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List of works by Ralph T Schermuly

5-HT2B receptor antagonists inhibit fibrosis and protect from RV heart failure

scientific article

A Combination Hybrid-Based Vaccination/Adoptive Cellular Therapy to Prevent Tumor Growth by Involvement of T Cells

scientific article published in June 2007

A Molecular Mechanism for Therapeutic Effects of cGMP-elevating Agents in Pulmonary Arterial Hypertension ⬇️

scientific article published on April 23, 2013

A pirinixic acid derivative (LP105) inhibits murine 5-lipoxygenase activity and attenuates vascular remodelling in a murine model of aortic aneurysm

scientific article

A role for coagulation factor Xa in experimental pulmonary arterial hypertension

scientific article published on 15 June 2011

ASK1 Inhibition Halts Disease Progression in Preclinical Models of Pulmonary Arterial Hypertension

scientific article published on 14 September 2017

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

article

Activation of TRPC6 channels is essential for lung ischaemia-reperfusion induced oedema in mice.

scientific article published on 31 January 2012

Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling

scientific article published on 3 January 2006

Acute effects of phosphodiesterase 5 (PDE5) inhibition, ANP and NO on epididymal contractility are preserved despite chronic PDE5 exposure.

scientific article published in August 2011

Acute effects of riociguat in borderline or manifest pulmonary hypertension associated with chronic obstructive pulmonary disease

scientific article published on June 2015

Acute effects of the combination of sildenafil and inhaled treprostinil on haemodynamics and gas exchange in pulmonary hypertension

scientific article published on 9 July 2008

Aerosolized Prostacyclin and Iloprost in Severe Pulmonary Hypertension

scientific article published on 01 May 1996

Altered proteasome function in right ventricular hypertrophy

scientific article published on 01 February 2020

Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension

scientific article published in November 2002

Amplified canonical transforming growth factor-β signalling via heat shock protein 90 in pulmonary fibrosis

scientific article published on 19 December 2016

Analysis of tumor vessel supply in Lewis lung carcinoma in mice by fluorescent microsphere distribution and imaging with micro- and flat-panel computed tomography

scientific article published on October 2005

Anticipated classes of new medications and molecular targets for pulmonary arterial hypertension

scientific article published on January 2013

Antihistone Properties of C1 Esterase Inhibitor Protect against Lung Injury

scientific article published on 22 December 2016

Antiremodeling effects of iloprost and the dual-selective phosphodiesterase 3/4 inhibitor tolafentrine in chronic experimental pulmonary hypertension

scientific article published on 18 March 2004

Are tyrosine kinase inhibitors the better serotonin inhibitors?

scientific article

Arterial hypertension in a murine model of sleep apnea: role of NADPH oxidase 2.

scientific article published on February 2014

Atrial natriuretic peptide in severe primary and nonprimary pulmonary hypertension: response to iloprost inhalation.

scientific article

Author Correction: NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

scientific article published on 01 July 2020

BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension

scientific article published on 8 October 2012

Basic features of hypoxic pulmonary vasoconstriction in mice

scientific article (publication date: 15 January 2004)

Biomarkers of tissue remodeling predict survival in patients with pulmonary hypertension

scientific article published on 13 August 2016

Bronchoscopic surfactant administration in patients with severe adult respiratory distress syndrome and sepsis

scientific article published on 01 July 1996

Bypassing mitochondrial complex III using alternative oxidase inhibits acute pulmonary oxygen sensing

scientific article published on 15 April 2020

Cellular pathophysiology and therapy of pulmonary hypertension.

scientific article

Characterization of a murine model of monocrotaline pyrrole-induced acute lung injury.

scientific article

Chronic intratracheal application of the soluble guanylyl cyclase stimulator BAY 41-8543 ameliorates experimental pulmonary hypertension

scientific article published on 31 March 2017

Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats

scientific article published on 4 September 2003

Chymase: a multifunctional player in pulmonary hypertension associated with lung fibrosis

scientific article published on 25 June 2015

Cigarette Smoke-Induced Emphysema and Pulmonary Hypertension Can Be Prevented by Phosphodiesterase 4 and 5 Inhibition in Mice

scientific article published on 9 June 2015

Circulating Angiopoietin-1 Is Not a Biomarker of Disease Severity or Prognosis in Pulmonary Hypertension

scientific article (publication date: 2016)

Classical transient receptor potential channel 1 in hypoxia-induced pulmonary hypertension.

scientific article

Classical transient receptor potential channel 6 (TRPC6) is essential for hypoxic pulmonary vasoconstriction and alveolar gas exchange

scholarly article

Cofilin, a hypoxia-regulated protein in murine lungs identified by 2DE: role of the cytoskeletal protein cofilin in pulmonary hypertension

scientific article

Combination therapy with oral sildenafil and inhaled iloprost for severe pulmonary hypertension.

scientific article

Comparison of pharmacokinetics and vasodilatory effect of nebulized and infused iloprost in experimental pulmonary hypertension: rapid tolerance development

scientific article published in January 2006

Conebulization of surfactant and urokinase restores gas exchange in perfused lungs with alveolar fibrin formation

scientific article published on 01 April 2001

Congenital erythropoietin over-expression causes "anti-pulmonary hypertensive" structural and functional changes in mice, both in normoxia and hypoxia

scientific article (publication date: September 2005)

Correction: Improvement of right heart structure and function by BAY41-8543 in pulmonary artery banded mice.

scientific article published on 14 September 2011

Deletion of Fn14 receptor protects from right heart fibrosis and dysfunction ⬇️

scientific article published on January 17, 2013

Depletion of Bone Marrow-Derived Fibrocytes Attenuates TAA-Induced Liver Fibrosis in Mice

scientific article published on 07 October 2019

Detection of reactive oxygen species in isolated, perfused lungs by electron spin resonance spectroscopy

scientific article

Developmental vascular remodeling defects and postnatal kidney failure in mice lacking Gpr116 (Adgrf5) and Eltd1 (Adgrl4).

scientific article published on 14 August 2017

Diacylglycerol regulates acute hypoxic pulmonary vasoconstriction via TRPC6.

scientific article published on 4 February 2011

Differences in hemodynamic and oxygenation responses to three different phosphodiesterase-5 inhibitors in patients with pulmonary arterial hypertension: a randomized prospective study

scientific article published in October 2004

Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.

scientific article published on 19 December 2017

Differential Impact of Ultrasonically Nebulized Versus Tracheal-instilled Surfactant on Ventilation-Perfusion (V˙A/Q˙) Mismatch in a Model of Acute Lung Injury

scientific article published on 01 January 2000

Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome

scientific article published on 01 March 1996

Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbits: effects of nitric oxide

scientific article published on 14 November 2002

Dry powder aerosolization of a recombinant surfactant protein-C-based surfactant for inhalative treatment of the acutely inflamed lung

scientific article published in July 2010

Dysregulated Bone Morphogenetic Protein Signaling in Monocrotaline-Induced Pulmonary Arterial Hypertension

scientific article published on 08 March 2007

Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension.

scientific article

Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding.

scientific article published on 3 January 2018

Effect of nitric oxide synthase (NOS) inhibition on macro- and microcirculation in a model of rat endotoxic shock

scientific article published on 01 April 2006

Effects of Multikinase inhibitors on pressure overload-induced right ventricular remodelling

scientific article published on 14 August 2013

Effects of aerosolized prostacyclin in severe pneumonia. Impact of fibrosis

scientific article published on 01 March 1995

Effects of anti-inflammatory vagus nerve stimulation on the cerebral microcirculation in endotoxinemic rats.

scientific article

Effects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs

scientific article

Effects of dimethylarginine dimethylaminohydrolase-1 overexpression on the response of the pulmonary vasculature to hypoxia.

scientific article published on September 2013

Effects of hypercapnia and NO synthase inhibition in sustained hypoxic pulmonary vasoconstriction.

scientific article published on 31 January 2012

Effects of hypercapnia with and without acidosis on hypoxic pulmonary vasoconstriction.

scientific article published on 28 August 2009

Effects of inhaled versus intravenous vasodilators in experimental pulmonary hypertension

scientific article published on 01 May 1997

Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in rabbit lungs

scientific article

Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling.

scientific article

Effects of phosphodiesterase 4 inhibition on bleomycin-induced pulmonary fibrosis in mice

scientific article

Effects of riociguat in severe experimental pulmonary hypertension.

scientific article published in August 2011

Elevated protein arginine methyltransferase 1 expression regulates fibroblast motility in pulmonary fibrosis

scientific article published on 21 September 2015

Endothelial actions of atrial natriuretic peptide prevent pulmonary hypertension in mice

scientific article

Endothelin-1 driven proliferation of pulmonary arterial smooth muscle cells is c-fos dependent.

scientific article published on 10 July 2014

Endotoxin induces proliferation of NSCLC in vitro and in vivo: role of COX-2 and EGFR activation.

scientific article published on 26 August 2012

Enhanced gene expression and reduced toxicity in mice using polyplexes of low-molecular-weight poly(ethylene imine) for pulmonary gene delivery

scientific article

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension.

scientific article published on 2 March 2018

Evaluating Systolic and Diastolic Cardiac Function in Rodents Using Microscopic Computed Tomography

scientific article published on 01 December 2018

Evaluation of angiogenesis using micro-computed tomography in a xenograft mouse model of lung cancer

scientific article published on January 2009

Evidence for a role of protein kinase C in hypoxic pulmonary vasoconstriction

article

Evidence for the Fucoidan/P-Selectin Axis as a Therapeutic Target in Hypoxia-induced Pulmonary Hypertension

scientific article published on 01 June 2019

Expression and activity of phosphodiesterase isoforms during epithelial mesenchymal transition: the role of phosphodiesterase 4.

scientific article published on 16 September 2009

Expression and function of soluble guanylate cyclase in pulmonary arterial hypertension.

scientific article

FGF1-mediated cardiomyocyte cell cycle reentry depends on the interaction of FGFR-1 and Fn14.

scientific article published on 26 February 2014

Farnesylation of RhoB: the cancer hypothesis of pulmonary hypertension revisited

scientific article published on 01 March 2017

Favorable effects of inhaled treprostinil in severe pulmonary hypertension: results from randomized controlled pilot studies

scientific article published on 26 September 2006

Fgf10 deficiency is causative for lethality in a mouse model of bronchopulmonary dysplasia.

scientific article

Fhl-1, a new key protein in pulmonary hypertension.

scientific article

Function of NADPH oxidase 1 in pulmonary arterial smooth muscle cells after monocrotaline-induced pulmonary vascular remodeling

scientific article published on 20 July 2013

Genes involved in pulmonary hypertension of mice with endothelial-specific ablation of guanylyl cyclase A.

scientific article published on 29 August 2013

Genetic Ablation of PDGF-Dependent Signaling Pathways Abolishes Vascular Remodeling and Experimental Pulmonary Hypertension

scientific article

Glycogen synthase kinase 3beta contributes to proliferation of arterial smooth muscle cells in pulmonary hypertension.

scientific article

HIF-1alpha attenuates tumor growth in spite of augmented vascularization in an A549 adenocarcinoma mouse model

scientific article published on August 2005

Heme oxygenase-2 and large-conductance Ca2+-activated K+ channels: lung vascular effects of hypoxia.

scientific article

Histological characterization of mast cell chymase in patients with pulmonary hypertension and chronic obstructive pulmonary disease.

scientific article

Hybrid-Primed Lymphocytes and Hybrid Vaccination Prevent Tumor Growth of Lewis Lung Carcinoma in Mice

scientific article published on 01 March 2006

Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia

scientific article published on 27 October 2006

Hypoxia enhances platelet-derived growth factor signaling in the pulmonary vasculature by down-regulation of protein tyrosine phosphatases.

scientific article

Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species

scientific article published on 16 December 2011

Hypoxia- and non-hypoxia-related pulmonary hypertension - established and new therapies.

scientific article published on August 2006

Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.

scientific article published on 18 September 2014

Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature

scientific article

Hypoxia-induced pulmonary hypertension: Different impact of iloprost, sildenafil, and nitric oxide

scientific article published on 20 July 2007

Hypoxia-induced pulmonary hypertension: comparison of soluble epoxide hydrolase deletion vs. inhibition.

scientific article

Hypoxic pulmonary hypertension in mice with constitutively active platelet-derived growth factor receptor-β.

scientific article

Hypoxic pulmonary vasoconstriction in isolated mouse pulmonary arterial vessels

scientific article published on 06 July 2018

Hypoxic pulmonary vasoconstriction--triggered by an increase in reactive oxygen species?

scientific article published on 01 January 2006

Identification of right heart-enriched genes in a murine model of chronic outflow tract obstruction

article

Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs

scientific article (publication date: 26 January 2007)

Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension

scientific article published on 6 September 2012

Impact of Fgf10 deficiency on pulmonary vasculature formation in a mouse model of bronchopulmonary dysplasia

scientific article published on 01 May 2019

Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling

scientific article published on 27 January 2014

Impact of mitochondria and NADPH oxidases on acute and sustained hypoxic pulmonary vasoconstriction

scientific article published on 15 December 2005

Improvement of right heart structure and function by BAY 41-8543 in pulmonary artery banded mice.

scientific article published in August 2011

In vivo characterization of the novel imidazopyridine BYK191023 [2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3H-imidazo[4,5-b]pyridine], a potent and highly selective inhibitor of inducible nitric-oxide synthase

scientific article published on 20 December 2005

Increased FGF1-FGFRc expression in idiopathic pulmonary fibrosis

scientific article published on 3 July 2015

Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention

scientific article published on 29 July 2010

Increased levels and reduced catabolism of asymmetric and symmetric dimethylarginines in pulmonary hypertension

scientific article published on 12 April 2005

Increased neutrophil mediator release in patients with pulmonary hypertension--suppression by inhaled iloprost

scientific article published in December 2003

Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension.

scientific article published on 30 April 2007

Inducible NOS Inhibition Reverses Tobacco-Smoke-Induced Emphysema and Pulmonary Hypertension in Mice

scientific article published on 01 October 2011

Inflammation, growth factors, and pulmonary vascular remodeling

scientific article published on June 2009

Inflammation, immunological reaction and role of infection in pulmonary hypertension.

scientific article published on January 2011

Inhaled iloprost is a potent acute pulmonary vasodilator in HIV-related severe pulmonary hypertension.

scientific article published on February 2004

Inhaled iloprost reverses vascular remodeling in chronic experimental pulmonary hypertension

scientific article published on 5 May 2005

Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to lung fibrosis.

scientific article

Inhaled prostacyclin and iloprost in severe pulmonary hypertension secondary to pulmonary fibrosis

scientific article

Inhaled tolafentrine reverses pulmonary vascular remodeling via inhibition of smooth muscle cell migration

scientific article

Inhibition of Urokinase Activity Reduces Primary Tumor Growth and Metastasis Formation in a Murine Lung Carcinoma Model

scientific article published on 07 January 2010

Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension

scientific article published on 8 December 2011

Inhibition of overactive transforming growth factor-β signaling by prostacyclin analogs in pulmonary arterial hypertension

scientific article

Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia.

scientific article

Inhibition of the soluble epoxide hydrolase attenuates monocrotaline-induced pulmonary hypertension in rats

scientific article

Interaction of bumetanide derivatives with hepatocellular bile acid uptake

scientific article published on 01 November 1993

Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats

scientific article

Is PKM2 Phosphorylation a Prerequisite for Oligomer Disassembly in Pulmonary Arterial Hypertension?

scientific article published on 01 December 2019

Jumonji domain-containing protein 6 (Jmjd6) is required for angiogenic sprouting and regulates splicing of VEGF-receptor 1

scientific journal article

L-type calcium channel inhibitor diltiazem prevents aneurysm formation by blood pressure-independent anti-inflammatory effects.

scientific article published on 30 September 2013

Levosimendan attenuates pulmonary vascular remodeling

scientific article published on 31 May 2011

Long Noncoding RNA MANTIS Facilitates Endothelial Angiogenic Function

scientific article published on 28 March 2017

Long-term treatment with sildenafil in chronic thromboembolic pulmonary hypertension

scientific article published on 09 August 2007

Loss of secreted frizzled-related protein-1 leads to deterioration of cardiac function in mice and plays a role in human cardiomyopathy.

scientific article published on 10 February 2015

Low-dose Systemic Phosphodiesterase Inhibitors Amplify the Pulmonary Vasodilatory Response to Inhaled Prostacyclin in Experimental Pulmonary Hypertension

scientific article published on 01 November 1999

Lung Ischaemia-Reperfusion Injury: The Role of Reactive Oxygen Species

scientific article published in January 2017

Lung cancer-associated pulmonary hypertension: Role of microenvironmental inflammation based on tumor cell-immune cell cross-talk

scientific article

Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors

scientific article

Lysine methyltransferase Smyd2 suppresses p53-dependent cardiomyocyte apoptosis

scientific article

Lysyl oxidase activity is dysregulated during impaired alveolarization of mouse and human lungs

scientific article

Maintained right ventricular pressure overload induces ventricular-arterial decoupling in mice

scientific article published on 19 December 2016

Mast cell chymase: an indispensable instrument in the pathological symphony of idiopathic pulmonary fibrosis?

scientific article published on 25 February 2013

Mast cells and fibroblasts work in concert to aggravate pulmonary fibrosis: role of transmembrane SCF and the PAR-2/PKC-α/Raf-1/p44/42 signaling pathway.

scientific article published on 4 April 2013

Mast cells promote lung vascular remodelling in pulmonary hypertension.

scientific article published on 09 December 2010

Measurement of exhaled hydrogen peroxide from rabbit lungs

scientific article

Mechanisms of cardiac depression caused by lipoteichoic acids from Staphylococcus aureus in isolated rat hearts

scientific article published on 25 July 2005

Mechanisms of disease: pulmonary arterial hypertension.

scientific article published on 21 June 2011

Metered dose inhaler delivery of treprostinil for the treatment of pulmonary hypertension

scientific article

Metformin induces lipogenic differentiation in myofibroblasts to reverse lung fibrosis

scientific article published on 05 July 2019

Mitochondrial Complex IV Subunit 4 Isoform 2 Is Essential for Acute Pulmonary Oxygen Sensing

scientific article published on 15 June 2017

Mitochondrial complex II is essential for hypoxia-induced pulmonary vasoconstriction of intra- but not of pre-acinar arteries.

scientific article

Mitochondrial cytochrome redox states and respiration in acute pulmonary oxygen sensing

scientific article published on 01 June 2010

Mitochondrial hyperpolarization in pulmonary vascular remodeling. Mitochondrial uncoupling protein deficiency as disease model

scientific article published in September 2013

NADPH oxidase subunit NOXO1 is a target for emphysema treatment in COPD

scientific article published on 08 June 2020

NADPH oxidases-do they play a role in TRPC regulation under hypoxia?

scientific article published on October 2015

NO and reactive oxygen species are involved in biphasic hypoxic vasoconstriction of isolated rabbit lungs.

scientific article

NPY/Y₁ receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension

scientific article

Nebulization of the acidified sodium nitrite formulation attenuates acute hypoxic pulmonary vasoconstriction

scientific article published on 21 June 2010

Nestin-expressing vascular wall cells drive development of pulmonary hypertension.

scientific article published on 23 December 2015

New potential diagnostic biomarkers for pulmonary hypertension.

scientific article published on 6 August 2015

Nitric oxide (NO)-dependent but not NO-independent guanylate cyclase activation attenuates hypoxic vasoconstriction in rabbit lungs

scientific article published in August 2000

Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension.

scientific article

Novel and emerging therapies for pulmonary hypertension

scientific article published on February 2014

Novel putative pharmacological therapies to protect the right ventricle in pulmonary hypertension: a review of current literature

scientific article published on 18 January 2017

Novel soluble guanylyl cyclase stimulator BAY 41-2272 attenuates ischemia-reperfusion-induced lung injury

scientific article

Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension

scientific article published on July 2003

Oxidative injury of the pulmonary circulation in the perinatal period: Short- and long-term consequences for the human cardiopulmonary system

scientific article

Oxygen sensors in hypoxic pulmonary vasoconstriction

scientific article published on September 2006

PAR-2 inhibition reverses experimental pulmonary hypertension.

scientific article

PDGF receptor and its antagonists: role in treatment of PAH.

scientific article published on January 2010

Partial reversal of experimental pulmonary hypertension by phosphodiesterase-3/4 inhibition.

scientific article published on 21 November 2007

Pathobiology, pathology and genetics of pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016

scientific article published on 19 October 2016

Pathology and pathobiology of pulmonary hypertension: state of the art and research perspectives

scientific article published on 24 January 2019

Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs

scientific article published in November 2002

Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy

scientific article

Phosphodiesterase 10A upregulation contributes to pulmonary vascular remodeling

scientific article

Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis.

scientific article

Physiologic basis for the treatment of pulmonary hypertension.

scientific article

Plasma MMP2/TIMP4 Ratio at Follow-up Assessment Predicts Disease Progression of Idiopathic Pulmonary Arterial Hypertension.

scientific article published on 17 May 2017

Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study.

scientific article published on 14 June 2017

Pressure overload leads to an increased accumulation and activity of mast cells in the right ventricle

scientific article

Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits

scientific article

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

scientific article published on 26 October 2014

Prolonged vasodilatory response to nanoencapsulated sildenafil in pulmonary hypertension

scientific article published on 19 September 2015

Prostacyclin and its analogues in the treatment of pulmonary hypertension

scientific article published on May 2004

Protective effects of 10-nitro-oleic acid in a hypoxia-induced murine model of pulmonary hypertension

scientific article

Pulmonary arterial hypertension--a disease of the immune system?

scientific article published on 9 December 2014

Pulmonary vascular remodeling correlates with lung eggs and cytokines in murine schistosomiasis

scientific article published on 3 December 2009

Receptor for Activated C-Kinase 1, a Novel Interaction Partner of Type II Bone Morphogenetic Protein Receptor, Regulates Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension

scientific article published on 21 May 2007

Redox signaling and reactive oxygen species in hypoxic pulmonary vasoconstriction

scientific article published on 27 August 2010

Reduced microRNA-150 is associated with poor survival in pulmonary arterial hypertension.

scientific article published on 6 December 2012

Regression of cardiac hypertrophy by granulocyte colony-stimulating factor-stimulated interleukin-1β synthesis

scientific article published on 21 November 2011

Regulation of hypoxic pulmonary vasoconstriction: basic mechanisms.

scientific article

Relevance of angiopoietin-2 and soluble P-selectin levels in patients with pulmonary arterial hypertension receiving combination therapy with oral treprostinil: a FREEDOM-C2 biomarker substudy.

scientific article published on December 2016

Relevant issues in the pathology and pathobiology of pulmonary hypertension

scientific article published on December 2013

Reply to Bogaard et al.: Emphysema Is-at the Most-Only a Mild Phenotype in the Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension

scientific article published on 01 December 2019

Response to Sympathoinhibitory Effect of Diltiazem and Prevention of Aneurysm Formation

scientific article published on 01 March 2014

Response to: Comment on "Effect of Riociguat and Sildenafil on Right Heart Remodeling and Function in Pressure Overload Induced Model of Pulmonary Arterial Banding"

scientific article published on 16 December 2018

Reversal of experimental pulmonary hypertension by PDGF inhibition

scientific article

Rhodiola: an ordinary plant or a promising future therapy for pulmonary hypertension? a brief review

scientific article published on September 2013

Riociguat for pulmonary hypertension

scientific article published on March 2010

Riociguat for the treatment of pulmonary hypertension.

scientific article published on 11 March 2011

Riociguat: Mode of action and clinical development in pulmonary hypertension

scientific article

Riociguat: Stimulation der löslichen Guanylatzyklase

scientific article published on 06 March 2015

Role of Src tyrosine kinases in experimental pulmonary hypertension

scientific article published on 19 April 2012

Role of epidermal growth factor inhibition in experimental pulmonary hypertension.

scientific article published on 22 October 2009

Role of fibroblast growth factors in organ regeneration and repair

scientific article published on 09 October 2015

Role of the prostanoid EP4 receptor in iloprost-mediated vasodilatation in pulmonary hypertension

scientific article published on 8 May 2008

Schistosomiasis causes remodeling of pulmonary vessels in the lung in a heterogeneous localized manner: Detailed study

scientific article published on April 2013

Severe Emphysema in the SU5416/Hypoxia Rat Model of Pulmonary Hypertension

scientific article published on 01 August 2019

Short-term improvement in pulmonary hemodynamics is strongly predictive of long-term survival in patients with pulmonary arterial hypertension

scientific article

Shroom expression is attenuated in pulmonary arterial hypertension.

scientific article

Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension

scientific article published on 24 January 2003

Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial

scientific article published in September 2002

Sildenafil improves dynamic vascular function in the brain: studies in patients with pulmonary hypertension

scientific article published on 23 December 2005

Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension

scientific article published on 8 November 2012

Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.

scientific article published on 3 June 2010

Small-dose nitric oxide improves oxygenation during one-lung ventilation: an experimental study

scientific article published in December 2002

Soluble epoxide hydrolase deficiency attenuates neointima formation in the femoral cuff model of hyperlipidemic mice.

scientific article

Soluble guanylate cyclase stimulator riociguat and phosphodiesterase 5 inhibitor sildenafil ameliorate pulmonary hypertension due to left heart disease in mice.

scientific article

Stimulation of soluble guanylate cyclase prevents cigarette smoke-induced pulmonary hypertension and emphysema

scientific article published in June 2014

Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice

scientific article published on 4 April 2014

Subthreshold doses of nebulized prostacyclin and rolipram synergistaically protect against lung ischemia-reperfusion

scientific article published in March 2003

TWEAK/Fn14 axis is a positive regulator of cardiac hypertrophy.

scientific article published on 10 June 2013

Targeting cyclin-dependent kinases for the treatment of pulmonary arterial hypertension

scientific article published on 17 May 2019

Targeting non-malignant disorders with tyrosine kinase inhibitors.

scientific article published on December 2010

Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats

scientific article published on 14 October 2010

The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular Function

scientific article published on 13 July 2015

The Giessen Pulmonary Hypertension Registry: Survival in pulmonary hypertension subgroups

scientific article published on 17 February 2017

The Role of Transient Receptor Potential Channel 6 Channels in the Pulmonary Vasculature

scientific article

The lectin-like domain of tumor necrosis factor-alpha improves alveolar fluid balance in injured isolated rabbit lungs

scientific article published in May 2008

The noncanonical WNT pathway is operative in idiopathic pulmonary arterial hypertension

scientific article

The peroxisome proliferator-activated receptor β/δ agonist GW0742 has direct protective effects on right heart hypertrophy.

scientific article

The prognostic impact of thyroid function in pulmonary hypertension.

scientific article published on 3 June 2016

The role of chemokines and chemokine receptors in pulmonary arterial hypertension

scientific article published on 10 August 2019

The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis

scientific article published on June 2011

The science of endothelin-1 and endothelin receptor antagonists in the management of pulmonary arterial hypertension: current understanding and future studies.

scientific article published on June 2009

The soluble guanylate cyclase activator HMR1766 reverses hypoxia-induced experimental pulmonary hypertension in mice.

scientific article published on 17 July 2009

The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats

scientific article

The soluble guanylate cyclase stimulator riociguat ameliorates pulmonary hypertension induced by hypoxia and SU5416 in rats.

scientific article

The transforming growth factor- /Smad2,3 signalling axis is impaired in experimental pulmonary hypertension

scientific article published on 28 March 2007

Therapeutic efficacy of TBC3711 in monocrotaline-induced pulmonary hypertension

scientific article

Therapeutic efficacy of azaindole-1 in experimental pulmonary hypertension

scientific article

Transcriptome profiling reveals the complexity of pirfenidone effects in idiopathic pulmonary fibrosis

scientific article published on 22 November 2018

Transforming growth factor-β signaling in schistosomiasis-induced pulmonary hypertension: a perspective for antifibrotic drugs?

scientific article

Translating Research into Improved Patient Care in Pulmonary Arterial Hypertension

scientific article published on 20 September 2016

Treprostinil inhibits the adhesion and differentiation of fibrocytes via the cyclic adenosine monophosphate-dependent and Ras-proximate protein-dependent inactivation of extracellular regulated kinase

scientific article

Treprostinil inhibits the recruitment of bone marrow-derived circulating fibrocytes in chronic hypoxic pulmonary hypertension.

scientific article published on 4 June 2010

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis

scientific article published on 01 April 2017

Two-Way Conversion between Lipogenic and Myogenic Fibroblastic Phenotypes Marks the Progression and Resolution of Lung Fibrosis.

scientific article published on 14 November 2016

Update in basic research in the therapy of pulmonary arterial hypertension

scientific article published on 23 September 2008

Update: Preclinical developments for the treatment of pulmonary arterial hypertension

scientific article published on 28 August 2009

Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species

scientific article

Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension: synergism upon coapplication.

scientific article

Vascular Receptor Autoantibodies in Pulmonary Arterial Hypertension Associated with Systemic Sclerosis

scientific article published on 01 October 2014

[Inhalative strategies for improvement of pulmonary hemodynamics and gas exchange in sepsis and severe pulmonary hypertension]

scientific article

[Prostacyclin and iloprost in aerosol form in severe pulmonary hypertension]

scientific article published on 01 January 1998

[Relevant issues in the pathology and pathobiology of pulmonary hypertension].

scientific article published in October 2014

[Reverse remodeling -- paradigm shift in the treatment of pulmonary hypertension]

scientific article

cAMP phosphodiesterase inhibitors increases nitric oxide production by modulating dimethylarginine dimethylaminohydrolases.

scientific article

miR-223-IGF-IR signalling in hypoxia- and load-induced right-ventricular failure: a novel therapeutic approach.

scientific article

p38 MAPK Inhibition Improves Heart Function in Pressure Loaded Right Ventricular Hypertrophy

scientific article

sGC activators and stimulators attenuate ischemia/reperfusion injury of the lung.

scientific article

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