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List of works by Yasuhiro Kobayashi

A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro

scientific article published on 14 July 2017

Action of RANKL and OPG for osteoclastogenesis.

scientific article published on January 2009

Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice.

scientific article published on 20 April 2010

Arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent NFATc1 pathways

scientific article (publication date: 2014)

Bone Formation Is Coupled to Resorption Via Suppression of Sclerostin Expression by Osteoclasts

scientific article published on 15 June 2017

Cell adhesion is a prerequisite for osteoclast survival

scientific article published on 01 April 2000

Coordination of microtubules and the actin cytoskeleton is important in osteoclast function, but calcitonin disrupts sealing zones without affecting microtubule networks.

scientific article published on 13 June 2006

DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway.

scientific article published on 23 February 2015

Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone.

scientific article published in February 2012

Diphenylhydantoin inhibits osteoclast differentiation and function through suppression of NFATc1 signaling.

scientific article published in August 2009

Docetaxel inhibits bone resorption through suppression of osteoclast formation and function in different manners

scientific article

Fluorescence microscopic demonstration of cathepsin K activity as the major lysosomal cysteine proteinase in osteoclasts.

scientific article published on April 1998

Fos plays an essential role in the upregulation of RANK expression in osteoclast precursors within the bone microenvironment

article

Identification of cell cycle-arrested quiescent osteoclast precursors in vivo

scientific article published on February 2009

Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator

scientific article published on 11 July 2016

Identification of osteoclasts in culture

scientific article published on 01 January 2011

Lineage-committed osteoclast precursors circulate in blood and settle down into bone.

scientific article published in December 2011

Luman is involved in osteoclastogenesis through the regulation of DC-STAMP expression, stability and localization

scientific article published on 26 October 2015

MKK6-p38 MAPK signaling pathway enhances survival but not bone-resorbing activity of osteoclasts.

scientific article published on 5 November 2007

Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function

scientific article published on 01 April 2009

Non-canonical Wnt signals regulate cytoskeletal remodeling in osteoclasts

scientific article published on 26 July 2018

Noncanonical Wnt5a enhances Wnt/β-catenin signaling during osteoblastogenesis.

scientific article published on 27 March 2014

Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy

scientific article published on 10 July 2017

Osteoprotegerin Regulates Bone Formation through a Coupling Mechanism with Bone Resorption ⬇️

scientific article published on September 18, 2003

Platypus and opossum calcitonins exhibit strong activities, even though they belong to mammals

scientific article published on 3 January 2017

Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices--a simple method for identifying polarized osteoclasts.

scientific article published on 29 September 2011

Prostaglandin E2 enhances osteoclastic differentiation of precursor cells through protein kinase A-dependent phosphorylation of TAK1.

scientific article published on 12 January 2005

Prostaglandin E2 receptors EP2 and EP4 are down-regulated during differentiation of mouse osteoclasts from their precursors

scientific article published on 15 April 2005

Prostaglandin E2 strongly inhibits human osteoclast formation

scientific article

Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines

scientific article published on 01 September 2000

Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling

scientific article published on 29 August 2017

Regulation of bone metabolism by Wnt signals

scientific article published on 28 December 2015

Roles of Wnt signaling in bone formation and resorption

Roles of Wnt signals in bone resorption during physiological and pathological states.

scientific article published on 31 October 2012

Roles of cathelicidin-related antimicrobial peptide in murine osteoclastogenesis.

scientific article published on November 2013

Specification of tissue-resident macrophages during organogenesis.

scientific article

Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice

scientific article

Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur

scientific article published on 01 December 1998

Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques

scientific article published on 14 December 2012

Tetracyclines convert the osteoclastic-differentiation pathway of progenitor cells to produce dendritic cell-like cells.

scientific article

The HIV co-receptor CCR5 regulates osteoclast function.

scientific article published on 20 December 2017

The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway

scientific article published on 09 July 2019

The Regulation of Bone Metabolism and Disorders by Wnt Signaling

scientific article published on 06 November 2019

The dynamin inhibitor dynasore inhibits bone resorption by rapidly disrupting actin rings of osteoclasts.

scientific article published on 11 June 2015

Treatment of OPG-deficient mice with WP9QY, a RANKL-binding peptide, recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesis

scientific article published on 22 September 2017

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways

scientific article published on 18 July 2015

Wnt16 regulates osteoclast differentiation in conjunction with Wnt5a.

scientific article

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis.

scientific article published on 19 February 2012

p38 Mitogen-activated protein kinase is crucially involved in osteoclast differentiation but not in cytokine production, phagocytosis, or dendritic cell differentiation of bone marrow macrophages

scientific article published on 24 July 2003

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