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List of works by Valerie Speirs

17Beta-hydroxysteroid dehydrogenase type 1, 2, 3, and 4 expression and enzyme activity in human anterior pituitary adenomas

scientific article (publication date: April 1999)

3-D tissue modelling and virtual pathology as new approaches to study ductal carcinoma in situ.

scientific article published on December 2015

91st annual meeting of the American Association for Cancer Research

scientific article

A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer ⬇️

scientific article published on 16 December 2016

A Global View of Breast Tissue Banking

scientific article published on January 2015

A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis ⬇️

scientific article

A comparative biomarker study of 514 matched cases of male and female breast cancer reveals gender-specific biological differences

scientific article

A comparative study of genome-wide SNP, CGH microarray and protein expression analysis to explore genotypic and phenotypic mechanisms of acquired antiestrogen resistance in breast cancer

scientific article

A multi-centre investigation towards reaching a consensus on the immunohistochemical detection of ERbeta in archival formalin-fixed paraffin embedded human breast tissue

scientific article published on August 2005

Abstract P4-19-02: Early experience of patient donation and researcher use of tissues donated to a national breast cancer tissue bank

Adding value to rare tissue samples donated to biobanks: characterisation of breast tissue and primary cell cultures obtained from a female-to-male transgender patient

scientific article published on 9 April 2014

Advances in the development of improved animal-free models for use in breast cancer biomedical research ⬇️

scientific article published on 26 July 2017

An Evaluation of Matrix-Containing and Humanised Matrix-Free 3-Dimensional Cell Culture Systems for Studying Breast Cancer ⬇️

scientific article

Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression. ⬇️

scientific article published on 14 August 2017

Androgen receptor and antiandrogen therapy in male breast cancer ⬇️

scientific article published on 11 August 2015

Articles selected from Faculty of 1000 in July 2003

scientific article

Association between AXL, Hippo Transducers, and Survival Outcomes in Male Breast Cancer ⬇️

scientific article

Attitudes of female staff and students from two United Kingdom Medical Schools towards donating normal healthy breast tissue and blood samples for biomedical research ⬇️

scientific article

Breast cancer cell lines: friend or foe?

scientific article

British Cancer Research Meeting, 30 June-3 July 2002, Glasgow

scientific article

CAPG and GIPC1: Breast Cancer Biomarkers for Bone Metastasis Development and Treatment ⬇️

scientific article published on 12 January 2016

CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction

scientific article published on 19 October 2011

CIP2A expression predicts recurrences of tamoxifen-treated breast cancer ⬇️

scientific article published in October 2017

Carcinoembryonic antigen cell adhesion molecule 6 predicts breast cancer recurrence following adjuvant tamoxifen

scientific article published on January 2008

Changes in expression of steroid receptors, their downstream target genes and their associated co-regulators during the sequential acquisition of tamoxifen resistance in vitro

scientific article published on September 2007

Characterisation of male breast cancer: a descriptive biomarker study from a large patient series ⬇️

scientific article published on 28 March 2017

Characterising the adipose-inflammatory microenvironment in male breast cancer ⬇️

scientific article published on 09 May 2018

Choosing the right cell line for breast cancer research

scientific article published on 12 August 2011

Clinical and functional significance of loss of caveolin-1 expression in breast cancer-associated fibroblasts

scientific article

Clinical importance of estrogen receptor beta isoforms in breast cancer

scientific article published on 10 November 2008

Comparison of microfluidic digital PCR and conventional quantitative PCR for measuring copy number variation

scientific article

Conditions of the male breast: Gynaecomastia and male breast cancer (Review) ⬇️

scientific article published on January 1, 2010

Constitutive co-expression of estrogen and progesterone receptor mRNA in human meningiomas by RT-PCR and response ofin vitro cell cultures to steroid hormones ⬇️

scientific article published on September 4, 1997

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

scientific article published on October 2013

Deregulation of IGF-binding proteins -2 and -5 contributes to the development of endocrine resistant breast cancer in vitro ⬇️

scientific article published on April 2016

Development and characterisation of a 3D multi-cellular in vitro model of normal human breast: a tool for cancer initiation studies ⬇️

scientific article

Differential regulation of oestrogen receptor β isoforms by 5' untranslated regions in cancer

scientific article published on January 2010

Differential response to phytoestrogens in endocrine sensitive and resistant breast cancer cells in vitro

scientific article published on August 2006

Distinct expression patterns of ER alpha and ER beta in normal human mammary gland ⬇️

scientific article published on May 2002

Down-Regulation of miR-92 in Breast Epithelial Cells and in Normal but Not Tumour Fibroblasts Contributes to Breast Carcinogenesis ⬇️

scientific article published on 5 October 2015

Downregulation of 15-hydroxyprostaglandin dehydrogenase during acquired tamoxifen resistance and association with poor prognosis in ERα-positive breast cancer

scientific article published on 30 October 2020

Downregulation of 15-hydroxyprostaglandin dehydrogenase in hormone-resistant breast cancer.

scientific article published on 13 May 2008

ERβ1 represses FOXM1 expression through targeting ERα to control cell proliferation in breast cancer

scientific article

Epithelial-mesenchymal interactions in breast cancer: evidence for a role of nuclear localized β-catenin in carcinoma-associated fibroblasts

scientific article published in October 2011

Estrogen receptor regulation: don’t forget translation

Estrogen receptor {beta}1 expression is regulated by miR-92 in breast cancer

scientific article

Estrogen receptor β: putting a positive into triple negative breast cancer?

scientific article

Evidence for transcriptional activation of ERalpha by IL-1beta in breast cancer cells

Expression and secretion of TGF-beta isoforms and expression of TGF-beta-receptors I, II and III in normal and neoplastic human breast

article published in 1999

Expression of COX-2, NF-kappaB-p65, NF-kappaB-p50 and IKKalpha in malignant and adjacent normal human colorectal tissue

scientific article published on 09 June 2009

Expression of oestrogen receptor beta isoforms is regulated by transcriptional and post-transcriptional mechanisms

scientific article

Expression of prostate specific antigen in male breast cancer

scientific article published on January 2005

Expression of regulators of mitotic fidelity are associated with intercellular heterogeneity and chromosomal instability in primary breast cancer

scientific article published on 7 October 2014

External validation of the ImmunoRatio image analysis application for ERα determination in breast cancer

scientific article

Functional inactivation of the oestrogen receptor by the antioestrogen, ZM 182780, sensitises tumour cells to reactive oxygen species

scientific article published on May 1999

Gene expression of ERbeta isoforms in laser microdissected human breast cancers: implications for gene expression analyses

scientific article

HMG-CoAR expression in male breast cancer: relationship with hormone receptors, Hippo transducers and survival outcomes ⬇️

scientific article published on 07 October 2016

Hormone receptors in defining breast cancer prognosis--time for a rethink?

scientific article published in April 2007

Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer ⬇️

scientific article published on 25 January 2019

Identification of stage-specific breast markers using quantitative proteomics

scientific article published on 29 October 2013

In vivo models in breast cancer research: progress, challenges and future directions ⬇️

scientific article

Inflammatory breast cancer: time to standardise diagnosis assessment and management, and for the joining of forces to facilitate effective research ⬇️

scientific article published on 31 March 2015

Insulin-like growth factor - oestradiol crosstalk and mammary gland tumourigenesis ⬇️

scientific article

Interleukin-3: a putative protective factor against breast cancer which is secreted by male but not female breast fibroblasts

scientific article published on May 1995

Introducing SEARCHBreast: a virtual resource to facilitate sharing of surplus animal material developed for breast cancer research ⬇️

scientific article

Lack of CD151/integrin α3β1 complex is predictive of poor outcome in node-negative lobular breast carcinoma: opposing roles of CD151 in invasive lobular and ductal breast cancers ⬇️

scientific article published on 29 September 2015

Localization of MOC-1 cell surface antigen in small-cell lung carcinoma cell lines: an immunohistochemical and immunoelectron microscopic study

scientific article published on September 1993

Loss of CSMD1 disrupts mammary epithelial morphogenesis

scientific article published on 18 May 2010

Loss of CSMD1 expression disrupts mammary duct formation while enhancing proliferation, migration and invasion ⬇️

scientific article

Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma

scientific article published on 8 August 2009

MCPH1, a potential predictor for response to cancer chemotherapy

scientific article published on 13 May 2008

Male breast carcinoma: increased awareness needed

scientific article published on 29 September 2011

Management and 5-year outcomes in 9938 women with screen-detected ductal carcinoma in situ: the UK Sloane Project

scientific article published on 06 August 2018

Management of breast cancer in an Asian man with post-traumatic stress disorder: a case report ⬇️

scientific article published on 29 March 2016

Mechanisms of FGFR3 actions in endocrine resistant breast cancer ⬇️

scientific article published on August 29, 2011

MiR-26b is down-regulated in carcinoma-associated fibroblasts from ER-positive breast cancers leading to enhanced cell migration and invasion

scientific article

MicroRNA-92 targets the 3' untranslated region of ERβ1 mRNA and post-transcriptionally regulates its expression in breast cancer.

scientific article published on 18 May 2010

Microcephalin is a new novel prognostic indicator in breast cancer associated with BRCA1 inactivation

scientific article published on 15 July 2010

Modelling breast cancer in a three-dimensional heterotypic culture system.

scientific article published on 18 May 2010

Nuclear and cytoplasmic expression of ERbeta1, ERbeta2, and ERbeta5 identifies distinct prognostic outcome for breast cancer patients

scientific article published in August 2008

Obesity and male breast cancer: provocative parallels? ⬇️

scientific article published on 4 June 2015

Oestrogen receptor beta in breast cancer: good, bad or still too early to tell?

scientific article

Oestrogen receptor beta: what it means for patients with breast cancer

scientific article published on March 2004

PSMD9 expression predicts radiotherapy response in breast cancer ⬇️

scientific article

Pan-cancer image-based detection of clinically actionable genetic alterations

scientific article published on 27 July 2020

Pattern of expression of genes linked to epigenetic silencing in human breast cancer

scientific article published in August 2006

Phosphorylation of estrogen receptor beta at serine 105 is associated with good prognosis in breast cancer

scientific article

Phyto-oestrogens and breast cancer chemoprevention

scientific article

Placental autophagy regulates trophoblast survival in placental dysfunction during pregnancy complications

scholarly article by Mohamed Elmoursi et al published September 2017 in Placenta

Problems (and solutions) in the study of male breast cancer

scientific article

Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer

scientific article (publication date: June 2002)

Reduced MCPH1 expression in breast cancer and response to chemotherapy

scientific article

Reduced expression of oestrogen receptor β in invasive breast cancer and its re‐expression using DNA methyl transferase inhibitors in a cell line model ⬇️

scientific article published on October 1, 2003

Reflections on the upsurge of virtual cancer conferences during the COVID-19 pandemic

scientific article published on 23 July 2020

Regulation of estrogen receptor β1 expression in breast cancer by epigenetic modification of the 5' regulatory region

scientific article published on 25 September 2013

Relationship between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the Arimidex, Tamoxifen, Alone or in Combination trial

scientific article published on 28 January 2008

Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer

scientific article

Reponse to: comment on, 'Tumour-stroma ratio (TSR) in oestrogen-positive breast cancer patients'. ⬇️

scientific article published on 13 November 2014

Role of ERβ in Clinical Breast Cancer

scientific article published in January 2009

Role of gonadotropin-releasing hormone analogues in metastatic male breast cancer: results from a pooled analysis ⬇️

scientific article published on 17 May 2015

SEARCHBreast: An online resource designed to increase the efficiency of using materials derived from breast cancer studies in animals ⬇️

scientific article published on 6 June 2016

SEARCHBreast: a new online resource to make surplus material from in vivo models of breast cancer visible and accessible to researchers ⬇️

scientific article published on 31 May 2016

SEARCHBreast: a new resource to locate and share surplus archival material from breast cancer animal models to help address the 3Rs. ⬇️

scientific article published on 15 April 2016

Small is beautiful: microRNAs and breast cancer-where are we now?

scientific article published on July 2008

Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer ⬇️

article published in 2018

Steroid hormone receptor expression in breast cancer stroma

scientific article published on 24 January 2014

Stromal fibroblasts with nuclear β-catenin are present within breast tumours and increase proliferation and invasion of epithelial breast cancer cells

scientific article published on 13 May 2008

The Hippo transducers TAZ/YAP and their target CTGF in male breast cancer ⬇️

scientific article published on 27 May 2016

The SEARCHBreast Portal: A Virtual Bioresource to Facilitate the Sharing of Surplus Animal Materials Derived from Breast Cancer Studies ⬇️

The Sharing Experimental Animal Resources, Coordinating Holdings (SEARCH) Framework: Encouraging Reduction, Replacement, and Refinement in Animal Research ⬇️

scientific article

The evolving role of oestrogen receptor beta in clinical breast cancer

scientific article published on 19 September 2008

The manufacture and assessment of tissue microarrays: suggestions and criteria for analysis, with breast cancer as an example

scientific article published on 19 October 2012

The potential role of ER beta isoforms in the clinical management of breast cancer

scientific article published on 23 February 2008

The potential utility of geminin as a predictive biomarker in breast cancer

scientific article published in December 2013

The practicalities of using tissue slices as preclinical organotypic breast cancer models

scientific article

The prognostic significance of tumour-stroma ratio in oestrogen receptor-positive breast cancer

scientific article published on 18 February 2014

The value of archival tissue blocks in understanding breast cancer biology

scientific article published on 29 October 2013

Three-dimensional reconstruction of ductal carcinoma in situ with virtual slides ⬇️

scientific article published on 5 February 2015

Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness ⬇️

scientific article published on 18 January 2016

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