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List of works by Hideaki Kakeya

5-Alkyl-1,2,3,4-tetrahydroquinolines, new membrane-interacting lipophilic metabolites produced by combined culture of Streptomyces nigrescens and Tsukamurella pulmonis.

scientific article

A 7-dimethylallyl tryptophan synthase from a fungal Neosartorya sp.: biochemical characterization and structural insight into the regioselective prenylation

scientific article

A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level

scientific article

A Competitive Enzyme-Linked Immunosorbent Assay System for Adenylation Domains in Nonribosomal Peptide Synthetases

scientific article published on 8 January 2016

A Facile and Effective Screening Method for p21WAF1 Promoter Activators from Microbial Metabolites ⬇️

scientific article published on October 1, 2001

A Multiple-Labeling Strategy for Nonribosomal Peptide Synthetases Using Active-Site-Directed Proteomic Probes for Adenylation Domains

scientific article published on 15 October 2015

A bridge between chemistry and biology

scientific article published in August 2006

A chemical proteomic probe for detecting native carrier protein motifs in nonribosomal peptide synthetases

scientific article published on 21 November 2016

A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats.

scientific article

A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning.

scientific article

Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains

scientific article published on 16 October 2015

Activation of MST/Krs and c-Jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis

scientific article published on 01 March 2000

Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases.

scientific article published on February 2015

Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases

scientific article published on 01 January 2019

Affinity Purification Method for the Identification of Nonribosomal Peptide Biosynthetic Enzymes Using a Synthetic Probe for Adenylation Domains

scientific article published on 01 January 2016

Amycolapeptins A and B, Cyclic Nonadepsipeptides Produced by Combined Culture of <i>Amycolatopsis</i> sp. and <i>Tsukamurella pulmonis</i>

scientific article published on 07 January 2021

An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes.

scientific article

Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells

scientific article published on 12 July 2013

Asymmetric Total Synthesis of Heronamides A-C: Stereochemical Confirmation and Impact of Long-Range Stereochemical Communication on the Biological Activity

scientific article published on 12 May 2016

Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor

scientific article published on 01 October 2002

Asymmetric total synthesis of pseurotin A

scientific article published on 01 June 2003

Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation

scientific article published on 10 July 2008

Azaspirene: a novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartorya sp

scientific article published on 01 August 2002

Balance between Exocytosis and Endocytosis Determines the Efficacy of Sterol-Targeting Antibiotics

scholarly article by Shinichi Nishimura published in December 2014

Biosynthetic origins of the epoxyquinone skeleton in epoxyquinols A and B

scientific article published on 03 December 2014

Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.

scientific article published in December 2002

Chemical Interactions of Cryptic Actinomycete Metabolite 5-Alkyl-1,2,3,4-tetrahydroquinolines through Aggregate Formation

scientific article published on 07 August 2019

Chemical tagging of a drug target using 5-sulfonyl tetrazole.

scientific article published on 30 January 2013

Chlorocatechelins A and B from Streptomyces sp.: new siderophores containing chlorinated catecholate groups and an acylguanidine structure

scientific article

Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A.

scientific article published in March 2006

Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

scientific article

Cryptic Chemical Communication: Secondary Metabolic Responses Revealed by Microbial Co-culture

scientific article published on 20 January 2020

Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes

scientific article published on 13 March 2018

Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo

scientific article published on 12 March 2020

Cytoxazone: A Novel Cytokine Modulator Containing a 2-Oxazolidinone Ring Produced by Streptomyces sp

scientific article published in February 1999

Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors.

scientific article published on 25 February 2015

Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells

scientific article published in May 2005

Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008

scientific article published on 05 December 2018

Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines

scientific article published on 06 January 2020

Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis.

scientific article

Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare ActinomyceteSaccharothrixsp. A1506

scientific article published on 19 July 2018

Drinkable preparation of Theracurmin exhibits high absorption efficiency--a single-dose, double-blind, 4-way crossover study

scientific article published in January 2013

Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus

scientific article published on 23 November 2019

Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives.

scientific article published on December 2006

Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene).

scientific article published on 5 July 2016

Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C2, by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis

scientific article published on 13 March 2019

Epolactaene binds human Hsp60 Cys442 resulting in the inhibition of chaperone activity

scientific article

Epolactaene, a Novel Neuritogenic Compound in Human Neuroblastoma Cells, Produced by a Marine Fungus ⬇️

scientific article published on July 1, 1995

Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex.

scientific article

Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites.

scientific article

Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappaB signaling by crosslinking TAK1.

scientific article published on 7 July 2008

Epoxytwinol A, a novel unique angiogenesis inhibitor with C2 symmetry, produced by a fungus.

scientific article published on 15 March 2005

Erratum to: The Inhibitory Effects of Crucumin Glucuronide on p300-HAT Activity and Hypertrophic Phenylephrine-Induced Responses in Cardiomyocytes

article

Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47.

scientific article published on 26 June 2015

First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry

scientific article published in July 2005

Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity.

scientific article published on 19 April 2006

Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling

scientific article published on 14 September 2015

Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation

scientific article published in February 2008

Highly Sensitive Labeling Reagents for Scarce Natural Products

scientific article published on 31 August 2020

Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD

scientific article published on 26 August 2016

Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus.

scientific article published in March 2009

Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines

scientific article published on 01 February 2019

In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line.

scientific article

In Vivo Linking of Membrane Lipids and the Anion Transporter Band 3 with Thiourea-modified Amphiphilic Lipid Probes

scientific article

Inhibition of translation by cytotrienin A--a member of the ansamycin family

scientific article

Innovative preparation of curcumin for improved oral bioavailability.

scientific article

Interaction between the marine sponge cyclic peptide theonellamide A and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state (2)H nuclear magnetic resonance

scientific article

Isolation and Structure Elucidation of Cytotoxic Saccharothriolides D to F from a Rare Actinomycete Saccharothrix sp. and Their Structure-Activity Relationship.

scientific article published on 22 June 2016

Isolation of a novel substrate-competitive tyrosine kinase inhibitor, desmal, from the plant Desmos chinensis. ⬇️

scientific article published on April 1993

Isolation, Structure Elucidation, and Conformational Regulation of Myropeptins, Lipopeptides from the Fungus Myrothecium roridum

scientific article published on 09 September 2019

Isolation, Structure Elucidation, and Total Synthesis of Tryptopeptins A and B, New TGF-β Signaling Modulators from Streptomyces sp

scientific article published on 05 January 2015

LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis

scientific article published on 29 August 2016

Longicatenamides A–D, Two Diastereomeric Pairs of Cyclic Hexapeptides Produced by Combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596

scientific article published on 22 January 2021

Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling

scientific article published on 13 June 2010

Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores

scientific article

Methylation deficiency disrupts biological rhythms from bacteria to humans

scientific article published on 06 May 2020

Multiple NF‐Y‐binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor‐associated gene ⬇️

scientific article published on September 26, 2011

Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification

scientific article published on 17 February 2016

Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors

scientific article published on 01 February 1997

Novel mammalian cell cycle inhibitors, cyclotroprostatins A–D, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase

Novel non-peptide inhibitors targeting death receptor-Mediated apoptosis ⬇️

scientific article published on November 3, 2003

Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells

scientific article published on 25 July 2002

Optimal dose-setting study of curcumin for improvement of left ventricular systolic function after myocardial infarction in rats

scientific article published on 19 November 2014

Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506

scientific article published on 21 December 2016

Prediction and determination of the stereochemistry of the 1,3,5-trimethyl-substituted alkyl chain in verucopeptin, a microbial metabolite.

scientific article published on 11 July 2014

Profiling Nonribosomal Peptide Synthetase Activities Using Chemical Proteomic Probes for Adenylation Domains

scientific article published on 17 June 2015

Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans

scientific article published on 04 June 2020

RK-95113, a New Angiogenesis Inhibitor Produced by Aspergillus fumigatus ⬇️

scientific article published on 19 January 2009

RKS-1778, a new mammalian cell-cycle inhibitor and a key intermediate of the [11]cytochalasin group

scientific article published on 01 July 1997

RNA-methylation-dependent RNA processing controls the speed of the circadian clock

scientific journal article

RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

scientific article published on 9 September 2015

Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis

scientific article published on 01 September 1999

Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp. ⬇️

scientific article

Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast

scientific article published on 20 April 2020

Specific enrichment of nonribosomal peptide synthetase module by an affinity probe for adenylation domains.

scientific article

Stereochemical Assignment and Biological Evaluation of BE-14106 Unveils the Importance of One Acetate Unit for the Antifungal Activity of Polyene Macrolactams.

scientific article published on 22 June 2016

Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by (1)H NMR.

scientific article

Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete.

scientific article

Structure and biological activity of 8-deoxyheronamide C from a marine-derived Streptomyces sp.: heronamides target saturated hydrocarbon chains in lipid membranes

scientific article published on 31 March 2014

Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity.

scientific article published in September 2004

Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage.

scientific article published on January 2006

Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein

scientific article

Synthesis of chemically stabilized phosmidosine analogues and the structure--activity relationship of phosmidosine.

scientific article

The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice

scientific article published on 28 April 2020

The asymmetric total synthesis of (+)-cytotrienin a, an ansamycin-type anticancer drug

scientific article published in January 2008

Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol

scientific article published on 25 July 2018

Thioamycolamides A-E, Sulfur-Containing Cycliclipopeptides Produced by the Rare Actinomycete Amycolatopsis sp

scientific article published on 02 April 2020

Total Synthesis and Antimicrobial Activity of Chlorocatechelin A

scientific article published on 05 June 2015

Total Synthesis and Antimicrobial Activity of Tumescenamide C and Its Derivatives

scientific article published on 26 February 2020

Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product

scientific article published on 05 April 2009

Total synthesis of thioamycolamide A via a biomimetic route

scientific article published on 08 October 2020

Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

scientific article published on 01 October 2019

UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.

scientific article

Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models

scientific article published on 10 December 2019

Visualization of sterol-rich membrane domains with fluorescently-labeled theonellamides

scientific article (publication date: 2013)

Visualizing the Adenylation Activities and Protein-Protein Interactions of Aryl Acid Adenylating Enzymes

scientific article published on 4 September 2017

pH-sensitive DNA cleaving agents: in situ activation by ring contraction of benzo-fused cyclobutanols

scientific article published in April 2013

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