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List of works by Alfons A den Broeder

(Bi)Weekly folic acid supplementation might be inferior to a daily folic acid dosing schedule in the prevention of methotrexate-related toxicity in patients with rheumatoid arthritis

scientific article published on 27 August 2015

A multi-biomarker score measuring disease activity in rheumatoid arthritis patients tapering adalimumab or etanercept: predictive value for clinical and radiographic outcomes

scientific article published on 22 February 2017

A multidisciplinary and multidimensional intervention for patients with hand osteoarthritis ⬇️

scientific article published on February 1, 2012

A single course of rituximab does not abrogate anti-infliximab antibodies in patients with rheumatoid arthritis

scientific article published on 01 August 2009

A single dose, placebo controlled study of the fully human anti-tumor necrosis factor-alpha antibody adalimumab (D2E7) in patients with rheumatoid arthritis

scientific article published on 01 November 2002

A tight control treatment strategy aiming for remission in early rheumatoid arthritis is more effective than usual care treatment in daily clinical practice: a study of two cohorts in the Dutch Rheumatoid Arthritis Monitoring registry

scientific article published on 30 December 2011

Acute and probable chronic Q fever during anti-TNFα and anti B-cell immunotherapy: a case report.

scientific article

Adalimumab and etanercept serum (anti)drug levels are not predictive for successful dose reduction or discontinuation in rheumatoid arthritis.

scientific article published on 4 September 2015

Adalimumab, a fully human anti-TNF-alpha monoclonal antibody, treatment does not influence experimental UV response in the skin of rheumatoid arthritis patients

scientific article published on 01 August 2003

Age-Related Health Hazards in Old Patients with First-Time Referral to a Rheumatologist: A Descriptive Study ⬇️

scientific article published on January 1, 2011

Anti-infliximab antibodies are already detectable in most patients with rheumatoid arthritis halfway through an infusion cycle: an open-label pharmacokinetic cohort study.

scientific article

Anticyclic Citrullinated Peptide Antibodies and Rheumatoid Factor as Risk Factors for 10-year Cardiovascular Morbidity in Patients with Rheumatoid Arthritis: A Large Inception Cohort Study.

scientific article

Antidrug antibodies to tumour necrosis factor specific neutralising agents in chronic inflammatory diseases: a real issue, a clinical perspective; comment on the article by Vincent et al.

scientific article published on 12 April 2013

Are ultrasonographic signs of inflammation predictors for response to intra-articular glucocorticoids in knee osteoarthritis?

scientific article published on 02 October 2014

Association between serum levels of the proinflammatory protein S100A8/A9 and clinical and structural characteristics of patients with established knee, hip, and hand osteoarthritis

scientific article published on 2 September 2014

Authors' reply

scientific article published on 13 December 2016

Biologic discontinuation studies: a systematic review of methods; comment on the article by Yoshida et al.

scientific article published on 27 September 2013

Can response duration after the first rituximab treatment be used in timing of rituximab retreatment?

scientific article published on 16 March 2013

Choosing Wisely in Daily Practice: An Intervention Study on Antinuclear Antibody Testing by Rheumatologists

scientific article published on 01 April 2016

Choosing wisely in daily practice: a mixed methods study on determinants of antinuclear antibody testing by rheumatologists.

scientific article published on 29 July 2016

Clinical utility of therapeutic drug monitoring in biological disease modifying anti-rheumatic drug treatment of rheumatic disorders: a systematic narrative review.

scientific article

Comment on l'Ami et al titled 'Successful reduction of overexposure in patients with rheumatoid arthritis with high serum adalimumab concentrations: an open-label, non-inferiority, randomised clinical trial'.

scientific article published in November 2017

Construct and criterion validity of several proposed DAS28-based rheumatoid arthritis flare criteria: an OMERACT cohort validation study.

scientific article published on 23 November 2012

Content and Construct Validity, Reliability, and Responsiveness of the Rheumatoid Arthritis Flare Questionnaire: OMERACT 2016 Workshop Report.

scientific article published on 15 August 2017

Correction: Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients

scientific article published on 01 December 2019

Cost-effectiveness of five different anti-tumour necrosis factor tapering strategies in rheumatoid arthritis: a modelling study

scientific article published on 21 June 2019

Coxiella burnetii infection (Q fever) in rheumatoid arthritis patients with and without anti-TNFα therapy

scientific article published on 02 May 2014

Determinants of range of joint motion in patients with early symptomatic osteoarthritis of the hip and/or knee: an exploratory study in the CHECK cohort

scientific article published on 25 January 2011

Development and content of a group-based intervention to improve medication adherence in non-adherent patients with rheumatoid arthritis

scientific article published on 09 August 2012

Development of quality indicators for monitoring of the disease course in rheumatoid arthritis.

scientific article published on 15 May 2009

Difference in the risk of serious infections in patients with rheumatoid arthritis treated with adalimumab, infliximab and etanercept: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry

scientific article published on 11 August 2012

Digital vasculitis in a patient with rheumatoid arthritis: good response on anti-TNF blockade.

scientific article published on 26 January 2001

Disease activity-guided dose optimisation of adalimumab and etanercept is a cost-effective strategy compared with non-tapering tight control rheumatoid arthritis care: analyses of the DRESS study

scientific article published on 13 January 2016

Disseminated Mycobacterium gordonae infection in a renal transplant recipient.

scientific article published on September 2003

Dose REduction strategy of subcutaneous TNF inhibitors in rheumatoid arthritis: design of a pragmatic randomised non inferiority trial, the DRESS study

scientific article

Dose de-escalation strategies and role of therapeutic drug monitoring of biologics in RA

scientific article published on 23 March 2010

Dose reduction of tocilizumab in rheumatoid arthritis patients with low disease activity

scholarly article by N van Herwaarden et al published 28 April 2014 in Clinical and Experimental Rheumatology

Dose titration using the Disease Activity Score (DAS28) in rheumatoid arthritis patients treated with anti-TNF-alpha

scientific article published on 01 June 2002

Down titration and discontinuation strategies of tumor necrosis factor blocking agents for rheumatoid arthritis in patients with low disease activity

scientific article

Down-titration and discontinuation of infliximab in rheumatoid arthritis patients with stable low disease activity and stable treatment: an observational cohort study

scientific article published on 13 April 2012

Down-titration and discontinuation strategies of tumor necrosis factor-blocking agents for rheumatoid arthritis in patients with low disease activity

scientific article

Down-titration and discontinuation strategies of tumour necrosis factor-blocking agents for rheumatoid arthritis in patients with low disease activity

scientific article published on 24 May 2019

Effectiveness of a group-based intervention to change medication beliefs and improve medication adherence in patients with rheumatoid arthritis: a randomized controlled trial

scientific article published on 11 December 2013

Effectiveness of a third tumor necrosis factor-α-blocking agent compared with rituximab after failure of 2 TNF-blocking agents in rheumatoid arthritis

scientific article published on 01 September 2011

Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis: a randomised, double-blinded, sham-controlled trial

scientific article published on 26 October 2018

Effects of treatment with a fully human anti-tumour necrosis factor alpha monoclonal antibody on the local and systemic homeostasis of interleukin 1 and TNFalpha in patients with rheumatoid arthritis.

scientific article published on July 2001

Etanercept-related extensive pulmonary nodulosis in a patient with rheumatoid arthritis.

scientific article published on 15 June 2007

Evidence-based tailored conservative treatment of knee and hip osteoarthritis: between knowing and doing

scientific article published on 25 January 2011

Ex-vivo inhibited cytokine profiling explains inferior treatment response to golimumab after adalimumab failure in rheumatoid arthritis

scientific article published on 18 October 2017

Exploring longitudinal associations of histologically assessed inflammation with symptoms and radiographic damage in knee osteoarthritis: combined results of three prospective cohort studies

scientific article published on 16 November 2018

Fatigue in knee and hip osteoarthritis: the role of pain and physical function.

scientific article published on 12 July 2011

Feasibility and potential effectiveness of a non-pharmacological multidisciplinary care programme for persons with generalised osteoarthritis: a randomised, multiple-baseline single-case study ⬇️

scientific article published on July 19, 2012

Frequency and effectiveness of dose increase of adalimumab, etanercept, and infliximab in daily clinical practice

scientific article published on 01 September 2010

Genetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients

scientific article published in Scientific Reports

How should worsening in osteoarthritis be defined? Development and initial validation of preliminary criteria for clinical worsening in knee and hip osteoarthritis

scientific article

Implementation of protocolized tight control and biological dose optimization in daily clinical practice: results of a pilot study

scientific article published on 27 July 2016

Implementing Psoriatic Arthritis Disease Activity Score-guided treat-to-target in psoriatic arthritis routine clinical practice: (im)possible?

scientific article published on 01 December 2019

Joint-pain comorbidity, health status, and medication use in hip and knee osteoarthritis: a cross-sectional study

scientific article

Lack of beneficial effects of low-dose radiation therapy on hand osteoarthritis symptoms and inflammation: a randomised, blinded, sham-controlled trial

scientific article published on 07 July 2018

Little Evidence for Usefulness of Biomarkers for Predicting Successful Dose Reduction or Discontinuation of a Biologic Agent in Rheumatoid Arthritis: A Systematic Review.

scientific article

Long term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation.

scientific article published on April 2002

Long-term effectiveness and safety of TNF-blocking agents in daily clinical practice: results from the Dutch Rheumatoid Arthritis Monitoring register.

scientific article

Long-term outcomes after disease activity-guided dose reduction of TNF inhibition in rheumatoid arthritis: 3-year data of the DRESS study - a randomised controlled pragmatic non-inferiority strategy trial

scientific article

Longitudinal impact of joint pain comorbidity on quality of life and activity levels in knee osteoarthritis: data from the Osteoarthritis Initiative ⬇️

scientific article published on November 30, 2012

Low disease activity (DAS28≤3.2) reduces the risk of first cardiovascular event in rheumatoid arthritis: a time-dependent Cox regression analysis in a large cohort study.

scientific article published on 12 June 2017

Low infliximab serum trough levels and anti-infliximab antibodies are prevalent in rheumatoid arthritis patients treated with infliximab in daily clinical practice: results of an observational cohort study.

scientific article

Making the rheumatologist aware of patients' non-adherence does not improve medication adherence in patients with rheumatoid arthritis

scientific article published on 26 October 2010

Measuring flares in rheumatoid arthritis. (Why) do we need validated criteria?

scientific article published on 01 February 2014

Nephrotic syndrome as a complication of anti-TNFalpha in a patient with rheumatoid arthritis

scientific article published on 01 April 2003

Nephrotic syndrome associated with anti-tumor necrosis factor alpha therapy in a patient with rheumatoid arthritis: comment on the article by Charles et al

scientific article published on 01 June 2002

No evidence for the effectiveness of a multidisciplinary group based treatment program in patients with osteoarthritis of hands on the short term; results of a randomized controlled trial

scientific article published on 11 April 2013

No relevant excess prevalence of myotonic dystrophy type 2 in patients with suspected fibromyalgia syndrome

scientific article published on 6 April 2016

Non-pharmacological care for patients with generalized osteoarthritis: design of a randomized clinical trial

scientific article

Open-Label Non-Mandatory Transitioning From Originator Etanercept to Biosimilar SB4: 6-Month Results From a Controlled Cohort Study.

scientific article

Patient Acceptable Symptom State in Knee Osteoarthritis Patients Succeeds Across Different Patient-reported Outcome Measures Assessing Physical Function, But Fails Across Other Dimensions and Rheumatic Diseases

scientific article

Perceived need to take medication is associated with medication non-adherence in patients with rheumatoid arthritis

scientific article

Performance of four current risk algorithms in predicting cardiovascular events in patients with early rheumatoid arthritis

scientific article published on 3 January 2014

Personalizing treatment targets in rheumatoid arthritis by using a simple prediction model.

scientific article published on 15 January 2015

Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients

scholarly article by Luz M. Canet et al published 5 October 2018 in The Pharmacogenomics Journal

Polymyalgia rheumatica: new developments and challenges

scientific article published in January 2017

Postural changes, dysphagia, and systemic sclerosis.

scientific article published on June 1998

Practice what you preach? An exploratory multilevel study on rheumatoid arthritis guideline adherence by rheumatologists.

scientific article published on 17 May 2016

Prediction of cardiovascular risk in rheumatoid arthritis: performance of original and adapted SCORE algorithms.

scientific article published on 17 February 2015

Prediction of successful dose reduction or discontinuation of adalimumab, etanercept, or infliximab in rheumatoid arthritis patients using serum drug levels and antidrug antibody measurement

scientific article published on 20 April 2017

Predictive value of ex-vivo drug-inhibited cytokine production for clinical response to biologic DMARD therapy in rheumatoid arthritis

scientific article published on 07 February 2019

Predictive value of serum calprotectin (S100A8/A9) for clinical response after starting or tapering anti-TNF treatment in patients with rheumatoid arthritis.

scientific article

Preface

Prevalence and predictors of health care use in patients with early hip or knee osteoarthritis: two-year follow-up data from the CHECK cohort.

scientific article

Randomized trial of the effectiveness of a non-pharmacological multidisciplinary face-to-face treatment program on daily function compared to a telephone-based treatment program in patients with generalized osteoarthritis.

scientific article published on 14 April 2015

Reactive Rather than Proactive Diabetes Management in the Perioperative Period

scientific article published on 24 April 2017

Regional migratory osteoporosis in a patient with ankylosing spondylitis

scientific article published on 01 January 2009

Reply

Response to: 'Effectiveness of low-dose radiation therapy on symptoms in patients with knee osteoarthritis' by Wu et al

scientific article published on 04 January 2019

Response to: 'Is it time to redefine the role of low-dose radiotherapy for benign disease?' by Montero et al

scientific article published on 01 February 2019

Responsiveness of four patient-reported outcome measures to assess physical function in patients with knee osteoarthritis

scientific article published on 7 April 2016

Rheumatologists' guideline adherence in rheumatoid arthritis: a randomised controlled study on electronic decision support, education and feedback

scientific article published on 5 June 2017

Serious infection due to biologicals: risk only mildly elevated in patients with rheumatoid arthritis

scientific article

Should we redefine treatment targets in rheumatoid arthritis? Low disease activity is sufficiently strict for patients who are anticitrullinated protein antibody-negative.

scientific article published in June 2013

Statins inhibit the antirheumatic effects of rituximab in rheumatoid arthritis: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry

scientific article published on 18 October 2010

Subjective Complaints as the Main Reason for Biosimilar Discontinuation After Open-Label Transition From Reference Infliximab to Biosimilar Infliximab

scientific article

Survival during treatment with tumour necrosis factor blocking agents in rheumatoid arthritis.

scientific article published on November 2003

Sustained effect after lowering high-dose infliximab in patients with rheumatoid arthritis: a prospective dose titration study

scientific article published on 31 January 2008

The Dutch Lower Extremity Functional Scale was highly reliable, valid and responsive in individuals with hip/knee osteoarthritis: a validation study ⬇️

scientific article published on July 2, 2012

The combined use of disease activity and infliximab serum trough concentrations for early prediction of (non-)response to infliximab in rheumatoid arthritis.

scientific article published on December 2013

The course of ultrasonographic abnormalities in knee osteoarthritis: 1 year follow up

scientific article published on 01 October 2014

The effect of disease duration and disease activity on the risk of cardiovascular disease in rheumatoid arthritis patients

scientific article published on 23 January 2014

The effects of doxycycline on reducing symptoms in knee osteoarthritis: results from a triple-blinded randomised controlled trial.

scientific article

The effects of methotrexate and hydroxychloroquine combination therapy vs methotrexate monotherapy in early rheumatoid arthritis patients

scientific article published on 01 January 2019

The efficacy and safety of low-dose radiotherapy on pain and functioning in patients with osteoarthritis: a systematic review

scientific article

The patient perspective on biologic DMARD dose reduction in rheumatoid arthritis: a mixed methods study

scientific article published on 01 November 2018

The reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent does not influence the effect of a second TNF blocking agent in patients with rheumatoid arthritis

scientific article published on 01 September 2009

The use of different methods for rapid determination of the ESR induces DAS28 misclassification in clinical practice.

scientific article published on July 2010

Therapeutic drug monitoring of biologicals in rheumatoid arthritis: a disconnect between beliefs and facts.

scientific article published on 31 January 2018

Tight controlled dose reduction of biologics in psoriasis patients with low disease activity: a randomized pragmatic non-inferiority trial

scientific article

Time to achieve remission determines time to be in remission.

scientific article

Treating to target in established rheumatoid arthritis: Challenges and opportunities in an era of novel targeted therapies and biosimilars.

scientific article published on August 2015

Treating to the target of remission in early rheumatoid arthritis is cost-effective: results of the DREAM registry.

scientific article

Treatment changes and improved outcomes in RA: an overview of a large inception cohort from 1989 to 2009.

scientific article

Treatment outcomes of a Numeric Rating Scale (NRS)-guided pharmacological pain management strategy in symptomatic knee and hip osteoarthritis in daily clinical practice

scientific article published on 01 March 2012

Treatment strategies aiming at remission in early rheumatoid arthritis patients: starting with methotrexate monotherapy is cost-effective

scientific article published on 02 March 2011

Ultrasonographic analysis in knee osteoarthritis: evaluation of inter-observer reliability

scientific article published on 01 September 2012

Ultrasonographic features in symptomatic osteoarthritis of the knee and relation with pain

scientific article published on 04 April 2014

Ultrasonographic predictors for clinical and radiological progression in knee osteoarthritis after 2 years of follow-up

scientific article published on 23 June 2015

Validation of a clinical pharmacogenetic model to predict methotrexate nonresponse in rheumatoid arthritis patients

scientific article published on 10 January 2019

Validation study of existing gene expression signatures for anti-TNF treatment in patients with rheumatoid arthritis

scientific article

What causes a small increase in radiographic progression in rheumatoid arthritis patients tapering TNF inhibitors?

scientific article published on 20 March 2017

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