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List of works by Andrew Worth

3D QSAR investigation of the blood-brain barrier penetration of chemical compounds

scientific article published in February 2005

A feasibility study developing an integrated testing strategy assessing skin irritation potential of chemicals

scientific article published on 21 May 2008

A rule for designing safer nanomaterials: do not interfere with the cellular redox equilibrium

scientific article published on 16 September 2013

A theoretical framework for predicting the oxidative stress potential of oxide nanoparticles

scientific article published on 15 July 2010

Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods

scientific article published on 01 November 2017

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

scientific article

Alternatives for skin sensitisation: Hazard identification and potency categorisation: Report from an EPAA/CEFIC LRI/Cosmetics Europe cross sector workshop, ECHA Helsinki, April 23rd and 24th 2015.

scientific article published on 8 October 2015

An evaluation of the implementation of the Cramer classification scheme in the Toxtree software

scientific article published in July 2008

An integrated approach for bioaccumulation assessment in mussels: Towards the development of Environmental Quality Standards for biota ⬇️

scientific article published on October 30, 2010

Analysis of the Local Lymph Node Assay (LLNA) variability for assessing the prediction of skin sensitisation potential and potency of chemicals with non-animal approaches

scientific article

Application of physiologically-based toxicokinetic modelling in oral-to-dermal extrapolation of threshold doses of cosmetic ingredients

scientific article published on 13 April 2014

Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop.

scientific article published on 25 September 2017

Applying Adverse Outcome Pathways (AOPs) to support Integrated Approaches to Testing and Assessment (IATA).

scientific article published on 27 September 2014

Applying quantitative structure-activity relationship approaches to nanotoxicology: current status and future potential.

scientific article published on 16 November 2012

Assessing herbal products with health claims

scientific article

CERAPP: Collaborative Estrogen Receptor Activity Prediction Project

scientific article published in July 2016

COMPARISON OF THE APPLICABILITY DOMAIN OF A QUANTITATIVE STRUCTURE–ACTIVITY RELATIONSHIP FOR ESTROGENICITY WITH A LARGE CHEMICAL INVENTORY

scientific article published on 01 May 2006

COSMOS next generation – A public knowledge base leveraging chemical and biological data to support the regulatory assessment of chemicals

scientific article published in 2021

Calculations of acute intravenous toxicity in mice based on local regression models in superoverlapping clusters (LRMSC)

Can currently available non-animal methods detect pre and pro-haptens relevant for skin sensitization?

scientific article published on 26 August 2016

Can in vitro mammalian cell genotoxicity test results be used to complement positive results in the Ames test and help predict carcinogenic or in vivo genotoxic activity? I. Reports of individual databases presented at an EURL ECVAM Workshop.

scientific article published on 23 October 2014

Capturing the applicability of in vitro-in silico membrane transporter data in chemical risk assessment and biomedical research

scientific article published on 14 July 2018

Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment

scientific article published on 09 May 2019

Challenges in working towards an internal threshold of toxicological concern (iTTC) for use in the safety assessment of cosmetics: Discussions from the Cosmetics Europe iTTC Working Group workshop

scientific article published on 15 January 2019

Chemical Safety Assessment Using Read-Across: Assessing the Use of Novel Testing Methods to Strengthen the Evidence Base for Decision Making

scientific article

Computational methods to predict the reactivity of nanoparticles through structure-property relationships

scientific article published on March 2010

Computational models for the assessment of manufactured nanomaterials: Development of model reporting standards and mapping of the model landscape

article

Computational toxicology at the European Commission's Joint Research Centre

scientific article published on July 2010

Computer models versus reality: how well do in silico models currently predict the sensitization potential of a substance

scientific article published on 30 September 2013

Consensus of classification trees for skin sensitisation hazard prediction

scientific article published on 22 July 2016

Corrigendum to “Establishing the level of safety concern for chemicals in food without the need for toxicity testing” [Regul. Toxicol. Pharmacol. 68 (2014) 275–296]

article

Development and analysis of an adverse outcome pathway network for human neurotoxicity

scientific article published on 23 August 2019

Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance

scientific article published on 09 August 2018

Establishing the level of safety concern for chemicals in food without the need for toxicity testing

scientific article published on 5 September 2013

Establishment of an in vitro reporter gene assay for developmental cardiac toxicity

scientific article

Evaluation of SARs for the prediction of eye irritation/corrosion potential–structural inclusion rules in the BfR decision support system†

scientific article published on 01 May 2007

Evaluation of SARs for the prediction of skin irritation/corrosion potential–structural inclusion rules in the BfR decision support system†

scientific article published on 01 May 2007

Exploring waiving opportunities for mammalian acute systemic toxicity tests

scientific article published on July 2016

From in vitro to in vivo: Integration of the virtual cell based assay with physiologically based kinetic modelling

scientific article published on 26 June 2017

Grouping of nanomaterials to read-across hazard endpoints: a review

scientific article published on 05 September 2018

Grouping of nanomaterials to read-across hazard endpoints: from data collection to assessment of the grouping hypothesis by application of chemoinformatic techniques

scientific article published on 24 September 2018

Improving the application of quantitative methods in validation work.

scientific article

In Silico Models for Acute Systemic Toxicity

scientific article published on January 2016

In vitro-to-in vivo correlation of the skin penetration, liver clearance and hepatotoxicity of caffeine

scientific article

Insights into in vitro biokinetics using Virtual Cell Based Assay simulations

scientific article published on 28 March 2019

Integrated Approaches to Testing and Assessment

scientific article published on January 2016

Investigating cell type specific mechanisms contributing to acute oral toxicity

scientific article published on 12 July 2018

Investigating the state of physiologically based kinetic modelling practices and challenges associated with gaining regulatory acceptance of model applications

scientific article published on 30 August 2017

Membrane transporter data to support kinetically-informed chemical risk assessment using non-animal methods: Scientific and regulatory perspectives

scientific article published on 08 March 2019

Mode of action-based classification and prediction of activity of uncouplers for the screening of chemical inventories

scientific article published on 01 January 2008

Modeling the structure-property relationships of nanoneedles: A journey toward nanomedicine

scientific article published on January 2009

Multiscale modelling approaches for assessing cosmetic ingredients safety.

scientific article

New publicly available chemical query language, CSRML, to support chemotype representations for application to data mining and modeling

scientific article published on 19 February 2015

Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making ⬇️

scientific article published on 01 February 2019

Physiologically based mathematical models of nanomaterials for regulatory toxicology: A review

scientific article published on 01 February 2019

Practical use of the Virtual Cell Based Assay: Simulation of repeated exposure experiments in liver cell lines.

scientific article published on 13 October 2016

Predicting toxicity of nanoparticles

article

Prediction of Acute Rodent Toxicity on the Basis of Chemical Structure and Physicochemical Similarity.

scientific article published on 17 March 2011

Prediction of acute toxicity to mice by the Arithmetic Mean Toxicity (AMT) modelling approach

article

Prediction of estrogenicity: validation of a classification model

scientific article published on 01 April 2006

Publicly-accessible QSAR software tools developed by the Joint Research Centre.

scientific article published on January 2008

QSAR Methods

scientific article published on January 2016

QSAR and Metabolic Assessment Tools in the Assessment of Genotoxicity

scientific article published on 01 January 2013

QSAR modeling of nanomaterials

scientific article published on 07 March 2011

QSARS for toxicity to the bacterium Sinorhizobium meliloti.

scientific article

Qsar investigation of a large data set for fish, algae and Daphnia toxicity

scientific article

Quantitative adverse outcome pathway (qAOP) models for toxicity prediction

scientific article published on 18 May 2020

Quantitative structure-activity relationships for human health effects: commonalities with other endpoints

scientific article

Quantitative structure-skin permeability relationships.

scientific article

Quantitative structure–activity–activity and quantitative structure–activity investigations of human and rodent toxicity

scientific article published on 22 May 2006

Recent advances in the molecular modeling of estrogen receptor-mediated toxicity

scientific article published on January 2011

Regulatory assessment and risk management of chemical mixtures: challenges and ways forward

scientific article published on 01 February 2019

Regulatory assessment of chemical mixtures: Requirements, current approaches and future perspectives

scientific article

Role of Physiologically Based Kinetic modelling in addressing environmental chemical mixtures – A review

scientific article published on 01 May 2019

Role of in silico genotoxicity tools in the regulatory assessment of pharmaceutical impurities.

scientific article published on 28 February 2012

Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods

scientific article published on 21 February 2018

Structural analysis and predictive value of the rodent in vivo micronucleus assay results

scientific article published in March 2010

Structural motifs modulating the carcinogenic risk of aromatic amines

article published in 2009

Structure-Based Classification of Antibacterial Activity

article

Testing strategies for the safety of nanoparticles used in medical applications

scientific article published on 01 August 2009

The ECVAM International Validation Study on In Vitro Tests for Skin Corrosivity. 1. Selection and Distribution of the Test Chemicals

scientific article

The Role of Qsar Methodology in the Regulatory Assessment of Chemicals

The acute effects of daily nicotine intake on heart rate--a toxicokinetic and toxicodynamic modelling study

scientific article

The application of molecular modelling in the safety assessment of chemicals: A case study on ligand-dependent PPARγ dysregulation.

scientific article published on 30 January 2016

The importance of hydrophobicity and electrophilicity descriptors in mechanistically-based QSARs for toxicological endpoints

scientific article

The influence of inter-particle forces on diffusion at the nanoscale

scientific article published on 03 September 2019

The margin of internal exposure (MOIE) concept for dermal risk assessment based on oral toxicity data - A case study with caffeine.

scientific article

The prospects for using (Q)SARs in a changing political environment--high expectations and a key role for the european commission's joint research centre

scientific article published on 01 October 2004

The role of the European centre for the validation of alternative methods (ECVAM) in the validation of (Q)SARs

scientific article published on 01 October 2004

The use of discriminant analysis, logistic regression and classification tree analysis in the development of classification models for human health effects

The use of genetically engineered cells for assessing CYP2D6-related polymorphic effects

scientific article

The use of pH measurements to predict the potential of chemicals to cause acute dermal and ocular toxicity

article

The virtual cell based assay: Current status and future perspectives.

scientific article published on 17 January 2017

Theoretical and mathematical foundation of the Virtual Cell Based Assay - A review

scientific article

Thresholds of Toxicological Concern for cosmetics-related substances: New database, thresholds, and enrichment of chemical space

scientific article published on 31 August 2017

Thresholds of toxicological concern for endocrine active substances in the aquatic environment

scientific article published on January 2010

Towards an alternative testing strategy for nanomaterials used in nanomedicine: lessons from NanoTEST.

scientific article published on May 2015

Toxicity Testing, Modeling

article

Toxmatch–a new software tool to aid in the development and evaluation of chemically similar groups

article

Toxmatch—A chemical classification and activity prediction tool based on similarity measures

scientific article published on 09 July 2008

Tuning the electronic properties by width and length modifications of narrow- diameter carbon nanotubes for nanomedicine

scientific article

Unlocking the potential of in silico chemical safety assessment - A report on a cross-sector symposium on current opportunities and future challenges

scientific article published on 01 May 2019

Use of New Approach Methodologies (NAMs) in regulatory decisions for chemical safety: Report from an EPAA Deep Dive Workshop

scientific article published in 2022

Use of computational tools in the field of food safety

scientific article published on 12 May 2011

Validation of Computational Methods

scientific article published on January 2016

Validation of a QSAR model for acute toxicity

scientific article published in April 2006

Validation of counter propagation neural network models for predictive toxicology according to the OECD principles: a case study

scientific article published in June 2006

Virtual Cell Based Assay simulations of intra-mitochondrial concentrations in hepatocytes and cardiomyocytes.

scientific article published on 11 September 2017

Waiving chronic fish tests: possible use of acute-to-chronic relationships and interspecies correlations

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