List of works - Benjamin T. Kile

A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency

scientific article published in February 2009

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo

scientific article published on 25 July 2014

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

scientific article published on 19 June 2020

A model for studying the hemostatic consumption or destruction of platelets

scientific article

A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis

scientific journal article

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

scientific article published on 9 June 2017

A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination

scientific article

A novel role for the EMT regulator, snai1, in hematopoiesis and leukemia

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

scientific article published on 07 October 2019

ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis

scientific article

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

scientific article published on 25 May 2015

Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury

scientific article published on January 2016

Acknowledgements: the Levin/Kile rule

scientific article published on 01 January 2019

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model.

scientific article published on 8 October 2015

Aging platelets stimulate TPO production.

scientific article published in January 2015

Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development

scientific journal article

Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling

scientific article published on 2 November 2017

An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation.

scientific article

An essential role for α4A-tubulin in platelet biogenesis

scientific article published on 13 February 2019

Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation

scientific article

Apoptosis in megakaryocytes and platelets: life and death of a lineage

scientific article published on 19 December 2017

Apoptotic Caspases: Multiple or Mistaken Identities?

scientific article published on 15 March 2018

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

scientific article published in December 2014

Apoptotic processes in megakaryocytes and platelets

scientific article published on July 2010

Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion

scientific article

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion.

scientific article published on 11 December 2017

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

scientific article published in February 2018

BCL-2 is dispensable for thrombopoiesis and platelet survival

scientific article

Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets

scientific article

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

scientific article

CHD7 deficiency in "Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment

scientific article

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

scientific article

Cell Death in the Hematopoietic System

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

scientific article published on 5 January 2017

Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway

scientific article published on 04 December 2019

Characterization of -mutant mice with microcytic phenotypes

scientific article published on 01 August 2018

Cloning, expression, and promoter structure of a mammalian inner centromere protein (INCENP).

scientific article published in April 1999

Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals

scientific article (publication date: November 2015)

Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

scientific article published on 8 May 2015

Critical roles for c-Myb in lymphoid priming and early B-cell development

scientific article

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia

scientific article

Description of a novel mutation leading to MYH9-related disease

scientific article published on 3 August 2008

Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice

scientific article published on 6 December 2017

Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia

scientific article published in November 2017

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets.

scientific article

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage

scientific article

ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level

scientific article published on 2 October 2012

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

scientific article

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

scientific article published in March 2017

Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia

scientific article

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice.

scientific article published on 14 June 2011

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

scientific article

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis.

scientific article published on 10 September 2014

Functional analysis of Asb-1 using genetic modification in mice

scientific article

Functional genetic analysis of mouse chromosome 11

scientific article (publication date: 4 September 2003)

Genetic Modifier Screens in Mice

scientific article published on March 2012

Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes

article

Genomic subtyping and therapeutic targeting of acute erythroleukemia

scientific article published on 29 March 2019

Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia.

scientific article

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

scientific article published on 20 October 2015

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

scientific article

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

scientific article published on August 2013

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

scientific article published on 21 May 2018

Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.

scientific article

Loss of Dynamin 2 GTPase function results in microcytic anaemia

scientific article published on 3 May 2017

Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).

scientific article

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

scientific article published in February 2013

MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication

scientific article

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

article

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

scientific article

Mice Haploinsufficient for Ets1 and Fli1 Display Middle Ear Abnormalities and Model Aspects of Jacobsen Syndrome

scientific article

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

scientific article

Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation

scientific article published on 17 August 2020

Mutation discovery in mice by whole exome sequencing

scientific article published on 14 September 2011

Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia

scientific article

Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia

scientific journal article

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia

scientific article

MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke.

scientific article

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells

scientific article

NLRP1 restricts butyrate producing commensals to exacerbate inflammatory bowel disease

scientific article published in Nature Communications

NLRP1a expression in Srebp-1a-deficient mice

scientific article published in March 2014

Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.

scientific article

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant

scientific article published on 28 January 2009

Pharmacological inhibition of TBK1/IKKε blunts immunopathology in a murine model of SARS-CoV-2 infection

scientific article published on 18 September 2023

Physiological restraint of Bak by Bcl-xL is essential for cell survival

scientific article published on 19 May 2016

Platelet Life Span and Apoptosis

scientific article published on 01 January 2012

Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways

scientific article

Platelet senescence is regulated by an internal timer, not damage inflicted by hits

scientific article published on 7 June 2010

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- mice

scientific journal article

Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

scientific article published on 24 January 2013

Probabilistic analysis of recessive mutagenesis screen strategies

scientific article published on 23 January 2007

Programmed anuclear cell death delimits platelet life span.

scientific article

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

scientific article published on 12 November 2018

Reduced Lymphocyte Longevity and Homeostatic Proliferation in Lamin B Receptor-Deficient Mice Results in Profound and Progressive Lymphopenia

scientific article published on 21 November 2011

Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments

scientific article

Regulation of platelet lifespan in the presence and absence of thrombopoietin signaling.

scientific article

SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity

scientific article

Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing

scientific article published on 18 May 2016

Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains

scientific article published on 01 January 2003

Shared roles for Scl and Lyl1 in murine platelet production and function

scientific article published on 12 July 2019

Stressed mitochondria sound the alarm

scientific article published on 10 March 2015

Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection

scientific article

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction.

scientific article

The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

scientific article published on 01 November 2018

The Regulation of Platelet Life Span

The SOCS box: a tale of destruction and degradation

scientific article (publication date: May 2002)

The art and design of genetic screens: mouse

scientific article

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

scientific article

The role of apoptosis in megakaryocytes and platelets

scientific article

The role of the ETS factor erg in zebrafish vasculogenesis

scientific article

The role of the intrinsic apoptosis pathway in platelet life and death.

scientific article published on July 2009

The spreading influence of platelet HDACs

scientific article published on 01 November 2012

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

scientific article

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain

scientific article

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

scientific article

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia

scholarly article published on 26 March 2013

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

scientific article published on 09 December 2009

Two ENU-induced alleles of Atp2b2 cause deafness in mice

scientific article

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.

scientific article published on 22 April 2009

Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice.

scientific article

List of works by Benjamin T. Kile

A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency

A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo

A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction

A model for studying the hemostatic consumption or destruction of platelets

A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis

A mouse model of hereditary coproporphyria identified in an ENU mutagenesis screen

A new mouse model of Canavan leukodystrophy displays hearing impairment due to central nervous system dysmyelination

A novel role for the EMT regulator, snai1, in hematopoiesis and leukemia

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis

Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

Ablation of Type-1 IFN Signaling in Hematopoietic Cells Confers Protection Following Traumatic Brain Injury

Acknowledgements: the Levin/Kile rule

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model.

Aging platelets stimulate TPO production.

Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development

Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling

An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation.

An essential role for α4A-tubulin in platelet biogenesis

Ankyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradation

Apoptosis in megakaryocytes and platelets: life and death of a lineage

Apoptotic Caspases: Multiple or Mistaken Identities?

Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production

Apoptotic processes in megakaryocytes and platelets

Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion

Autophagy induced during apoptosis degrades mitochondria and inhibits type I interferon secretion.

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.

BCL-2 is dispensable for thrombopoiesis and platelet survival

Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

CHD7 deficiency in "Looper", a new mouse model of CHARGE syndrome, results in ossicle malformation, otosclerosis and hearing impairment

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

Cell Death in the Hematopoietic System

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway

Characterization of -mutant mice with microcytic phenotypes

Cloning, expression, and promoter structure of a mammalian inner centromere protein (INCENP).

Conserved piRNA Expression from a Distinct Set of piRNA Cluster Loci in Eutherian Mammals

Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Critical roles for c-Myb in lymphoid priming and early B-cell development

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia

Description of a novel mutation leading to MYH9-related disease

Developmental Stage-Specific Manifestations of Absent TPO/c-MPL Signalling in Newborn Mice

Diagnosis and treatment of MYH9-RD in an Australasian cohort with thrombocytopenia

Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets.

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage

ENU mutagenesis identifies the first mouse mutants reproducing human β-thalassemia at the genomic level

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

ETO2-GLIS2 Hijacks Transcriptional Complexes to Drive Cellular Identity and Self-Renewal in Pediatric Acute Megakaryoblastic Leukemia.

Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice.

Expansion of the neonatal platelet mass is achieved via an extension of platelet lifespan

Fetal inhibition of inflammation improves disease phenotypes in harlequin ichthyosis.

Functional analysis of Asb-1 using genetic modification in mice

Functional genetic analysis of mouse chromosome 11

Genetic Modifier Screens in Mice

Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes

Genomic subtyping and therapeutic targeting of acute erythroleukemia

Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia.

IL-18 Production from the NLRP1 Inflammasome Prevents Obesity and Metabolic Syndrome.

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

Interleukin-11 is the dominant IL-6 family cytokine during gastrointestinal tumorigenesis and can be targeted therapeutically

Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion

Loss of Bak enhances lymphocytosis but does not ameliorate thrombocytopaenia in BCL-2 transgenic mice.

Loss of Dynamin 2 GTPase function results in microcytic anaemia

Loss of PUMA (BBC3) does not prevent thrombocytopenia caused by the loss of BCL-XL (BCL2L1).

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263).

MCMV-mediated inhibition of the pro-apoptotic Bak protein is required for optimal in vivo replication

Mcl-1 and Bcl-xL coordinately regulate megakaryocyte survival

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

Mice Haploinsufficient for Ets1 and Fli1 Display Middle Ear Abnormalities and Model Aspects of Jacobsen Syndrome

Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming

Mitochondrial dysfunction caused by outer membrane vesicles from Gram-negative bacteria activates intrinsic apoptosis and inflammation

Mutation discovery in mice by whole exome sequencing

Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia

Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia

Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia

MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke.

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells