List of works - Jean-Paul Pirnay

A Design of Experiment Approach to Optimize Spray-Dried Powders Containing Pseudomonas aeruginosaPodoviridae and Myoviridae Bacteriophages ⬇️

scientific article published on 24 September 2021

A bacteriophage journey at the European Medicines Agency

scientific article published on 10 December 2015

Access to bacteriophage therapy: discouraging experiences from the human cell and tissue legal framework

scientific article published on 16 December 2015

Access to human tissues for research and product development: From EU regulation to alarming legal developments in Belgium

scientific article published on 7 April 2015

Actin dynamics regulate immediate PAR-2-dependent responses to acute epidermal permeability barrier abrogation

scientific article published on 7 December 2010

Analysis of epidemic Pseudomonas aeruginosa isolates by isoelectric focusing of pyoverdine and RAPD-PCR: modern tools for an integrated anti-nosocomial infection strategy in burn wound centres

scientific article published on 01 August 1997

Analysis of the Pseudomonas aeruginosa oprD gene from clinical and environmental isolates.

scientific article published in December 2002

Antibiotic Resistance Profiling of Phenotypic and Genomic Characterized Pseudomonas aeruginosa Isolates from Animal and Human Origin

scholarly article by D. De Vos et al published December 2008 in International Journal of Infectious Diseases

Antimicrobial resistance and genomic rep-PCR fingerprints of Pseudomonas aeruginosa strains from animals on the background of the global population structure.

scientific article

Art-175 is a highly efficient antibacterial against multidrug-resistant strains and persisters of Pseudomonas aeruginosa

scientific article

Bacteriophage Application for Difficult-to-treat Musculoskeletal Infections: Development of a Standardized Multidisciplinary Treatment Protocol

scientific article published on 23 September 2019

Bacteriophage Production in Compliance with Regulatory Requirements

scientific article published in January 2018

Bacteriophage therapy as a treatment strategy for orthopaedic-device-related infections: where do we stand?

scientific article published on 05 May 2020

Bacteriophage therapy: Fast-forward to the past lessons identified from the advanced therapy regulation

scientific article published on 15 December 2015

Bacteriophages: it's a medicine, Jim, but not as we know it

scientific article published on 16 September 2020

Beware of the commercialization of human cells and tissues: situation in the European Union

scientific article

Beyond antibiotic therapy - Future antiinfective strategies - Update 2017

scientific article

Biological tests carried out on serum/plasma samples from donors of human body material for transplantation: Belgian experience and practical recommendations

article

Business oriented EU human cell and tissue product legislation will adversely impact Member States' health care systems

scientific article published on 20 September 2013

Call for a dedicated European legal framework for bacteriophage therapy.

scientific article published on 06 February 2014

Characterization of Salmonella Isolates from Various Geographical Regions of the Caucasus and Their Susceptibility to Bacteriophages

scientific article published on 10 December 2020

Characterization of newly isolated lytic bacteriophages active against Acinetobacter baumannii

scientific article

Cleanrooms and tissue banking how happy I could be with either GMP or GTP?

scientific article published on 04 January 2013

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

scientific article

Comparison of the sensitivity of culture, PCR and quantitative real-time PCR for the detection of Pseudomonas aeruginosa in sputum of cystic fibrosis patients.

scientific article

Correction to: Biological tests carried out on serum/plasma samples from donors of human body material for transplantation: Belgian experience and practical recommendations

article

Correlation between cytotoxicity induced by Pseudomonas aeruginosa clinical isolates from acute infections and IL-1β secretion in a model of human THP-1 monocytes.

scientific article

Developing an international Pseudomonas aeruginosa reference panel

scientific article

Development of a qPCR platform for quantification of the five bacteriophages within bacteriophage cocktail 2 (BFC2)

scientific article published on 25 September 2019

Direct detection and identification of Pseudomonas aeruginosa in clinical samples such as skin biopsy specimens and expectorations by multiplex PCR based on two outer membrane lipoprotein genes, oprI and oprL.

scientific article published on June 1997

Distribution and evolution of ferripyoverdine receptors in Pseudomonas aeruginosa.

scientific article published on 21 April 2009

Effectiveness of bacteriophages in the sputum of cystic fibrosis patients.

scientific article published on 26 July 2014

Effects of sequential and simultaneous applications of bacteriophages on populations of Pseudomonas aeruginosa in vitro and in wax moth larvae.

scientific article

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

scholarly article by Patrick Jault et al published 3 October 2018 in Lancet Infectious Diseases

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

scholarly article by Patrick Jault et al published January 2019 in Lancet Infectious Diseases

Engineered endolysin-based "Artilysins" to combat multidrug-resistant gram-negative pathogens

scientific article (publication date: July 2014)

European regulatory conundrum of phage therapy

scientific article

Evaluation of a microbiological screening and acceptance procedure for cryopreserved skin allografts based on 14 day cultures

scientific article

Evaluation of oprI and oprL genes as molecular markers for the genus Pseudomonas and their use in studying the biodiversity of a small Belgian River.

scientific article

Evaluation of the Stability of Bacteriophages in Different Solutions Suitable for the Production of Magistral Preparations in Belgium

scientific article published on 10 May 2021

Experimental phage therapy of burn wound infection: difficult first steps

scientific article

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.

scientific article published on 5 April 2018

Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica

scientific article published on 22 December 2020

Feeder layer- and animal product-free culture of neonatal foreskin keratinocytes: improved performance, usability, quality and safety

scientific article published on 11 March 2011

FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa

scientific article

Genomics of an endemic cystic fibrosis Burkholderia multivorans strain reveals low within-patient evolution but high between-patient diversity

scientific article published in 2021

Global Pseudomonas aeruginosa biodiversity as reflected in a Belgian river

scientific article published in July 2005

Glycerol treatment as recovery procedure for cryopreserved human skin allografts positive for bacteria and fungi

scientific article published on March 2011

Guidelines to Compose an Ideal Bacteriophage Cocktail

scientific article published in January 2018

HIV transmission by transplantation of allograft skin: a review of the literature.

scientific article published on February 1997

Human cells and tissues: the need for a global ethical framework

scientific article

Identification of new, conserved, non-ribosomal peptide synthetases from fluorescent pseudomonads involved in the biosynthesis of the siderophore pyoverdine

scientific journal article

In Vitro and In Vivo Assessments of Two Newly Isolated Bacteriophages against an ST13 Urinary Tract Infection Klebsiella pneumoniae

scientific article published on 17 May 2022

In vivo development of antimicrobial resistance in Pseudomonas aeruginosa strains isolated from the lower respiratory tract of Intensive Care Unit patients with nosocomial pneumonia and receiving antipseudomonal therapy

scientific article published on December 2010

Increase of efflux-mediated resistance in Pseudomonas aeruginosa during antibiotic treatment in patients suffering from nosocomial pneumonia

scientific article published on 26 November 2015

Isolation and Characterization of Lytic Pseudomonas aeruginosa Bacteriophages Isolated from Sewage Samples from Tunisia

scientific article published in 2022

Microbiological and molecular assessment of bacteriophage ISP for the control of Staphylococcus aureus

scientific article

Molecular Epidemiology and Clinical Impact of Acinetobacter calcoaceticus-baumannii Complex in a Belgian Burn Wound Center

scientific article

Molecular epidemiology of Pseudomonas aeruginosa colonization in a burn unit: persistence of a multidrug-resistant clone and a silver sulfadiazine-resistant clone

scientific article

No easy way to exterminate 'superbugs' at the dawn of the third millennium

scientific article

O serotype-independent susceptibility of Pseudomonas aeruginosa to lectin-like pyocins

scientific article published on 16 September 2014

Optimizing the European regulatory framework for sustainable bacteriophage therapy in human medicine

scientific article published on 17 April 2012

Paving a regulatory pathway for phage therapy. Europe should muster the resources to financially, technically and legally support the introduction of phage therapy.

scientific article published on 18 October 2013

Phage Therapy ⬇️

scholarly article

Phage Therapy in the Year 2035

scientific article published on 03 June 2020

Potential release of aluminum and other metals by food-grade aluminum foil used for skin allograft cryo preservation.

scientific article published on 10 February 2010

Pre-adapting parasitic phages to a pathogen leads to increased pathogen clearance and lowered resistance evolution with Pseudomonas aeruginosa cystic fibrosis bacterial isolates

scientific article

Prevalence of Anaplasma phagocytophilum in humans in Belgium for the period 2013-2016

article

Processing Phage Therapy Requests in a Brussels Military Hospital: Lessons Identified

scientific article published on 17 March 2019

Pseudomonas aeruginosa displays an epidemic population structure

scientific article published in December 2002

Pseudomonas aeruginosa population structure revisited

scientific article

Quality and safety requirements for sustainable phage therapy products

scientific article published on 14 January 2015

Quality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials

scientific article

Quantitation of Pseudomonas aeruginosa in wound biopsy samples: from bacterial culture to rapid 'real-time' polymerase chain reaction

scientific article

Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography.

scientific article published on October 2014

Recellularizing of human acellular dermal matrices imaged by high-definition optical coherence tomography.

scientific article

Schistosomiasis in Belgian Military Personnel Returning From the Democratic Republic of Congo ⬇️

scientific article published on November 1, 2011

Selection and characterization of a candidate therapeutic bacteriophage that lyses the Escherichia coli O104:H4 strain from the 2011 outbreak in Germany

scientific article

Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo.

scientific article

Seoul hantavirus in Europe: first demonstration of the virus genome in wild Rattus norvegicus captured in France.

scientific article

Silk Route to the Acceptance and Re-Implementation of Bacteriophage Therapy-Part II.

scientific article published on 23 April 2018

Stability of Staphylococcus aureus phage ISP after freeze-drying (lyophilization)

scientific article

Stability of bacteriophages in burn wound care products.

scientific article

Study of a SARS-CoV-2 Outbreak in a Belgian Military Education and Training Center in Maradi, Niger

scientific article published on 27 August 2020

Survey of Pseudomonas aeruginosa and its phages: de novo peptide sequencing as a novel tool to assess the diversity of worldwide collected viruses

scientific article

Taking bacteriophage therapy seriously: a moral argument

scientific article

The Developing World Urgently Needs Phages to Combat Pathogenic Bacteria

scientific article published on 08 June 2016

The Magistral Phage

scientific article published on 6 February 2018

The Phage Therapy Paradigm: Prêt-à-Porter or Sur-mesure?

scientific article published on 10 November 2010

The Unique Role That WHO Could Play in Implementing Phage Therapy to Combat the Global Antibiotic Resistance Crisis

scientific article published on 03 September 2020

The Widespread Multidrug-Resistant Serotype O12 Pseudomonas aeruginosa Clone Emerged through Concomitant Horizontal Transfer of Serotype Antigen and Antibiotic Resistance Gene Clusters

scientific article

Use of bacteriophages in the treatment of colistin-only-sensitive Pseudomonas aeruginosa septicaemia in a patient with acute kidney injury-a case report.

scientific article published on 4 June 2017

List of works by Jean-Paul Pirnay

A Design of Experiment Approach to Optimize Spray-Dried Powders Containing Pseudomonas aeruginosaPodoviridae and Myoviridae Bacteriophages ⬇️

A bacteriophage journey at the European Medicines Agency

Access to bacteriophage therapy: discouraging experiences from the human cell and tissue legal framework

Access to human tissues for research and product development: From EU regulation to alarming legal developments in Belgium

Actin dynamics regulate immediate PAR-2-dependent responses to acute epidermal permeability barrier abrogation

Analysis of epidemic Pseudomonas aeruginosa isolates by isoelectric focusing of pyoverdine and RAPD-PCR: modern tools for an integrated anti-nosocomial infection strategy in burn wound centres

Analysis of the Pseudomonas aeruginosa oprD gene from clinical and environmental isolates.

Antibiotic Resistance Profiling of Phenotypic and Genomic Characterized Pseudomonas aeruginosa Isolates from Animal and Human Origin

Antimicrobial resistance and genomic rep-PCR fingerprints of Pseudomonas aeruginosa strains from animals on the background of the global population structure.

Art-175 is a highly efficient antibacterial against multidrug-resistant strains and persisters of Pseudomonas aeruginosa

Bacteriophage Application for Difficult-to-treat Musculoskeletal Infections: Development of a Standardized Multidisciplinary Treatment Protocol

Bacteriophage Production in Compliance with Regulatory Requirements

Bacteriophage therapy as a treatment strategy for orthopaedic-device-related infections: where do we stand?

Bacteriophage therapy: Fast-forward to the past lessons identified from the advanced therapy regulation

Bacteriophages: it's a medicine, Jim, but not as we know it

Beware of the commercialization of human cells and tissues: situation in the European Union

Beyond antibiotic therapy - Future antiinfective strategies - Update 2017

Biological tests carried out on serum/plasma samples from donors of human body material for transplantation: Belgian experience and practical recommendations

Business oriented EU human cell and tissue product legislation will adversely impact Member States' health care systems

Call for a dedicated European legal framework for bacteriophage therapy.

Characterization of <i>Salmonella</i> Isolates from Various Geographical Regions of the Caucasus and Their Susceptibility to Bacteriophages

Characterization of newly isolated lytic bacteriophages active against Acinetobacter baumannii

Cleanrooms and tissue banking how happy I could be with either GMP or GTP?

Clinical utilization of genomics data produced by the international Pseudomonas aeruginosa consortium

Comparison of the sensitivity of culture, PCR and quantitative real-time PCR for the detection of Pseudomonas aeruginosa in sputum of cystic fibrosis patients.

Correction to: Biological tests carried out on serum/plasma samples from donors of human body material for transplantation: Belgian experience and practical recommendations

Correlation between cytotoxicity induced by Pseudomonas aeruginosa clinical isolates from acute infections and IL-1β secretion in a model of human THP-1 monocytes.

Developing an international Pseudomonas aeruginosa reference panel

Development of a qPCR platform for quantification of the five bacteriophages within bacteriophage cocktail 2 (BFC2)

Direct detection and identification of Pseudomonas aeruginosa in clinical samples such as skin biopsy specimens and expectorations by multiplex PCR based on two outer membrane lipoprotein genes, oprI and oprL.

Distribution and evolution of ferripyoverdine receptors in Pseudomonas aeruginosa.

Effectiveness of bacteriophages in the sputum of cystic fibrosis patients.

Effects of sequential and simultaneous applications of bacteriophages on populations of Pseudomonas aeruginosa in vitro and in wax moth larvae.

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

Engineered endolysin-based "Artilysins" to combat multidrug-resistant gram-negative pathogens

European regulatory conundrum of phage therapy

Evaluation of a microbiological screening and acceptance procedure for cryopreserved skin allografts based on 14 day cultures

Evaluation of oprI and oprL genes as molecular markers for the genus Pseudomonas and their use in studying the biodiversity of a small Belgian River.

Evaluation of the Stability of Bacteriophages in Different Solutions Suitable for the Production of Magistral Preparations in Belgium

Experimental phage therapy of burn wound infection: difficult first steps

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains.

Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal <i>Salmonella enterica</i>

Feeder layer- and animal product-free culture of neonatal foreskin keratinocytes: improved performance, usability, quality and safety

FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa

Genomics of an endemic cystic fibrosis Burkholderia multivorans strain reveals low within-patient evolution but high between-patient diversity

Global Pseudomonas aeruginosa biodiversity as reflected in a Belgian river

Glycerol treatment as recovery procedure for cryopreserved human skin allografts positive for bacteria and fungi

Guidelines to Compose an Ideal Bacteriophage Cocktail

HIV transmission by transplantation of allograft skin: a review of the literature.

Human cells and tissues: the need for a global ethical framework

Identification of new, conserved, non-ribosomal peptide synthetases from fluorescent pseudomonads involved in the biosynthesis of the siderophore pyoverdine

In Vitro and In Vivo Assessments of Two Newly Isolated Bacteriophages against an ST13 Urinary Tract Infection <i>Klebsiella pneumoniae</i>

In vivo development of antimicrobial resistance in Pseudomonas aeruginosa strains isolated from the lower respiratory tract of Intensive Care Unit patients with nosocomial pneumonia and receiving antipseudomonal therapy

Increase of efflux-mediated resistance in Pseudomonas aeruginosa during antibiotic treatment in patients suffering from nosocomial pneumonia

Isolation and Characterization of Lytic Pseudomonas aeruginosa Bacteriophages Isolated from Sewage Samples from Tunisia

Microbiological and molecular assessment of bacteriophage ISP for the control of Staphylococcus aureus

Molecular Epidemiology and Clinical Impact of Acinetobacter calcoaceticus-baumannii Complex in a Belgian Burn Wound Center

Molecular epidemiology of Pseudomonas aeruginosa colonization in a burn unit: persistence of a multidrug-resistant clone and a silver sulfadiazine-resistant clone

No easy way to exterminate 'superbugs' at the dawn of the third millennium

O serotype-independent susceptibility of Pseudomonas aeruginosa to lectin-like pyocins

Optimizing the European regulatory framework for sustainable bacteriophage therapy in human medicine

Paving a regulatory pathway for phage therapy. Europe should muster the resources to financially, technically and legally support the introduction of phage therapy.

Phage Therapy ⬇️

Phage Therapy in the Year 2035

Potential release of aluminum and other metals by food-grade aluminum foil used for skin allograft cryo preservation.

Pre-adapting parasitic phages to a pathogen leads to increased pathogen clearance and lowered resistance evolution with Pseudomonas aeruginosa cystic fibrosis bacterial isolates

Prevalence of Anaplasma phagocytophilum in humans in Belgium for the period 2013-2016

Processing Phage Therapy Requests in a Brussels Military Hospital: Lessons Identified

Pseudomonas aeruginosa displays an epidemic population structure

Pseudomonas aeruginosa population structure revisited

Quality and safety requirements for sustainable phage therapy products

Quality-controlled small-scale production of a well-defined bacteriophage cocktail for use in human clinical trials

Quantitation of Pseudomonas aeruginosa in wound biopsy samples: from bacterial culture to rapid 'real-time' polymerase chain reaction

Real-time three-dimensional imaging of epidermal splitting and removal by high-definition optical coherence tomography.

Recellularizing of human acellular dermal matrices imaged by high-definition optical coherence tomography.

Schistosomiasis in Belgian Military Personnel Returning From the Democratic Republic of Congo ⬇️

Selection and characterization of a candidate therapeutic bacteriophage that lyses the Escherichia coli O104:H4 strain from the 2011 outbreak in Germany

Selection of Potential Therapeutic Bacteriophages that Lyse a CTX-M-15 Extended Spectrum β-Lactamase Producing Salmonella enterica Serovar Typhi Strain from the Democratic Republic of the Congo.