Dictate the Dynamics of Class C GPCR Activation

article

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

scientific article published on 13 October 2013

Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1

scientific article

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors

scientific article

Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.

scientific article

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

scientific article published on 27 February 2012

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

scientific article

The Complex Roles of μ-Opioid Receptor Phosphorylation: A Key Determinant in Receptor Signaling and Regulation

scientific article published on 7 July 2015

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

scientific article published on July 2013

The role of kinetic context in apparent biased agonism at GPCRs

scientific article published on 24 February 2016

Ticks from diverse genera encode chemokine-inhibitory evasin proteins.

scientific article

Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1)

scientific article published on 13 February 2013

Ubiquitination of CXCR7 controls receptor trafficking

scientific article

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain

scientific article published on 7 July 2006

List of works by Meritxell Canals

A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

Adenosine A2A receptor and dopamine D3 receptor interactions: evidence of functional A2A/D3 heteromeric complexes

Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

Adenosine A2A-dopamine D2 receptor-receptor heteromers. Targets for neuro-psychiatric disorders

Agonist activation of the G protein-coupled receptor GPR35 involves transmembrane domain III and is transduced via Gα₁₃ and β-arrestin-2.

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Allosteric modulation of M1 muscarinic acetylcholine receptor internalization and subcellular trafficking

Allosteric modulation of a chemogenetically modified G protein-coupled receptor.

Allostery in GPCRs: 'MWC' revisited.

Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor.

Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity

Cannabinoid Receptor Type 1 Protects against Age- Related Osteoporosis by Regulating Osteoblast and Adipocyte Differentiation in Marrow Stromal Cells

Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors

Constitutive activity of the cannabinoid CB1 receptor regulates the function of co-expressed Mu opioid receptors

Design and receptor interactions of obligate dimeric mutant of chemokine monocyte chemoattractant protein-1 (MCP-1).

Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging

Detection and quantification of allosteric modulation of endogenous m4 muscarinic acetylcholine receptor using impedance-based label-free technology in a neuronal cell line.

Discovery, synthesis, and molecular pharmacology of selective positive allosteric modulators of the δ-opioid receptor

Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig.

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

G-Protein-Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Genetically Encoded FRET Biosensors to Illuminate Compartmentalised GPCR Signalling.

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211.

Inflammation-associated changes in DOR expression and function in the mouse colon

Intramembrane receptor-receptor interactions: a novel principle in molecular medicine.

Key determinants of selective binding and activation by the monocyte chemoattractant proteins at the chemokine receptor CCR2.

Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks

Low intrinsic efficacy for G protein activation can explain the improved side effect profiles of new opioid agonists

Mechanistic insights into allosteric structure-function relationships at the M1 muscarinic acetylcholine receptor.

Molecular determinants of allosteric modulation at the M1 muscarinic acetylcholine receptor.

Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Novel GPCR paradigms at the μ-opioid receptor

Pharmacological Evidence for a Putative Conserved Allosteric Site on Opioid Receptors.

Pharmacological characterization of a small‐molecule agonist for the chemokine receptor CXCR3 ⬇️

Pharmacological modulation of chemokine receptor function.

Phosphoproteomic characterization of the signaling network resulting from activation of chemokine receptor CCR2

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane

Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization.

Regulation of G protein-coupled receptors by allosteric ligands

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

Sequential Conformational Rearrangements Dictate the Dynamics of Class C GPCR Activation

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

Structural basis of receptor sulfotyrosine recognition by a CC chemokine: the N-terminal region of CCR3 bound to CCL11/eotaxin-1

Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors

Synthesis, Biological Evaluation, and Utility of Fluorescent Ligands Targeting the μ-Opioid Receptor.

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor.

The Complex Roles of μ-Opioid Receptor Phosphorylation: A Key Determinant in Receptor Signaling and Regulation

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

The role of kinetic context in apparent biased agonism at GPCRs

Ticks from diverse genera encode chemokine-inhibitory evasin proteins.

Tyrosine sulfation of chemokine receptor CCR2 enhances interactions with both monomeric and dimeric forms of the chemokine monocyte chemoattractant protein-1 (MCP-1)

Ubiquitination of CXCR7 controls receptor trafficking

Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain