List of works - Ignacio Brouard

3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells

scientific article published on 3 October 2017

3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK.

scientific article published on 6 April 2018

6'-Benzyloxy-4-bromo-2'-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis

scientific article published on 19 December 2018

A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands.

scientific article published on 25 May 2013

A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells

scientific article

A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M.

scientific article published on 4 August 2011

A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides ⬇️

scientific article

A practical improvement, enhancing the large-scale synthesis of (+)-discodermolide: a third-generation approach

scientific article published on 01 November 2003

Anthraquinone glycosides from Cassia roxburghii and evaluation of its free radical scavenging activity

scientific article published on 8 August 2012

Antiproliferative activity and apoptosis induction by 3',4'-dibenzyloxyflavonol on human leukemia cells

scientific article published on 21 February 2017

Chemotaxonomy of Gonospermum and related genera

scientific article published on 22 January 2010

Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes

scientific article published on 01 November 2005

Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide.

scientific article

Effect of C-ring modifications on the cytotoxicity of spirostan saponins and related glycosides.

scientific article

Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl- 4-butanolides in relation to PGE2.

scientific article

Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells

scientific article published on September 2006

Multicomponent Ligation of Steroids: Creating Diversity at the Linkage Moiety of Bis-spirostanic Conjugates by Ugi Reactions ⬇️

scientific article published on May 7, 2013

Multicomponent synthesis of Ugi-type ceramide analogues and neoglycolipids from lipidic isocyanides

scientific article published on 10 May 2012

New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides.

scientific article

New quinoline alkaloid from Ruta graveolens aerial parts and evaluation of the antifertility activity.

scientific article

Phenolic metabolites from Pyruscalleryana and evaluation of its free radical scavenging activity.

scientific article published on 3 December 2010

Secondary metabolites and bioactivities of Albizia anthelmintica.

scientific article published on April 2013

Secondary metabolites from two species of Pulicaria and their cytotoxic activity.

scientific article published in November 2011

Secondary metabolites from two species of Tolpis and their biological activities.

scientific article published in November 2012

Sesquiterpene lactones and other constituents from Matricaria chamomilla L

scientific article

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

scientific article

Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance

scientific article published on 4 May 2016

Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells

scientific article published on 4 July 2014

Synthesis of novel spirostanic saponins and their cytotoxic activity

scientific article published on 4 November 2007

Toward understanding how the lactone moiety of discodermolide affects activity.

scientific article

List of works by Ignacio Brouard

3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells

3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK.

6'-Benzyloxy-4-bromo-2'-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis

A chemotaxonomic study of endemic species of genus Tanacetum from the Canary Islands.

A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells

A new flavonoid and other constituents from Centaurea nicaeensis All. var. walliana M.

A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides ⬇️

A practical improvement, enhancing the large-scale synthesis of (+)-discodermolide: a third-generation approach

Anthraquinone glycosides from Cassia roxburghii and evaluation of its free radical scavenging activity

Antiproliferative activity and apoptosis induction by 3',4'-dibenzyloxyflavonol on human leukemia cells

Chemotaxonomy of Gonospermum and related genera

Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes

Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide.

Effect of C-ring modifications on the cytotoxicity of spirostan saponins and related glycosides.

Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl- 4-butanolides in relation to PGE2.

Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells

Multicomponent Ligation of Steroids: Creating Diversity at the Linkage Moiety of Bis-spirostanic Conjugates by Ugi Reactions ⬇️

Multicomponent synthesis of Ugi-type ceramide analogues and neoglycolipids from lipidic isocyanides

New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides.

New quinoline alkaloid from Ruta graveolens aerial parts and evaluation of the antifertility activity.

Phenolic metabolites from Pyruscalleryana and evaluation of its free radical scavenging activity.

Secondary metabolites and bioactivities of Albizia anthelmintica.

Secondary metabolites from two species of Pulicaria and their cytotoxic activity.

Secondary metabolites from two species of Tolpis and their biological activities.

Sesquiterpene lactones and other constituents from Matricaria chamomilla L

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance

Synthesis and effects on cell viability of flavonols and 3-methyl ether derivatives on human leukemia cells

Synthesis of novel spirostanic saponins and their cytotoxic activity

Toward understanding how the lactone moiety of discodermolide affects activity.