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List of works by Jim X. Shen

A UHPLC-MS/MS bioanalytical assay for the determination of BMS-911543, a JAK2 inhibitor, in human plasma.

scientific article

A high-throughput LC-MS/MS method for the quantitation of posaconazole in human plasma: Implementing fused core silica liquid chromatography.

scientific article published on 7 April 2009

A novel and cost effective method of removing excess albumin from plasma/serum samples and its impacts on LC-MS/MS bioanalysis of therapeutic proteins

scientific article published on 8 August 2014

A sensitive liquid chromatography and mass spectrometry method for the determination of posaconazole in human plasma

scientific article

A validated LC-MS/MS method for the quantitative measurement of creatinine as an endogenous biomarker in human plasma

scientific article published on 9 September 2016

A validated enantioselective LC-MS/MS assay for the simultaneous determination of carvedilol and its pharmacologically active 4'-hydroxyphenyl metabolite in human plasma: application to a clinical pharmacokinetic study

scientific article published on 30 May 2012

Determination of a novel thrombin receptor antagonist (SCH 530348) in human plasma: evaluation of Ultra Performance Liquid Chromatography™-tandem mass spectrometry for routine bioanalytical analysis

scientific article published on 24 February 2011

Development and validation of a liquid chromatography tandem mass spectrometry assay for the quantitation of a protein therapeutic in cynomolgus monkey serum

scientific article

Dried blood spot analysis without dilution: Application to the LC-MS/MS determination of BMS-986001 in rat dried blood spot.

scientific article published on 28 August 2015

Evaluation of automated micro solid phase extraction tips (micro-SPE) for the validation of a LC-MS/MS bioanalytical method

scientific article published on 26 July 2006

Fit-for-purpose bioanalytical cross-validation for LC-MS/MS assays in clinical studies

scientific article

Implementation of high-temperature superficially porous technologies for rapid LC-MS/MS diastereomer bioanalysis

scientific article published on 01 April 2011

Improved ruggedness of an ion-pairing liquid chromatography/tandem mass spectrometry assay for the quantitative analysis of the triphosphate metabolite of a nucleoside reverse transcriptase inhibitor in peripheral blood mononuclear cells

scientific article published on 01 February 2013

LC-MS/MS determination of apixaban (BMS-562247) and its major metabolite in human plasma: an application of polarity switching and monolithic HPLC column

scientific article published on 01 August 2014

Minimization of ion suppression in LC-MS/MS analysis through the application of strong cation exchange solid-phase extraction (SCX-SPE)

scientific article published on 01 February 2005

Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL.

scientific article published on 10 August 2005

Overcoming bioanalytical challenges in an Onglyza(®) intravenous [(14)C]microdose absolute bioavailability study with accelerator MS.

scientific article published in August 2012

Reasons for calibration standard curve slope variation in LC-MS assays and how to address it

scientific article published on 01 June 2014

Regulated bioanalytical laboratory automation: where we came from, where we are and where we are going

scientific article published on 01 July 2011

Selective reaction monitoring of negative electrospray ionization acetate adduct ions for the bioanalysis of dapagliflozin in clinical studies

scientific article published on 24 February 2015

Sensitivity-based analytical approaches to support human absolute bioavailability studies

scientific article published in February 2014

Simultaneous determination of desloratadine and pseudoephedrine in human plasma using micro solid-phase extraction tips and aqueous normal-phase liquid chromatography/tandem mass spectrometry

scientific article published in January 2007

Stereoselective quantitation of a serine protease inhibitor using LC-MS/MS at elevated column temperature

scientific article

Strategies for improving sensitivity and selectivity for the quantitation of biotherapeutics in biological matrix using LC-MS/MS.

scientific article published on 16 March 2015

Using temperature to optimize resolution and reduce analysis times for bioanalytical diastereomer LC-MS/MS separations

scientific article published on 22 August 2010

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